Epilepsy research 150 years after Darwin's theory of evolution

Detalhes bibliográficos
Autor(a) principal: Scorza, Fulvio Alexandre [UNIFESP]
Data de Publicação: 2009
Outros Autores: Terra, Vera Cristina, Scorza, Carla Alessandra [UNIFESP], Arida, Ricardo Mario [UNIFESP], Cavalheiro, Esper Abrão [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0004-282X2009000600032
http://repositorio.unifesp.br/handle/11600/5426
Resumo: On February 12, 2009, we commemorated the 200th anniversary of Charles Darwin's birth and the 150th anniversary of the publication of the ûrst edition of the On the origin of species. Only in the sixth edition of the Origin Darwin explicitly stated that natural selection applied to the brain as to all other organs and contemporary epilepsy research plays an interesting role in this scenario. Epilepsy affects approximately 3 percent of the general population and is a complex disease. At least 11 genes have now been described for human epilepsy and over 50 more genes have been identified in animal models of epilepsy. The complex gene to gene interactions and gene-environment interactions may account for epilepsy susceptibility and antiepileptic drug response. Darwin's thoughts on evolution are relevant to understand these gene interactions, contributing to current development of new treatments and prevention of chronic diseases, such as epilepsy.
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spelling Epilepsy research 150 years after Darwin's theory of evolutionPesquisas em epilepsia 150 anos após a teoria da evolução de DarwinDarwinepilepsygeneDarwinepilepsiagenesOn February 12, 2009, we commemorated the 200th anniversary of Charles Darwin's birth and the 150th anniversary of the publication of the ûrst edition of the On the origin of species. Only in the sixth edition of the Origin Darwin explicitly stated that natural selection applied to the brain as to all other organs and contemporary epilepsy research plays an interesting role in this scenario. Epilepsy affects approximately 3 percent of the general population and is a complex disease. At least 11 genes have now been described for human epilepsy and over 50 more genes have been identified in animal models of epilepsy. The complex gene to gene interactions and gene-environment interactions may account for epilepsy susceptibility and antiepileptic drug response. Darwin's thoughts on evolution are relevant to understand these gene interactions, contributing to current development of new treatments and prevention of chronic diseases, such as epilepsy.Em 12 de Fevereiro de 2009 nós comemoramos o aniversário de 200 anos de Charles Darwin e os 150 anos da publicação da primeira edição do livro A Origem das Espécies. Apenas na sexta edição do livro A Origem, Darwin explicitamente definiu que a seleção natural se aplicava ao cérebro, assim como a todos os outros órgãos e as pesquisas contemporâneas em epilepsia tem um papel interessante neste cenário. A epilepsia afeta aproximadamente 3% da população geral e é uma doença complexa. Ao menos 11 genes foram descritos até o momento na epilepsia humana e mais de 50 genes foram identificados em modelos animais de epilepsia. As complexas interações gene-gene e genes-meio ambiente podem estar relacionadas com a susceptibilidade à epilepsia e respostas às drogas antiepilépticas. Os pensamentos de Darwin quanto à evolução são relevantes para a compreensão dessas interações gênicas, contribuindo para o desenvolvimento de novos tratamentos e na prevenção de doenças crônicas, como a epilepsia.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de MedicinaUniversidade de São Paulo Faculdade de Medicina de Ribeirão Preto Departamento de Neurociências e Ciências do ComportamentoUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de FisiologiaUNIFESP, EPM, Depto. de FisiologiaSciELOAcademia Brasileira de Neurologia - ABNEUROUniversidade Federal de São Paulo (UNIFESP)Universidade de São Paulo (USP)Scorza, Fulvio Alexandre [UNIFESP]Terra, Vera CristinaScorza, Carla Alessandra [UNIFESP]Arida, Ricardo Mario [UNIFESP]Cavalheiro, Esper Abrão [UNIFESP]2015-06-14T13:41:20Z2015-06-14T13:41:20Z2009-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1114-1116application/pdfhttp://dx.doi.org/10.1590/S0004-282X2009000600032Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 67, n. 4, p. 1114-1116, 2009.10.1590/S0004-282X2009000600032S0004-282X2009000600032.pdf0004-282XS0004-282X2009000600032http://repositorio.unifesp.br/handle/11600/5426WOS:000272736500032engArquivos de Neuro-Psiquiatriainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-29T12:11:31Zoai:repositorio.unifesp.br/:11600/5426Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-29T12:11:31Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Epilepsy research 150 years after Darwin's theory of evolution
Pesquisas em epilepsia 150 anos após a teoria da evolução de Darwin
title Epilepsy research 150 years after Darwin's theory of evolution
spellingShingle Epilepsy research 150 years after Darwin's theory of evolution
Scorza, Fulvio Alexandre [UNIFESP]
Darwin
epilepsy
gene
Darwin
epilepsia
genes
title_short Epilepsy research 150 years after Darwin's theory of evolution
title_full Epilepsy research 150 years after Darwin's theory of evolution
title_fullStr Epilepsy research 150 years after Darwin's theory of evolution
title_full_unstemmed Epilepsy research 150 years after Darwin's theory of evolution
title_sort Epilepsy research 150 years after Darwin's theory of evolution
author Scorza, Fulvio Alexandre [UNIFESP]
author_facet Scorza, Fulvio Alexandre [UNIFESP]
Terra, Vera Cristina
Scorza, Carla Alessandra [UNIFESP]
Arida, Ricardo Mario [UNIFESP]
Cavalheiro, Esper Abrão [UNIFESP]
author_role author
author2 Terra, Vera Cristina
Scorza, Carla Alessandra [UNIFESP]
Arida, Ricardo Mario [UNIFESP]
Cavalheiro, Esper Abrão [UNIFESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
dc.contributor.author.fl_str_mv Scorza, Fulvio Alexandre [UNIFESP]
Terra, Vera Cristina
Scorza, Carla Alessandra [UNIFESP]
Arida, Ricardo Mario [UNIFESP]
Cavalheiro, Esper Abrão [UNIFESP]
dc.subject.por.fl_str_mv Darwin
epilepsy
gene
Darwin
epilepsia
genes
topic Darwin
epilepsy
gene
Darwin
epilepsia
genes
description On February 12, 2009, we commemorated the 200th anniversary of Charles Darwin's birth and the 150th anniversary of the publication of the ûrst edition of the On the origin of species. Only in the sixth edition of the Origin Darwin explicitly stated that natural selection applied to the brain as to all other organs and contemporary epilepsy research plays an interesting role in this scenario. Epilepsy affects approximately 3 percent of the general population and is a complex disease. At least 11 genes have now been described for human epilepsy and over 50 more genes have been identified in animal models of epilepsy. The complex gene to gene interactions and gene-environment interactions may account for epilepsy susceptibility and antiepileptic drug response. Darwin's thoughts on evolution are relevant to understand these gene interactions, contributing to current development of new treatments and prevention of chronic diseases, such as epilepsy.
publishDate 2009
dc.date.none.fl_str_mv 2009-12-01
2015-06-14T13:41:20Z
2015-06-14T13:41:20Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0004-282X2009000600032
Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 67, n. 4, p. 1114-1116, 2009.
10.1590/S0004-282X2009000600032
S0004-282X2009000600032.pdf
0004-282X
S0004-282X2009000600032
http://repositorio.unifesp.br/handle/11600/5426
WOS:000272736500032
url http://dx.doi.org/10.1590/S0004-282X2009000600032
http://repositorio.unifesp.br/handle/11600/5426
identifier_str_mv Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 67, n. 4, p. 1114-1116, 2009.
10.1590/S0004-282X2009000600032
S0004-282X2009000600032.pdf
0004-282X
S0004-282X2009000600032
WOS:000272736500032
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Arquivos de Neuro-Psiquiatria
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1114-1116
application/pdf
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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