Peripheral Vascular Resistance Impairment during Isometric Physical Exercise in Normotensive Offspring of Hypertensive Parents

Detalhes bibliográficos
Autor(a) principal: Portela, Natalia
Data de Publicação: 2017
Outros Autores: Amaral, Josaria Ferraz, de Carvalho Mira, Pedro Augusto, de Souza, Livia Victorino [UNIFESP], Martinez, Daniel Godoy, Laterza, Mateus Camaroti
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.5935/abc.20170096
http://repositorio.unifesp.br/handle/11600/51416
Resumo: Background: A family history of hypertension is associated with vascular and autonomic abnormalities, as well as an impaired neurohemodynamic response to exercise. Objective: To test the hypothesis that normotensive individuals with a family history of hypertension present an impaired peripheral vascular resistance response to exercise. Methods: The study included 37 normotensive volunteers of both sexes who were sedentary, eutrophic, and nonsmokers, comprising 23 with (FH+
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spelling Peripheral Vascular Resistance Impairment during Isometric Physical Exercise in Normotensive Offspring of Hypertensive ParentsPrejuízo da Resistência Vascular Periférica durante o Exercício Físico Isométrico em Indivíduos Normotensos Filhos de HipertensosVascular ResistanceExercisePatient SelectionHypertensionHeredityResistência VascularExercícioSeleção de PacientesHipertensãoHereditariedadeBackground: A family history of hypertension is associated with vascular and autonomic abnormalities, as well as an impaired neurohemodynamic response to exercise. Objective: To test the hypothesis that normotensive individuals with a family history of hypertension present an impaired peripheral vascular resistance response to exercise. Methods: The study included 37 normotensive volunteers of both sexes who were sedentary, eutrophic, and nonsmokers, comprising 23 with (FH+24 +/- 3 years) and 14 without (FH-27 +/- 5 years) a family history of hypertension. Blood pressure, heart rate (DIXTAL (R)), forearm blood flow (Hokanson (R)), and peripheral vascular resistance were simultaneously measured for 3 minutes during rest and, subsequently, for 3 minutes during an isometric exercise at 30% of maximal voluntary contraction (Jamar (R)). Results: At rest, the FH+ and FH-groups present similar mean blood pressure (83 +/- 7 versus 83 +/- 5 mmHg, p = 0.96), heart rate (69 +/- 8 bpm versus 66 +/- 7 bpm, p = 0.18), forearm blood flow (3 +/- 1 mL/min/100 mL versus 2.7 +/- 1 mL/min/100 mL, p = 0.16), and peripheral vascular resistance (30 +/- 9 units versus 34 +/- 9 units, p = 0.21), respectively. Both groups showed a significant and similar increase in mean blood pressure (Delta = 15 +/- 7 mmHg versus 14 +/- 7 mmHg, p = 0.86), heart rate (Delta = 12 +/- 8 bpm versus 13 +/- 7 bpm, p = 0.86), and forearm blood flow (Delta = 0.8 +/- 1.2 mL/ min/100mL versus 1.4 +/- 1.1 mL/min/100 mL, p = 0.25), respectively, during exercise. However, individuals in the FH+ group showed no reduction in peripheral vascular resistance during exercise, which was observed in the FH-group (Delta = -0.4 +/- 8.6 units versus -7.2 +/- 6.3 units, p = 0.03). Conclusion: Normotensive individuals with a family history of hypertension present an impaired peripheral vascular resistance response to exercise.Fundamento: O histórico familiar para hipertensão arterial está relacionado a anormalidades vasculares e autonômicas, bem como disfunções no comportamento neuro-hemodinâmico durante o exercício físico. Objetivo: Testar a hipótese de que indivíduos normotensos com histórico familiar de hipertensão arterial apresentam resposta prejudicada da resistência vascular periférica durante o exercício físico. Métodos: Foram avaliados 37 normotensos de ambos os sexos, sedentários, eutróficos e não tabagistas, sendo 23 com histórico familiar positivo (HF+, 24 ± 3 anos) e 14 com histórico familiar negativo (HF-, 27 ± 5 anos) para hipertensão arterial. Foram identificados pressão arterial, frequência cardíaca (DIXTAL®), fluxo sanguíneo muscular do antebraço e resistência vascular periférica local (Hokanson®) por 3 minutos durante o repouso e, em seguida, 3 minutos durante exercício isométrico de preensão palmar a 30% da contração voluntária máxima (Jamar®). Resultados: Em repouso, os grupos HF+ e HF- apresentaram valores semelhantes de pressão arterial média (83 ± 7 mmHg versus 83 ± 5 mmHg, p = 0,96), frequência cardíaca (69 ± 8 bpm versus 66 ± 7 bpm, p = 0,18), fluxo sanguíneo muscular (3 ± 1 mL/min/199 mL versus 2,7 ± 1 mL/min/100 mL, p = 0,16) e resistência vascular periférica (30 ± 9 unidades versus 34 ± 9 unidades, p = 0,21), respectivamente. Durante o exercício, HF+ e HF- mostraram aumento significativo e semelhante da pressão arterial média (∆ = 15 ± 7 mmHg versus 14 ± 7 mmHg, p = 0,86), frequência cardíaca (∆ = 12 ± 8 bpm versus 13 ± 7 bpm, p = 0,86) e fluxo sanguíneo muscular (∆ = 0,8 ± 1,2 mL/min/100 mL versus 1,4 ± 1,1 mL/min/100 mL, p = 0,25), respectivamente. Entretanto, no grupo HF+ não houve redução significativa da resistência vascular periférica durante o exercício, fato que ocorreu no grupo HF- (∆ = -0,4 ± 8,6 unidades versus -7,2 ± 6,3 unidades, p = 0,03). Conclusão: Indivíduos normotensos com histórico familiar de hipertensão arterial apresentam resposta prejudicada da resistência vascular periférica durante o exercício físico.Univ Fed Juiz de Fora, Unidade Invest Cardiovasc & Fisiol Exercicio, Fac Educ Fis & Desportos, Juiz De Fora, MG, BrazilUniv Fed São Paulo, Fac Med, Disciplina Nefrol, São Paulo, SP, BrazilUniv Fed São Paulo, Fac Med, Disciplina Nefrol, São Paulo, SP, BrazilWeb of ScienceArquivos Brasileiros Cardiologia2019-08-19T11:49:50Z2019-08-19T11:49:50Z2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion110-116application/pdfapplication/pdfhttp://dx.doi.org/10.5935/abc.20170096Arquivos Brasileiros De Cardiologia. Rio De Janeiro, v. 109, n. 2, p. 110-116, 2017.10.5935/abc.20170096WOS000410775300004-en.pdfWOS000410775300004-pt.pdf0066-782XS0066-782X2017000800110http://repositorio.unifesp.br/handle/11600/51416WOS:000410775300004enginfo:eu-repo/semantics/openAccessPortela, NataliaAmaral, Josaria Ferrazde Carvalho Mira, Pedro Augustode Souza, Livia Victorino [UNIFESP]Martinez, Daniel GodoyLaterza, Mateus Camarotireponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-10T23:37:45Zoai:repositorio.unifesp.br/:11600/51416Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-10T23:37:45Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Peripheral Vascular Resistance Impairment during Isometric Physical Exercise in Normotensive Offspring of Hypertensive Parents
Prejuízo da Resistência Vascular Periférica durante o Exercício Físico Isométrico em Indivíduos Normotensos Filhos de Hipertensos
title Peripheral Vascular Resistance Impairment during Isometric Physical Exercise in Normotensive Offspring of Hypertensive Parents
spellingShingle Peripheral Vascular Resistance Impairment during Isometric Physical Exercise in Normotensive Offspring of Hypertensive Parents
Portela, Natalia
Vascular Resistance
Exercise
Patient Selection
Hypertension
Heredity
Resistência Vascular
Exercício
Seleção de Pacientes
Hipertensão
Hereditariedade
title_short Peripheral Vascular Resistance Impairment during Isometric Physical Exercise in Normotensive Offspring of Hypertensive Parents
title_full Peripheral Vascular Resistance Impairment during Isometric Physical Exercise in Normotensive Offspring of Hypertensive Parents
title_fullStr Peripheral Vascular Resistance Impairment during Isometric Physical Exercise in Normotensive Offspring of Hypertensive Parents
title_full_unstemmed Peripheral Vascular Resistance Impairment during Isometric Physical Exercise in Normotensive Offspring of Hypertensive Parents
title_sort Peripheral Vascular Resistance Impairment during Isometric Physical Exercise in Normotensive Offspring of Hypertensive Parents
author Portela, Natalia
author_facet Portela, Natalia
Amaral, Josaria Ferraz
de Carvalho Mira, Pedro Augusto
de Souza, Livia Victorino [UNIFESP]
Martinez, Daniel Godoy
Laterza, Mateus Camaroti
author_role author
author2 Amaral, Josaria Ferraz
de Carvalho Mira, Pedro Augusto
de Souza, Livia Victorino [UNIFESP]
Martinez, Daniel Godoy
Laterza, Mateus Camaroti
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Portela, Natalia
Amaral, Josaria Ferraz
de Carvalho Mira, Pedro Augusto
de Souza, Livia Victorino [UNIFESP]
Martinez, Daniel Godoy
Laterza, Mateus Camaroti
dc.subject.por.fl_str_mv Vascular Resistance
Exercise
Patient Selection
Hypertension
Heredity
Resistência Vascular
Exercício
Seleção de Pacientes
Hipertensão
Hereditariedade
topic Vascular Resistance
Exercise
Patient Selection
Hypertension
Heredity
Resistência Vascular
Exercício
Seleção de Pacientes
Hipertensão
Hereditariedade
description Background: A family history of hypertension is associated with vascular and autonomic abnormalities, as well as an impaired neurohemodynamic response to exercise. Objective: To test the hypothesis that normotensive individuals with a family history of hypertension present an impaired peripheral vascular resistance response to exercise. Methods: The study included 37 normotensive volunteers of both sexes who were sedentary, eutrophic, and nonsmokers, comprising 23 with (FH+
publishDate 2017
dc.date.none.fl_str_mv 2017
2019-08-19T11:49:50Z
2019-08-19T11:49:50Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.5935/abc.20170096
Arquivos Brasileiros De Cardiologia. Rio De Janeiro, v. 109, n. 2, p. 110-116, 2017.
10.5935/abc.20170096
WOS000410775300004-en.pdf
WOS000410775300004-pt.pdf
0066-782X
S0066-782X2017000800110
http://repositorio.unifesp.br/handle/11600/51416
WOS:000410775300004
url http://dx.doi.org/10.5935/abc.20170096
http://repositorio.unifesp.br/handle/11600/51416
identifier_str_mv Arquivos Brasileiros De Cardiologia. Rio De Janeiro, v. 109, n. 2, p. 110-116, 2017.
10.5935/abc.20170096
WOS000410775300004-en.pdf
WOS000410775300004-pt.pdf
0066-782X
S0066-782X2017000800110
WOS:000410775300004
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 110-116
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Arquivos Brasileiros Cardiologia
publisher.none.fl_str_mv Arquivos Brasileiros Cardiologia
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268423328235520

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