Bone Mass and Hormone Analysis in Patients With Spinal Cord Injury: Evidence for a Gonadal Axis Disruption

• Autor(a) principal: Gaspar, Alexandra Passos [UNIFESP]
• Data de Publicação: 2014
• Outros Autores: Brandao, Cynthia Maria Alvares [UNIFESP], Lazaretti-Castro, Marise [UNIFESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• dARK ID: ark:/48912/0013000015crt
• DOI: 10.1210/jc.2014-2165
• Texto Completo: http://dx.doi.org/10.1210/jc.2014-2165; http://repositorio.unifesp.br/handle/11600/38480

Context: Bone loss is a constant finding in patients with spinal cord injury (SCI).Objective: We sought to evaluate potential modifiable factors that could lead to bone loss in complete motor paraplegia by examining gonadal axis hormones, vitamin D status, and bone markers.Design: This is a cross sectional.Setting: It includes SCI Outpatient.Patients and other Participants: Twenty-nine chronic male patients with SCI were compared with 17 age-matched, able-bodied men.Main Outcome Measure: the bone mineral density (BMD) of lower limbs and lumbar spine were measured using dual x-ray absorptiometry. Parathormone, 25-hydroxyvitamin D [ 25(OH) D], collagen type I C-terminal telopeptide (CTX), and sexual hormone were measured.Results: Patients with SCI had lower BMD at the inferior limbs sites. CTX showed an inverse relationship with the time since injury. Patients had lower free T levels (SCI, 12.00 +/- 2.91 vs controls, 19.51 +/- 5.72; P <= .001), and the majority (72%) had normal/low levels of gonadotropins. Low T, however, was not related to low bone mass in patients with SCI. in the controls, the 25(OH) D level was positively correlated with the T and with the lumbar spine BMD, but these correlations were not observed in the SCI.Conclusions: Impairment of testicular function after SCI was indicated by the low levels of T and the loss of correlation between T and 25(OH) D levels; this correlation was present in the able-bodied controls. Inappropriate levels of gonadotropins were identified in most patients, featuring a hypogonadotropic hypogonadism and suggesting a disruption of the pituitary-gonadal axis. T concentrations might not be an effective target for bone loss therapy.