Cardiovascular Responses Induced by Obstructive Apnea Are Enhanced in Hypertensive Rats Due to Enhanced Chemoreceptor Responsivity
Autor(a) principal: | |
---|---|
Data de Publicação: | 2014 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/37324 http://dx.doi.org/10.1371/journal.pone.0086868 |
Resumo: | Spontaneously hypertensive rats (SHR), like patients with sleep apnea, have hypertension, increased sympathetic activity, and increased chemoreceptor drive. We investigated the role of carotid chemoreceptors in cardiovascular responses induced by obstructive apnea in awake SHR. A tracheal balloon and vascular cannulas were implanted, and a week later, apneas of 15 s each were induced. the effects of apnea were more pronounced in SHR than in control rats (Wistar Kyoto; WKY). Blood pressure increased by 57 +/- 3 mmHg during apnea in SHR and by 28 +/- 3 mmHg in WKY (p < 0.05, n = 14/13). the respiratory effort increased by 53 +/- 6 mmHg in SHR and by 34 +/- 5 mmHg in WKY. the heart rate fell by 209 +/- 19 bpm in SHR and by 155 +/- 16 bpm in WKY. the carotid chemoreceptors were then inactivated by the ligation of the carotid body artery, and apneas were induced two days later. the inactivation of chemoreceptors reduced the responses to apnea and abolished the difference between SHR and controls. the apnea-induced hypertension was 11 +/- 4 mmHg in SHR and 8 +/- 4 mmHg in WKY. the respiratory effort was 15 +/- 2 mmHg in SHR and 15 +/- 2 mmHg in WKY. the heart rate fell 63 +/- 18 bpm in SHR and 52 +/- 14 bpm in WKY. Similarly, when the chemoreceptors were unloaded by the administration of 100% oxygen, the responses to apnea were reduced. in conclusion, arterial chemoreceptors contribute to the responses induced by apnea in both strains, but they are more important in SHR and account for the exaggerated responses of this strain to apnea. |
id |
UFSP_ee283bc5bb29d40e11cf23d01816bbd3 |
---|---|
oai_identifier_str |
oai:repositorio.unifesp.br:11600/37324 |
network_acronym_str |
UFSP |
network_name_str |
Repositório Institucional da UNIFESP |
repository_id_str |
3465 |
spelling |
Angheben, Juliana M. M. [UNIFESP]Schoorlemmer, Gerhardus Hermanus Maria [UNIFESP]Rossi, Marcio V. [UNIFESP]Silva, Thiago A. [UNIFESP]Cravo, Sergio Luiz [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2016-01-24T14:35:09Z2016-01-24T14:35:09Z2014-01-23Plos One. San Francisco: Public Library Science, v. 9, n. 1, 9 p., 2014.1932-6203http://repositorio.unifesp.br/handle/11600/37324http://dx.doi.org/10.1371/journal.pone.0086868WOS000330288000160.pdf10.1371/journal.pone.0086868WOS:000330288000160Spontaneously hypertensive rats (SHR), like patients with sleep apnea, have hypertension, increased sympathetic activity, and increased chemoreceptor drive. We investigated the role of carotid chemoreceptors in cardiovascular responses induced by obstructive apnea in awake SHR. A tracheal balloon and vascular cannulas were implanted, and a week later, apneas of 15 s each were induced. the effects of apnea were more pronounced in SHR than in control rats (Wistar Kyoto; WKY). Blood pressure increased by 57 +/- 3 mmHg during apnea in SHR and by 28 +/- 3 mmHg in WKY (p < 0.05, n = 14/13). the respiratory effort increased by 53 +/- 6 mmHg in SHR and by 34 +/- 5 mmHg in WKY. the heart rate fell by 209 +/- 19 bpm in SHR and by 155 +/- 16 bpm in WKY. the carotid chemoreceptors were then inactivated by the ligation of the carotid body artery, and apneas were induced two days later. the inactivation of chemoreceptors reduced the responses to apnea and abolished the difference between SHR and controls. the apnea-induced hypertension was 11 +/- 4 mmHg in SHR and 8 +/- 4 mmHg in WKY. the respiratory effort was 15 +/- 2 mmHg in SHR and 15 +/- 2 mmHg in WKY. the heart rate fell 63 +/- 18 bpm in SHR and 52 +/- 14 bpm in WKY. Similarly, when the chemoreceptors were unloaded by the administration of 100% oxygen, the responses to apnea were reduced. in conclusion, arterial chemoreceptors contribute to the responses induced by apnea in both strains, but they are more important in SHR and account for the exaggerated responses of this strain to apnea.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Universidade Federal de São Paulo, Escola Paulista Med, Dept Physiol, São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med, Dept Physiol, São Paulo, BrazilFAPESP: 2010/19705-6CNPq: 472187/2010-4Web of Science9engPublic Library SciencePlos OneCardiovascular Responses Induced by Obstructive Apnea Are Enhanced in Hypertensive Rats Due to Enhanced Chemoreceptor Responsivityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000330288000160.pdfapplication/pdf615328${dspace.ui.url}/bitstream/11600/37324/1/WOS000330288000160.pdf5895c102430c3a22b55c08f62008cd16MD51open accessTEXTWOS000330288000160.pdf.txtWOS000330288000160.pdf.txtExtracted texttext/plain33578${dspace.ui.url}/bitstream/11600/37324/2/WOS000330288000160.pdf.txtdae4d4e37c66dcc6f5208078b1a70ee7MD52open access11600/373242022-07-08 10:54:14.138open accessoai:repositorio.unifesp.br:11600/37324Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652022-07-08T13:54:14Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Cardiovascular Responses Induced by Obstructive Apnea Are Enhanced in Hypertensive Rats Due to Enhanced Chemoreceptor Responsivity |
title |
Cardiovascular Responses Induced by Obstructive Apnea Are Enhanced in Hypertensive Rats Due to Enhanced Chemoreceptor Responsivity |
spellingShingle |
Cardiovascular Responses Induced by Obstructive Apnea Are Enhanced in Hypertensive Rats Due to Enhanced Chemoreceptor Responsivity Angheben, Juliana M. M. [UNIFESP] |
title_short |
Cardiovascular Responses Induced by Obstructive Apnea Are Enhanced in Hypertensive Rats Due to Enhanced Chemoreceptor Responsivity |
title_full |
Cardiovascular Responses Induced by Obstructive Apnea Are Enhanced in Hypertensive Rats Due to Enhanced Chemoreceptor Responsivity |
title_fullStr |
Cardiovascular Responses Induced by Obstructive Apnea Are Enhanced in Hypertensive Rats Due to Enhanced Chemoreceptor Responsivity |
title_full_unstemmed |
Cardiovascular Responses Induced by Obstructive Apnea Are Enhanced in Hypertensive Rats Due to Enhanced Chemoreceptor Responsivity |
title_sort |
Cardiovascular Responses Induced by Obstructive Apnea Are Enhanced in Hypertensive Rats Due to Enhanced Chemoreceptor Responsivity |
author |
Angheben, Juliana M. M. [UNIFESP] |
author_facet |
Angheben, Juliana M. M. [UNIFESP] Schoorlemmer, Gerhardus Hermanus Maria [UNIFESP] Rossi, Marcio V. [UNIFESP] Silva, Thiago A. [UNIFESP] Cravo, Sergio Luiz [UNIFESP] |
author_role |
author |
author2 |
Schoorlemmer, Gerhardus Hermanus Maria [UNIFESP] Rossi, Marcio V. [UNIFESP] Silva, Thiago A. [UNIFESP] Cravo, Sergio Luiz [UNIFESP] |
author2_role |
author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Angheben, Juliana M. M. [UNIFESP] Schoorlemmer, Gerhardus Hermanus Maria [UNIFESP] Rossi, Marcio V. [UNIFESP] Silva, Thiago A. [UNIFESP] Cravo, Sergio Luiz [UNIFESP] |
description |
Spontaneously hypertensive rats (SHR), like patients with sleep apnea, have hypertension, increased sympathetic activity, and increased chemoreceptor drive. We investigated the role of carotid chemoreceptors in cardiovascular responses induced by obstructive apnea in awake SHR. A tracheal balloon and vascular cannulas were implanted, and a week later, apneas of 15 s each were induced. the effects of apnea were more pronounced in SHR than in control rats (Wistar Kyoto; WKY). Blood pressure increased by 57 +/- 3 mmHg during apnea in SHR and by 28 +/- 3 mmHg in WKY (p < 0.05, n = 14/13). the respiratory effort increased by 53 +/- 6 mmHg in SHR and by 34 +/- 5 mmHg in WKY. the heart rate fell by 209 +/- 19 bpm in SHR and by 155 +/- 16 bpm in WKY. the carotid chemoreceptors were then inactivated by the ligation of the carotid body artery, and apneas were induced two days later. the inactivation of chemoreceptors reduced the responses to apnea and abolished the difference between SHR and controls. the apnea-induced hypertension was 11 +/- 4 mmHg in SHR and 8 +/- 4 mmHg in WKY. the respiratory effort was 15 +/- 2 mmHg in SHR and 15 +/- 2 mmHg in WKY. the heart rate fell 63 +/- 18 bpm in SHR and 52 +/- 14 bpm in WKY. Similarly, when the chemoreceptors were unloaded by the administration of 100% oxygen, the responses to apnea were reduced. in conclusion, arterial chemoreceptors contribute to the responses induced by apnea in both strains, but they are more important in SHR and account for the exaggerated responses of this strain to apnea. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014-01-23 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:35:09Z |
dc.date.available.fl_str_mv |
2016-01-24T14:35:09Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Plos One. San Francisco: Public Library Science, v. 9, n. 1, 9 p., 2014. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/37324 http://dx.doi.org/10.1371/journal.pone.0086868 |
dc.identifier.issn.none.fl_str_mv |
1932-6203 |
dc.identifier.file.none.fl_str_mv |
WOS000330288000160.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pone.0086868 |
dc.identifier.wos.none.fl_str_mv |
WOS:000330288000160 |
identifier_str_mv |
Plos One. San Francisco: Public Library Science, v. 9, n. 1, 9 p., 2014. 1932-6203 WOS000330288000160.pdf 10.1371/journal.pone.0086868 WOS:000330288000160 |
url |
http://repositorio.unifesp.br/handle/11600/37324 http://dx.doi.org/10.1371/journal.pone.0086868 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Plos One |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
9 |
dc.publisher.none.fl_str_mv |
Public Library Science |
publisher.none.fl_str_mv |
Public Library Science |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
bitstream.url.fl_str_mv |
${dspace.ui.url}/bitstream/11600/37324/1/WOS000330288000160.pdf ${dspace.ui.url}/bitstream/11600/37324/2/WOS000330288000160.pdf.txt |
bitstream.checksum.fl_str_mv |
5895c102430c3a22b55c08f62008cd16 dae4d4e37c66dcc6f5208078b1a70ee7 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1802764156250619904 |