Insulin, Hyperglycemia, and Severe Retinopathy of Prematurity in Extremely Low-Birth-Weight Infants
Autor(a) principal: | |
---|---|
Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/57882 http://dx.doi.org/10.1055/s-0035-1565999 |
Resumo: | Objective This study aims to determine the association between hyperglycemia, insulin therapy, and severe retinopathy of prematurity (ROP) in extremely low-birth-weight (ELBW) infants. Study Design In this retrospective database study, we included all ELBW infants who were <= 32 weeks gestational age (GA). We excluded infants without any ophthalmology evaluation and infants who died before 28 days of life. A multivariable model was constructed to determine the association between hyperglycemia, insulin use, and severe ROP. We defined hyperglycemia as blood glucose (BG) > 180 mg/dL. Covariates were GA, small for GA status, discharge year, sex, Apgar score at 5 minutes, mechanical ventilation, oxygen use, bacteremia, and postnatal steroid exposure. We defined severe ROP as ROP requiring bevacizumab, cryotherapy, laser therapy, or vitrectomy. Sensitivity analysis using BG > 150 mg/dL and > 200 mg/dL was performed. Results A total of 24,548 infants were included; 2,547 (10%) had severe ROP. Hyperglycemia alone was not associated with severe ROP (odds ratio [OR], 0.88; 95% confidence interval [CI], 0.66-1.17). Hyperglycemia and insulin use were not associated with severe ROP (OR, 1.43; 95% CI, 0.91-2.23). BG > 150 mg/dL and insulin use were associated with severe ROP (OR, 1.34; 95% CI, 1.02-1.76). Conclusions Hyperglycemia alone was not associated with severe ROP in ELBW infants. However, we did observe a possible trend between the use of insulin and severe ROP. |
id |
UFSP_fa346784295c5921a8c45055b17c4bbf |
---|---|
oai_identifier_str |
oai:repositorio.unifesp.br:11600/57882 |
network_acronym_str |
UFSP |
network_name_str |
Repositório Institucional da UNIFESP |
repository_id_str |
3465 |
spelling |
Lee, Jan HauHornik, Christoph P.Testoni, Daniela [UNIFESP]Laughon, Matthew M.Cotten, C. MichaelMaldonado, Ramiro S.Belcastro, Marc R.Clark, Reese H.Smith, P. Brian2020-08-21T17:00:08Z2020-08-21T17:00:08Z2016American Journal Of Perinatology. New York, v. 33, n. 4, p. 393-400, 2016.0735-1631https://repositorio.unifesp.br/handle/11600/57882http://dx.doi.org/10.1055/s-0035-1565999WOS000372062200010.pdf10.1055/s-0035-1565999WOS:000372062200010Objective This study aims to determine the association between hyperglycemia, insulin therapy, and severe retinopathy of prematurity (ROP) in extremely low-birth-weight (ELBW) infants. Study Design In this retrospective database study, we included all ELBW infants who were <= 32 weeks gestational age (GA). We excluded infants without any ophthalmology evaluation and infants who died before 28 days of life. A multivariable model was constructed to determine the association between hyperglycemia, insulin use, and severe ROP. We defined hyperglycemia as blood glucose (BG) > 180 mg/dL. Covariates were GA, small for GA status, discharge year, sex, Apgar score at 5 minutes, mechanical ventilation, oxygen use, bacteremia, and postnatal steroid exposure. We defined severe ROP as ROP requiring bevacizumab, cryotherapy, laser therapy, or vitrectomy. Sensitivity analysis using BG > 150 mg/dL and > 200 mg/dL was performed. Results A total of 24,548 infants were included; 2,547 (10%) had severe ROP. Hyperglycemia alone was not associated with severe ROP (odds ratio [OR], 0.88; 95% confidence interval [CI], 0.66-1.17). Hyperglycemia and insulin use were not associated with severe ROP (OR, 1.43; 95% CI, 0.91-2.23). BG > 150 mg/dL and insulin use were associated with severe ROP (OR, 1.34; 95% CI, 1.02-1.76). Conclusions Hyperglycemia alone was not associated with severe ROP in ELBW infants. However, we did observe a possible trend between the use of insulin and severe ROP.National Center for Advancing Translational Sciences of the National Institutes of Health (NIH)U.S. governmentNational Institute of Child Health and Human DevelopmentNIHNational Center for Advancing Translational Sciences of the NIHU.S. Food and Drug AdministrationCempra PharmaceuticalsDuke Univ, Dept Pediat, Sch Med, Durham, NC 27706 USADuke Univ, Sch Med, Duke Clin Res Inst, Durham, NC USAKK Womens & Childrens Hosp, Childrens Intens Care Unit, Singapore, SingaporeUniv Fed Sao Paulo, Ecola Paulista Med, Div Neonatal Med, Sao Paulo, BrazilUniv N Carolina, Dept Pediat, Chapel Hill, NC USAMEDNAX Inc, Pediat Med Grp, Jacksonville, FL USAUniv Fed Sao Paulo, Ecola Paulista Med, Div Neonatal Med, Sao Paulo, BrazilNIH: UL1TR001117U.S. government: HHSN267200700051CNational Institute of Child Health and Human Development: K23HD068497National Institute of Child Health and Human Development: HHSN275201000003INational Institute of Child Health and Human Development: 1R01-HD081044-01National Center for Advancing Translational Sciences of the NIH: UL1TR001117U.S. Food and Drug Administration: 1R18-FD005292-01Cempra Pharmaceuticals: HHS0100201300009CWeb of Science393-400engThieme Medical Publ IncAmerican Journal Of Perinatologyhyperglycemiaretinopathy of prematurityextremely low birth weightinfantsInsulin, Hyperglycemia, and Severe Retinopathy of Prematurity in Extremely Low-Birth-Weight Infantsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleNew York334info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000372062200010.pdfapplication/pdf351274${dspace.ui.url}/bitstream/11600/57882/1/WOS000372062200010.pdf9a57e0c5ec05916d04538acab65fc8caMD51open accessTEXTWOS000372062200010.pdf.txtWOS000372062200010.pdf.txtExtracted texttext/plain32638${dspace.ui.url}/bitstream/11600/57882/2/WOS000372062200010.pdf.txt31bb0546b76bc577e6f6a36e13d22e53MD52open accessTHUMBNAILWOS000372062200010.pdf.jpgWOS000372062200010.pdf.jpgIM Thumbnailimage/jpeg7034${dspace.ui.url}/bitstream/11600/57882/4/WOS000372062200010.pdf.jpg86d9e790e6366e9bf8ee5837a9788a6aMD54open access11600/578822022-07-31 19:43:05.749open accessoai:repositorio.unifesp.br:11600/57882Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652022-07-31T22:43:05Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Insulin, Hyperglycemia, and Severe Retinopathy of Prematurity in Extremely Low-Birth-Weight Infants |
title |
Insulin, Hyperglycemia, and Severe Retinopathy of Prematurity in Extremely Low-Birth-Weight Infants |
spellingShingle |
Insulin, Hyperglycemia, and Severe Retinopathy of Prematurity in Extremely Low-Birth-Weight Infants Lee, Jan Hau hyperglycemia retinopathy of prematurity extremely low birth weight infants |
title_short |
Insulin, Hyperglycemia, and Severe Retinopathy of Prematurity in Extremely Low-Birth-Weight Infants |
title_full |
Insulin, Hyperglycemia, and Severe Retinopathy of Prematurity in Extremely Low-Birth-Weight Infants |
title_fullStr |
Insulin, Hyperglycemia, and Severe Retinopathy of Prematurity in Extremely Low-Birth-Weight Infants |
title_full_unstemmed |
Insulin, Hyperglycemia, and Severe Retinopathy of Prematurity in Extremely Low-Birth-Weight Infants |
title_sort |
Insulin, Hyperglycemia, and Severe Retinopathy of Prematurity in Extremely Low-Birth-Weight Infants |
author |
Lee, Jan Hau |
author_facet |
Lee, Jan Hau Hornik, Christoph P. Testoni, Daniela [UNIFESP] Laughon, Matthew M. Cotten, C. Michael Maldonado, Ramiro S. Belcastro, Marc R. Clark, Reese H. Smith, P. Brian |
author_role |
author |
author2 |
Hornik, Christoph P. Testoni, Daniela [UNIFESP] Laughon, Matthew M. Cotten, C. Michael Maldonado, Ramiro S. Belcastro, Marc R. Clark, Reese H. Smith, P. Brian |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Lee, Jan Hau Hornik, Christoph P. Testoni, Daniela [UNIFESP] Laughon, Matthew M. Cotten, C. Michael Maldonado, Ramiro S. Belcastro, Marc R. Clark, Reese H. Smith, P. Brian |
dc.subject.eng.fl_str_mv |
hyperglycemia retinopathy of prematurity extremely low birth weight infants |
topic |
hyperglycemia retinopathy of prematurity extremely low birth weight infants |
description |
Objective This study aims to determine the association between hyperglycemia, insulin therapy, and severe retinopathy of prematurity (ROP) in extremely low-birth-weight (ELBW) infants. Study Design In this retrospective database study, we included all ELBW infants who were <= 32 weeks gestational age (GA). We excluded infants without any ophthalmology evaluation and infants who died before 28 days of life. A multivariable model was constructed to determine the association between hyperglycemia, insulin use, and severe ROP. We defined hyperglycemia as blood glucose (BG) > 180 mg/dL. Covariates were GA, small for GA status, discharge year, sex, Apgar score at 5 minutes, mechanical ventilation, oxygen use, bacteremia, and postnatal steroid exposure. We defined severe ROP as ROP requiring bevacizumab, cryotherapy, laser therapy, or vitrectomy. Sensitivity analysis using BG > 150 mg/dL and > 200 mg/dL was performed. Results A total of 24,548 infants were included; 2,547 (10%) had severe ROP. Hyperglycemia alone was not associated with severe ROP (odds ratio [OR], 0.88; 95% confidence interval [CI], 0.66-1.17). Hyperglycemia and insulin use were not associated with severe ROP (OR, 1.43; 95% CI, 0.91-2.23). BG > 150 mg/dL and insulin use were associated with severe ROP (OR, 1.34; 95% CI, 1.02-1.76). Conclusions Hyperglycemia alone was not associated with severe ROP in ELBW infants. However, we did observe a possible trend between the use of insulin and severe ROP. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2020-08-21T17:00:08Z |
dc.date.available.fl_str_mv |
2020-08-21T17:00:08Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
American Journal Of Perinatology. New York, v. 33, n. 4, p. 393-400, 2016. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/57882 http://dx.doi.org/10.1055/s-0035-1565999 |
dc.identifier.issn.none.fl_str_mv |
0735-1631 |
dc.identifier.file.none.fl_str_mv |
WOS000372062200010.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1055/s-0035-1565999 |
dc.identifier.wos.none.fl_str_mv |
WOS:000372062200010 |
identifier_str_mv |
American Journal Of Perinatology. New York, v. 33, n. 4, p. 393-400, 2016. 0735-1631 WOS000372062200010.pdf 10.1055/s-0035-1565999 WOS:000372062200010 |
url |
https://repositorio.unifesp.br/handle/11600/57882 http://dx.doi.org/10.1055/s-0035-1565999 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
American Journal Of Perinatology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
393-400 |
dc.coverage.none.fl_str_mv |
New York |
dc.publisher.none.fl_str_mv |
Thieme Medical Publ Inc |
publisher.none.fl_str_mv |
Thieme Medical Publ Inc |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
bitstream.url.fl_str_mv |
${dspace.ui.url}/bitstream/11600/57882/1/WOS000372062200010.pdf ${dspace.ui.url}/bitstream/11600/57882/2/WOS000372062200010.pdf.txt ${dspace.ui.url}/bitstream/11600/57882/4/WOS000372062200010.pdf.jpg |
bitstream.checksum.fl_str_mv |
9a57e0c5ec05916d04538acab65fc8ca 31bb0546b76bc577e6f6a36e13d22e53 86d9e790e6366e9bf8ee5837a9788a6a |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1802764129555972096 |