Neuropsychological predictors of response to randomized treatment in obsessive-compulsive disorder

Detalhes bibliográficos
Autor(a) principal: D'Alcante, Carina Chaubet
Data de Publicação: 2012
Outros Autores: Diniz, Juliana Belo, Fossaluza, Victor, Batistuzzo, Marcelo Camargo, Lopes, Antonio Carlos, Shavitt, Roseli Gedanke, Deckersbach, Thilo, Malloy-Diniz, Leandro, Miguel, Euripedes Constantino, Hoexter, Marcelo Queiroz [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1016/j.pnpbp.2012.07.002
http://repositorio.unifesp.br/handle/11600/35605
Resumo: Objective: To identify neuropsychological predictors of treatment response to cognitive-behavioral therapy (CBT) and fluoxetine in treatment-naive adults with obsessive-compulsive disorder (OCD).Method: Thirty-eight adult outpatients with OCD underwent neuropsychological assessment, including tasks of intellectual function, executive functioning and visual and verbal memory, before randomization to a 12-week clinical trial of either CBT or fluoxetine. Neuropsychological measures were used to identify predictors of treatment response in OCD.Results: Neuropsychological measures that predicted a better treatment response to either CBT or fluoxetine were higher verbal IQ (Wechsler Abbreviated Scale of Intelligence) (p = 0.008); higher verbal memory on the California Verbal Learning Test (p = 0.710); shorter time to complete part D (Dots) (p<0.001), longer time to complete part W (Words) (p = 0.025) and less errors on part C (Colors) (p<0.001) in the Victoria Stroop Test (VST). Fewer perseverations on the California Verbal Learning Test, a measure of mental flexibility, predicted better response to CBT, but worse response to fluoxetine (p = 0.002).Conclusion: in general, OCD patients with better cognitive and executive abilities at baseline were more prone to respond to either CBT or fluoxetine. Our finding that neuropsychological measures of mental flexibility predicted response to treatment in opposite directions for CBT and fluoxetine suggests that OCD patients with different neuropsychological profiles may respond preferentially to one type of treatment versus the other. Further studies with larger samples of OCD patients are necessary to investigate the heuristic value of such findings in a clinical context. (C) 2012 Elsevier Inc. All rights reserved.
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spelling Neuropsychological predictors of response to randomized treatment in obsessive-compulsive disorderCognitive-behavioral therapyNeuropsychologyObsessive-compulsive disorderSerotonin reuptake inhibitorsTreatment-naiveObjective: To identify neuropsychological predictors of treatment response to cognitive-behavioral therapy (CBT) and fluoxetine in treatment-naive adults with obsessive-compulsive disorder (OCD).Method: Thirty-eight adult outpatients with OCD underwent neuropsychological assessment, including tasks of intellectual function, executive functioning and visual and verbal memory, before randomization to a 12-week clinical trial of either CBT or fluoxetine. Neuropsychological measures were used to identify predictors of treatment response in OCD.Results: Neuropsychological measures that predicted a better treatment response to either CBT or fluoxetine were higher verbal IQ (Wechsler Abbreviated Scale of Intelligence) (p = 0.008); higher verbal memory on the California Verbal Learning Test (p = 0.710); shorter time to complete part D (Dots) (p<0.001), longer time to complete part W (Words) (p = 0.025) and less errors on part C (Colors) (p<0.001) in the Victoria Stroop Test (VST). Fewer perseverations on the California Verbal Learning Test, a measure of mental flexibility, predicted better response to CBT, but worse response to fluoxetine (p = 0.002).Conclusion: in general, OCD patients with better cognitive and executive abilities at baseline were more prone to respond to either CBT or fluoxetine. Our finding that neuropsychological measures of mental flexibility predicted response to treatment in opposite directions for CBT and fluoxetine suggests that OCD patients with different neuropsychological profiles may respond preferentially to one type of treatment versus the other. Further studies with larger samples of OCD patients are necessary to investigate the heuristic value of such findings in a clinical context. (C) 2012 Elsevier Inc. All rights reserved.Univ São Paulo, Sch Med, Dept Psychiat, Obsess Compuls Disorder Spectrum Project Clin, BR-78505453 São Paulo, BrazilUniv São Paulo, Inst Math & Stat, BR-78505453 São Paulo, BrazilHarvard Univ, Sch Med, Dept Psychiat, Massachusetts Gen Hosp, Boston, MA 02115 USAUniv Fed Minas Gerais, Inst Biol Sci, Grad Program Neurosci, Belo Horizonte, MG, BrazilFed Univ São Paulo UNIFESP, Dept Psychiat, Interdisciplinary Lab Clin Neurosci LiNC, São Paulo, BrazilFed Univ São Paulo UNIFESP, Dept Psychiat, Interdisciplinary Lab Clin Neurosci LiNC, São Paulo, BrazilWeb of ScienceConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)CNPq: 521369/96-7CNPq: 475919/2006-8CNPq: 481791/2004-3FAPESP: 05/55628-08FAPESP: 05/04206-6FAPESP: 06/61459-7FAPESP: 06/50273-0FAPESP: 06/58286-3Elsevier B.V.Universidade de São Paulo (USP)Harvard UnivUniversidade Federal de Minas Gerais (UFMG)Universidade Federal de São Paulo (UNIFESP)D'Alcante, Carina ChaubetDiniz, Juliana BeloFossaluza, VictorBatistuzzo, Marcelo CamargoLopes, Antonio CarlosShavitt, Roseli GedankeDeckersbach, ThiloMalloy-Diniz, LeandroMiguel, Euripedes ConstantinoHoexter, Marcelo Queiroz [UNIFESP]2016-01-24T14:28:08Z2016-01-24T14:28:08Z2012-12-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion310-317application/pdfhttp://dx.doi.org/10.1016/j.pnpbp.2012.07.002Progress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 39, n. 2, p. 310-317, 2012.10.1016/j.pnpbp.2012.07.002WOS000310943500014.pdf0278-5846http://repositorio.unifesp.br/handle/11600/35605WOS:000310943500014engProgress in Neuro-psychopharmacology & Biological Psychiatryinfo:eu-repo/semantics/openAccesshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policyreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-01T03:56:08Zoai:repositorio.unifesp.br/:11600/35605Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-01T03:56:08Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Neuropsychological predictors of response to randomized treatment in obsessive-compulsive disorder
title Neuropsychological predictors of response to randomized treatment in obsessive-compulsive disorder
spellingShingle Neuropsychological predictors of response to randomized treatment in obsessive-compulsive disorder
D'Alcante, Carina Chaubet
Cognitive-behavioral therapy
Neuropsychology
Obsessive-compulsive disorder
Serotonin reuptake inhibitors
Treatment-naive
title_short Neuropsychological predictors of response to randomized treatment in obsessive-compulsive disorder
title_full Neuropsychological predictors of response to randomized treatment in obsessive-compulsive disorder
title_fullStr Neuropsychological predictors of response to randomized treatment in obsessive-compulsive disorder
title_full_unstemmed Neuropsychological predictors of response to randomized treatment in obsessive-compulsive disorder
title_sort Neuropsychological predictors of response to randomized treatment in obsessive-compulsive disorder
author D'Alcante, Carina Chaubet
author_facet D'Alcante, Carina Chaubet
Diniz, Juliana Belo
Fossaluza, Victor
Batistuzzo, Marcelo Camargo
Lopes, Antonio Carlos
Shavitt, Roseli Gedanke
Deckersbach, Thilo
Malloy-Diniz, Leandro
Miguel, Euripedes Constantino
Hoexter, Marcelo Queiroz [UNIFESP]
author_role author
author2 Diniz, Juliana Belo
Fossaluza, Victor
Batistuzzo, Marcelo Camargo
Lopes, Antonio Carlos
Shavitt, Roseli Gedanke
Deckersbach, Thilo
Malloy-Diniz, Leandro
Miguel, Euripedes Constantino
Hoexter, Marcelo Queiroz [UNIFESP]
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Harvard Univ
Universidade Federal de Minas Gerais (UFMG)
Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv D'Alcante, Carina Chaubet
Diniz, Juliana Belo
Fossaluza, Victor
Batistuzzo, Marcelo Camargo
Lopes, Antonio Carlos
Shavitt, Roseli Gedanke
Deckersbach, Thilo
Malloy-Diniz, Leandro
Miguel, Euripedes Constantino
Hoexter, Marcelo Queiroz [UNIFESP]
dc.subject.por.fl_str_mv Cognitive-behavioral therapy
Neuropsychology
Obsessive-compulsive disorder
Serotonin reuptake inhibitors
Treatment-naive
topic Cognitive-behavioral therapy
Neuropsychology
Obsessive-compulsive disorder
Serotonin reuptake inhibitors
Treatment-naive
description Objective: To identify neuropsychological predictors of treatment response to cognitive-behavioral therapy (CBT) and fluoxetine in treatment-naive adults with obsessive-compulsive disorder (OCD).Method: Thirty-eight adult outpatients with OCD underwent neuropsychological assessment, including tasks of intellectual function, executive functioning and visual and verbal memory, before randomization to a 12-week clinical trial of either CBT or fluoxetine. Neuropsychological measures were used to identify predictors of treatment response in OCD.Results: Neuropsychological measures that predicted a better treatment response to either CBT or fluoxetine were higher verbal IQ (Wechsler Abbreviated Scale of Intelligence) (p = 0.008); higher verbal memory on the California Verbal Learning Test (p = 0.710); shorter time to complete part D (Dots) (p<0.001), longer time to complete part W (Words) (p = 0.025) and less errors on part C (Colors) (p<0.001) in the Victoria Stroop Test (VST). Fewer perseverations on the California Verbal Learning Test, a measure of mental flexibility, predicted better response to CBT, but worse response to fluoxetine (p = 0.002).Conclusion: in general, OCD patients with better cognitive and executive abilities at baseline were more prone to respond to either CBT or fluoxetine. Our finding that neuropsychological measures of mental flexibility predicted response to treatment in opposite directions for CBT and fluoxetine suggests that OCD patients with different neuropsychological profiles may respond preferentially to one type of treatment versus the other. Further studies with larger samples of OCD patients are necessary to investigate the heuristic value of such findings in a clinical context. (C) 2012 Elsevier Inc. All rights reserved.
publishDate 2012
dc.date.none.fl_str_mv 2012-12-03
2016-01-24T14:28:08Z
2016-01-24T14:28:08Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.pnpbp.2012.07.002
Progress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 39, n. 2, p. 310-317, 2012.
10.1016/j.pnpbp.2012.07.002
WOS000310943500014.pdf
0278-5846
http://repositorio.unifesp.br/handle/11600/35605
WOS:000310943500014
url http://dx.doi.org/10.1016/j.pnpbp.2012.07.002
http://repositorio.unifesp.br/handle/11600/35605
identifier_str_mv Progress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 39, n. 2, p. 310-317, 2012.
10.1016/j.pnpbp.2012.07.002
WOS000310943500014.pdf
0278-5846
WOS:000310943500014
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Progress in Neuro-psychopharmacology & Biological Psychiatry
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
eu_rights_str_mv openAccess
rights_invalid_str_mv http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.format.none.fl_str_mv 310-317
application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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