Efeitos em curto prazo da aplicação de aloxana para indução de diabetes em ratos Wistar

Detalhes bibliográficos
Autor(a) principal: Leme, Jose Alexandre Curiacos de Almeida
Data de Publicação: 2010
Outros Autores: Castellar, Alexandre, Remedio, Rafael Neodini, Barbosa, Rodrigo Avelaira, Moura, Leandro Pereira de, Dalia, Rodrigo Augusto, Gomes, Ricardo José [UNIFESP], Caetano, Flavio Henrique, Mello, Maria Alice Rostom de, Luciano, Eliete
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: https://repositorio.unifesp.br/11600/42839
https://www.seer.ufu.br/index.php/biosciencejournal/article/view/7094/4858
Resumo: The present study aimed to verify action of alloxan in metabolic and immune parameters after 24 and 192 hours of the injection in Wistar rats. Thus, eight rats were fasted and received monohidrated alloxan Sigma (32 mg/kg body weight) via endovenous. Glycemia and trglyceridemia analyzes were performed before and 192 hours after alloxan application. After 24 hours, alloxan application increased water intake and decreased body mass, food intake and leucocytes counting. 192 hours after alloxan application, there was a recuperation in food intake and leucocytes counting. On the other hand, in this period there was an increase of glycemia and water intake and reduction of body mass. These results indicate that some of diabetic signs caused by alloxan occur in short-term after drug administration.
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spelling Leme, Jose Alexandre Curiacos de AlmeidaCastellar, AlexandreRemedio, Rafael NeodiniBarbosa, Rodrigo AvelairaMoura, Leandro Pereira deDalia, Rodrigo AugustoGomes, Ricardo José [UNIFESP]Caetano, Flavio HenriqueMello, Maria Alice Rostom deLuciano, ElieteUniv Estadual PaulistaUniversidade Federal de São Paulo (UNIFESP)2018-06-15T14:04:27Z2018-06-15T14:04:27Z2010-05-01Bioscience Journal. Uberlandia: Univ Federal Uberlandia, v. 26, n. 3, p. 442-447, 2010.1516-3725https://repositorio.unifesp.br/11600/42839https://www.seer.ufu.br/index.php/biosciencejournal/article/view/7094/4858WOS000282056200015.pdfWOS:000282056200015The present study aimed to verify action of alloxan in metabolic and immune parameters after 24 and 192 hours of the injection in Wistar rats. Thus, eight rats were fasted and received monohidrated alloxan Sigma (32 mg/kg body weight) via endovenous. Glycemia and trglyceridemia analyzes were performed before and 192 hours after alloxan application. After 24 hours, alloxan application increased water intake and decreased body mass, food intake and leucocytes counting. 192 hours after alloxan application, there was a recuperation in food intake and leucocytes counting. On the other hand, in this period there was an increase of glycemia and water intake and reduction of body mass. These results indicate that some of diabetic signs caused by alloxan occur in short-term after drug administration.Univ Estadual Paulista, Dept Educ Fis, Sao Paulo, BrazilUniv Estadual Paulista, Dept Biol, Sao Paulo, BrazilUniv Fed Sao Paulo Baixada Santista, Sao Paulo, BrazilUniv Estadual Paulista, Dept Ciencias Biol, Sao Paulo, BrazilUniv Fed Sao Paulo Baixada Santista, Sao Paulo, BrazilWeb of Science442-447porUniv Federal UberlandiaBioscience JournalAlloxanDiabetesMetabolismImmune SystemEfeitos em curto prazo da aplicação de aloxana para indução de diabetes em ratos WistarEffects in short-term of alloxan application to diabetes induction in Wistar ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000282056200015.pdfapplication/pdf119649${dspace.ui.url}/bitstream/11600/42839/1/WOS000282056200015.pdfd3f588e00fab24db29ec3484e94041edMD51open accessTEXTWOS000282056200015.pdf.txtWOS000282056200015.pdf.txtExtracted texttext/plain21031${dspace.ui.url}/bitstream/11600/42839/5/WOS000282056200015.pdf.txtf68d6dabe1eb4449ad372dc75c466f8dMD55open accessTHUMBNAILWOS000282056200015.pdf.jpgWOS000282056200015.pdf.jpgIM Thumbnailimage/jpeg7377${dspace.ui.url}/bitstream/11600/42839/7/WOS000282056200015.pdf.jpga73a9d8deb88b7f51ccdf02525192a84MD57open access11600/428392023-06-05 19:06:57.138open accessoai:repositorio.unifesp.br:11600/42839Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:06:57Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.pt.fl_str_mv Efeitos em curto prazo da aplicação de aloxana para indução de diabetes em ratos Wistar
dc.title.alternative.en.fl_str_mv Effects in short-term of alloxan application to diabetes induction in Wistar rats
title Efeitos em curto prazo da aplicação de aloxana para indução de diabetes em ratos Wistar
spellingShingle Efeitos em curto prazo da aplicação de aloxana para indução de diabetes em ratos Wistar
Leme, Jose Alexandre Curiacos de Almeida
Alloxan
Diabetes
Metabolism
Immune System
title_short Efeitos em curto prazo da aplicação de aloxana para indução de diabetes em ratos Wistar
title_full Efeitos em curto prazo da aplicação de aloxana para indução de diabetes em ratos Wistar
title_fullStr Efeitos em curto prazo da aplicação de aloxana para indução de diabetes em ratos Wistar
title_full_unstemmed Efeitos em curto prazo da aplicação de aloxana para indução de diabetes em ratos Wistar
title_sort Efeitos em curto prazo da aplicação de aloxana para indução de diabetes em ratos Wistar
author Leme, Jose Alexandre Curiacos de Almeida
author_facet Leme, Jose Alexandre Curiacos de Almeida
Castellar, Alexandre
Remedio, Rafael Neodini
Barbosa, Rodrigo Avelaira
Moura, Leandro Pereira de
Dalia, Rodrigo Augusto
Gomes, Ricardo José [UNIFESP]
Caetano, Flavio Henrique
Mello, Maria Alice Rostom de
Luciano, Eliete
author_role author
author2 Castellar, Alexandre
Remedio, Rafael Neodini
Barbosa, Rodrigo Avelaira
Moura, Leandro Pereira de
Dalia, Rodrigo Augusto
Gomes, Ricardo José [UNIFESP]
Caetano, Flavio Henrique
Mello, Maria Alice Rostom de
Luciano, Eliete
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.institution.none.fl_str_mv Univ Estadual Paulista
Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Leme, Jose Alexandre Curiacos de Almeida
Castellar, Alexandre
Remedio, Rafael Neodini
Barbosa, Rodrigo Avelaira
Moura, Leandro Pereira de
Dalia, Rodrigo Augusto
Gomes, Ricardo José [UNIFESP]
Caetano, Flavio Henrique
Mello, Maria Alice Rostom de
Luciano, Eliete
dc.subject.eng.fl_str_mv Alloxan
Diabetes
Metabolism
Immune System
topic Alloxan
Diabetes
Metabolism
Immune System
description The present study aimed to verify action of alloxan in metabolic and immune parameters after 24 and 192 hours of the injection in Wistar rats. Thus, eight rats were fasted and received monohidrated alloxan Sigma (32 mg/kg body weight) via endovenous. Glycemia and trglyceridemia analyzes were performed before and 192 hours after alloxan application. After 24 hours, alloxan application increased water intake and decreased body mass, food intake and leucocytes counting. 192 hours after alloxan application, there was a recuperation in food intake and leucocytes counting. On the other hand, in this period there was an increase of glycemia and water intake and reduction of body mass. These results indicate that some of diabetic signs caused by alloxan occur in short-term after drug administration.
publishDate 2010
dc.date.issued.fl_str_mv 2010-05-01
dc.date.accessioned.fl_str_mv 2018-06-15T14:04:27Z
dc.date.available.fl_str_mv 2018-06-15T14:04:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv Bioscience Journal. Uberlandia: Univ Federal Uberlandia, v. 26, n. 3, p. 442-447, 2010.
dc.identifier.uri.fl_str_mv https://repositorio.unifesp.br/11600/42839
https://www.seer.ufu.br/index.php/biosciencejournal/article/view/7094/4858
dc.identifier.issn.none.fl_str_mv 1516-3725
dc.identifier.file.none.fl_str_mv WOS000282056200015.pdf
dc.identifier.wos.none.fl_str_mv WOS:000282056200015
identifier_str_mv Bioscience Journal. Uberlandia: Univ Federal Uberlandia, v. 26, n. 3, p. 442-447, 2010.
1516-3725
WOS000282056200015.pdf
WOS:000282056200015
url https://repositorio.unifesp.br/11600/42839
https://www.seer.ufu.br/index.php/biosciencejournal/article/view/7094/4858
dc.language.iso.fl_str_mv por
language por
dc.relation.ispartof.none.fl_str_mv Bioscience Journal
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 442-447
dc.publisher.none.fl_str_mv Univ Federal Uberlandia
publisher.none.fl_str_mv Univ Federal Uberlandia
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
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