Effects of daily intake of zidovudine-stavudine on rat pregnancy outcome: biological essay

Detalhes bibliográficos
Autor(a) principal: Antonio, Eliana Maria Restum [UNIFESP]
Data de Publicação: 2012
Outros Autores: Fontes, Tereza Maria Pereira [UNIFESP], Simoes, Ricardo Santos [UNIFESP], Carvalho, Adelino Moreira de [UNIFESP], Espiridião, Silvia [UNIFESP], Nakamura, Mary Uchiyama [UNIFESP], Kulay Júnior, Luiz [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://www.irog.net/download/?magazine=21
http://repositorio.unifesp.br/handle/11600/43294
Resumo: Purpose: To evaluate the effects at term of a highly active antiretroviral drug association when administered for the whole period of rat pregnancy. Methods: Forty pregnant rats weighing about 200 g were randomly divided into four groups: a control group (Ctr = drug vehicle control, n = 10) and three experimental groups. which were treated with an oral solution of zidovudine-stavudine (Exp1x = 10/1 mg/kg b.w., n = 10; Exp3x = 30/3 mg/kg b.w., n = 10; Exp9x = 90/9 mg/kg b.w., n = 10) from day 0 up to the 20th day of pregnancy. Maternal body weights were recorded at the start of the experiment and on the 7th, 14th and 20th day thereafter. At term (20th day) the rats were anesthetized and submitted to hysterotomy. Implantations, reabsorptions, living fetuses, placentae and intrauterine deaths were looked for and recorded. The collected fetuses and placentae were weighed and the concepts were examined by a stereoscopic microscope looking for external malformations. Results: No significant alterations due to the antiretroviral drug treatment could be detected regarding the number of implantations, fetuses, placentae, absorptions and malformations nor regarding maternal and fetal mortality. Conclusions: Administration of the association zidovudine/stavudine for the whole period of rat pregnancy did not interfere with the maternal, fetal and placental weight gain as well as abnormalities detectable by the employed methodology.
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spelling Effects of daily intake of zidovudine-stavudine on rat pregnancy outcome: biological essayRatPregnancyZidovudineStavudineAdverse effectsPurpose: To evaluate the effects at term of a highly active antiretroviral drug association when administered for the whole period of rat pregnancy. Methods: Forty pregnant rats weighing about 200 g were randomly divided into four groups: a control group (Ctr = drug vehicle control, n = 10) and three experimental groups. which were treated with an oral solution of zidovudine-stavudine (Exp1x = 10/1 mg/kg b.w., n = 10; Exp3x = 30/3 mg/kg b.w., n = 10; Exp9x = 90/9 mg/kg b.w., n = 10) from day 0 up to the 20th day of pregnancy. Maternal body weights were recorded at the start of the experiment and on the 7th, 14th and 20th day thereafter. At term (20th day) the rats were anesthetized and submitted to hysterotomy. Implantations, reabsorptions, living fetuses, placentae and intrauterine deaths were looked for and recorded. The collected fetuses and placentae were weighed and the concepts were examined by a stereoscopic microscope looking for external malformations. Results: No significant alterations due to the antiretroviral drug treatment could be detected regarding the number of implantations, fetuses, placentae, absorptions and malformations nor regarding maternal and fetal mortality. Conclusions: Administration of the association zidovudine/stavudine for the whole period of rat pregnancy did not interfere with the maternal, fetal and placental weight gain as well as abnormalities detectable by the employed methodology.Univ Fed Sao Paulo, Sch Med UNIFESP EPM, Dept Obstet, Sao Paulo, BrazilUniv Sao Paulo, Fac Med FMUSP, Dept Obstet, Sao Paulo, BrazilJose do Rosario Vellano Univ, Sch Med, Dept Internal Med, Alfenas, MG, BrazilABC Med Fdn FUABC, Dept Obstet & Pediat, Sao Paulo, BrazilUniv Fed Sao Paulo, Sch Med UNIFESP EPM, Dept Obstet, Sao Paulo, BrazilWeb of ScienceI R O G Canada, IncUniversidade Federal de São Paulo (UNIFESP)Universidade de São Paulo (USP)Jose do Rosario Vellano UnivABC Med Fdn FUABCAntonio, Eliana Maria Restum [UNIFESP]Fontes, Tereza Maria Pereira [UNIFESP]Simoes, Ricardo Santos [UNIFESP]Carvalho, Adelino Moreira de [UNIFESP]Espiridião, Silvia [UNIFESP]Nakamura, Mary Uchiyama [UNIFESP]Kulay Júnior, Luiz [UNIFESP]2018-06-15T16:52:39Z2018-06-15T16:52:39Z2012-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion205-208http://www.irog.net/download/?magazine=21Clinical And Experimental Obstetrics & Gynecology. Montreal: I R O G Canada, Inc, v. 39, n. 2, p. 205-208, 2012.0390-6663http://repositorio.unifesp.br/handle/11600/43294WOS:000304899500018engClinical And Experimental Obstetrics & Gynecologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-05-02T15:52:26Zoai:repositorio.unifesp.br/:11600/43294Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-05-02T15:52:26Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Effects of daily intake of zidovudine-stavudine on rat pregnancy outcome: biological essay
title Effects of daily intake of zidovudine-stavudine on rat pregnancy outcome: biological essay
spellingShingle Effects of daily intake of zidovudine-stavudine on rat pregnancy outcome: biological essay
Antonio, Eliana Maria Restum [UNIFESP]
Rat
Pregnancy
Zidovudine
Stavudine
Adverse effects
title_short Effects of daily intake of zidovudine-stavudine on rat pregnancy outcome: biological essay
title_full Effects of daily intake of zidovudine-stavudine on rat pregnancy outcome: biological essay
title_fullStr Effects of daily intake of zidovudine-stavudine on rat pregnancy outcome: biological essay
title_full_unstemmed Effects of daily intake of zidovudine-stavudine on rat pregnancy outcome: biological essay
title_sort Effects of daily intake of zidovudine-stavudine on rat pregnancy outcome: biological essay
author Antonio, Eliana Maria Restum [UNIFESP]
author_facet Antonio, Eliana Maria Restum [UNIFESP]
Fontes, Tereza Maria Pereira [UNIFESP]
Simoes, Ricardo Santos [UNIFESP]
Carvalho, Adelino Moreira de [UNIFESP]
Espiridião, Silvia [UNIFESP]
Nakamura, Mary Uchiyama [UNIFESP]
Kulay Júnior, Luiz [UNIFESP]
author_role author
author2 Fontes, Tereza Maria Pereira [UNIFESP]
Simoes, Ricardo Santos [UNIFESP]
Carvalho, Adelino Moreira de [UNIFESP]
Espiridião, Silvia [UNIFESP]
Nakamura, Mary Uchiyama [UNIFESP]
Kulay Júnior, Luiz [UNIFESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Jose do Rosario Vellano Univ
ABC Med Fdn FUABC
dc.contributor.author.fl_str_mv Antonio, Eliana Maria Restum [UNIFESP]
Fontes, Tereza Maria Pereira [UNIFESP]
Simoes, Ricardo Santos [UNIFESP]
Carvalho, Adelino Moreira de [UNIFESP]
Espiridião, Silvia [UNIFESP]
Nakamura, Mary Uchiyama [UNIFESP]
Kulay Júnior, Luiz [UNIFESP]
dc.subject.por.fl_str_mv Rat
Pregnancy
Zidovudine
Stavudine
Adverse effects
topic Rat
Pregnancy
Zidovudine
Stavudine
Adverse effects
description Purpose: To evaluate the effects at term of a highly active antiretroviral drug association when administered for the whole period of rat pregnancy. Methods: Forty pregnant rats weighing about 200 g were randomly divided into four groups: a control group (Ctr = drug vehicle control, n = 10) and three experimental groups. which were treated with an oral solution of zidovudine-stavudine (Exp1x = 10/1 mg/kg b.w., n = 10; Exp3x = 30/3 mg/kg b.w., n = 10; Exp9x = 90/9 mg/kg b.w., n = 10) from day 0 up to the 20th day of pregnancy. Maternal body weights were recorded at the start of the experiment and on the 7th, 14th and 20th day thereafter. At term (20th day) the rats were anesthetized and submitted to hysterotomy. Implantations, reabsorptions, living fetuses, placentae and intrauterine deaths were looked for and recorded. The collected fetuses and placentae were weighed and the concepts were examined by a stereoscopic microscope looking for external malformations. Results: No significant alterations due to the antiretroviral drug treatment could be detected regarding the number of implantations, fetuses, placentae, absorptions and malformations nor regarding maternal and fetal mortality. Conclusions: Administration of the association zidovudine/stavudine for the whole period of rat pregnancy did not interfere with the maternal, fetal and placental weight gain as well as abnormalities detectable by the employed methodology.
publishDate 2012
dc.date.none.fl_str_mv 2012-01-01
2018-06-15T16:52:39Z
2018-06-15T16:52:39Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.irog.net/download/?magazine=21
Clinical And Experimental Obstetrics & Gynecology. Montreal: I R O G Canada, Inc, v. 39, n. 2, p. 205-208, 2012.
0390-6663
http://repositorio.unifesp.br/handle/11600/43294
WOS:000304899500018
url http://www.irog.net/download/?magazine=21
http://repositorio.unifesp.br/handle/11600/43294
identifier_str_mv Clinical And Experimental Obstetrics & Gynecology. Montreal: I R O G Canada, Inc, v. 39, n. 2, p. 205-208, 2012.
0390-6663
WOS:000304899500018
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Clinical And Experimental Obstetrics & Gynecology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 205-208
dc.publisher.none.fl_str_mv I R O G Canada, Inc
publisher.none.fl_str_mv I R O G Canada, Inc
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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