Effects of alcohol on sleep parameters of sleep-deprived healthy volunteers

Detalhes bibliográficos
Autor(a) principal: Lobo, Leticia L. [UNIFESP]
Data de Publicação: 1997
Outros Autores: Tufik, Sergio [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: https://doi.org/10.1093/sleep/20.1.52
http://repositorio.unifesp.br/handle/11600/45602
Resumo: Both partial and total sleep deprivation frequently result in a rebound of paradoxical sleep (PS), as well as of slow-wave or delta sleep. Acute administration of ethanol inhibits PS in normal volunteers. This effect is dose-dependent and consists of increased latency to and reduced duration of paradoxical sleep. It has also been shown that PS rebound may occur on the same night, as blood alcohol concentration (BAC) declines. The present study examined the effects of sleep deprivation prior to ethanol administration on nocturnal-sleep parameters in healthy male volunteers. Polysomnograms were performed with a randomized, crossover design on baseline, placebo, post-placebo, ethanol (0.9 g/kg), and post-ethanol recovery nights. Subjects were submitted to partial (PSD) (n = 6) or total (TSD) (n = 6) sleep deprivation for 40 hours before placebo or ethanol conditions. Results evidenced a PS inhibition after ethanol treatment in both deprivation groups, despite their sleep debt (PSD, placebo = 103.7 minutes and ethanol = 72.7 minutes; TSD, placebo = 111.8 minutes and ethanol = 76.6 minutes). This inhibition was BAC-dependent and specific to PS, since delta sleep remained unaltered. These effects could be due to the reduction of cholinergic release and/or glutamatergic inhibition, both of which modulate acetylcholine release.
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spelling Effects of alcohol on sleep parameters of sleep-deprived healthy volunteerspartial sleep deprivationtotal sleep deprivationparadoxical (REM) sleepdelta sleepethanolvolunteersBoth partial and total sleep deprivation frequently result in a rebound of paradoxical sleep (PS), as well as of slow-wave or delta sleep. Acute administration of ethanol inhibits PS in normal volunteers. This effect is dose-dependent and consists of increased latency to and reduced duration of paradoxical sleep. It has also been shown that PS rebound may occur on the same night, as blood alcohol concentration (BAC) declines. The present study examined the effects of sleep deprivation prior to ethanol administration on nocturnal-sleep parameters in healthy male volunteers. Polysomnograms were performed with a randomized, crossover design on baseline, placebo, post-placebo, ethanol (0.9 g/kg), and post-ethanol recovery nights. Subjects were submitted to partial (PSD) (n = 6) or total (TSD) (n = 6) sleep deprivation for 40 hours before placebo or ethanol conditions. Results evidenced a PS inhibition after ethanol treatment in both deprivation groups, despite their sleep debt (PSD, placebo = 103.7 minutes and ethanol = 72.7 minutes; TSD, placebo = 111.8 minutes and ethanol = 76.6 minutes). This inhibition was BAC-dependent and specific to PS, since delta sleep remained unaltered. These effects could be due to the reduction of cholinergic release and/or glutamatergic inhibition, both of which modulate acetylcholine release.UNIV FED SAO PAULO,ESCOLA PAULISTA MED,DEPT PSYCHOBIOL,BR-04023062 SAO PAULO,BRAZILUNIV FED SAO PAULO,ESCOLA PAULISTA MED,DEPT PSYCHOBIOL,BR-04023062 SAO PAULO,BRAZILWeb of ScienceAmer Sleep Disorders AssocUniversidade Federal de São Paulo (UNIFESP)Lobo, Leticia L. [UNIFESP]Tufik, Sergio [UNIFESP]2018-06-18T12:11:57Z2018-06-18T12:11:57Z1997-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion52-59https://doi.org/10.1093/sleep/20.1.52Sleep. Rochester: Amer Sleep Disorders Assoc, v. 20, n. 1, p. 52-59, 1997.0161-8105http://repositorio.unifesp.br/handle/11600/45602WOS:A1997WV60300009engSleepinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-05-02T13:44:22Zoai:repositorio.unifesp.br/:11600/45602Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-05-02T13:44:22Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Effects of alcohol on sleep parameters of sleep-deprived healthy volunteers
title Effects of alcohol on sleep parameters of sleep-deprived healthy volunteers
spellingShingle Effects of alcohol on sleep parameters of sleep-deprived healthy volunteers
Lobo, Leticia L. [UNIFESP]
partial sleep deprivation
total sleep deprivation
paradoxical (REM) sleep
delta sleep
ethanol
volunteers
title_short Effects of alcohol on sleep parameters of sleep-deprived healthy volunteers
title_full Effects of alcohol on sleep parameters of sleep-deprived healthy volunteers
title_fullStr Effects of alcohol on sleep parameters of sleep-deprived healthy volunteers
title_full_unstemmed Effects of alcohol on sleep parameters of sleep-deprived healthy volunteers
title_sort Effects of alcohol on sleep parameters of sleep-deprived healthy volunteers
author Lobo, Leticia L. [UNIFESP]
author_facet Lobo, Leticia L. [UNIFESP]
Tufik, Sergio [UNIFESP]
author_role author
author2 Tufik, Sergio [UNIFESP]
author2_role author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Lobo, Leticia L. [UNIFESP]
Tufik, Sergio [UNIFESP]
dc.subject.por.fl_str_mv partial sleep deprivation
total sleep deprivation
paradoxical (REM) sleep
delta sleep
ethanol
volunteers
topic partial sleep deprivation
total sleep deprivation
paradoxical (REM) sleep
delta sleep
ethanol
volunteers
description Both partial and total sleep deprivation frequently result in a rebound of paradoxical sleep (PS), as well as of slow-wave or delta sleep. Acute administration of ethanol inhibits PS in normal volunteers. This effect is dose-dependent and consists of increased latency to and reduced duration of paradoxical sleep. It has also been shown that PS rebound may occur on the same night, as blood alcohol concentration (BAC) declines. The present study examined the effects of sleep deprivation prior to ethanol administration on nocturnal-sleep parameters in healthy male volunteers. Polysomnograms were performed with a randomized, crossover design on baseline, placebo, post-placebo, ethanol (0.9 g/kg), and post-ethanol recovery nights. Subjects were submitted to partial (PSD) (n = 6) or total (TSD) (n = 6) sleep deprivation for 40 hours before placebo or ethanol conditions. Results evidenced a PS inhibition after ethanol treatment in both deprivation groups, despite their sleep debt (PSD, placebo = 103.7 minutes and ethanol = 72.7 minutes; TSD, placebo = 111.8 minutes and ethanol = 76.6 minutes). This inhibition was BAC-dependent and specific to PS, since delta sleep remained unaltered. These effects could be due to the reduction of cholinergic release and/or glutamatergic inhibition, both of which modulate acetylcholine release.
publishDate 1997
dc.date.none.fl_str_mv 1997-01-01
2018-06-18T12:11:57Z
2018-06-18T12:11:57Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.1093/sleep/20.1.52
Sleep. Rochester: Amer Sleep Disorders Assoc, v. 20, n. 1, p. 52-59, 1997.
0161-8105
http://repositorio.unifesp.br/handle/11600/45602
WOS:A1997WV60300009
url https://doi.org/10.1093/sleep/20.1.52
http://repositorio.unifesp.br/handle/11600/45602
identifier_str_mv Sleep. Rochester: Amer Sleep Disorders Assoc, v. 20, n. 1, p. 52-59, 1997.
0161-8105
WOS:A1997WV60300009
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Sleep
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 52-59
dc.publisher.none.fl_str_mv Amer Sleep Disorders Assoc
publisher.none.fl_str_mv Amer Sleep Disorders Assoc
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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