Role of the caudal pressor area in the regulation of sympathetic vasomotor tone

Detalhes bibliográficos
Autor(a) principal: Campos, Ruy Ribeiro [UNIFESP]
Data de Publicação: 2008
Outros Autores: Carillo, Bruno de Arruda [UNIFESP], Oliveira-Sales, Elizabeth Barbosa de [UNIFESP], Silva, Adilson Marques da [UNIFESP], Silva, Nyam Florencio da, Futuro Neto, Henrique Azevedo, Bergamaschi, Cassia Toledo [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0100-879X2008000700002
http://repositorio.unifesp.br/handle/11600/4465
Resumo: It is well known that the ventrolateral medulla contains neurons involved in the tonic and reflex control of the cardiovascular system. Two regions within the ventrolateral medulla were initially identified: the rostral ventrolateral medulla (RVLM) and the caudal ventrolateral medulla (CVLM). Activation of the RVLM raises arterial blood pressure and sympathetic nerve activity, and activation of the CVLM causes opposite effects. The RVLM premotor neurons project directly to sympathetic preganglionic neurons and are involved in the maintenance of resting sympathetic vasomotor tone. A significant proportion of tonic activity in the RVLM sympathetic premotor neurons is driven by neurons located in a third region of the ventrolateral medulla denominated caudal pressor area (CPA). The CPA is a pressor region located at the extreme caudal part of the ventrolateral medulla that appears to have an important role controlling the activity of RVLM neurons. In this brief review, we will address the importance of the ventrolateral medulla neurons for the generation of resting sympathetic tone related to arterial blood pressure control focusing on two regions, the RVLM and the CPA.
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spelling Role of the caudal pressor area in the regulation of sympathetic vasomotor toneRostral ventrolateral medullaRatGlutamateBlood pressureCaudal pressor areaSympathetic vasomotor toneIt is well known that the ventrolateral medulla contains neurons involved in the tonic and reflex control of the cardiovascular system. Two regions within the ventrolateral medulla were initially identified: the rostral ventrolateral medulla (RVLM) and the caudal ventrolateral medulla (CVLM). Activation of the RVLM raises arterial blood pressure and sympathetic nerve activity, and activation of the CVLM causes opposite effects. The RVLM premotor neurons project directly to sympathetic preganglionic neurons and are involved in the maintenance of resting sympathetic vasomotor tone. A significant proportion of tonic activity in the RVLM sympathetic premotor neurons is driven by neurons located in a third region of the ventrolateral medulla denominated caudal pressor area (CPA). The CPA is a pressor region located at the extreme caudal part of the ventrolateral medulla that appears to have an important role controlling the activity of RVLM neurons. In this brief review, we will address the importance of the ventrolateral medulla neurons for the generation of resting sympathetic tone related to arterial blood pressure control focusing on two regions, the RVLM and the CPA.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Disciplina de Fisiologia Cardiovascular e RespiratóriaUniversidade Federal do Espírito Santo Laboratório de NeuromorfologiaUniversidade Federal do Espírito Santo Programa de Pós-Graduação em Ciências FisiológicasSanta Casa de Misericórdia de Vitória (EMESCAM) Escola Superior de CiênciasUniversidade Federal de São Paulo (UNIFESP) Campus Baixada Santista Departamento de BiociênicasUNIFESP, EPM, Disciplina de Fisiologia Cardiovascular e RespiratóriaUNIFESP, Campus Baixada Santista Depto. de BiociênicasSciELOFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Associação Brasileira de Divulgação CientíficaUniversidade Federal de São Paulo (UNIFESP)Universidade Federal do Espírito Santo Laboratório de NeuromorfologiaUniversidade Federal do Espírito Santo Programa de Pós-Graduação em Ciências FisiológicasSanta Casa de Misericórdia de Vitória (EMESCAM) Escola Superior de CiênciasCampos, Ruy Ribeiro [UNIFESP]Carillo, Bruno de Arruda [UNIFESP]Oliveira-Sales, Elizabeth Barbosa de [UNIFESP]Silva, Adilson Marques da [UNIFESP]Silva, Nyam Florencio daFuturo Neto, Henrique AzevedoBergamaschi, Cassia Toledo [UNIFESP]2015-06-14T13:38:38Z2015-06-14T13:38:38Z2008-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion557-562application/pdfhttp://dx.doi.org/10.1590/S0100-879X2008000700002Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 41, n. 7, p. 557-562, 2008.10.1590/S0100-879X2008000700002S0100-879X2008000700002.pdf0100-879XS0100-879X2008000700002http://repositorio.unifesp.br/handle/11600/4465WOS:000259326100002engBrazilian Journal of Medical and Biological Researchinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-29T07:00:41Zoai:repositorio.unifesp.br/:11600/4465Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-29T07:00:41Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Role of the caudal pressor area in the regulation of sympathetic vasomotor tone
title Role of the caudal pressor area in the regulation of sympathetic vasomotor tone
spellingShingle Role of the caudal pressor area in the regulation of sympathetic vasomotor tone
Campos, Ruy Ribeiro [UNIFESP]
Rostral ventrolateral medulla
Rat
Glutamate
Blood pressure
Caudal pressor area
Sympathetic vasomotor tone
title_short Role of the caudal pressor area in the regulation of sympathetic vasomotor tone
title_full Role of the caudal pressor area in the regulation of sympathetic vasomotor tone
title_fullStr Role of the caudal pressor area in the regulation of sympathetic vasomotor tone
title_full_unstemmed Role of the caudal pressor area in the regulation of sympathetic vasomotor tone
title_sort Role of the caudal pressor area in the regulation of sympathetic vasomotor tone
author Campos, Ruy Ribeiro [UNIFESP]
author_facet Campos, Ruy Ribeiro [UNIFESP]
Carillo, Bruno de Arruda [UNIFESP]
Oliveira-Sales, Elizabeth Barbosa de [UNIFESP]
Silva, Adilson Marques da [UNIFESP]
Silva, Nyam Florencio da
Futuro Neto, Henrique Azevedo
Bergamaschi, Cassia Toledo [UNIFESP]
author_role author
author2 Carillo, Bruno de Arruda [UNIFESP]
Oliveira-Sales, Elizabeth Barbosa de [UNIFESP]
Silva, Adilson Marques da [UNIFESP]
Silva, Nyam Florencio da
Futuro Neto, Henrique Azevedo
Bergamaschi, Cassia Toledo [UNIFESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do Espírito Santo Laboratório de Neuromorfologia
Universidade Federal do Espírito Santo Programa de Pós-Graduação em Ciências Fisiológicas
Santa Casa de Misericórdia de Vitória (EMESCAM) Escola Superior de Ciências
dc.contributor.author.fl_str_mv Campos, Ruy Ribeiro [UNIFESP]
Carillo, Bruno de Arruda [UNIFESP]
Oliveira-Sales, Elizabeth Barbosa de [UNIFESP]
Silva, Adilson Marques da [UNIFESP]
Silva, Nyam Florencio da
Futuro Neto, Henrique Azevedo
Bergamaschi, Cassia Toledo [UNIFESP]
dc.subject.por.fl_str_mv Rostral ventrolateral medulla
Rat
Glutamate
Blood pressure
Caudal pressor area
Sympathetic vasomotor tone
topic Rostral ventrolateral medulla
Rat
Glutamate
Blood pressure
Caudal pressor area
Sympathetic vasomotor tone
description It is well known that the ventrolateral medulla contains neurons involved in the tonic and reflex control of the cardiovascular system. Two regions within the ventrolateral medulla were initially identified: the rostral ventrolateral medulla (RVLM) and the caudal ventrolateral medulla (CVLM). Activation of the RVLM raises arterial blood pressure and sympathetic nerve activity, and activation of the CVLM causes opposite effects. The RVLM premotor neurons project directly to sympathetic preganglionic neurons and are involved in the maintenance of resting sympathetic vasomotor tone. A significant proportion of tonic activity in the RVLM sympathetic premotor neurons is driven by neurons located in a third region of the ventrolateral medulla denominated caudal pressor area (CPA). The CPA is a pressor region located at the extreme caudal part of the ventrolateral medulla that appears to have an important role controlling the activity of RVLM neurons. In this brief review, we will address the importance of the ventrolateral medulla neurons for the generation of resting sympathetic tone related to arterial blood pressure control focusing on two regions, the RVLM and the CPA.
publishDate 2008
dc.date.none.fl_str_mv 2008-07-01
2015-06-14T13:38:38Z
2015-06-14T13:38:38Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0100-879X2008000700002
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 41, n. 7, p. 557-562, 2008.
10.1590/S0100-879X2008000700002
S0100-879X2008000700002.pdf
0100-879X
S0100-879X2008000700002
http://repositorio.unifesp.br/handle/11600/4465
WOS:000259326100002
url http://dx.doi.org/10.1590/S0100-879X2008000700002
http://repositorio.unifesp.br/handle/11600/4465
identifier_str_mv Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 41, n. 7, p. 557-562, 2008.
10.1590/S0100-879X2008000700002
S0100-879X2008000700002.pdf
0100-879X
S0100-879X2008000700002
WOS:000259326100002
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Journal of Medical and Biological Research
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 557-562
application/pdf
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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