The pilocarpine model of epilepsy: what have we learned?

Detalhes bibliográficos
Autor(a) principal: Scorza, Fulvio Alexandre [UNIFESP]
Data de Publicação: 2009
Outros Autores: Arida, Ricardo Mario [UNIFESP], Naffah-Mazzacoratti, Maria da Graca [UNIFESP], Amado, Débora [UNIFESP], Calderazzo, Lineu [UNIFESP], Cavalheiro, Esper Abrão [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0001-37652009000300003
http://repositorio.unifesp.br/handle/11600/5261
Resumo: The systemic administration of a potent muscarinic agonist pilocarpine in rats promotes sequential behavioral and electrographic changes that can be divided into 3 distinct periods: (a) an acute period that built up progressively into a limbic status epilepticus and that lasts 24 h, (b) a silent period with a progressive normalization of EEG and behavior which varies from 4 to 44 days, and (c) a chronic period with spontaneous recurrent seizures (SRSs). The main features of the SRSs observed during the long-term period resemble those of human complex partial seizures and recurs 2-3 times per week per animal. Therefore, the pilocarpine model of epilepsy is a valuable tool not only to study the pathogenesis of temporal lobe epilepsy in human condition, but also to evaluate potential antiepileptogenic drugs. This review concentrates on data from pilocarpine model of epilepsy.
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spelling The pilocarpine model of epilepsy: what have we learned?hippocampuspilocarpinetemporal lobe epilepsyrathipocampopilocarpinaepilepsia do lobo temporalratoThe systemic administration of a potent muscarinic agonist pilocarpine in rats promotes sequential behavioral and electrographic changes that can be divided into 3 distinct periods: (a) an acute period that built up progressively into a limbic status epilepticus and that lasts 24 h, (b) a silent period with a progressive normalization of EEG and behavior which varies from 4 to 44 days, and (c) a chronic period with spontaneous recurrent seizures (SRSs). The main features of the SRSs observed during the long-term period resemble those of human complex partial seizures and recurs 2-3 times per week per animal. Therefore, the pilocarpine model of epilepsy is a valuable tool not only to study the pathogenesis of temporal lobe epilepsy in human condition, but also to evaluate potential antiepileptogenic drugs. This review concentrates on data from pilocarpine model of epilepsy.A administração sistêmica do potente agonista muscarínico pilocarpina em ratos promove alterações comportamentais e eletrográficas que podem ser divididas em três períodos distintos: (a) período agudo o animal evolui progressivamente para o status epilepticus, que perdura por até 24h; (b) período silencioso, caracterizado pela normalização progressiva do comportamento e do EEG e pode ter uma duração de 4 a 44 dias; período crônico, aparecimento de crises epilépticas espontâneas e recorrentes (SRSs). As características das SRSs observadas nos animas durante o período crônico são semelhantes às crises parciais complexas dos seres humanos e recorrem de 2-3 vezes por semana/animal. Além disso, o modelo de epilepsia induzido pela pilocarpina é válido não somente para se estudar a patogênese da epilepsia do lobo temporal em humanos como também para se testar a viabilidade de drogas antiepilépticas. Esse artigo de revisão aborda diversos aspectos do modelo de epilepsia induzido pela pilocarpina.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de MedicinaUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de FisiologiaUNIFESP, EPM, Depto. de FisiologiaSciELOAcademia Brasileira de CiênciasUniversidade Federal de São Paulo (UNIFESP)Scorza, Fulvio Alexandre [UNIFESP]Arida, Ricardo Mario [UNIFESP]Naffah-Mazzacoratti, Maria da Graca [UNIFESP]Amado, Débora [UNIFESP]Calderazzo, Lineu [UNIFESP]Cavalheiro, Esper Abrão [UNIFESP]2015-06-14T13:41:11Z2015-06-14T13:41:11Z2009-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion345-365application/pdfhttp://dx.doi.org/10.1590/S0001-37652009000300003Anais da Academia Brasileira de Ciências. Academia Brasileira de Ciências, v. 81, n. 3, p. 345-365, 2009.10.1590/S0001-37652009000300003S0001-37652009000300003.pdf0001-3765S0001-37652009000300003http://repositorio.unifesp.br/handle/11600/5261WOS:000269462300003engAnais da Academia Brasileira de Ciênciasinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-05T14:03:08Zoai:repositorio.unifesp.br/:11600/5261Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-05T14:03:08Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv The pilocarpine model of epilepsy: what have we learned?
title The pilocarpine model of epilepsy: what have we learned?
spellingShingle The pilocarpine model of epilepsy: what have we learned?
Scorza, Fulvio Alexandre [UNIFESP]
hippocampus
pilocarpine
temporal lobe epilepsy
rat
hipocampo
pilocarpina
epilepsia do lobo temporal
rato
title_short The pilocarpine model of epilepsy: what have we learned?
title_full The pilocarpine model of epilepsy: what have we learned?
title_fullStr The pilocarpine model of epilepsy: what have we learned?
title_full_unstemmed The pilocarpine model of epilepsy: what have we learned?
title_sort The pilocarpine model of epilepsy: what have we learned?
author Scorza, Fulvio Alexandre [UNIFESP]
author_facet Scorza, Fulvio Alexandre [UNIFESP]
Arida, Ricardo Mario [UNIFESP]
Naffah-Mazzacoratti, Maria da Graca [UNIFESP]
Amado, Débora [UNIFESP]
Calderazzo, Lineu [UNIFESP]
Cavalheiro, Esper Abrão [UNIFESP]
author_role author
author2 Arida, Ricardo Mario [UNIFESP]
Naffah-Mazzacoratti, Maria da Graca [UNIFESP]
Amado, Débora [UNIFESP]
Calderazzo, Lineu [UNIFESP]
Cavalheiro, Esper Abrão [UNIFESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Scorza, Fulvio Alexandre [UNIFESP]
Arida, Ricardo Mario [UNIFESP]
Naffah-Mazzacoratti, Maria da Graca [UNIFESP]
Amado, Débora [UNIFESP]
Calderazzo, Lineu [UNIFESP]
Cavalheiro, Esper Abrão [UNIFESP]
dc.subject.por.fl_str_mv hippocampus
pilocarpine
temporal lobe epilepsy
rat
hipocampo
pilocarpina
epilepsia do lobo temporal
rato
topic hippocampus
pilocarpine
temporal lobe epilepsy
rat
hipocampo
pilocarpina
epilepsia do lobo temporal
rato
description The systemic administration of a potent muscarinic agonist pilocarpine in rats promotes sequential behavioral and electrographic changes that can be divided into 3 distinct periods: (a) an acute period that built up progressively into a limbic status epilepticus and that lasts 24 h, (b) a silent period with a progressive normalization of EEG and behavior which varies from 4 to 44 days, and (c) a chronic period with spontaneous recurrent seizures (SRSs). The main features of the SRSs observed during the long-term period resemble those of human complex partial seizures and recurs 2-3 times per week per animal. Therefore, the pilocarpine model of epilepsy is a valuable tool not only to study the pathogenesis of temporal lobe epilepsy in human condition, but also to evaluate potential antiepileptogenic drugs. This review concentrates on data from pilocarpine model of epilepsy.
publishDate 2009
dc.date.none.fl_str_mv 2009-09-01
2015-06-14T13:41:11Z
2015-06-14T13:41:11Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0001-37652009000300003
Anais da Academia Brasileira de Ciências. Academia Brasileira de Ciências, v. 81, n. 3, p. 345-365, 2009.
10.1590/S0001-37652009000300003
S0001-37652009000300003.pdf
0001-3765
S0001-37652009000300003
http://repositorio.unifesp.br/handle/11600/5261
WOS:000269462300003
url http://dx.doi.org/10.1590/S0001-37652009000300003
http://repositorio.unifesp.br/handle/11600/5261
identifier_str_mv Anais da Academia Brasileira de Ciências. Academia Brasileira de Ciências, v. 81, n. 3, p. 345-365, 2009.
10.1590/S0001-37652009000300003
S0001-37652009000300003.pdf
0001-3765
S0001-37652009000300003
WOS:000269462300003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Anais da Academia Brasileira de Ciências
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 345-365
application/pdf
dc.publisher.none.fl_str_mv Academia Brasileira de Ciências
publisher.none.fl_str_mv Academia Brasileira de Ciências
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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