Glutamine/Glutamate Metabolism Studied with Magnetic Resonance Spectroscopic Imaging for the Characterization of Adrenal Nodules and Masses
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/35709 http://dx.doi.org/10.1155/2013/835385 |
Resumo: | Purpose. To assess glutamine/glutamate (Glx) and lactate (Lac) metabolism using proton magnetic resonance spectroscopic imaging (1H-MRS) in order to differentiate between adrenal gland nodules and masses (adenomas, pheochromocytomas, carcinomas, and metastases). Materials and Methods. Institutional review board approval and informed consent were obtained. A total of 130 patients (47 men) with 132 adrenal nodules/masses were prospectively assessed (54 +/- 14.8 years). A multivoxel system was used with a two-dimensional point-resolved spectroscopy/chemical-shift imaging sequence. Spectroscopic data were interpreted by visual inspection and peak amplitudes of lipids (Lip), choline (Cho), creatine (Cr), Lac, and Glx. Lac/Cr and Glx/Cr were calculated. Glx/Cr was assessed in relation to lesion size. Results. Statistically significant differences were observed in Glx/Cr results between adenomas and pheochromocytomas (P < 0.05), however, with a low positive predictive value (PPV). Glx levels were directly proportional to lesion size in carcinomas. A cutoff point of 1.44 was established for the differentiation between carcinomas larger versus smaller than 4 cm, with 75% sensitivity, 100% specificity, 100% PPV, and 80% accuracy. Lac/Cr results showed no differences across lesions. A cutoff point of -6.5 for Lac/Cr was established for carcinoma diagnosis. Conclusion. Glx levels are directly proportional to lesion size in carcinomas. A cutoff point of -6.5 Lac/Cr differentiates carcinomas from noncarcinomas. |
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Goldman, Suzan M. [UNIFESP]Nunes, Thiago F. [UNIFESP]Melo, Homero J. F. [UNIFESP]Dalavia, Claudio [UNIFESP]Szejnfeld, Denis [UNIFESP]Kater, Claudio [UNIFESP]Andreoni, Cassio [UNIFESP]Szejnfeld, Jacob [UNIFESP]Ajzen, Sergio A. [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2016-01-24T14:30:54Z2016-01-24T14:30:54Z2013-01-01Biomed Research International. New York: Hindawi Publishing Corporation, 9 p., 2013.2314-6133http://repositorio.unifesp.br/handle/11600/35709http://dx.doi.org/10.1155/2013/835385WOS000325657500001.pdf10.1155/2013/835385WOS:000325657500001Purpose. To assess glutamine/glutamate (Glx) and lactate (Lac) metabolism using proton magnetic resonance spectroscopic imaging (1H-MRS) in order to differentiate between adrenal gland nodules and masses (adenomas, pheochromocytomas, carcinomas, and metastases). Materials and Methods. Institutional review board approval and informed consent were obtained. A total of 130 patients (47 men) with 132 adrenal nodules/masses were prospectively assessed (54 +/- 14.8 years). A multivoxel system was used with a two-dimensional point-resolved spectroscopy/chemical-shift imaging sequence. Spectroscopic data were interpreted by visual inspection and peak amplitudes of lipids (Lip), choline (Cho), creatine (Cr), Lac, and Glx. Lac/Cr and Glx/Cr were calculated. Glx/Cr was assessed in relation to lesion size. Results. Statistically significant differences were observed in Glx/Cr results between adenomas and pheochromocytomas (P < 0.05), however, with a low positive predictive value (PPV). Glx levels were directly proportional to lesion size in carcinomas. A cutoff point of 1.44 was established for the differentiation between carcinomas larger versus smaller than 4 cm, with 75% sensitivity, 100% specificity, 100% PPV, and 80% accuracy. Lac/Cr results showed no differences across lesions. A cutoff point of -6.5 for Lac/Cr was established for carcinoma diagnosis. Conclusion. Glx levels are directly proportional to lesion size in carcinomas. A cutoff point of -6.5 Lac/Cr differentiates carcinomas from noncarcinomas.Universidade Federal de São Paulo, Dept Diagnost Imaging, BR-04024002 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Endocrinol, BR-04024002 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Urol, BR-04024002 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Diagnost Imaging, BR-04024002 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Endocrinol, BR-04024002 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Urol, BR-04024002 São Paulo, BrazilWeb of Science9engHindawi Publishing CorporationBiomed Research InternationalGlutamine/Glutamate Metabolism Studied with Magnetic Resonance Spectroscopic Imaging for the Characterization of Adrenal Nodules and Massesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000325657500001.pdfapplication/pdf5674110${dspace.ui.url}/bitstream/11600/35709/1/WOS000325657500001.pdff8c088098a490fa6da56df350479ae2dMD51open accessTEXTWOS000325657500001.pdf.txtWOS000325657500001.pdf.txtExtracted texttext/plain33831${dspace.ui.url}/bitstream/11600/35709/2/WOS000325657500001.pdf.txtcd57a806221fd215b4c982b1e24d32a9MD52open access11600/357092022-02-18 10:14:11.279open accessoai:repositorio.unifesp.br:11600/35709Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652022-02-18T13:14:11Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Glutamine/Glutamate Metabolism Studied with Magnetic Resonance Spectroscopic Imaging for the Characterization of Adrenal Nodules and Masses |
title |
Glutamine/Glutamate Metabolism Studied with Magnetic Resonance Spectroscopic Imaging for the Characterization of Adrenal Nodules and Masses |
spellingShingle |
Glutamine/Glutamate Metabolism Studied with Magnetic Resonance Spectroscopic Imaging for the Characterization of Adrenal Nodules and Masses Goldman, Suzan M. [UNIFESP] |
title_short |
Glutamine/Glutamate Metabolism Studied with Magnetic Resonance Spectroscopic Imaging for the Characterization of Adrenal Nodules and Masses |
title_full |
Glutamine/Glutamate Metabolism Studied with Magnetic Resonance Spectroscopic Imaging for the Characterization of Adrenal Nodules and Masses |
title_fullStr |
Glutamine/Glutamate Metabolism Studied with Magnetic Resonance Spectroscopic Imaging for the Characterization of Adrenal Nodules and Masses |
title_full_unstemmed |
Glutamine/Glutamate Metabolism Studied with Magnetic Resonance Spectroscopic Imaging for the Characterization of Adrenal Nodules and Masses |
title_sort |
Glutamine/Glutamate Metabolism Studied with Magnetic Resonance Spectroscopic Imaging for the Characterization of Adrenal Nodules and Masses |
author |
Goldman, Suzan M. [UNIFESP] |
author_facet |
Goldman, Suzan M. [UNIFESP] Nunes, Thiago F. [UNIFESP] Melo, Homero J. F. [UNIFESP] Dalavia, Claudio [UNIFESP] Szejnfeld, Denis [UNIFESP] Kater, Claudio [UNIFESP] Andreoni, Cassio [UNIFESP] Szejnfeld, Jacob [UNIFESP] Ajzen, Sergio A. [UNIFESP] |
author_role |
author |
author2 |
Nunes, Thiago F. [UNIFESP] Melo, Homero J. F. [UNIFESP] Dalavia, Claudio [UNIFESP] Szejnfeld, Denis [UNIFESP] Kater, Claudio [UNIFESP] Andreoni, Cassio [UNIFESP] Szejnfeld, Jacob [UNIFESP] Ajzen, Sergio A. [UNIFESP] |
author2_role |
author author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Goldman, Suzan M. [UNIFESP] Nunes, Thiago F. [UNIFESP] Melo, Homero J. F. [UNIFESP] Dalavia, Claudio [UNIFESP] Szejnfeld, Denis [UNIFESP] Kater, Claudio [UNIFESP] Andreoni, Cassio [UNIFESP] Szejnfeld, Jacob [UNIFESP] Ajzen, Sergio A. [UNIFESP] |
description |
Purpose. To assess glutamine/glutamate (Glx) and lactate (Lac) metabolism using proton magnetic resonance spectroscopic imaging (1H-MRS) in order to differentiate between adrenal gland nodules and masses (adenomas, pheochromocytomas, carcinomas, and metastases). Materials and Methods. Institutional review board approval and informed consent were obtained. A total of 130 patients (47 men) with 132 adrenal nodules/masses were prospectively assessed (54 +/- 14.8 years). A multivoxel system was used with a two-dimensional point-resolved spectroscopy/chemical-shift imaging sequence. Spectroscopic data were interpreted by visual inspection and peak amplitudes of lipids (Lip), choline (Cho), creatine (Cr), Lac, and Glx. Lac/Cr and Glx/Cr were calculated. Glx/Cr was assessed in relation to lesion size. Results. Statistically significant differences were observed in Glx/Cr results between adenomas and pheochromocytomas (P < 0.05), however, with a low positive predictive value (PPV). Glx levels were directly proportional to lesion size in carcinomas. A cutoff point of 1.44 was established for the differentiation between carcinomas larger versus smaller than 4 cm, with 75% sensitivity, 100% specificity, 100% PPV, and 80% accuracy. Lac/Cr results showed no differences across lesions. A cutoff point of -6.5 for Lac/Cr was established for carcinoma diagnosis. Conclusion. Glx levels are directly proportional to lesion size in carcinomas. A cutoff point of -6.5 Lac/Cr differentiates carcinomas from noncarcinomas. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013-01-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:30:54Z |
dc.date.available.fl_str_mv |
2016-01-24T14:30:54Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Biomed Research International. New York: Hindawi Publishing Corporation, 9 p., 2013. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/35709 http://dx.doi.org/10.1155/2013/835385 |
dc.identifier.issn.none.fl_str_mv |
2314-6133 |
dc.identifier.file.none.fl_str_mv |
WOS000325657500001.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1155/2013/835385 |
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WOS:000325657500001 |
identifier_str_mv |
Biomed Research International. New York: Hindawi Publishing Corporation, 9 p., 2013. 2314-6133 WOS000325657500001.pdf 10.1155/2013/835385 WOS:000325657500001 |
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http://repositorio.unifesp.br/handle/11600/35709 http://dx.doi.org/10.1155/2013/835385 |
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eng |
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9 |
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Hindawi Publishing Corporation |
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Hindawi Publishing Corporation |
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