Anti-beta(2)-glycoprotein i antibodies are highly prevalent in a large number of Brazilian leprosy patients

• Autor(a) principal: Ribeiro, Sandra Lucia Euzebio [UNIFESP]
• Data de Publicação: 2011
• Outros Autores: Pereira, Helena Lúcia Alves [UNIFESP], Silva, Neusa Pereira da [UNIFESP], Souza, Alexandre Wagner Silva de [UNIFESP], Sato, Emilia Inoue [UNIFESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: https://www.actareumatologica.pt/article_download.php?id=648; https://repositorio.unifesp.br/handle/11600/42090
• topic: Leprosy; Anti-beta(2)-glycoprotein I antibodies; Antiphospholipid antibodies; Anticardiolipin antibodies; Antiphospholipid syndrome

Objectives: To determine the prevalence of anticardiolipin (aCL) and anti-beta(2)-glycoprotein I (anti-beta(2)GPI) antibodies in leprosy patients, during and after specific multidrug therapy (MDT), and to evaluate a possible association between these antibodies and some clinical characteristics of leprosy, including clinical forms, reactional episodes and treatment.Methods: The study included 158 leprosy patients, 129 gender-and-age matched healthy individuals, and 38 women with primary antiphospholipid syndrome (APS). Clinical and demographic characteristic of leprosy patients were collected, and serum samples, obtained from all participants, were kept frozen at - 20 degrees C. Antibodies were measured either by an in house-developed ELISA (aCL) or by a commercial ELISA (anti-beta(2)GPI).Results and Conclusions: Increased levels of aCL and anti-beta(2)GPI antibodies were found in leprosy patients and in the APS group, however, in contrast to APS, the predominant isotype in leprosy was IgM. The frequency of aCL and anti-beta(2)GPI antibodies was significantly higher in leprosy patients than in healthy individuals (15.8% vs. 3.1%; p < 0.01; 46.2% vs. 9.4%, p < 0.01), respectively. The lepromatous form predominated among aCL positive leprosy patients (p < 0.01). There was no difference in aCL and anti-beta(2)GPI positivity between leprosy patients taking MDT and those completed MDT as cured. Furthermore the duration of discharged period (period between discharge from MDT and the realization of the study) had no effect on anti-beta(2)GPI positivity, and a slight increase in aCL positivity was observed in patients with longer follow up periods (p=0.04), suggesting that the presence of antiphospholipid antibodies (aPL) was not a transient phenomenon. Although aPL in leprosy were frequent and beta(2)GPI-dependent as those found in APS, IgM was the predominant isotype, and there was no association with thrombosis or other APS manifestations.