Gender and hemispheric differences in temporal lobe epilepsy: A VBM study

Detalhes bibliográficos
Autor(a) principal: Santana, Maria Teresa Castilho Garcia de [UNIFESP]
Data de Publicação: 2014
Outros Autores: Jackowski, Andrea Parolin [UNIFESP], Britto, Fernanda dos Santos [UNIFESP], Sandim, Gabriel Barbosa [UNIFESP], Caboclo, Luís Otávio Sales Ferreira [UNIFESP], Centeno, Ricardo Silva [UNIFESP], Carrete Junior, Henrique [UNIFESP], Yacubian, Elza Márcia Targas [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
dARK ID: ark:/48912/0013000013r3c
Texto Completo: http://dx.doi.org/10.1016/j.seizure.2013.12.006
http://repositorio.unifesp.br/handle/11600/37568
Resumo: Purpose: Gender differences are recognized in the functional and anatomical organization of the human brain. Differences between genders are probably expressed early in life, when differential rates of cerebral maturation occur. Sexual dimorphism has been described in temporal lobe epilepsy with mesial temporal sclerosis (TLE-MTS). Several voxel-based morphometry (VBM) studies have shown that TLE-MTS extends beyond mesial temporal structures, and that there are differences in the extent of anatomical damage between hemispheres, although none have approached gender differences. Our aim was to investigate gender differences and anatomical abnormalities in TLE-MTS.Methods: VBM5 was employed to analyze gender and hemispheric differences in 120 patients with TLE-MTS and 50 controls.Results: VBM abnormalities were more widespread in left-TLE; while in women changes were mostly seen in temporal areas, frontal regions were more affected in men.Conclusions: Our study confirmed that gender and laterality are important factors determining the nature and severity of brain damage in TLE-MTS. Differential rates of maturation between gender and hemispheres may explain the distinct areas of anatomical damage in men and women. (C) 2013 British Epilepsy Association. Published by Elsevier B.V. All rights reserved.
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spelling Gender and hemispheric differences in temporal lobe epilepsy: A VBM studyGenderMesial temporal sclerosisTemporal lobe epilepsyVoxel-based morphometryPurpose: Gender differences are recognized in the functional and anatomical organization of the human brain. Differences between genders are probably expressed early in life, when differential rates of cerebral maturation occur. Sexual dimorphism has been described in temporal lobe epilepsy with mesial temporal sclerosis (TLE-MTS). Several voxel-based morphometry (VBM) studies have shown that TLE-MTS extends beyond mesial temporal structures, and that there are differences in the extent of anatomical damage between hemispheres, although none have approached gender differences. Our aim was to investigate gender differences and anatomical abnormalities in TLE-MTS.Methods: VBM5 was employed to analyze gender and hemispheric differences in 120 patients with TLE-MTS and 50 controls.Results: VBM abnormalities were more widespread in left-TLE; while in women changes were mostly seen in temporal areas, frontal regions were more affected in men.Conclusions: Our study confirmed that gender and laterality are important factors determining the nature and severity of brain damage in TLE-MTS. Differential rates of maturation between gender and hemispheres may explain the distinct areas of anatomical damage in men and women. (C) 2013 British Epilepsy Association. Published by Elsevier B.V. All rights reserved.Universidade Federal de São Paulo, Unidade Pesquisa & Tratamento Epilepsias UNIPETE, Dept Neurol & Neurosurg, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psychiat, Lab Interdisciplinar Neurociencias Clin LiNC, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Diagnost Imagem, São Paulo, BrazilUniversidade Federal de São Paulo, Unidade Pesquisa & Tratamento Epilepsias UNIPETE, Dept Neurol & Neurosurg, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psychiat, Lab Interdisciplinar Neurociencias Clin LiNC, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Diagnost Imagem, São Paulo, BrazilWeb of ScienceFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)W B Saunders Co LtdUniversidade Federal de São Paulo (UNIFESP)Santana, Maria Teresa Castilho Garcia de [UNIFESP]Jackowski, Andrea Parolin [UNIFESP]Britto, Fernanda dos Santos [UNIFESP]Sandim, Gabriel Barbosa [UNIFESP]Caboclo, Luís Otávio Sales Ferreira [UNIFESP]Centeno, Ricardo Silva [UNIFESP]Carrete Junior, Henrique [UNIFESP]Yacubian, Elza Márcia Targas [UNIFESP]2016-01-24T14:35:28Z2016-01-24T14:35:28Z2014-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion274-279application/pdfhttp://dx.doi.org/10.1016/j.seizure.2013.12.006Seizure-european Journal of Epilepsy. London: W B Saunders Co Ltd, v. 23, n. 4, p. 274-279, 2014.10.1016/j.seizure.2013.12.006WOS000334980700005.pdf1059-1311http://repositorio.unifesp.br/handle/11600/37568WOS:000334980700005ark:/48912/0013000013r3cengSeizure-european Journal of Epilepsyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-08T08:06:05Zoai:repositorio.unifesp.br/:11600/37568Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T20:54:05.028707Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Gender and hemispheric differences in temporal lobe epilepsy: A VBM study
title Gender and hemispheric differences in temporal lobe epilepsy: A VBM study
spellingShingle Gender and hemispheric differences in temporal lobe epilepsy: A VBM study
Santana, Maria Teresa Castilho Garcia de [UNIFESP]
Gender
Mesial temporal sclerosis
Temporal lobe epilepsy
Voxel-based morphometry
title_short Gender and hemispheric differences in temporal lobe epilepsy: A VBM study
title_full Gender and hemispheric differences in temporal lobe epilepsy: A VBM study
title_fullStr Gender and hemispheric differences in temporal lobe epilepsy: A VBM study
title_full_unstemmed Gender and hemispheric differences in temporal lobe epilepsy: A VBM study
title_sort Gender and hemispheric differences in temporal lobe epilepsy: A VBM study
author Santana, Maria Teresa Castilho Garcia de [UNIFESP]
author_facet Santana, Maria Teresa Castilho Garcia de [UNIFESP]
Jackowski, Andrea Parolin [UNIFESP]
Britto, Fernanda dos Santos [UNIFESP]
Sandim, Gabriel Barbosa [UNIFESP]
Caboclo, Luís Otávio Sales Ferreira [UNIFESP]
Centeno, Ricardo Silva [UNIFESP]
Carrete Junior, Henrique [UNIFESP]
Yacubian, Elza Márcia Targas [UNIFESP]
author_role author
author2 Jackowski, Andrea Parolin [UNIFESP]
Britto, Fernanda dos Santos [UNIFESP]
Sandim, Gabriel Barbosa [UNIFESP]
Caboclo, Luís Otávio Sales Ferreira [UNIFESP]
Centeno, Ricardo Silva [UNIFESP]
Carrete Junior, Henrique [UNIFESP]
Yacubian, Elza Márcia Targas [UNIFESP]
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Santana, Maria Teresa Castilho Garcia de [UNIFESP]
Jackowski, Andrea Parolin [UNIFESP]
Britto, Fernanda dos Santos [UNIFESP]
Sandim, Gabriel Barbosa [UNIFESP]
Caboclo, Luís Otávio Sales Ferreira [UNIFESP]
Centeno, Ricardo Silva [UNIFESP]
Carrete Junior, Henrique [UNIFESP]
Yacubian, Elza Márcia Targas [UNIFESP]
dc.subject.por.fl_str_mv Gender
Mesial temporal sclerosis
Temporal lobe epilepsy
Voxel-based morphometry
topic Gender
Mesial temporal sclerosis
Temporal lobe epilepsy
Voxel-based morphometry
description Purpose: Gender differences are recognized in the functional and anatomical organization of the human brain. Differences between genders are probably expressed early in life, when differential rates of cerebral maturation occur. Sexual dimorphism has been described in temporal lobe epilepsy with mesial temporal sclerosis (TLE-MTS). Several voxel-based morphometry (VBM) studies have shown that TLE-MTS extends beyond mesial temporal structures, and that there are differences in the extent of anatomical damage between hemispheres, although none have approached gender differences. Our aim was to investigate gender differences and anatomical abnormalities in TLE-MTS.Methods: VBM5 was employed to analyze gender and hemispheric differences in 120 patients with TLE-MTS and 50 controls.Results: VBM abnormalities were more widespread in left-TLE; while in women changes were mostly seen in temporal areas, frontal regions were more affected in men.Conclusions: Our study confirmed that gender and laterality are important factors determining the nature and severity of brain damage in TLE-MTS. Differential rates of maturation between gender and hemispheres may explain the distinct areas of anatomical damage in men and women. (C) 2013 British Epilepsy Association. Published by Elsevier B.V. All rights reserved.
publishDate 2014
dc.date.none.fl_str_mv 2014-04-01
2016-01-24T14:35:28Z
2016-01-24T14:35:28Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.seizure.2013.12.006
Seizure-european Journal of Epilepsy. London: W B Saunders Co Ltd, v. 23, n. 4, p. 274-279, 2014.
10.1016/j.seizure.2013.12.006
WOS000334980700005.pdf
1059-1311
http://repositorio.unifesp.br/handle/11600/37568
WOS:000334980700005
dc.identifier.dark.fl_str_mv ark:/48912/0013000013r3c
url http://dx.doi.org/10.1016/j.seizure.2013.12.006
http://repositorio.unifesp.br/handle/11600/37568
identifier_str_mv Seizure-european Journal of Epilepsy. London: W B Saunders Co Ltd, v. 23, n. 4, p. 274-279, 2014.
10.1016/j.seizure.2013.12.006
WOS000334980700005.pdf
1059-1311
WOS:000334980700005
ark:/48912/0013000013r3c
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Seizure-european Journal of Epilepsy
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 274-279
application/pdf
dc.publisher.none.fl_str_mv W B Saunders Co Ltd
publisher.none.fl_str_mv W B Saunders Co Ltd
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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