Leptin Modulates Allograft Survival by Favoring a Th2 and a Regulatory Immune Profile

• Autor(a) principal: Moraes-Vieira, P. M. M.
• Data de Publicação: 2013
• Outros Autores: Bassi, E. J., Larocca, R. A., Castoldi, A., Burghos, M., Lepique, A. P., Quintana, F. J., Araújo, Ronaldo de Carvalho [UNIFESP], Basso, A. S. [UNIFESP], Strom, T. B., Camara, N. O. S. [UNIFESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• dARK ID: ark:/48912/0013000004ws5
• Texto Completo: http://dx.doi.org/10.1111/j.1600-6143.2012.04283.x; http://repositorio.unifesp.br/handle/11600/35668
• topic: Alloimmunity; leptin; regulatory T cell; tolerance

Leptin, an adipose-secreted hormone, links metabolism and immunity. Our aim was to determine whether leptin affects the alloimmune response. We used an allogeneic skin transplant model as a means to analyze the allograft immune response in Lepob/ob and wild-type mice. Leptin deficiency results in an increased frequency of Treg and Th2 cells and a prolonged graft survival. These effects of leptin deficiency indicate the importance of leptin and obesity in modulating the allograft immune responses. Our data suggest a possible explanation for the increased susceptibility of hyperleptinemic obese patients to acute and chronic graft rejection.