Gender and hemispheric differences in temporal lobe epilepsy: A VBM study
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
dARK ID: | ark:/48912/0013000013r3c |
Texto Completo: | http://dx.doi.org/10.1016/j.seizure.2013.12.006 http://repositorio.unifesp.br/handle/11600/37568 |
Resumo: | Purpose: Gender differences are recognized in the functional and anatomical organization of the human brain. Differences between genders are probably expressed early in life, when differential rates of cerebral maturation occur. Sexual dimorphism has been described in temporal lobe epilepsy with mesial temporal sclerosis (TLE-MTS). Several voxel-based morphometry (VBM) studies have shown that TLE-MTS extends beyond mesial temporal structures, and that there are differences in the extent of anatomical damage between hemispheres, although none have approached gender differences. Our aim was to investigate gender differences and anatomical abnormalities in TLE-MTS.Methods: VBM5 was employed to analyze gender and hemispheric differences in 120 patients with TLE-MTS and 50 controls.Results: VBM abnormalities were more widespread in left-TLE; while in women changes were mostly seen in temporal areas, frontal regions were more affected in men.Conclusions: Our study confirmed that gender and laterality are important factors determining the nature and severity of brain damage in TLE-MTS. Differential rates of maturation between gender and hemispheres may explain the distinct areas of anatomical damage in men and women. (C) 2013 British Epilepsy Association. Published by Elsevier B.V. All rights reserved. |
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Gender and hemispheric differences in temporal lobe epilepsy: A VBM studyGenderMesial temporal sclerosisTemporal lobe epilepsyVoxel-based morphometryPurpose: Gender differences are recognized in the functional and anatomical organization of the human brain. Differences between genders are probably expressed early in life, when differential rates of cerebral maturation occur. Sexual dimorphism has been described in temporal lobe epilepsy with mesial temporal sclerosis (TLE-MTS). Several voxel-based morphometry (VBM) studies have shown that TLE-MTS extends beyond mesial temporal structures, and that there are differences in the extent of anatomical damage between hemispheres, although none have approached gender differences. Our aim was to investigate gender differences and anatomical abnormalities in TLE-MTS.Methods: VBM5 was employed to analyze gender and hemispheric differences in 120 patients with TLE-MTS and 50 controls.Results: VBM abnormalities were more widespread in left-TLE; while in women changes were mostly seen in temporal areas, frontal regions were more affected in men.Conclusions: Our study confirmed that gender and laterality are important factors determining the nature and severity of brain damage in TLE-MTS. Differential rates of maturation between gender and hemispheres may explain the distinct areas of anatomical damage in men and women. (C) 2013 British Epilepsy Association. Published by Elsevier B.V. All rights reserved.Universidade Federal de São Paulo, Unidade Pesquisa & Tratamento Epilepsias UNIPETE, Dept Neurol & Neurosurg, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psychiat, Lab Interdisciplinar Neurociencias Clin LiNC, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Diagnost Imagem, São Paulo, BrazilUniversidade Federal de São Paulo, Unidade Pesquisa & Tratamento Epilepsias UNIPETE, Dept Neurol & Neurosurg, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psychiat, Lab Interdisciplinar Neurociencias Clin LiNC, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Diagnost Imagem, São Paulo, BrazilWeb of ScienceFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)W B Saunders Co LtdUniversidade Federal de São Paulo (UNIFESP)Santana, Maria Teresa Castilho Garcia de [UNIFESP]Jackowski, Andrea Parolin [UNIFESP]Britto, Fernanda dos Santos [UNIFESP]Sandim, Gabriel Barbosa [UNIFESP]Caboclo, Luís Otávio Sales Ferreira [UNIFESP]Centeno, Ricardo Silva [UNIFESP]Carrete Junior, Henrique [UNIFESP]Yacubian, Elza Márcia Targas [UNIFESP]2016-01-24T14:35:28Z2016-01-24T14:35:28Z2014-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion274-279application/pdfhttp://dx.doi.org/10.1016/j.seizure.2013.12.006Seizure-european Journal of Epilepsy. London: W B Saunders Co Ltd, v. 23, n. 4, p. 274-279, 2014.10.1016/j.seizure.2013.12.006WOS000334980700005.pdf1059-1311http://repositorio.unifesp.br/handle/11600/37568WOS:000334980700005ark:/48912/0013000013r3cengSeizure-european Journal of Epilepsyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-08T08:06:05Zoai:repositorio.unifesp.br/:11600/37568Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T20:54:05.028707Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Gender and hemispheric differences in temporal lobe epilepsy: A VBM study |
title |
Gender and hemispheric differences in temporal lobe epilepsy: A VBM study |
spellingShingle |
Gender and hemispheric differences in temporal lobe epilepsy: A VBM study Santana, Maria Teresa Castilho Garcia de [UNIFESP] Gender Mesial temporal sclerosis Temporal lobe epilepsy Voxel-based morphometry |
title_short |
Gender and hemispheric differences in temporal lobe epilepsy: A VBM study |
title_full |
Gender and hemispheric differences in temporal lobe epilepsy: A VBM study |
title_fullStr |
Gender and hemispheric differences in temporal lobe epilepsy: A VBM study |
title_full_unstemmed |
Gender and hemispheric differences in temporal lobe epilepsy: A VBM study |
title_sort |
Gender and hemispheric differences in temporal lobe epilepsy: A VBM study |
author |
Santana, Maria Teresa Castilho Garcia de [UNIFESP] |
author_facet |
Santana, Maria Teresa Castilho Garcia de [UNIFESP] Jackowski, Andrea Parolin [UNIFESP] Britto, Fernanda dos Santos [UNIFESP] Sandim, Gabriel Barbosa [UNIFESP] Caboclo, Luís Otávio Sales Ferreira [UNIFESP] Centeno, Ricardo Silva [UNIFESP] Carrete Junior, Henrique [UNIFESP] Yacubian, Elza Márcia Targas [UNIFESP] |
author_role |
author |
author2 |
Jackowski, Andrea Parolin [UNIFESP] Britto, Fernanda dos Santos [UNIFESP] Sandim, Gabriel Barbosa [UNIFESP] Caboclo, Luís Otávio Sales Ferreira [UNIFESP] Centeno, Ricardo Silva [UNIFESP] Carrete Junior, Henrique [UNIFESP] Yacubian, Elza Márcia Targas [UNIFESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Santana, Maria Teresa Castilho Garcia de [UNIFESP] Jackowski, Andrea Parolin [UNIFESP] Britto, Fernanda dos Santos [UNIFESP] Sandim, Gabriel Barbosa [UNIFESP] Caboclo, Luís Otávio Sales Ferreira [UNIFESP] Centeno, Ricardo Silva [UNIFESP] Carrete Junior, Henrique [UNIFESP] Yacubian, Elza Márcia Targas [UNIFESP] |
dc.subject.por.fl_str_mv |
Gender Mesial temporal sclerosis Temporal lobe epilepsy Voxel-based morphometry |
topic |
Gender Mesial temporal sclerosis Temporal lobe epilepsy Voxel-based morphometry |
description |
Purpose: Gender differences are recognized in the functional and anatomical organization of the human brain. Differences between genders are probably expressed early in life, when differential rates of cerebral maturation occur. Sexual dimorphism has been described in temporal lobe epilepsy with mesial temporal sclerosis (TLE-MTS). Several voxel-based morphometry (VBM) studies have shown that TLE-MTS extends beyond mesial temporal structures, and that there are differences in the extent of anatomical damage between hemispheres, although none have approached gender differences. Our aim was to investigate gender differences and anatomical abnormalities in TLE-MTS.Methods: VBM5 was employed to analyze gender and hemispheric differences in 120 patients with TLE-MTS and 50 controls.Results: VBM abnormalities were more widespread in left-TLE; while in women changes were mostly seen in temporal areas, frontal regions were more affected in men.Conclusions: Our study confirmed that gender and laterality are important factors determining the nature and severity of brain damage in TLE-MTS. Differential rates of maturation between gender and hemispheres may explain the distinct areas of anatomical damage in men and women. (C) 2013 British Epilepsy Association. Published by Elsevier B.V. All rights reserved. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-04-01 2016-01-24T14:35:28Z 2016-01-24T14:35:28Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.seizure.2013.12.006 Seizure-european Journal of Epilepsy. London: W B Saunders Co Ltd, v. 23, n. 4, p. 274-279, 2014. 10.1016/j.seizure.2013.12.006 WOS000334980700005.pdf 1059-1311 http://repositorio.unifesp.br/handle/11600/37568 WOS:000334980700005 |
dc.identifier.dark.fl_str_mv |
ark:/48912/0013000013r3c |
url |
http://dx.doi.org/10.1016/j.seizure.2013.12.006 http://repositorio.unifesp.br/handle/11600/37568 |
identifier_str_mv |
Seizure-european Journal of Epilepsy. London: W B Saunders Co Ltd, v. 23, n. 4, p. 274-279, 2014. 10.1016/j.seizure.2013.12.006 WOS000334980700005.pdf 1059-1311 WOS:000334980700005 ark:/48912/0013000013r3c |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Seizure-european Journal of Epilepsy |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
274-279 application/pdf |
dc.publisher.none.fl_str_mv |
W B Saunders Co Ltd |
publisher.none.fl_str_mv |
W B Saunders Co Ltd |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1818602565092245504 |