Concentrações séricas de 25-hidroxivitamina D e suas associações com intolerância à glicose em uma população indígena, os índios Xavante
Autor(a) principal: | |
---|---|
Data de Publicação: | 2020 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=9969095 https://repositorio.unifesp.br/xmlui/handle/11600/64761 |
Resumo: | Background and aims: Type 2 diabetes is a multifactorial disease resulting from diverse genetic and environmental factors as well as the interaction between them. Low levels of 25-hydroxyvitamin D [25(OH)D], an indicator of vitamin D status, have been associated with an increased risk of type 2 diabetes, but not consistently. Also, it remains to be determined if this association differs among ethnic groups. Therefore, we aimed to evaluate vitamin D status and its association with glucose intolerance in a Brazilian indigenous population, the Xavante Indians. Methods: The study population consisted of 819 full Xavante Indians (410 women), aged !18 years and living in two indigenous reserves located in Mato Grosso State, central region of Brazil. Clinical examination and anthropometrical measurements were made, blood samples were obtained for total cholesterol, HDL-cholesterol, triglycerides and 25(OH)D measurement. Fasting and 2-h post 75 g oral glucose load capillary glucose was measured. Vitamin D status was defined by serum 25(OH)D levels: vitamin D sufficiency (25(OH)D: 30e100 ng/mL), vitamin D insufficiency (25(OH)D: 20- <30 ng/mL) and vitamin D deficiency (25(OH)D: < 20 ng/mL). Multiple logistic regression was performed to identify independent associations between 25(OH)D levels and impaired glucose tolerance or diabetes mellitus. Results: Analyses stratified by 25(OH)D levels shows that 65.5% of the population had vitamin D deficiency/insufficiency (25(OH)D < 30 ng/mL). 25(OH)D concentrations were lower in individuals with impaired glucose tolerance or diabetes mellitus than in normal glucose tolerant individuals. Multiple logistic regression analysis showed an inverse association between increments of 25(OH)D and presence of diabetes mellitus (OR per 1 ng/mL increase in 25(OH)D: 0.97; 95% confidence interval: 0.95e0.99), or impaired glucose tolerance (OR per 1 ng/mL increase in 25(OH)D: 0.87; 95% confidence interval: 0.85 e0.89), in an age, sex, BMI and season of sampling-adjusted model. Conclusions: The present population-based study found a high prevalence of hypovitaminosis D among Xavante Indians. In this at-risk population of type 2 diabetes, a significant association of higher serum 25(OH)D with a decreased prevalence of diabetes mellitus and impaired glucose tolerance was observed. |
id |
UFSP_f4cb6c103223533ff4c2f164ea895ec2 |
---|---|
oai_identifier_str |
oai:repositorio.unifesp.br:11600/64761 |
network_acronym_str |
UFSP |
network_name_str |
Repositório Institucional da UNIFESP |
repository_id_str |
3465 |
spelling |
Abrahao, Giovanna Campos Paranhos [UNIFESP]Universidade Federal de São PauloMoises, Regina Celia Mello Santiago [UNIFESP]2022-07-22T13:50:46Z2022-07-22T13:50:46Z2020-12-18https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=9969095https://repositorio.unifesp.br/xmlui/handle/11600/64761GIOVANNA CAMPOS PARANHOS ABRAHAO.pdfBackground and aims: Type 2 diabetes is a multifactorial disease resulting from diverse genetic and environmental factors as well as the interaction between them. Low levels of 25-hydroxyvitamin D [25(OH)D], an indicator of vitamin D status, have been associated with an increased risk of type 2 diabetes, but not consistently. Also, it remains to be determined if this association differs among ethnic groups. Therefore, we aimed to evaluate vitamin D status and its association with glucose intolerance in a Brazilian indigenous population, the Xavante Indians. Methods: The study population consisted of 819 full Xavante Indians (410 women), aged !18 years and living in two indigenous reserves located in Mato Grosso State, central region of Brazil. Clinical examination and anthropometrical measurements were made, blood samples were obtained for total cholesterol, HDL-cholesterol, triglycerides and 25(OH)D measurement. Fasting and 2-h post 75 g oral glucose load capillary glucose was measured. Vitamin D status was defined by serum 25(OH)D levels: vitamin D sufficiency (25(OH)D: 30e100 ng/mL), vitamin D insufficiency (25(OH)D: 20- <30 ng/mL) and vitamin D deficiency (25(OH)D: < 20 ng/mL). Multiple logistic regression was performed to identify independent associations between 25(OH)D levels and impaired glucose tolerance or diabetes mellitus. Results: Analyses stratified by 25(OH)D levels shows that 65.5% of the population had vitamin D deficiency/insufficiency (25(OH)D < 30 ng/mL). 25(OH)D concentrations were lower in individuals with impaired glucose tolerance or diabetes mellitus than in normal glucose tolerant individuals. Multiple logistic regression analysis showed an inverse association between increments of 25(OH)D and presence of diabetes mellitus (OR per 1 ng/mL increase in 25(OH)D: 0.97; 95% confidence interval: 0.95e0.99), or impaired glucose tolerance (OR per 1 ng/mL increase in 25(OH)D: 0.87; 95% confidence interval: 0.85 e0.89), in an age, sex, BMI and season of sampling-adjusted model. Conclusions: The present population-based study found a high prevalence of hypovitaminosis D among Xavante Indians. In this at-risk population of type 2 diabetes, a significant association of higher serum 25(OH)D with a decreased prevalence of diabetes mellitus and impaired glucose tolerance was observed.Dados abertos - Sucupira - Teses e dissertações (2020)65 p.porUniversidade Federal de São Paulo (UNIFESP)25-Hidroxivitamina DIntolerância À GlicoseÍndios Xavante25-Hydroxyvitamin DGlucose IntoleranceXavante IndiansConcentrações séricas de 25-hidroxivitamina D e suas associações com intolerância à glicose em uma população indígena, os índios Xavanteinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisMestradoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPSão Paulo, Escola Paulista de Medicina (EPM)Medicina (Endocrinologia e Metabologia)Endocrinologia E MetabologiaFisiologia, Fisiopatologia E EtiopatogeniaORIGINALGIOVANNA CAMPOS PARANHOS ABRAHAO.pdfGIOVANNA CAMPOS PARANHOS ABRAHAO.pdfapplication/pdf1075886${dspace.ui.url}/bitstream/11600/64761/1/GIOVANNA%20CAMPOS%20PARANHOS%20ABRAHAO.pdf8856950adae9eda2574463d05ae33f4aMD51open accessTEXTGIOVANNA CAMPOS PARANHOS ABRAHAO.pdf.txtGIOVANNA CAMPOS PARANHOS ABRAHAO.pdf.txtExtracted texttext/plain105490${dspace.ui.url}/bitstream/11600/64761/2/GIOVANNA%20CAMPOS%20PARANHOS%20ABRAHAO.pdf.txtc0c43e218d96ef000f221eef4019e4a9MD52open accessTHUMBNAILGIOVANNA CAMPOS PARANHOS ABRAHAO.pdf.jpgGIOVANNA CAMPOS PARANHOS ABRAHAO.pdf.jpgIM Thumbnailimage/jpeg3735${dspace.ui.url}/bitstream/11600/64761/4/GIOVANNA%20CAMPOS%20PARANHOS%20ABRAHAO.pdf.jpged7dadecc5aec33c63f5b1e9254fb944MD54open access11600/647612023-05-12 06:05:02.451open accessoai:repositorio.unifesp.br:11600/64761Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-12T09:05:02Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.pt.fl_str_mv |
Concentrações séricas de 25-hidroxivitamina D e suas associações com intolerância à glicose em uma população indígena, os índios Xavante |
title |
Concentrações séricas de 25-hidroxivitamina D e suas associações com intolerância à glicose em uma população indígena, os índios Xavante |
spellingShingle |
Concentrações séricas de 25-hidroxivitamina D e suas associações com intolerância à glicose em uma população indígena, os índios Xavante Abrahao, Giovanna Campos Paranhos [UNIFESP] 25-Hidroxivitamina D Intolerância À Glicose Índios Xavante 25-Hydroxyvitamin D Glucose Intolerance Xavante Indians |
title_short |
Concentrações séricas de 25-hidroxivitamina D e suas associações com intolerância à glicose em uma população indígena, os índios Xavante |
title_full |
Concentrações séricas de 25-hidroxivitamina D e suas associações com intolerância à glicose em uma população indígena, os índios Xavante |
title_fullStr |
Concentrações séricas de 25-hidroxivitamina D e suas associações com intolerância à glicose em uma população indígena, os índios Xavante |
title_full_unstemmed |
Concentrações séricas de 25-hidroxivitamina D e suas associações com intolerância à glicose em uma população indígena, os índios Xavante |
title_sort |
Concentrações séricas de 25-hidroxivitamina D e suas associações com intolerância à glicose em uma população indígena, os índios Xavante |
author |
Abrahao, Giovanna Campos Paranhos [UNIFESP] |
author_facet |
Abrahao, Giovanna Campos Paranhos [UNIFESP] |
author_role |
author |
dc.contributor.institution.pt.fl_str_mv |
Universidade Federal de São Paulo |
dc.contributor.author.fl_str_mv |
Abrahao, Giovanna Campos Paranhos [UNIFESP] |
dc.contributor.advisor1.fl_str_mv |
Moises, Regina Celia Mello Santiago [UNIFESP] |
contributor_str_mv |
Moises, Regina Celia Mello Santiago [UNIFESP] |
dc.subject.por.fl_str_mv |
25-Hidroxivitamina D Intolerância À Glicose Índios Xavante |
topic |
25-Hidroxivitamina D Intolerância À Glicose Índios Xavante 25-Hydroxyvitamin D Glucose Intolerance Xavante Indians |
dc.subject.eng.fl_str_mv |
25-Hydroxyvitamin D Glucose Intolerance Xavante Indians |
description |
Background and aims: Type 2 diabetes is a multifactorial disease resulting from diverse genetic and environmental factors as well as the interaction between them. Low levels of 25-hydroxyvitamin D [25(OH)D], an indicator of vitamin D status, have been associated with an increased risk of type 2 diabetes, but not consistently. Also, it remains to be determined if this association differs among ethnic groups. Therefore, we aimed to evaluate vitamin D status and its association with glucose intolerance in a Brazilian indigenous population, the Xavante Indians. Methods: The study population consisted of 819 full Xavante Indians (410 women), aged !18 years and living in two indigenous reserves located in Mato Grosso State, central region of Brazil. Clinical examination and anthropometrical measurements were made, blood samples were obtained for total cholesterol, HDL-cholesterol, triglycerides and 25(OH)D measurement. Fasting and 2-h post 75 g oral glucose load capillary glucose was measured. Vitamin D status was defined by serum 25(OH)D levels: vitamin D sufficiency (25(OH)D: 30e100 ng/mL), vitamin D insufficiency (25(OH)D: 20- <30 ng/mL) and vitamin D deficiency (25(OH)D: < 20 ng/mL). Multiple logistic regression was performed to identify independent associations between 25(OH)D levels and impaired glucose tolerance or diabetes mellitus. Results: Analyses stratified by 25(OH)D levels shows that 65.5% of the population had vitamin D deficiency/insufficiency (25(OH)D < 30 ng/mL). 25(OH)D concentrations were lower in individuals with impaired glucose tolerance or diabetes mellitus than in normal glucose tolerant individuals. Multiple logistic regression analysis showed an inverse association between increments of 25(OH)D and presence of diabetes mellitus (OR per 1 ng/mL increase in 25(OH)D: 0.97; 95% confidence interval: 0.95e0.99), or impaired glucose tolerance (OR per 1 ng/mL increase in 25(OH)D: 0.87; 95% confidence interval: 0.85 e0.89), in an age, sex, BMI and season of sampling-adjusted model. Conclusions: The present population-based study found a high prevalence of hypovitaminosis D among Xavante Indians. In this at-risk population of type 2 diabetes, a significant association of higher serum 25(OH)D with a decreased prevalence of diabetes mellitus and impaired glucose tolerance was observed. |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020-12-18 |
dc.date.accessioned.fl_str_mv |
2022-07-22T13:50:46Z |
dc.date.available.fl_str_mv |
2022-07-22T13:50:46Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.pt.fl_str_mv |
https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=9969095 |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/xmlui/handle/11600/64761 |
dc.identifier.file.none.fl_str_mv |
GIOVANNA CAMPOS PARANHOS ABRAHAO.pdf |
url |
https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=9969095 https://repositorio.unifesp.br/xmlui/handle/11600/64761 |
identifier_str_mv |
GIOVANNA CAMPOS PARANHOS ABRAHAO.pdf |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
65 p. |
dc.publisher.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
publisher.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
bitstream.url.fl_str_mv |
${dspace.ui.url}/bitstream/11600/64761/1/GIOVANNA%20CAMPOS%20PARANHOS%20ABRAHAO.pdf ${dspace.ui.url}/bitstream/11600/64761/2/GIOVANNA%20CAMPOS%20PARANHOS%20ABRAHAO.pdf.txt ${dspace.ui.url}/bitstream/11600/64761/4/GIOVANNA%20CAMPOS%20PARANHOS%20ABRAHAO.pdf.jpg |
bitstream.checksum.fl_str_mv |
8856950adae9eda2574463d05ae33f4a c0c43e218d96ef000f221eef4019e4a9 ed7dadecc5aec33c63f5b1e9254fb944 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1802764154031833088 |