Role of the caudal pressor area in the regulation of sympathetic vasomotor tone
Autor(a) principal: | |
---|---|
Data de Publicação: | 2008 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1590/S0100-879X2008000700002 http://repositorio.unifesp.br/handle/11600/4465 |
Resumo: | It is well known that the ventrolateral medulla contains neurons involved in the tonic and reflex control of the cardiovascular system. Two regions within the ventrolateral medulla were initially identified: the rostral ventrolateral medulla (RVLM) and the caudal ventrolateral medulla (CVLM). Activation of the RVLM raises arterial blood pressure and sympathetic nerve activity, and activation of the CVLM causes opposite effects. The RVLM premotor neurons project directly to sympathetic preganglionic neurons and are involved in the maintenance of resting sympathetic vasomotor tone. A significant proportion of tonic activity in the RVLM sympathetic premotor neurons is driven by neurons located in a third region of the ventrolateral medulla denominated caudal pressor area (CPA). The CPA is a pressor region located at the extreme caudal part of the ventrolateral medulla that appears to have an important role controlling the activity of RVLM neurons. In this brief review, we will address the importance of the ventrolateral medulla neurons for the generation of resting sympathetic tone related to arterial blood pressure control focusing on two regions, the RVLM and the CPA. |
id |
UFSP_f0b1eb2da7991f5edb5f2364005d12ab |
---|---|
oai_identifier_str |
oai:repositorio.unifesp.br/:11600/4465 |
network_acronym_str |
UFSP |
network_name_str |
Repositório Institucional da UNIFESP |
repository_id_str |
3465 |
spelling |
Role of the caudal pressor area in the regulation of sympathetic vasomotor toneRostral ventrolateral medullaRatGlutamateBlood pressureCaudal pressor areaSympathetic vasomotor toneIt is well known that the ventrolateral medulla contains neurons involved in the tonic and reflex control of the cardiovascular system. Two regions within the ventrolateral medulla were initially identified: the rostral ventrolateral medulla (RVLM) and the caudal ventrolateral medulla (CVLM). Activation of the RVLM raises arterial blood pressure and sympathetic nerve activity, and activation of the CVLM causes opposite effects. The RVLM premotor neurons project directly to sympathetic preganglionic neurons and are involved in the maintenance of resting sympathetic vasomotor tone. A significant proportion of tonic activity in the RVLM sympathetic premotor neurons is driven by neurons located in a third region of the ventrolateral medulla denominated caudal pressor area (CPA). The CPA is a pressor region located at the extreme caudal part of the ventrolateral medulla that appears to have an important role controlling the activity of RVLM neurons. In this brief review, we will address the importance of the ventrolateral medulla neurons for the generation of resting sympathetic tone related to arterial blood pressure control focusing on two regions, the RVLM and the CPA.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Disciplina de Fisiologia Cardiovascular e RespiratóriaUniversidade Federal do Espírito Santo Laboratório de NeuromorfologiaUniversidade Federal do Espírito Santo Programa de Pós-Graduação em Ciências FisiológicasSanta Casa de Misericórdia de Vitória (EMESCAM) Escola Superior de CiênciasUniversidade Federal de São Paulo (UNIFESP) Campus Baixada Santista Departamento de BiociênicasUNIFESP, EPM, Disciplina de Fisiologia Cardiovascular e RespiratóriaUNIFESP, Campus Baixada Santista Depto. de BiociênicasSciELOFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Associação Brasileira de Divulgação CientíficaUniversidade Federal de São Paulo (UNIFESP)Universidade Federal do Espírito Santo Laboratório de NeuromorfologiaUniversidade Federal do Espírito Santo Programa de Pós-Graduação em Ciências FisiológicasSanta Casa de Misericórdia de Vitória (EMESCAM) Escola Superior de CiênciasCampos, Ruy Ribeiro [UNIFESP]Carillo, Bruno de Arruda [UNIFESP]Oliveira-Sales, Elizabeth Barbosa de [UNIFESP]Silva, Adilson Marques da [UNIFESP]Silva, Nyam Florencio daFuturo Neto, Henrique AzevedoBergamaschi, Cassia Toledo [UNIFESP]2015-06-14T13:38:38Z2015-06-14T13:38:38Z2008-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion557-562application/pdfhttp://dx.doi.org/10.1590/S0100-879X2008000700002Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 41, n. 7, p. 557-562, 2008.10.1590/S0100-879X2008000700002S0100-879X2008000700002.pdf0100-879XS0100-879X2008000700002http://repositorio.unifesp.br/handle/11600/4465WOS:000259326100002engBrazilian Journal of Medical and Biological Researchinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-29T07:00:41Zoai:repositorio.unifesp.br/:11600/4465Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-29T07:00:41Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Role of the caudal pressor area in the regulation of sympathetic vasomotor tone |
title |
Role of the caudal pressor area in the regulation of sympathetic vasomotor tone |
spellingShingle |
Role of the caudal pressor area in the regulation of sympathetic vasomotor tone Campos, Ruy Ribeiro [UNIFESP] Rostral ventrolateral medulla Rat Glutamate Blood pressure Caudal pressor area Sympathetic vasomotor tone |
title_short |
Role of the caudal pressor area in the regulation of sympathetic vasomotor tone |
title_full |
Role of the caudal pressor area in the regulation of sympathetic vasomotor tone |
title_fullStr |
Role of the caudal pressor area in the regulation of sympathetic vasomotor tone |
title_full_unstemmed |
Role of the caudal pressor area in the regulation of sympathetic vasomotor tone |
title_sort |
Role of the caudal pressor area in the regulation of sympathetic vasomotor tone |
author |
Campos, Ruy Ribeiro [UNIFESP] |
author_facet |
Campos, Ruy Ribeiro [UNIFESP] Carillo, Bruno de Arruda [UNIFESP] Oliveira-Sales, Elizabeth Barbosa de [UNIFESP] Silva, Adilson Marques da [UNIFESP] Silva, Nyam Florencio da Futuro Neto, Henrique Azevedo Bergamaschi, Cassia Toledo [UNIFESP] |
author_role |
author |
author2 |
Carillo, Bruno de Arruda [UNIFESP] Oliveira-Sales, Elizabeth Barbosa de [UNIFESP] Silva, Adilson Marques da [UNIFESP] Silva, Nyam Florencio da Futuro Neto, Henrique Azevedo Bergamaschi, Cassia Toledo [UNIFESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Universidade Federal do Espírito Santo Laboratório de Neuromorfologia Universidade Federal do Espírito Santo Programa de Pós-Graduação em Ciências Fisiológicas Santa Casa de Misericórdia de Vitória (EMESCAM) Escola Superior de Ciências |
dc.contributor.author.fl_str_mv |
Campos, Ruy Ribeiro [UNIFESP] Carillo, Bruno de Arruda [UNIFESP] Oliveira-Sales, Elizabeth Barbosa de [UNIFESP] Silva, Adilson Marques da [UNIFESP] Silva, Nyam Florencio da Futuro Neto, Henrique Azevedo Bergamaschi, Cassia Toledo [UNIFESP] |
dc.subject.por.fl_str_mv |
Rostral ventrolateral medulla Rat Glutamate Blood pressure Caudal pressor area Sympathetic vasomotor tone |
topic |
Rostral ventrolateral medulla Rat Glutamate Blood pressure Caudal pressor area Sympathetic vasomotor tone |
description |
It is well known that the ventrolateral medulla contains neurons involved in the tonic and reflex control of the cardiovascular system. Two regions within the ventrolateral medulla were initially identified: the rostral ventrolateral medulla (RVLM) and the caudal ventrolateral medulla (CVLM). Activation of the RVLM raises arterial blood pressure and sympathetic nerve activity, and activation of the CVLM causes opposite effects. The RVLM premotor neurons project directly to sympathetic preganglionic neurons and are involved in the maintenance of resting sympathetic vasomotor tone. A significant proportion of tonic activity in the RVLM sympathetic premotor neurons is driven by neurons located in a third region of the ventrolateral medulla denominated caudal pressor area (CPA). The CPA is a pressor region located at the extreme caudal part of the ventrolateral medulla that appears to have an important role controlling the activity of RVLM neurons. In this brief review, we will address the importance of the ventrolateral medulla neurons for the generation of resting sympathetic tone related to arterial blood pressure control focusing on two regions, the RVLM and the CPA. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-07-01 2015-06-14T13:38:38Z 2015-06-14T13:38:38Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0100-879X2008000700002 Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 41, n. 7, p. 557-562, 2008. 10.1590/S0100-879X2008000700002 S0100-879X2008000700002.pdf 0100-879X S0100-879X2008000700002 http://repositorio.unifesp.br/handle/11600/4465 WOS:000259326100002 |
url |
http://dx.doi.org/10.1590/S0100-879X2008000700002 http://repositorio.unifesp.br/handle/11600/4465 |
identifier_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 41, n. 7, p. 557-562, 2008. 10.1590/S0100-879X2008000700002 S0100-879X2008000700002.pdf 0100-879X S0100-879X2008000700002 WOS:000259326100002 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
557-562 application/pdf |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268430723842048 |