Head tremor in patients with cervical dystonia: different outcome?
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1590/S0004-282X2008000600005 http://repositorio.unifesp.br/handle/11600/4667 |
Resumo: | OBJECTIVE: The association of cervical dystonia (CD) with other movement disorders have been already described, but data on clinical outcome regarding these patients are scant. The aim of this paper was to investigate whether patients with CD and head tremor (HT) would have a different outcome regarding to botulinum toxin type-A (BTX-A) treatment response and clinical and demographic parameters. METHOD: We retrospectively evaluated 118 medical charts of patients with CD and divided them into two groups: with (HT+) and without (HT-) head tremor. We compared the following clinical and demographic parameters: age at onset, disease duration, progression of symptoms, etiology, familial history, presence of hand tremor. We also analyzed the response to BTX-A according to Tsui score in both groups. RESULTS: The occurrence of head tremor in our sample was of 38.2%. The occurrence of postural hand tremor in the patients from the HT+ group was higher than in the HT- one (p=0.015) and if we compare BTX-A response in each group, we observe that patients with HT present a better outcome in a setting of longer follow-up. In HT+ group, Tsui score pre treatment was 10 (6-12.5) and after follow-up was 8 (5.5-10.5); p<0.001. In HT- group there was no significant difference 9 (7-12) in pre treatment and after follow-up; p=0.07. CONCLUSION: According to our data it seems that head tremor may influence the clinical outcome or treatment response with BTX-A in patients with CD. |
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Head tremor in patients with cervical dystonia: different outcome?Tremor cefálico em pacientes com distonia cervical: evolução diferente?cervical dystoniahead tremorbotulinum toxin type-Aoutcomedistonia cervicaltremor cefálicotoxina botulínicaevoluçãoOBJECTIVE: The association of cervical dystonia (CD) with other movement disorders have been already described, but data on clinical outcome regarding these patients are scant. The aim of this paper was to investigate whether patients with CD and head tremor (HT) would have a different outcome regarding to botulinum toxin type-A (BTX-A) treatment response and clinical and demographic parameters. METHOD: We retrospectively evaluated 118 medical charts of patients with CD and divided them into two groups: with (HT+) and without (HT-) head tremor. We compared the following clinical and demographic parameters: age at onset, disease duration, progression of symptoms, etiology, familial history, presence of hand tremor. We also analyzed the response to BTX-A according to Tsui score in both groups. RESULTS: The occurrence of head tremor in our sample was of 38.2%. The occurrence of postural hand tremor in the patients from the HT+ group was higher than in the HT- one (p=0.015) and if we compare BTX-A response in each group, we observe that patients with HT present a better outcome in a setting of longer follow-up. In HT+ group, Tsui score pre treatment was 10 (6-12.5) and after follow-up was 8 (5.5-10.5); p<0.001. In HT- group there was no significant difference 9 (7-12) in pre treatment and after follow-up; p=0.07. CONCLUSION: According to our data it seems that head tremor may influence the clinical outcome or treatment response with BTX-A in patients with CD.OBJETIVO: A associação de distonia cervical (DC) com outros transtornos do movimento já foi descrita, mas há poucos dados quanto à evolução clínica destes pacientes. Avaliamos se os pacientes com DC e tremor cefálico (TC) apresentam características clínicas e demográficas, assim como a resposta ao tratamento com toxina botulínica tipo A, diferentes. MÉTODOS: Analisamos retrospectivamente 118 prontuários de pacientes com DC e os dividimos em dois grupos: com (TC+) e sem (TC-) tremor cefálico. Comparamos os seguintes parâmetros clínicos e demográficos entre os grupos: idade de início, duração da doença, progressão de sintomas, etiologia, história familiar, presença de tremor em mãos. Também analisamos a resposta ao tratamento com toxina botulínica de acordo com escore Tsui em ambos os grupos. RESULTADOS: A ocorrência de tremor cefálico em nosso grupo de pacientes foi 38,2%. A ocorrência de tremor postural nas mãos em pacientes TC+ foi maior (p=0,015) e se compararmos a resposta ao tratamento com toxina botulínica em cada grupo, observamos que os pacientes com TC têm melhor evolução em uma situação de seguimento mais prolongado. No grupo TC+, o escore Tsui pré-tratamento foi 10 (6-12,5) e após o período de follow-up foi 8 (5,5-10,5); p<0,001. No grupo TC-, não houve diferença significante: 9 (7-12) no pré-tratamento e após período de follow-up; p=0,07. CONCLUSÃO: Nossos dados apontam que o tremor cefálico pode influenciar a evolução clínica ou resposta ao tratamento com toxina botulínica em pacientes com DC.Federal University of São Paulo Department of Neurology and Neurosurgery Movement Disorders UnitUNIFESP, Department of Neurology and Neurosurgery Movement Disorders UnitSciELOAcademia Brasileira de Neurologia - ABNEUROUniversidade Federal de São Paulo (UNIFESP)Godeiro-Junior, Clecio [UNIFESP]Felício, André Carvalho [UNIFESP]Aguiar, Patricia C. [UNIFESP]Borges, Vanderci [UNIFESP]Silva, Sonia M.a. [UNIFESP]Ferraz, Henrique B. [UNIFESP]2015-06-14T13:38:51Z2015-06-14T13:38:51Z2008-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion805-808application/pdfhttp://dx.doi.org/10.1590/S0004-282X2008000600005Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 66, n. 4, p. 805-808, 2008.10.1590/S0004-282X2008000600005S0004-282X2008000600005.pdf0004-282XS0004-282X2008000600005http://repositorio.unifesp.br/handle/11600/4667WOS:000262070600005engArquivos de Neuro-Psiquiatriainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-04T20:44:59Zoai:repositorio.unifesp.br/:11600/4667Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-04T20:44:59Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Head tremor in patients with cervical dystonia: different outcome? Tremor cefálico em pacientes com distonia cervical: evolução diferente? |
title |
Head tremor in patients with cervical dystonia: different outcome? |
spellingShingle |
Head tremor in patients with cervical dystonia: different outcome? Godeiro-Junior, Clecio [UNIFESP] cervical dystonia head tremor botulinum toxin type-A outcome distonia cervical tremor cefálico toxina botulínica evolução |
title_short |
Head tremor in patients with cervical dystonia: different outcome? |
title_full |
Head tremor in patients with cervical dystonia: different outcome? |
title_fullStr |
Head tremor in patients with cervical dystonia: different outcome? |
title_full_unstemmed |
Head tremor in patients with cervical dystonia: different outcome? |
title_sort |
Head tremor in patients with cervical dystonia: different outcome? |
author |
Godeiro-Junior, Clecio [UNIFESP] |
author_facet |
Godeiro-Junior, Clecio [UNIFESP] Felício, André Carvalho [UNIFESP] Aguiar, Patricia C. [UNIFESP] Borges, Vanderci [UNIFESP] Silva, Sonia M.a. [UNIFESP] Ferraz, Henrique B. [UNIFESP] |
author_role |
author |
author2 |
Felício, André Carvalho [UNIFESP] Aguiar, Patricia C. [UNIFESP] Borges, Vanderci [UNIFESP] Silva, Sonia M.a. [UNIFESP] Ferraz, Henrique B. [UNIFESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Godeiro-Junior, Clecio [UNIFESP] Felício, André Carvalho [UNIFESP] Aguiar, Patricia C. [UNIFESP] Borges, Vanderci [UNIFESP] Silva, Sonia M.a. [UNIFESP] Ferraz, Henrique B. [UNIFESP] |
dc.subject.por.fl_str_mv |
cervical dystonia head tremor botulinum toxin type-A outcome distonia cervical tremor cefálico toxina botulínica evolução |
topic |
cervical dystonia head tremor botulinum toxin type-A outcome distonia cervical tremor cefálico toxina botulínica evolução |
description |
OBJECTIVE: The association of cervical dystonia (CD) with other movement disorders have been already described, but data on clinical outcome regarding these patients are scant. The aim of this paper was to investigate whether patients with CD and head tremor (HT) would have a different outcome regarding to botulinum toxin type-A (BTX-A) treatment response and clinical and demographic parameters. METHOD: We retrospectively evaluated 118 medical charts of patients with CD and divided them into two groups: with (HT+) and without (HT-) head tremor. We compared the following clinical and demographic parameters: age at onset, disease duration, progression of symptoms, etiology, familial history, presence of hand tremor. We also analyzed the response to BTX-A according to Tsui score in both groups. RESULTS: The occurrence of head tremor in our sample was of 38.2%. The occurrence of postural hand tremor in the patients from the HT+ group was higher than in the HT- one (p=0.015) and if we compare BTX-A response in each group, we observe that patients with HT present a better outcome in a setting of longer follow-up. In HT+ group, Tsui score pre treatment was 10 (6-12.5) and after follow-up was 8 (5.5-10.5); p<0.001. In HT- group there was no significant difference 9 (7-12) in pre treatment and after follow-up; p=0.07. CONCLUSION: According to our data it seems that head tremor may influence the clinical outcome or treatment response with BTX-A in patients with CD. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-12-01 2015-06-14T13:38:51Z 2015-06-14T13:38:51Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0004-282X2008000600005 Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 66, n. 4, p. 805-808, 2008. 10.1590/S0004-282X2008000600005 S0004-282X2008000600005.pdf 0004-282X S0004-282X2008000600005 http://repositorio.unifesp.br/handle/11600/4667 WOS:000262070600005 |
url |
http://dx.doi.org/10.1590/S0004-282X2008000600005 http://repositorio.unifesp.br/handle/11600/4667 |
identifier_str_mv |
Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 66, n. 4, p. 805-808, 2008. 10.1590/S0004-282X2008000600005 S0004-282X2008000600005.pdf 0004-282X S0004-282X2008000600005 WOS:000262070600005 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
805-808 application/pdf |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268349683597312 |