Cytogenetic studies of Brazilian pediatric myelodysplastic syndrome cases: challenges and difficulties in a large and emerging country
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/35720 http://dx.doi.org/10.1590/1414-431X20122449 |
Resumo: | Myelodysplastic syndromes (MDS) and juvenile myelomonocytic leukemia (JMML) are rare hematopoietic stem cell diseases affecting children. Cytogenetics plays an important role in the diagnosis of these diseases. We report here the experience of the Cytogenetic Subcommittee of the Brazilian Cooperative Group on Pediatric Myelodysplastic Syndromes (BCG-MDS-PED). We analyzed 168 cytogenetic studies performed in 23 different cytogenetic centers; 84 of these studies were performed in patients with confirmed MDS (primary MDS, secondary MDS, JMML, and acute myeloid leukemia/MDS+Down syndrome). Clonal abnormalities were found in 36.9% of the MDS cases and cytogenetic studies were important for the detection of constitutional diseases and for differential diagnosis with other myeloid neoplasms. These data show the importance of the Cooperative Group for continuing education in order to avoid a late or wrong diagnosis. |
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Velloso, Elvira Deolinda Rodrigues PereiraChauffaille, Maria de Lourdes [UNIFESP]Pelicario, L. M.Tanizawa, Roberta Sandra da SilvaToledo, Silvia Regina Caminada de [UNIFESP]Gaiolla, R. D.Lopes, L. F.Universidade de São Paulo (USP)Universidade Federal de São Paulo (UNIFESP)Hosp Canc BarretosCtr Tratamento Fabiana Macedo de Morais2016-01-24T14:30:55Z2016-01-24T14:30:55Z2013-01-01Brazilian Journal of Medical and Biological Research. São Paulo: Assoc Bras Divulg Cientifica, v. 46, n. 1, p. 85-90, 2013.0100-879Xhttp://repositorio.unifesp.br/handle/11600/35720http://dx.doi.org/10.1590/1414-431X20122449S0100-879X2013000100085.pdfS0100-879X201300010008510.1590/1414-431X20122449WOS:000316126700011Myelodysplastic syndromes (MDS) and juvenile myelomonocytic leukemia (JMML) are rare hematopoietic stem cell diseases affecting children. Cytogenetics plays an important role in the diagnosis of these diseases. We report here the experience of the Cytogenetic Subcommittee of the Brazilian Cooperative Group on Pediatric Myelodysplastic Syndromes (BCG-MDS-PED). We analyzed 168 cytogenetic studies performed in 23 different cytogenetic centers; 84 of these studies were performed in patients with confirmed MDS (primary MDS, secondary MDS, JMML, and acute myeloid leukemia/MDS+Down syndrome). Clonal abnormalities were found in 36.9% of the MDS cases and cytogenetic studies were important for the detection of constitutional diseases and for differential diagnosis with other myeloid neoplasms. These data show the importance of the Cooperative Group for continuing education in order to avoid a late or wrong diagnosis.Univ São Paulo, Fac Med, Dept Hematol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Hematol, São Paulo, BrazilUniv São Paulo, Fac Med, Dept Hematol, Lab Citogenet, São Paulo, BrazilUniversidade Federal de São Paulo, Inst Oncol Pediat, São Paulo, BrazilUniv Estadual Paulista, Fac Med Botucatu, Dept Clin Med, Botucatu, SP, BrazilHosp Canc Barretos, Barretos, SP, BrazilCtr Tratamento Fabiana Macedo de Morais, Grp Assistencia Crianca Canc, Grp Cooperat Brasileiro Sindrome Mielodisplas Ped, Sao Jose Dos Campos, SP, BrazilUniversidade Federal de São Paulo, Dept Hematol, São Paulo, BrazilUniversidade Federal de São Paulo, Inst Oncol Pediat, São Paulo, BrazilWeb of Science85-90engAssoc Bras Divulg CientificaBrazilian Journal of Medical and Biological ResearchChildhood myelodysplastic syndromesJuvenile myelomonocytic leukemiaCytogeneticsKaryotypeDiagnosisCytogenetic studies of Brazilian pediatric myelodysplastic syndrome cases: challenges and difficulties in a large and emerging countryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0100-879X2013000100085.pdfapplication/pdf308946${dspace.ui.url}/bitstream/11600/35720/1/S0100-879X2013000100085.pdf3dcdea54bb6afb74c86d9c869bbe9258MD51open access11600/357202022-06-02 09:05:59.836open accessoai:repositorio.unifesp.br:11600/35720Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652022-06-02T12:05:59Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Cytogenetic studies of Brazilian pediatric myelodysplastic syndrome cases: challenges and difficulties in a large and emerging country |
title |
Cytogenetic studies of Brazilian pediatric myelodysplastic syndrome cases: challenges and difficulties in a large and emerging country |
spellingShingle |
Cytogenetic studies of Brazilian pediatric myelodysplastic syndrome cases: challenges and difficulties in a large and emerging country Velloso, Elvira Deolinda Rodrigues Pereira Childhood myelodysplastic syndromes Juvenile myelomonocytic leukemia Cytogenetics Karyotype Diagnosis |
title_short |
Cytogenetic studies of Brazilian pediatric myelodysplastic syndrome cases: challenges and difficulties in a large and emerging country |
title_full |
Cytogenetic studies of Brazilian pediatric myelodysplastic syndrome cases: challenges and difficulties in a large and emerging country |
title_fullStr |
Cytogenetic studies of Brazilian pediatric myelodysplastic syndrome cases: challenges and difficulties in a large and emerging country |
title_full_unstemmed |
Cytogenetic studies of Brazilian pediatric myelodysplastic syndrome cases: challenges and difficulties in a large and emerging country |
title_sort |
Cytogenetic studies of Brazilian pediatric myelodysplastic syndrome cases: challenges and difficulties in a large and emerging country |
author |
Velloso, Elvira Deolinda Rodrigues Pereira |
author_facet |
Velloso, Elvira Deolinda Rodrigues Pereira Chauffaille, Maria de Lourdes [UNIFESP] Pelicario, L. M. Tanizawa, Roberta Sandra da Silva Toledo, Silvia Regina Caminada de [UNIFESP] Gaiolla, R. D. Lopes, L. F. |
author_role |
author |
author2 |
Chauffaille, Maria de Lourdes [UNIFESP] Pelicario, L. M. Tanizawa, Roberta Sandra da Silva Toledo, Silvia Regina Caminada de [UNIFESP] Gaiolla, R. D. Lopes, L. F. |
author2_role |
author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Federal de São Paulo (UNIFESP) Hosp Canc Barretos Ctr Tratamento Fabiana Macedo de Morais |
dc.contributor.author.fl_str_mv |
Velloso, Elvira Deolinda Rodrigues Pereira Chauffaille, Maria de Lourdes [UNIFESP] Pelicario, L. M. Tanizawa, Roberta Sandra da Silva Toledo, Silvia Regina Caminada de [UNIFESP] Gaiolla, R. D. Lopes, L. F. |
dc.subject.eng.fl_str_mv |
Childhood myelodysplastic syndromes Juvenile myelomonocytic leukemia Cytogenetics Karyotype Diagnosis |
topic |
Childhood myelodysplastic syndromes Juvenile myelomonocytic leukemia Cytogenetics Karyotype Diagnosis |
description |
Myelodysplastic syndromes (MDS) and juvenile myelomonocytic leukemia (JMML) are rare hematopoietic stem cell diseases affecting children. Cytogenetics plays an important role in the diagnosis of these diseases. We report here the experience of the Cytogenetic Subcommittee of the Brazilian Cooperative Group on Pediatric Myelodysplastic Syndromes (BCG-MDS-PED). We analyzed 168 cytogenetic studies performed in 23 different cytogenetic centers; 84 of these studies were performed in patients with confirmed MDS (primary MDS, secondary MDS, JMML, and acute myeloid leukemia/MDS+Down syndrome). Clonal abnormalities were found in 36.9% of the MDS cases and cytogenetic studies were important for the detection of constitutional diseases and for differential diagnosis with other myeloid neoplasms. These data show the importance of the Cooperative Group for continuing education in order to avoid a late or wrong diagnosis. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013-01-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:30:55Z |
dc.date.available.fl_str_mv |
2016-01-24T14:30:55Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Brazilian Journal of Medical and Biological Research. São Paulo: Assoc Bras Divulg Cientifica, v. 46, n. 1, p. 85-90, 2013. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/35720 http://dx.doi.org/10.1590/1414-431X20122449 |
dc.identifier.issn.none.fl_str_mv |
0100-879X |
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S0100-879X2013000100085.pdf |
dc.identifier.scielo.none.fl_str_mv |
S0100-879X2013000100085 |
dc.identifier.doi.none.fl_str_mv |
10.1590/1414-431X20122449 |
dc.identifier.wos.none.fl_str_mv |
WOS:000316126700011 |
identifier_str_mv |
Brazilian Journal of Medical and Biological Research. São Paulo: Assoc Bras Divulg Cientifica, v. 46, n. 1, p. 85-90, 2013. 0100-879X S0100-879X2013000100085.pdf S0100-879X2013000100085 10.1590/1414-431X20122449 WOS:000316126700011 |
url |
http://repositorio.unifesp.br/handle/11600/35720 http://dx.doi.org/10.1590/1414-431X20122449 |
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85-90 |
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Assoc Bras Divulg Cientifica |
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Assoc Bras Divulg Cientifica |
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