Head tremor in patients with cervical dystonia: different outcome?

Detalhes bibliográficos
Autor(a) principal: Godeiro-Junior, Clecio [UNIFESP]
Data de Publicação: 2008
Outros Autores: Felício, André Carvalho [UNIFESP], Aguiar, Patricia C. [UNIFESP], Borges, Vanderci [UNIFESP], Silva, Sonia M.a. [UNIFESP], Ferraz, Henrique B. [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0004-282X2008000600005
http://repositorio.unifesp.br/handle/11600/4667
Resumo: OBJECTIVE: The association of cervical dystonia (CD) with other movement disorders have been already described, but data on clinical outcome regarding these patients are scant. The aim of this paper was to investigate whether patients with CD and head tremor (HT) would have a different outcome regarding to botulinum toxin type-A (BTX-A) treatment response and clinical and demographic parameters. METHOD: We retrospectively evaluated 118 medical charts of patients with CD and divided them into two groups: with (HT+) and without (HT-) head tremor. We compared the following clinical and demographic parameters: age at onset, disease duration, progression of symptoms, etiology, familial history, presence of hand tremor. We also analyzed the response to BTX-A according to Tsui score in both groups. RESULTS: The occurrence of head tremor in our sample was of 38.2%. The occurrence of postural hand tremor in the patients from the HT+ group was higher than in the HT- one (p=0.015) and if we compare BTX-A response in each group, we observe that patients with HT present a better outcome in a setting of longer follow-up. In HT+ group, Tsui score pre treatment was 10 (6-12.5) and after follow-up was 8 (5.5-10.5); p<0.001. In HT- group there was no significant difference 9 (7-12) in pre treatment and after follow-up; p=0.07. CONCLUSION: According to our data it seems that head tremor may influence the clinical outcome or treatment response with BTX-A in patients with CD.
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spelling Head tremor in patients with cervical dystonia: different outcome?Tremor cefálico em pacientes com distonia cervical: evolução diferente?cervical dystoniahead tremorbotulinum toxin type-Aoutcomedistonia cervicaltremor cefálicotoxina botulínicaevoluçãoOBJECTIVE: The association of cervical dystonia (CD) with other movement disorders have been already described, but data on clinical outcome regarding these patients are scant. The aim of this paper was to investigate whether patients with CD and head tremor (HT) would have a different outcome regarding to botulinum toxin type-A (BTX-A) treatment response and clinical and demographic parameters. METHOD: We retrospectively evaluated 118 medical charts of patients with CD and divided them into two groups: with (HT+) and without (HT-) head tremor. We compared the following clinical and demographic parameters: age at onset, disease duration, progression of symptoms, etiology, familial history, presence of hand tremor. We also analyzed the response to BTX-A according to Tsui score in both groups. RESULTS: The occurrence of head tremor in our sample was of 38.2%. The occurrence of postural hand tremor in the patients from the HT+ group was higher than in the HT- one (p=0.015) and if we compare BTX-A response in each group, we observe that patients with HT present a better outcome in a setting of longer follow-up. In HT+ group, Tsui score pre treatment was 10 (6-12.5) and after follow-up was 8 (5.5-10.5); p<0.001. In HT- group there was no significant difference 9 (7-12) in pre treatment and after follow-up; p=0.07. CONCLUSION: According to our data it seems that head tremor may influence the clinical outcome or treatment response with BTX-A in patients with CD.OBJETIVO: A associação de distonia cervical (DC) com outros transtornos do movimento já foi descrita, mas há poucos dados quanto à evolução clínica destes pacientes. Avaliamos se os pacientes com DC e tremor cefálico (TC) apresentam características clínicas e demográficas, assim como a resposta ao tratamento com toxina botulínica tipo A, diferentes. MÉTODOS: Analisamos retrospectivamente 118 prontuários de pacientes com DC e os dividimos em dois grupos: com (TC+) e sem (TC-) tremor cefálico. Comparamos os seguintes parâmetros clínicos e demográficos entre os grupos: idade de início, duração da doença, progressão de sintomas, etiologia, história familiar, presença de tremor em mãos. Também analisamos a resposta ao tratamento com toxina botulínica de acordo com escore Tsui em ambos os grupos. RESULTADOS: A ocorrência de tremor cefálico em nosso grupo de pacientes foi 38,2%. A ocorrência de tremor postural nas mãos em pacientes TC+ foi maior (p=0,015) e se compararmos a resposta ao tratamento com toxina botulínica em cada grupo, observamos que os pacientes com TC têm melhor evolução em uma situação de seguimento mais prolongado. No grupo TC+, o escore Tsui pré-tratamento foi 10 (6-12,5) e após o período de follow-up foi 8 (5,5-10,5); p<0,001. No grupo TC-, não houve diferença significante: 9 (7-12) no pré-tratamento e após período de follow-up; p=0,07. CONCLUSÃO: Nossos dados apontam que o tremor cefálico pode influenciar a evolução clínica ou resposta ao tratamento com toxina botulínica em pacientes com DC.Federal University of São Paulo Department of Neurology and Neurosurgery Movement Disorders UnitUNIFESP, Department of Neurology and Neurosurgery Movement Disorders UnitSciELOAcademia Brasileira de Neurologia - ABNEUROUniversidade Federal de São Paulo (UNIFESP)Godeiro-Junior, Clecio [UNIFESP]Felício, André Carvalho [UNIFESP]Aguiar, Patricia C. [UNIFESP]Borges, Vanderci [UNIFESP]Silva, Sonia M.a. [UNIFESP]Ferraz, Henrique B. [UNIFESP]2015-06-14T13:38:51Z2015-06-14T13:38:51Z2008-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion805-808application/pdfhttp://dx.doi.org/10.1590/S0004-282X2008000600005Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 66, n. 4, p. 805-808, 2008.10.1590/S0004-282X2008000600005S0004-282X2008000600005.pdf0004-282XS0004-282X2008000600005http://repositorio.unifesp.br/handle/11600/4667WOS:000262070600005engArquivos de Neuro-Psiquiatriainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-04T20:44:59Zoai:repositorio.unifesp.br/:11600/4667Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-04T20:44:59Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Head tremor in patients with cervical dystonia: different outcome?
Tremor cefálico em pacientes com distonia cervical: evolução diferente?
title Head tremor in patients with cervical dystonia: different outcome?
spellingShingle Head tremor in patients with cervical dystonia: different outcome?
Godeiro-Junior, Clecio [UNIFESP]
cervical dystonia
head tremor
botulinum toxin type-A
outcome
distonia cervical
tremor cefálico
toxina botulínica
evolução
title_short Head tremor in patients with cervical dystonia: different outcome?
title_full Head tremor in patients with cervical dystonia: different outcome?
title_fullStr Head tremor in patients with cervical dystonia: different outcome?
title_full_unstemmed Head tremor in patients with cervical dystonia: different outcome?
title_sort Head tremor in patients with cervical dystonia: different outcome?
author Godeiro-Junior, Clecio [UNIFESP]
author_facet Godeiro-Junior, Clecio [UNIFESP]
Felício, André Carvalho [UNIFESP]
Aguiar, Patricia C. [UNIFESP]
Borges, Vanderci [UNIFESP]
Silva, Sonia M.a. [UNIFESP]
Ferraz, Henrique B. [UNIFESP]
author_role author
author2 Felício, André Carvalho [UNIFESP]
Aguiar, Patricia C. [UNIFESP]
Borges, Vanderci [UNIFESP]
Silva, Sonia M.a. [UNIFESP]
Ferraz, Henrique B. [UNIFESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Godeiro-Junior, Clecio [UNIFESP]
Felício, André Carvalho [UNIFESP]
Aguiar, Patricia C. [UNIFESP]
Borges, Vanderci [UNIFESP]
Silva, Sonia M.a. [UNIFESP]
Ferraz, Henrique B. [UNIFESP]
dc.subject.por.fl_str_mv cervical dystonia
head tremor
botulinum toxin type-A
outcome
distonia cervical
tremor cefálico
toxina botulínica
evolução
topic cervical dystonia
head tremor
botulinum toxin type-A
outcome
distonia cervical
tremor cefálico
toxina botulínica
evolução
description OBJECTIVE: The association of cervical dystonia (CD) with other movement disorders have been already described, but data on clinical outcome regarding these patients are scant. The aim of this paper was to investigate whether patients with CD and head tremor (HT) would have a different outcome regarding to botulinum toxin type-A (BTX-A) treatment response and clinical and demographic parameters. METHOD: We retrospectively evaluated 118 medical charts of patients with CD and divided them into two groups: with (HT+) and without (HT-) head tremor. We compared the following clinical and demographic parameters: age at onset, disease duration, progression of symptoms, etiology, familial history, presence of hand tremor. We also analyzed the response to BTX-A according to Tsui score in both groups. RESULTS: The occurrence of head tremor in our sample was of 38.2%. The occurrence of postural hand tremor in the patients from the HT+ group was higher than in the HT- one (p=0.015) and if we compare BTX-A response in each group, we observe that patients with HT present a better outcome in a setting of longer follow-up. In HT+ group, Tsui score pre treatment was 10 (6-12.5) and after follow-up was 8 (5.5-10.5); p<0.001. In HT- group there was no significant difference 9 (7-12) in pre treatment and after follow-up; p=0.07. CONCLUSION: According to our data it seems that head tremor may influence the clinical outcome or treatment response with BTX-A in patients with CD.
publishDate 2008
dc.date.none.fl_str_mv 2008-12-01
2015-06-14T13:38:51Z
2015-06-14T13:38:51Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0004-282X2008000600005
Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 66, n. 4, p. 805-808, 2008.
10.1590/S0004-282X2008000600005
S0004-282X2008000600005.pdf
0004-282X
S0004-282X2008000600005
http://repositorio.unifesp.br/handle/11600/4667
WOS:000262070600005
url http://dx.doi.org/10.1590/S0004-282X2008000600005
http://repositorio.unifesp.br/handle/11600/4667
identifier_str_mv Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 66, n. 4, p. 805-808, 2008.
10.1590/S0004-282X2008000600005
S0004-282X2008000600005.pdf
0004-282X
S0004-282X2008000600005
WOS:000262070600005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Arquivos de Neuro-Psiquiatria
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 805-808
application/pdf
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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