Time to blood culture positivity as a predictor of clinical outcome of Staphylococcus aureus bloodstream infection
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/28805 http://dx.doi.org/10.1128/JCM.44.4.1342-1346.2006 |
Resumo: | Few studies have assessed the time to blood culture positivity as a predictor of clinical outcome in bloodstream infections (BSIs). the purpose of this study was to evaluate the time to positivity (TTP) of blood cultures in patients with Staphylococcus aureus BSIs and to assess its impact on clinical outcome. We performed a historical cohort study with 91 adult patients with S. aureus BSIs. TTP was defined as the time between the start of incubation and the time that the automated alert signal indicating growth. in the culture bottle sounded. Patients with BSIs and TTPs of culture of <= 12 h (n = 44) and > 12 h (n = 47) were compared. Septic shock occurred in 13.6% of patients with TTPs of <= 12 h and in 8.5% of patients with TIP of > 12 h (P = 0.51). A central venous catheter source was more common with a BSI TTP of :512 h (P = 0.010). Univariate analysis revealed that a Charlson score of >= 3, the failure of at least one organ (respiratory, cardiovascular, renal, hematologic, or hepatic), infection with methicillin-resistant S. aureus, and TTPs of <= 12 h were associated with death. Age, gender, an APACHE II score of >= 20 at BSI onset, inadequate empirical antibiotic therapy, hospital-acquired bacteremia, and endocarditis were not associated with mortality. Multivariate analysis revealed that independent predictors of hospital mortality were a Charlson score of >= 3 (odds ratio [OR], 14.4; 95% confidence interval [CI], 2.24 to 92.55), infection with methicillin-resistant S. aureus (OR, 9.3; 95% CI, 1.45 to 59.23), and TTPs of <= 12 h (OR, 6.9; 95% Cl, 1.07 to 44.66). in this historical cohort study of BSIs due to S. aureus, a TTP of :512 h was a predictor of the clinical outcome. |
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Marra, Alexandre R. [UNIFESP]Edmond, Michael B.Forbes, Betty A.Wenzel, Richard P.Bearman, Gonzalo MLUniversidade Federal de São Paulo (UNIFESP)Virginia Commonwealth Univ2016-01-24T12:41:03Z2016-01-24T12:41:03Z2006-04-01Journal of Clinical Microbiology. Washington: Amer Soc Microbiology, v. 44, n. 4, p. 1342-1346, 2006.0095-1137http://repositorio.unifesp.br/handle/11600/28805http://dx.doi.org/10.1128/JCM.44.4.1342-1346.2006WOS000236810500021.pdf10.1128/JCM.44.4.1342-1346.2006WOS:000236810500021Few studies have assessed the time to blood culture positivity as a predictor of clinical outcome in bloodstream infections (BSIs). the purpose of this study was to evaluate the time to positivity (TTP) of blood cultures in patients with Staphylococcus aureus BSIs and to assess its impact on clinical outcome. We performed a historical cohort study with 91 adult patients with S. aureus BSIs. TTP was defined as the time between the start of incubation and the time that the automated alert signal indicating growth. in the culture bottle sounded. Patients with BSIs and TTPs of culture of <= 12 h (n = 44) and > 12 h (n = 47) were compared. Septic shock occurred in 13.6% of patients with TTPs of <= 12 h and in 8.5% of patients with TIP of > 12 h (P = 0.51). A central venous catheter source was more common with a BSI TTP of :512 h (P = 0.010). Univariate analysis revealed that a Charlson score of >= 3, the failure of at least one organ (respiratory, cardiovascular, renal, hematologic, or hepatic), infection with methicillin-resistant S. aureus, and TTPs of <= 12 h were associated with death. Age, gender, an APACHE II score of >= 20 at BSI onset, inadequate empirical antibiotic therapy, hospital-acquired bacteremia, and endocarditis were not associated with mortality. Multivariate analysis revealed that independent predictors of hospital mortality were a Charlson score of >= 3 (odds ratio [OR], 14.4; 95% confidence interval [CI], 2.24 to 92.55), infection with methicillin-resistant S. aureus (OR, 9.3; 95% CI, 1.45 to 59.23), and TTPs of <= 12 h (OR, 6.9; 95% Cl, 1.07 to 44.66). in this historical cohort study of BSIs due to S. aureus, a TTP of :512 h was a predictor of the clinical outcome.Universidade Federal de São Paulo, Dept Infect Dis, São Paulo, BrazilVirginia Commonwealth Univ, Med Coll Virginia, Sch Med, Dept Internal Med, Richmond, VA 23298 USAVirginia Commonwealth Univ, Med Coll Virginia, Sch Med, Dept Pathol, Richmond, VA 23298 USAUniversidade Federal de São Paulo, Dept Infect Dis, São Paulo, BrazilWeb of Science1342-1346engAmer Soc MicrobiologyJournal of Clinical MicrobiologyTime to blood culture positivity as a predictor of clinical outcome of Staphylococcus aureus bloodstream infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000236810500021.pdfapplication/pdf62278${dspace.ui.url}/bitstream/11600/28805/1/WOS000236810500021.pdfbf957520929444ecbc4aece28ff9dad1MD51open accessTEXTWOS000236810500021.pdf.txtWOS000236810500021.pdf.txtExtracted texttext/plain29693${dspace.ui.url}/bitstream/11600/28805/2/WOS000236810500021.pdf.txt54952c0b598a639e7066a916e3576747MD52open access11600/288052022-06-02 09:12:58.563open accessoai:repositorio.unifesp.br:11600/28805Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652022-06-02T12:12:58Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Time to blood culture positivity as a predictor of clinical outcome of Staphylococcus aureus bloodstream infection |
title |
Time to blood culture positivity as a predictor of clinical outcome of Staphylococcus aureus bloodstream infection |
spellingShingle |
Time to blood culture positivity as a predictor of clinical outcome of Staphylococcus aureus bloodstream infection Marra, Alexandre R. [UNIFESP] |
title_short |
Time to blood culture positivity as a predictor of clinical outcome of Staphylococcus aureus bloodstream infection |
title_full |
Time to blood culture positivity as a predictor of clinical outcome of Staphylococcus aureus bloodstream infection |
title_fullStr |
Time to blood culture positivity as a predictor of clinical outcome of Staphylococcus aureus bloodstream infection |
title_full_unstemmed |
Time to blood culture positivity as a predictor of clinical outcome of Staphylococcus aureus bloodstream infection |
title_sort |
Time to blood culture positivity as a predictor of clinical outcome of Staphylococcus aureus bloodstream infection |
author |
Marra, Alexandre R. [UNIFESP] |
author_facet |
Marra, Alexandre R. [UNIFESP] Edmond, Michael B. Forbes, Betty A. Wenzel, Richard P. Bearman, Gonzalo ML |
author_role |
author |
author2 |
Edmond, Michael B. Forbes, Betty A. Wenzel, Richard P. Bearman, Gonzalo ML |
author2_role |
author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Virginia Commonwealth Univ |
dc.contributor.author.fl_str_mv |
Marra, Alexandre R. [UNIFESP] Edmond, Michael B. Forbes, Betty A. Wenzel, Richard P. Bearman, Gonzalo ML |
description |
Few studies have assessed the time to blood culture positivity as a predictor of clinical outcome in bloodstream infections (BSIs). the purpose of this study was to evaluate the time to positivity (TTP) of blood cultures in patients with Staphylococcus aureus BSIs and to assess its impact on clinical outcome. We performed a historical cohort study with 91 adult patients with S. aureus BSIs. TTP was defined as the time between the start of incubation and the time that the automated alert signal indicating growth. in the culture bottle sounded. Patients with BSIs and TTPs of culture of <= 12 h (n = 44) and > 12 h (n = 47) were compared. Septic shock occurred in 13.6% of patients with TTPs of <= 12 h and in 8.5% of patients with TIP of > 12 h (P = 0.51). A central venous catheter source was more common with a BSI TTP of :512 h (P = 0.010). Univariate analysis revealed that a Charlson score of >= 3, the failure of at least one organ (respiratory, cardiovascular, renal, hematologic, or hepatic), infection with methicillin-resistant S. aureus, and TTPs of <= 12 h were associated with death. Age, gender, an APACHE II score of >= 20 at BSI onset, inadequate empirical antibiotic therapy, hospital-acquired bacteremia, and endocarditis were not associated with mortality. Multivariate analysis revealed that independent predictors of hospital mortality were a Charlson score of >= 3 (odds ratio [OR], 14.4; 95% confidence interval [CI], 2.24 to 92.55), infection with methicillin-resistant S. aureus (OR, 9.3; 95% CI, 1.45 to 59.23), and TTPs of <= 12 h (OR, 6.9; 95% Cl, 1.07 to 44.66). in this historical cohort study of BSIs due to S. aureus, a TTP of :512 h was a predictor of the clinical outcome. |
publishDate |
2006 |
dc.date.issued.fl_str_mv |
2006-04-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T12:41:03Z |
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2016-01-24T12:41:03Z |
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info:eu-repo/semantics/publishedVersion |
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dc.identifier.citation.fl_str_mv |
Journal of Clinical Microbiology. Washington: Amer Soc Microbiology, v. 44, n. 4, p. 1342-1346, 2006. |
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http://repositorio.unifesp.br/handle/11600/28805 http://dx.doi.org/10.1128/JCM.44.4.1342-1346.2006 |
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0095-1137 |
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WOS000236810500021.pdf |
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10.1128/JCM.44.4.1342-1346.2006 |
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WOS:000236810500021 |
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Journal of Clinical Microbiology. Washington: Amer Soc Microbiology, v. 44, n. 4, p. 1342-1346, 2006. 0095-1137 WOS000236810500021.pdf 10.1128/JCM.44.4.1342-1346.2006 WOS:000236810500021 |
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http://repositorio.unifesp.br/handle/11600/28805 http://dx.doi.org/10.1128/JCM.44.4.1342-1346.2006 |
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