Comparative study of the growth and nutritional status of Brazilian and Nigerian school-aged children with sickle cell disease
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/58203 http://dx.doi.org/10.1093/inthealth/ihx035 |
Resumo: | Background: Comparative studies of patients in different sociogeographic/ecological zones may unravel potential environmental and nutritional factors influencing disease phenotype. In sickle cell disease (SCD), differential access to comprehensive care may influence their growth and nutritional status. Methods: From June 2015 to February 2016, steady-state nutritional parameters of 109 Brazilian and 95 Nigerian children with SCD attending routine clinic visits at Universidade Federal de Sao Paulo, Brazil and Obafemi Awolowo University Teaching Hospital, Ile-Ife (Ilesa unit), respectively, were compared. Results: A relatively high proportion of the children in both centres (23.5%) were wasted [body-mass index (BMI)-for-age z-score<-2). BMI-for-age z-score, height-for-age z-score, upper arm fat area and fat percentage were lower in the Nigerian cohorts. More Nigerians, 29.5% (28/95) against 18.3% (20/109) were wasted, and had short stature, [12.6% (12/95) vs. 3.7% (4/109)] than Brazilians. A higher proportion of Brazilian patients were overweight or obese (9.2 vs. 4.3%), and taller for age (15.6 vs. 8.4%). None of the Nigerian patients had severe vitamin D deficiency, only 12.6% (12/95) had suboptimal vitamin D and 1.1% (1/95) had low serum zinc levels, unlike 79.8% (87/109) of the Brazilian patients with suboptimal vitamin D and 10.1% (11/109) with low zinc. Conclusion: Undernutrition is still prevalent among the two cohorts. Nigerian patients were thinner and had reduced linear growth for age. This observation justifies the continued need for specialized nutritional care for children with SCD. In addition to hydroxyurea therapy, research is needed to determine appropriate nutritional intervention and exercise regimens for these children. |
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Adegoke, Samuel A. [UNIFESP]Figueiredo, Maria S. [UNIFESP]Adekile, Adekunle D.Braga, Josefina A. P. [UNIFESP]2020-09-01T13:21:20Z2020-09-01T13:21:20Z2017International Health. Oxford, v. 9, n. 6, p. 327-334, 2017.1876-3413https://repositorio.unifesp.br/handle/11600/58203http://dx.doi.org/10.1093/inthealth/ihx035WOS000419582000002.pdf10.1093/inthealth/ihx035WOS:000419582000002Background: Comparative studies of patients in different sociogeographic/ecological zones may unravel potential environmental and nutritional factors influencing disease phenotype. In sickle cell disease (SCD), differential access to comprehensive care may influence their growth and nutritional status. Methods: From June 2015 to February 2016, steady-state nutritional parameters of 109 Brazilian and 95 Nigerian children with SCD attending routine clinic visits at Universidade Federal de Sao Paulo, Brazil and Obafemi Awolowo University Teaching Hospital, Ile-Ife (Ilesa unit), respectively, were compared. Results: A relatively high proportion of the children in both centres (23.5%) were wasted [body-mass index (BMI)-for-age z-score<-2). BMI-for-age z-score, height-for-age z-score, upper arm fat area and fat percentage were lower in the Nigerian cohorts. More Nigerians, 29.5% (28/95) against 18.3% (20/109) were wasted, and had short stature, [12.6% (12/95) vs. 3.7% (4/109)] than Brazilians. A higher proportion of Brazilian patients were overweight or obese (9.2 vs. 4.3%), and taller for age (15.6 vs. 8.4%). None of the Nigerian patients had severe vitamin D deficiency, only 12.6% (12/95) had suboptimal vitamin D and 1.1% (1/95) had low serum zinc levels, unlike 79.8% (87/109) of the Brazilian patients with suboptimal vitamin D and 10.1% (11/109) with low zinc. Conclusion: Undernutrition is still prevalent among the two cohorts. Nigerian patients were thinner and had reduced linear growth for age. This observation justifies the continued need for specialized nutritional care for children with SCD. In addition to hydroxyurea therapy, research is needed to determine appropriate nutritional intervention and exercise regimens for these children.CNPqUniv Fed Sao Paulo, Escola Paulista Med, Haematol & Blood Transfus Div, Sao Paulo, BrazilObafemi Awolowo Univ, Dept Pediat & Child Hlth, Ife, NigeriaKuwait Univ, Fac Med, Dept Paediat, Kuwait, KuwaitUniv Fed Sao Paulo, Escola Paulista Med, Dept Pediat, Sao Paulo, BrazilUniv Fed Sao Paulo, Escola Paulista Med, Haematol & Blood Transfus Div, Sao Paulo, BrazilUniv Fed Sao Paulo, Escola Paulista Med, Dept Pediat, Sao Paulo, BrazilCNPq: 159581/2014-1Web of Science327-334engOxford Univ PressInternational HealthBrazilianChildrenGrowthNigerianNutritional statusSickle cell diseaseComparative study of the growth and nutritional status of Brazilian and Nigerian school-aged children with sickle cell diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleOxford96info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000419582000002.pdfapplication/pdf427725${dspace.ui.url}/bitstream/11600/58203/1/WOS000419582000002.pdfb989d99d8c2395473492a7244ad5405fMD51open accessTEXTWOS000419582000002.pdf.txtWOS000419582000002.pdf.txtExtracted texttext/plain40257${dspace.ui.url}/bitstream/11600/58203/2/WOS000419582000002.pdf.txt2bc2ce61d73f5c0edf12fe72125d5f4dMD52open accessTHUMBNAILWOS000419582000002.pdf.jpgWOS000419582000002.pdf.jpgIM Thumbnailimage/jpeg7681${dspace.ui.url}/bitstream/11600/58203/4/WOS000419582000002.pdf.jpge0b6efdbeeaef16512c34336a6d635f5MD54open access11600/582032022-07-31 18:39:31.864open accessoai:repositorio.unifesp.br:11600/58203Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652022-07-31T21:39:31Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Comparative study of the growth and nutritional status of Brazilian and Nigerian school-aged children with sickle cell disease |
title |
Comparative study of the growth and nutritional status of Brazilian and Nigerian school-aged children with sickle cell disease |
spellingShingle |
Comparative study of the growth and nutritional status of Brazilian and Nigerian school-aged children with sickle cell disease Adegoke, Samuel A. [UNIFESP] Brazilian Children Growth Nigerian Nutritional status Sickle cell disease |
title_short |
Comparative study of the growth and nutritional status of Brazilian and Nigerian school-aged children with sickle cell disease |
title_full |
Comparative study of the growth and nutritional status of Brazilian and Nigerian school-aged children with sickle cell disease |
title_fullStr |
Comparative study of the growth and nutritional status of Brazilian and Nigerian school-aged children with sickle cell disease |
title_full_unstemmed |
Comparative study of the growth and nutritional status of Brazilian and Nigerian school-aged children with sickle cell disease |
title_sort |
Comparative study of the growth and nutritional status of Brazilian and Nigerian school-aged children with sickle cell disease |
author |
Adegoke, Samuel A. [UNIFESP] |
author_facet |
Adegoke, Samuel A. [UNIFESP] Figueiredo, Maria S. [UNIFESP] Adekile, Adekunle D. Braga, Josefina A. P. [UNIFESP] |
author_role |
author |
author2 |
Figueiredo, Maria S. [UNIFESP] Adekile, Adekunle D. Braga, Josefina A. P. [UNIFESP] |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Adegoke, Samuel A. [UNIFESP] Figueiredo, Maria S. [UNIFESP] Adekile, Adekunle D. Braga, Josefina A. P. [UNIFESP] |
dc.subject.eng.fl_str_mv |
Brazilian Children Growth Nigerian Nutritional status Sickle cell disease |
topic |
Brazilian Children Growth Nigerian Nutritional status Sickle cell disease |
description |
Background: Comparative studies of patients in different sociogeographic/ecological zones may unravel potential environmental and nutritional factors influencing disease phenotype. In sickle cell disease (SCD), differential access to comprehensive care may influence their growth and nutritional status. Methods: From June 2015 to February 2016, steady-state nutritional parameters of 109 Brazilian and 95 Nigerian children with SCD attending routine clinic visits at Universidade Federal de Sao Paulo, Brazil and Obafemi Awolowo University Teaching Hospital, Ile-Ife (Ilesa unit), respectively, were compared. Results: A relatively high proportion of the children in both centres (23.5%) were wasted [body-mass index (BMI)-for-age z-score<-2). BMI-for-age z-score, height-for-age z-score, upper arm fat area and fat percentage were lower in the Nigerian cohorts. More Nigerians, 29.5% (28/95) against 18.3% (20/109) were wasted, and had short stature, [12.6% (12/95) vs. 3.7% (4/109)] than Brazilians. A higher proportion of Brazilian patients were overweight or obese (9.2 vs. 4.3%), and taller for age (15.6 vs. 8.4%). None of the Nigerian patients had severe vitamin D deficiency, only 12.6% (12/95) had suboptimal vitamin D and 1.1% (1/95) had low serum zinc levels, unlike 79.8% (87/109) of the Brazilian patients with suboptimal vitamin D and 10.1% (11/109) with low zinc. Conclusion: Undernutrition is still prevalent among the two cohorts. Nigerian patients were thinner and had reduced linear growth for age. This observation justifies the continued need for specialized nutritional care for children with SCD. In addition to hydroxyurea therapy, research is needed to determine appropriate nutritional intervention and exercise regimens for these children. |
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2017 |
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2017 |
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2020-09-01T13:21:20Z |
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International Health. Oxford, v. 9, n. 6, p. 327-334, 2017. |
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https://repositorio.unifesp.br/handle/11600/58203 http://dx.doi.org/10.1093/inthealth/ihx035 |
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1876-3413 |
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WOS000419582000002.pdf |
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