Effects of alcohol on sleep parameters of sleep-deprived healthy volunteers
Autor(a) principal: | |
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Data de Publicação: | 1997 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://doi.org/10.1093/sleep/20.1.52 http://repositorio.unifesp.br/handle/11600/45602 |
Resumo: | Both partial and total sleep deprivation frequently result in a rebound of paradoxical sleep (PS), as well as of slow-wave or delta sleep. Acute administration of ethanol inhibits PS in normal volunteers. This effect is dose-dependent and consists of increased latency to and reduced duration of paradoxical sleep. It has also been shown that PS rebound may occur on the same night, as blood alcohol concentration (BAC) declines. The present study examined the effects of sleep deprivation prior to ethanol administration on nocturnal-sleep parameters in healthy male volunteers. Polysomnograms were performed with a randomized, crossover design on baseline, placebo, post-placebo, ethanol (0.9 g/kg), and post-ethanol recovery nights. Subjects were submitted to partial (PSD) (n = 6) or total (TSD) (n = 6) sleep deprivation for 40 hours before placebo or ethanol conditions. Results evidenced a PS inhibition after ethanol treatment in both deprivation groups, despite their sleep debt (PSD, placebo = 103.7 minutes and ethanol = 72.7 minutes; TSD, placebo = 111.8 minutes and ethanol = 76.6 minutes). This inhibition was BAC-dependent and specific to PS, since delta sleep remained unaltered. These effects could be due to the reduction of cholinergic release and/or glutamatergic inhibition, both of which modulate acetylcholine release. |
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Effects of alcohol on sleep parameters of sleep-deprived healthy volunteerspartial sleep deprivationtotal sleep deprivationparadoxical (REM) sleepdelta sleepethanolvolunteersBoth partial and total sleep deprivation frequently result in a rebound of paradoxical sleep (PS), as well as of slow-wave or delta sleep. Acute administration of ethanol inhibits PS in normal volunteers. This effect is dose-dependent and consists of increased latency to and reduced duration of paradoxical sleep. It has also been shown that PS rebound may occur on the same night, as blood alcohol concentration (BAC) declines. The present study examined the effects of sleep deprivation prior to ethanol administration on nocturnal-sleep parameters in healthy male volunteers. Polysomnograms were performed with a randomized, crossover design on baseline, placebo, post-placebo, ethanol (0.9 g/kg), and post-ethanol recovery nights. Subjects were submitted to partial (PSD) (n = 6) or total (TSD) (n = 6) sleep deprivation for 40 hours before placebo or ethanol conditions. Results evidenced a PS inhibition after ethanol treatment in both deprivation groups, despite their sleep debt (PSD, placebo = 103.7 minutes and ethanol = 72.7 minutes; TSD, placebo = 111.8 minutes and ethanol = 76.6 minutes). This inhibition was BAC-dependent and specific to PS, since delta sleep remained unaltered. These effects could be due to the reduction of cholinergic release and/or glutamatergic inhibition, both of which modulate acetylcholine release.UNIV FED SAO PAULO,ESCOLA PAULISTA MED,DEPT PSYCHOBIOL,BR-04023062 SAO PAULO,BRAZILUNIV FED SAO PAULO,ESCOLA PAULISTA MED,DEPT PSYCHOBIOL,BR-04023062 SAO PAULO,BRAZILWeb of ScienceAmer Sleep Disorders AssocUniversidade Federal de São Paulo (UNIFESP)Lobo, Leticia L. [UNIFESP]Tufik, Sergio [UNIFESP]2018-06-18T12:11:57Z2018-06-18T12:11:57Z1997-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion52-59https://doi.org/10.1093/sleep/20.1.52Sleep. Rochester: Amer Sleep Disorders Assoc, v. 20, n. 1, p. 52-59, 1997.0161-8105http://repositorio.unifesp.br/handle/11600/45602WOS:A1997WV60300009engSleepinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-05-02T13:44:22Zoai:repositorio.unifesp.br/:11600/45602Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-05-02T13:44:22Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Effects of alcohol on sleep parameters of sleep-deprived healthy volunteers |
title |
Effects of alcohol on sleep parameters of sleep-deprived healthy volunteers |
spellingShingle |
Effects of alcohol on sleep parameters of sleep-deprived healthy volunteers Lobo, Leticia L. [UNIFESP] partial sleep deprivation total sleep deprivation paradoxical (REM) sleep delta sleep ethanol volunteers |
title_short |
Effects of alcohol on sleep parameters of sleep-deprived healthy volunteers |
title_full |
Effects of alcohol on sleep parameters of sleep-deprived healthy volunteers |
title_fullStr |
Effects of alcohol on sleep parameters of sleep-deprived healthy volunteers |
title_full_unstemmed |
Effects of alcohol on sleep parameters of sleep-deprived healthy volunteers |
title_sort |
Effects of alcohol on sleep parameters of sleep-deprived healthy volunteers |
author |
Lobo, Leticia L. [UNIFESP] |
author_facet |
Lobo, Leticia L. [UNIFESP] Tufik, Sergio [UNIFESP] |
author_role |
author |
author2 |
Tufik, Sergio [UNIFESP] |
author2_role |
author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Lobo, Leticia L. [UNIFESP] Tufik, Sergio [UNIFESP] |
dc.subject.por.fl_str_mv |
partial sleep deprivation total sleep deprivation paradoxical (REM) sleep delta sleep ethanol volunteers |
topic |
partial sleep deprivation total sleep deprivation paradoxical (REM) sleep delta sleep ethanol volunteers |
description |
Both partial and total sleep deprivation frequently result in a rebound of paradoxical sleep (PS), as well as of slow-wave or delta sleep. Acute administration of ethanol inhibits PS in normal volunteers. This effect is dose-dependent and consists of increased latency to and reduced duration of paradoxical sleep. It has also been shown that PS rebound may occur on the same night, as blood alcohol concentration (BAC) declines. The present study examined the effects of sleep deprivation prior to ethanol administration on nocturnal-sleep parameters in healthy male volunteers. Polysomnograms were performed with a randomized, crossover design on baseline, placebo, post-placebo, ethanol (0.9 g/kg), and post-ethanol recovery nights. Subjects were submitted to partial (PSD) (n = 6) or total (TSD) (n = 6) sleep deprivation for 40 hours before placebo or ethanol conditions. Results evidenced a PS inhibition after ethanol treatment in both deprivation groups, despite their sleep debt (PSD, placebo = 103.7 minutes and ethanol = 72.7 minutes; TSD, placebo = 111.8 minutes and ethanol = 76.6 minutes). This inhibition was BAC-dependent and specific to PS, since delta sleep remained unaltered. These effects could be due to the reduction of cholinergic release and/or glutamatergic inhibition, both of which modulate acetylcholine release. |
publishDate |
1997 |
dc.date.none.fl_str_mv |
1997-01-01 2018-06-18T12:11:57Z 2018-06-18T12:11:57Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.1093/sleep/20.1.52 Sleep. Rochester: Amer Sleep Disorders Assoc, v. 20, n. 1, p. 52-59, 1997. 0161-8105 http://repositorio.unifesp.br/handle/11600/45602 WOS:A1997WV60300009 |
url |
https://doi.org/10.1093/sleep/20.1.52 http://repositorio.unifesp.br/handle/11600/45602 |
identifier_str_mv |
Sleep. Rochester: Amer Sleep Disorders Assoc, v. 20, n. 1, p. 52-59, 1997. 0161-8105 WOS:A1997WV60300009 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Sleep |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
52-59 |
dc.publisher.none.fl_str_mv |
Amer Sleep Disorders Assoc |
publisher.none.fl_str_mv |
Amer Sleep Disorders Assoc |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268436768882688 |