Mutação G20210A no gene da protrombina, fator V de Leiden e anticorpos anticardiolipina não influenciam a sobrevida do enxerto renal após o transplante

• Autor(a) principal: Rocha, Luis Klaus A. da [UNIFESP]
• Data de Publicação: 2009
• Outros Autores: Galante, Nelson Zocoler [UNIFESP], Alvarez, Vivian Angélica Castilho, Areco, Kelsy C. N. [UNIFESP], Noguti, Maria Aparecida Eiko [UNIFESP], Amaral, Rogério Q. [UNIFESP], Andrade, Luiz Eduardo Coelho [UNIFESP], Peres, Clovis de Araujo [UNIFESP], Pestana, Jose Osmar Medina [UNIFESP], Lourenco, Dayse Maria [UNIFESP]
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1590/S0101-28002009000400006; http://repositorio.unifesp.br/handle/11600/5415
• topic: thrombophilia; anticardiolipin antibodies; factor V Leiden mutation; prothrombin G20210A mutation; renal transplantation; graft rejection; survival analysis; logistic models; trombofilia; anticorpos anticardiolipina; fator V de Leiden; mutação G20210A no gene da protrombina; transplante renal; rejeição de enxerto; análise de sobrevida; modelos logísticos

INTRODUCTION: Thromboembolic complications are important risk factors for graft failure and worse renal transplantation outcome. Patients with thrombophilic disorders have a higher risk of thromboembolic complications. The prevalence of thrombophilic disorders and the associated risk for graft failure and for intravascular thrombosis were analyzed in renal transplant recipients. METHODS: This is a cohort study of 388 adult recipients investigated regarding the presence of thrombophilia, through the search for anticardiolipin antibodies (aCL) via ELISA and FV G1691A and PT G20210A gene mutations by multiplex PCR. RESULTS: Thrombophilic disorders were identified in 25.8% of the patients. The 2-year graft survival was similar among patients with and without thrombophilic disorder (94% versus 94%, p = 0.53), and so was the survival free of intravascular thrombosis (97% versus 97%, p = 0.83). The prevalence of intravascular thrombosis was similar in both groups (3% versus 3.5%, p = 0.82). Patients with previous kidney transplantation had a higher risk of graft failure (OR 20.8, p < 0.001) and of intravascular thrombosis (OR 6.8, p = 0.008). CONCLUSIONS: The prevalences of FV G1691A and PT G20210A gene mutations in this cohort of patients were similar to those of the general non-transplanted population. The prevalence of aCL antibodies was higher in this cohort than that observed in healthy individuals. The thrombophilic markers studied did not predict the medium-term survival of renal transplant.