Effects of daily intake of zidovudine-stavudine on rat pregnancy outcome: biological essay
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://www.irog.net/download/?magazine=21 http://repositorio.unifesp.br/handle/11600/43294 |
Resumo: | Purpose: To evaluate the effects at term of a highly active antiretroviral drug association when administered for the whole period of rat pregnancy. Methods: Forty pregnant rats weighing about 200 g were randomly divided into four groups: a control group (Ctr = drug vehicle control, n = 10) and three experimental groups. which were treated with an oral solution of zidovudine-stavudine (Exp1x = 10/1 mg/kg b.w., n = 10; Exp3x = 30/3 mg/kg b.w., n = 10; Exp9x = 90/9 mg/kg b.w., n = 10) from day 0 up to the 20th day of pregnancy. Maternal body weights were recorded at the start of the experiment and on the 7th, 14th and 20th day thereafter. At term (20th day) the rats were anesthetized and submitted to hysterotomy. Implantations, reabsorptions, living fetuses, placentae and intrauterine deaths were looked for and recorded. The collected fetuses and placentae were weighed and the concepts were examined by a stereoscopic microscope looking for external malformations. Results: No significant alterations due to the antiretroviral drug treatment could be detected regarding the number of implantations, fetuses, placentae, absorptions and malformations nor regarding maternal and fetal mortality. Conclusions: Administration of the association zidovudine/stavudine for the whole period of rat pregnancy did not interfere with the maternal, fetal and placental weight gain as well as abnormalities detectable by the employed methodology. |
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Effects of daily intake of zidovudine-stavudine on rat pregnancy outcome: biological essayRatPregnancyZidovudineStavudineAdverse effectsPurpose: To evaluate the effects at term of a highly active antiretroviral drug association when administered for the whole period of rat pregnancy. Methods: Forty pregnant rats weighing about 200 g were randomly divided into four groups: a control group (Ctr = drug vehicle control, n = 10) and three experimental groups. which were treated with an oral solution of zidovudine-stavudine (Exp1x = 10/1 mg/kg b.w., n = 10; Exp3x = 30/3 mg/kg b.w., n = 10; Exp9x = 90/9 mg/kg b.w., n = 10) from day 0 up to the 20th day of pregnancy. Maternal body weights were recorded at the start of the experiment and on the 7th, 14th and 20th day thereafter. At term (20th day) the rats were anesthetized and submitted to hysterotomy. Implantations, reabsorptions, living fetuses, placentae and intrauterine deaths were looked for and recorded. The collected fetuses and placentae were weighed and the concepts were examined by a stereoscopic microscope looking for external malformations. Results: No significant alterations due to the antiretroviral drug treatment could be detected regarding the number of implantations, fetuses, placentae, absorptions and malformations nor regarding maternal and fetal mortality. Conclusions: Administration of the association zidovudine/stavudine for the whole period of rat pregnancy did not interfere with the maternal, fetal and placental weight gain as well as abnormalities detectable by the employed methodology.Univ Fed Sao Paulo, Sch Med UNIFESP EPM, Dept Obstet, Sao Paulo, BrazilUniv Sao Paulo, Fac Med FMUSP, Dept Obstet, Sao Paulo, BrazilJose do Rosario Vellano Univ, Sch Med, Dept Internal Med, Alfenas, MG, BrazilABC Med Fdn FUABC, Dept Obstet & Pediat, Sao Paulo, BrazilUniv Fed Sao Paulo, Sch Med UNIFESP EPM, Dept Obstet, Sao Paulo, BrazilWeb of ScienceI R O G Canada, IncUniversidade Federal de São Paulo (UNIFESP)Universidade de São Paulo (USP)Jose do Rosario Vellano UnivABC Med Fdn FUABCAntonio, Eliana Maria Restum [UNIFESP]Fontes, Tereza Maria Pereira [UNIFESP]Simoes, Ricardo Santos [UNIFESP]Carvalho, Adelino Moreira de [UNIFESP]Espiridião, Silvia [UNIFESP]Nakamura, Mary Uchiyama [UNIFESP]Kulay Júnior, Luiz [UNIFESP]2018-06-15T16:52:39Z2018-06-15T16:52:39Z2012-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion205-208http://www.irog.net/download/?magazine=21Clinical And Experimental Obstetrics & Gynecology. Montreal: I R O G Canada, Inc, v. 39, n. 2, p. 205-208, 2012.0390-6663http://repositorio.unifesp.br/handle/11600/43294WOS:000304899500018engClinical And Experimental Obstetrics & Gynecologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-05-02T15:52:26Zoai:repositorio.unifesp.br/:11600/43294Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-05-02T15:52:26Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Effects of daily intake of zidovudine-stavudine on rat pregnancy outcome: biological essay |
title |
Effects of daily intake of zidovudine-stavudine on rat pregnancy outcome: biological essay |
spellingShingle |
Effects of daily intake of zidovudine-stavudine on rat pregnancy outcome: biological essay Antonio, Eliana Maria Restum [UNIFESP] Rat Pregnancy Zidovudine Stavudine Adverse effects |
title_short |
Effects of daily intake of zidovudine-stavudine on rat pregnancy outcome: biological essay |
title_full |
Effects of daily intake of zidovudine-stavudine on rat pregnancy outcome: biological essay |
title_fullStr |
Effects of daily intake of zidovudine-stavudine on rat pregnancy outcome: biological essay |
title_full_unstemmed |
Effects of daily intake of zidovudine-stavudine on rat pregnancy outcome: biological essay |
title_sort |
Effects of daily intake of zidovudine-stavudine on rat pregnancy outcome: biological essay |
author |
Antonio, Eliana Maria Restum [UNIFESP] |
author_facet |
Antonio, Eliana Maria Restum [UNIFESP] Fontes, Tereza Maria Pereira [UNIFESP] Simoes, Ricardo Santos [UNIFESP] Carvalho, Adelino Moreira de [UNIFESP] Espiridião, Silvia [UNIFESP] Nakamura, Mary Uchiyama [UNIFESP] Kulay Júnior, Luiz [UNIFESP] |
author_role |
author |
author2 |
Fontes, Tereza Maria Pereira [UNIFESP] Simoes, Ricardo Santos [UNIFESP] Carvalho, Adelino Moreira de [UNIFESP] Espiridião, Silvia [UNIFESP] Nakamura, Mary Uchiyama [UNIFESP] Kulay Júnior, Luiz [UNIFESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Universidade de São Paulo (USP) Jose do Rosario Vellano Univ ABC Med Fdn FUABC |
dc.contributor.author.fl_str_mv |
Antonio, Eliana Maria Restum [UNIFESP] Fontes, Tereza Maria Pereira [UNIFESP] Simoes, Ricardo Santos [UNIFESP] Carvalho, Adelino Moreira de [UNIFESP] Espiridião, Silvia [UNIFESP] Nakamura, Mary Uchiyama [UNIFESP] Kulay Júnior, Luiz [UNIFESP] |
dc.subject.por.fl_str_mv |
Rat Pregnancy Zidovudine Stavudine Adverse effects |
topic |
Rat Pregnancy Zidovudine Stavudine Adverse effects |
description |
Purpose: To evaluate the effects at term of a highly active antiretroviral drug association when administered for the whole period of rat pregnancy. Methods: Forty pregnant rats weighing about 200 g were randomly divided into four groups: a control group (Ctr = drug vehicle control, n = 10) and three experimental groups. which were treated with an oral solution of zidovudine-stavudine (Exp1x = 10/1 mg/kg b.w., n = 10; Exp3x = 30/3 mg/kg b.w., n = 10; Exp9x = 90/9 mg/kg b.w., n = 10) from day 0 up to the 20th day of pregnancy. Maternal body weights were recorded at the start of the experiment and on the 7th, 14th and 20th day thereafter. At term (20th day) the rats were anesthetized and submitted to hysterotomy. Implantations, reabsorptions, living fetuses, placentae and intrauterine deaths were looked for and recorded. The collected fetuses and placentae were weighed and the concepts were examined by a stereoscopic microscope looking for external malformations. Results: No significant alterations due to the antiretroviral drug treatment could be detected regarding the number of implantations, fetuses, placentae, absorptions and malformations nor regarding maternal and fetal mortality. Conclusions: Administration of the association zidovudine/stavudine for the whole period of rat pregnancy did not interfere with the maternal, fetal and placental weight gain as well as abnormalities detectable by the employed methodology. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-01-01 2018-06-15T16:52:39Z 2018-06-15T16:52:39Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.irog.net/download/?magazine=21 Clinical And Experimental Obstetrics & Gynecology. Montreal: I R O G Canada, Inc, v. 39, n. 2, p. 205-208, 2012. 0390-6663 http://repositorio.unifesp.br/handle/11600/43294 WOS:000304899500018 |
url |
http://www.irog.net/download/?magazine=21 http://repositorio.unifesp.br/handle/11600/43294 |
identifier_str_mv |
Clinical And Experimental Obstetrics & Gynecology. Montreal: I R O G Canada, Inc, v. 39, n. 2, p. 205-208, 2012. 0390-6663 WOS:000304899500018 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Clinical And Experimental Obstetrics & Gynecology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
205-208 |
dc.publisher.none.fl_str_mv |
I R O G Canada, Inc |
publisher.none.fl_str_mv |
I R O G Canada, Inc |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268276845314048 |