Sudden unexpected death in children with epilepsy: the many faces of fungal pathogenicity
Autor(a) principal: | |
---|---|
Data de Publicação: | 2012 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/35099 http://dx.doi.org/10.1016/j.mehy.2012.03.015 |
Resumo: | Epilepsy is one of the most prevalent neurological diseases worldwide. the mortality rates are considerably higher in people with epilepsy than would be expected in a healthy population and sudden unexpected death in epilepsy (SUDEP) is the most frequent epilepsy-related category of death. Most children had seizures before the occurrence of the fatal event and autonomic dysfunction has been proposed as mechanisms of sudden death in this population. Is this sense, we raise the question whether is there a possible relationship between SUDEP in children and fungal pathogenicity. Indeed, the role of fungal pathogenicity in the establishment of epilepsy and even in cases of SUDEP has an interesting role in this scenario. Moreover, maternal infections during pregnancy have been associated with an increased risk for several brain disorders, however, this fact is still considered uncertain with respect to epilepsy.Based on this information and considering that maternal-fetal yeast infection is directly associated with an increased risk for epilepsy in childhood and that some patients have medically intractable epilepsy, the chances of these children suffering a fatal event cannot be overlooked by healthcare professionals. Thus, as exact knowledge regarding this association is lacking, some possibilities could be evaluated, and more emphasis on translational research would contribute to further progress to the knowledge of SUDEP. (C) 2012 Elsevier B.V. All rights reserved. |
id |
UFSP_ed513f149339575d63be2faa202d76c8 |
---|---|
oai_identifier_str |
oai:repositorio.unifesp.br:11600/35099 |
network_acronym_str |
UFSP |
network_name_str |
Repositório Institucional da UNIFESP |
repository_id_str |
3465 |
spelling |
Andersen, Monica Levy [UNIFESP]Tufik, Sergio [UNIFESP]Colombo, Arnaldo Lopes [UNIFESP]Cavalheiro, Esper Abrão [UNIFESP]Cysneiros, Roberta Monterazzo [UNIFESP]Scorza, Fulvio Alexandre [UNIFESP]Universidade Federal de São Paulo (UNIFESP)UPM2016-01-24T14:27:28Z2016-01-24T14:27:28Z2012-08-01Medical Hypotheses. Edinburgh: Churchill Livingstone, v. 79, n. 2, p. 127-128, 2012.0306-9877http://repositorio.unifesp.br/handle/11600/35099http://dx.doi.org/10.1016/j.mehy.2012.03.015WOS000306770700001.pdf10.1016/j.mehy.2012.03.015WOS:000306770700001Epilepsy is one of the most prevalent neurological diseases worldwide. the mortality rates are considerably higher in people with epilepsy than would be expected in a healthy population and sudden unexpected death in epilepsy (SUDEP) is the most frequent epilepsy-related category of death. Most children had seizures before the occurrence of the fatal event and autonomic dysfunction has been proposed as mechanisms of sudden death in this population. Is this sense, we raise the question whether is there a possible relationship between SUDEP in children and fungal pathogenicity. Indeed, the role of fungal pathogenicity in the establishment of epilepsy and even in cases of SUDEP has an interesting role in this scenario. Moreover, maternal infections during pregnancy have been associated with an increased risk for several brain disorders, however, this fact is still considered uncertain with respect to epilepsy.Based on this information and considering that maternal-fetal yeast infection is directly associated with an increased risk for epilepsy in childhood and that some patients have medically intractable epilepsy, the chances of these children suffering a fatal event cannot be overlooked by healthcare professionals. Thus, as exact knowledge regarding this association is lacking, some possibilities could be evaluated, and more emphasis on translational research would contribute to further progress to the knowledge of SUDEP. (C) 2012 Elsevier B.V. All rights reserved.Universidade Federal de São Paulo, Escola Paulista Med UNIFESP EPM, Disciplina Neurol Expt, São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med UNIFESP EPM, Dept Psicobiol, São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med UNIFESP EPM, Disciplina Doencas Infecciosas, Dept Med, São Paulo, BrazilUPM, Neurobiol Lab, Programa Posgrad Disturbios Desenvolvimento, São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med UNIFESP EPM, Disciplina Neurol Expt, São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med UNIFESP EPM, Dept Psicobiol, São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med UNIFESP EPM, Disciplina Doencas Infecciosas, Dept Med, São Paulo, BrazilWeb of Science127-128engChurchill LivingstoneMedical HypothesesSudden unexpected death in children with epilepsy: the many faces of fungal pathogenicityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000306770700001.pdfapplication/pdf254643${dspace.ui.url}/bitstream/11600/35099/1/WOS000306770700001.pdfe9c9ae53aa80198fadbf5a8490cfe64cMD51open accessTEXTWOS000306770700001.pdf.txtWOS000306770700001.pdf.txtExtracted texttext/plain11480${dspace.ui.url}/bitstream/11600/35099/2/WOS000306770700001.pdf.txtc3fe7601b26a6fbd9eab903beac9d356MD52open access11600/350992021-10-05 21:28:54.026open accessoai:repositorio.unifesp.br:11600/35099Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652021-10-06T00:28:54Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Sudden unexpected death in children with epilepsy: the many faces of fungal pathogenicity |
title |
Sudden unexpected death in children with epilepsy: the many faces of fungal pathogenicity |
spellingShingle |
Sudden unexpected death in children with epilepsy: the many faces of fungal pathogenicity Andersen, Monica Levy [UNIFESP] |
title_short |
Sudden unexpected death in children with epilepsy: the many faces of fungal pathogenicity |
title_full |
Sudden unexpected death in children with epilepsy: the many faces of fungal pathogenicity |
title_fullStr |
Sudden unexpected death in children with epilepsy: the many faces of fungal pathogenicity |
title_full_unstemmed |
Sudden unexpected death in children with epilepsy: the many faces of fungal pathogenicity |
title_sort |
Sudden unexpected death in children with epilepsy: the many faces of fungal pathogenicity |
author |
Andersen, Monica Levy [UNIFESP] |
author_facet |
Andersen, Monica Levy [UNIFESP] Tufik, Sergio [UNIFESP] Colombo, Arnaldo Lopes [UNIFESP] Cavalheiro, Esper Abrão [UNIFESP] Cysneiros, Roberta Monterazzo [UNIFESP] Scorza, Fulvio Alexandre [UNIFESP] |
author_role |
author |
author2 |
Tufik, Sergio [UNIFESP] Colombo, Arnaldo Lopes [UNIFESP] Cavalheiro, Esper Abrão [UNIFESP] Cysneiros, Roberta Monterazzo [UNIFESP] Scorza, Fulvio Alexandre [UNIFESP] |
author2_role |
author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) UPM |
dc.contributor.author.fl_str_mv |
Andersen, Monica Levy [UNIFESP] Tufik, Sergio [UNIFESP] Colombo, Arnaldo Lopes [UNIFESP] Cavalheiro, Esper Abrão [UNIFESP] Cysneiros, Roberta Monterazzo [UNIFESP] Scorza, Fulvio Alexandre [UNIFESP] |
description |
Epilepsy is one of the most prevalent neurological diseases worldwide. the mortality rates are considerably higher in people with epilepsy than would be expected in a healthy population and sudden unexpected death in epilepsy (SUDEP) is the most frequent epilepsy-related category of death. Most children had seizures before the occurrence of the fatal event and autonomic dysfunction has been proposed as mechanisms of sudden death in this population. Is this sense, we raise the question whether is there a possible relationship between SUDEP in children and fungal pathogenicity. Indeed, the role of fungal pathogenicity in the establishment of epilepsy and even in cases of SUDEP has an interesting role in this scenario. Moreover, maternal infections during pregnancy have been associated with an increased risk for several brain disorders, however, this fact is still considered uncertain with respect to epilepsy.Based on this information and considering that maternal-fetal yeast infection is directly associated with an increased risk for epilepsy in childhood and that some patients have medically intractable epilepsy, the chances of these children suffering a fatal event cannot be overlooked by healthcare professionals. Thus, as exact knowledge regarding this association is lacking, some possibilities could be evaluated, and more emphasis on translational research would contribute to further progress to the knowledge of SUDEP. (C) 2012 Elsevier B.V. All rights reserved. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012-08-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:27:28Z |
dc.date.available.fl_str_mv |
2016-01-24T14:27:28Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Medical Hypotheses. Edinburgh: Churchill Livingstone, v. 79, n. 2, p. 127-128, 2012. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/35099 http://dx.doi.org/10.1016/j.mehy.2012.03.015 |
dc.identifier.issn.none.fl_str_mv |
0306-9877 |
dc.identifier.file.none.fl_str_mv |
WOS000306770700001.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.mehy.2012.03.015 |
dc.identifier.wos.none.fl_str_mv |
WOS:000306770700001 |
identifier_str_mv |
Medical Hypotheses. Edinburgh: Churchill Livingstone, v. 79, n. 2, p. 127-128, 2012. 0306-9877 WOS000306770700001.pdf 10.1016/j.mehy.2012.03.015 WOS:000306770700001 |
url |
http://repositorio.unifesp.br/handle/11600/35099 http://dx.doi.org/10.1016/j.mehy.2012.03.015 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Medical Hypotheses |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
127-128 |
dc.publisher.none.fl_str_mv |
Churchill Livingstone |
publisher.none.fl_str_mv |
Churchill Livingstone |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
bitstream.url.fl_str_mv |
${dspace.ui.url}/bitstream/11600/35099/1/WOS000306770700001.pdf ${dspace.ui.url}/bitstream/11600/35099/2/WOS000306770700001.pdf.txt |
bitstream.checksum.fl_str_mv |
e9c9ae53aa80198fadbf5a8490cfe64c c3fe7601b26a6fbd9eab903beac9d356 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1802764125699309568 |