Use of cardiopulmonary exercise testing to assess early ventilatory changes related to occupational particulate matter
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/53797 https://dx.doi.org/10.1590/1414-431X20186486 |
Resumo: | Spirometry has been used as the main strategy for assessing ventilatory changes related to occupational exposure to particulate matter (OEPM). However, in some cases, as one of its limitations, it may not be sensitive enough to show abnormalities before extensive damage, as seen in restrictive lung diseases. Therefore, we hypothesized that cardiopulmonary exercise testing (CPET) may be better than spirometry to detect early ventilatory impairment caused by OEPM. We selected 135 male workers with at least one year of exposure. After collection of self-reported socioeconomic status, educational level, and cardiovascular risk data, participants underwent spirometry, CPET, body composition assessment (bioelectrical impedance), and triaxial accelerometry (for level of physical activity in daily life). CPET was performed using a ramp protocol on a treadmill. Metabolic, cardiovascular, ventilatory, and submaximal relationships were measured. We compared 52 exposed to 83 non-exposed workers. Multiple linear regressions were developed using spirometry and CPET variables as outcomes and OEPM as the main predictor, and adjusted by the main covariates. Our results showed that OEPM was associated with significant reductions in peak minute ventilation, peak tidal volume, and breathing reserve index. Exposed participants presented shallower slope of Delta VT/Delta ln<(V)over dot>E (breathing pattern), i.e., increased tachypneic breathing pattern. The OEPM explained 7.4% of the Delta VT/Delta ln<(V)over dot>E variability. We found no significant influence of spirometric indices after multiple linear regressions. We conclude that CPET might be a more sensitive feature of assessing early pulmonary impairment related to OEPM. Our cross-sectional results suggested that CPET is a promising tool for the screening of asymptomatic male workers. |
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Chao, Tsai Ping [UNIFESP]Sperandio, Evandro Fornias [UNIFESP]Ostolin, Thatiane Lopes Valentim Di Paschoale [UNIFESP]Almeida, Vitor Rossi de [UNIFESP]Romiti, MarcelloGagliardi, Antônio Ricardo de ToledoArantes, Rodolfo LeiteDourado, Victor Zuniga [UNIFESP]2020-07-02T18:51:58Z2020-07-02T18:51:58Z2018Brazilian Journal of Medical and Biological Research. Sao Paulo, v. 51, n. 5, p. -, 2018.0100-879Xhttps://repositorio.unifesp.br/handle/11600/53797https://dx.doi.org/10.1590/1414-431X20186486WOS000428568600001.pdf10.1590/1414-431X20186486WOS:000428568600001Spirometry has been used as the main strategy for assessing ventilatory changes related to occupational exposure to particulate matter (OEPM). However, in some cases, as one of its limitations, it may not be sensitive enough to show abnormalities before extensive damage, as seen in restrictive lung diseases. Therefore, we hypothesized that cardiopulmonary exercise testing (CPET) may be better than spirometry to detect early ventilatory impairment caused by OEPM. We selected 135 male workers with at least one year of exposure. After collection of self-reported socioeconomic status, educational level, and cardiovascular risk data, participants underwent spirometry, CPET, body composition assessment (bioelectrical impedance), and triaxial accelerometry (for level of physical activity in daily life). CPET was performed using a ramp protocol on a treadmill. Metabolic, cardiovascular, ventilatory, and submaximal relationships were measured. We compared 52 exposed to 83 non-exposed workers. Multiple linear regressions were developed using spirometry and CPET variables as outcomes and OEPM as the main predictor, and adjusted by the main covariates. Our results showed that OEPM was associated with significant reductions in peak minute ventilation, peak tidal volume, and breathing reserve index. Exposed participants presented shallower slope of Delta VT/Delta ln<(V)over dot>E (breathing pattern), i.e., increased tachypneic breathing pattern. The OEPM explained 7.4% of the Delta VT/Delta ln<(V)over dot>E variability. We found no significant influence of spirometric indices after multiple linear regressions. We conclude that CPET might be a more sensitive feature of assessing early pulmonary impairment related to OEPM. Our cross-sectional results suggested that CPET is a promising tool for the screening of asymptomatic male workers.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Fed Sao Paulo, Dept Ciencias Movimento Humano, Lab Epidemiol & Movimento Humano, Santos, SP, BrazilInst Med Cardiovasc Angiocorpore, Santos, SP, BrazilUniv Fed Sao Paulo, Dept Ciencias Movimento Humano, Lab Epidemiol & Movimento Humano, Santos, SP, BrazilFAPESP: 2011/07282-6Web of Science-engAssoc Bras Divulg CientificaBrazilian Journal of Medical and Biological ResearchOccupational exposure to particulate matterCardiopulmonary exercise testingDetectionSpirometryVentilatory impairmentUse of cardiopulmonary exercise testing to assess early ventilatory changes related to occupational particulate matterinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSao Paulo515info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000428568600001.pdfapplication/pdf106425${dspace.ui.url}/bitstream/11600/53797/1/WOS000428568600001.pdf60aec96cb73b81ab0699acc02a39c9e3MD51open accessTEXTWOS000428568600001.pdf.txtWOS000428568600001.pdf.txtExtracted texttext/plain38756${dspace.ui.url}/bitstream/11600/53797/5/WOS000428568600001.pdf.txt416f07532f3701f6e165b17372567781MD55open accessTHUMBNAILWOS000428568600001.pdf.jpgWOS000428568600001.pdf.jpgIM Thumbnailimage/jpeg6804${dspace.ui.url}/bitstream/11600/53797/7/WOS000428568600001.pdf.jpg9d9c6cf86fd656b0dfed0e5932f68f69MD57open access11600/537972023-06-05 19:09:35.268open accessoai:repositorio.unifesp.br:11600/53797Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:09:35Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Use of cardiopulmonary exercise testing to assess early ventilatory changes related to occupational particulate matter |
title |
Use of cardiopulmonary exercise testing to assess early ventilatory changes related to occupational particulate matter |
spellingShingle |
Use of cardiopulmonary exercise testing to assess early ventilatory changes related to occupational particulate matter Chao, Tsai Ping [UNIFESP] Occupational exposure to particulate matter Cardiopulmonary exercise testing Detection Spirometry Ventilatory impairment |
title_short |
Use of cardiopulmonary exercise testing to assess early ventilatory changes related to occupational particulate matter |
title_full |
Use of cardiopulmonary exercise testing to assess early ventilatory changes related to occupational particulate matter |
title_fullStr |
Use of cardiopulmonary exercise testing to assess early ventilatory changes related to occupational particulate matter |
title_full_unstemmed |
Use of cardiopulmonary exercise testing to assess early ventilatory changes related to occupational particulate matter |
title_sort |
Use of cardiopulmonary exercise testing to assess early ventilatory changes related to occupational particulate matter |
author |
Chao, Tsai Ping [UNIFESP] |
author_facet |
Chao, Tsai Ping [UNIFESP] Sperandio, Evandro Fornias [UNIFESP] Ostolin, Thatiane Lopes Valentim Di Paschoale [UNIFESP] Almeida, Vitor Rossi de [UNIFESP] Romiti, Marcello Gagliardi, Antônio Ricardo de Toledo Arantes, Rodolfo Leite Dourado, Victor Zuniga [UNIFESP] |
author_role |
author |
author2 |
Sperandio, Evandro Fornias [UNIFESP] Ostolin, Thatiane Lopes Valentim Di Paschoale [UNIFESP] Almeida, Vitor Rossi de [UNIFESP] Romiti, Marcello Gagliardi, Antônio Ricardo de Toledo Arantes, Rodolfo Leite Dourado, Victor Zuniga [UNIFESP] |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Chao, Tsai Ping [UNIFESP] Sperandio, Evandro Fornias [UNIFESP] Ostolin, Thatiane Lopes Valentim Di Paschoale [UNIFESP] Almeida, Vitor Rossi de [UNIFESP] Romiti, Marcello Gagliardi, Antônio Ricardo de Toledo Arantes, Rodolfo Leite Dourado, Victor Zuniga [UNIFESP] |
dc.subject.eng.fl_str_mv |
Occupational exposure to particulate matter Cardiopulmonary exercise testing Detection Spirometry Ventilatory impairment |
topic |
Occupational exposure to particulate matter Cardiopulmonary exercise testing Detection Spirometry Ventilatory impairment |
description |
Spirometry has been used as the main strategy for assessing ventilatory changes related to occupational exposure to particulate matter (OEPM). However, in some cases, as one of its limitations, it may not be sensitive enough to show abnormalities before extensive damage, as seen in restrictive lung diseases. Therefore, we hypothesized that cardiopulmonary exercise testing (CPET) may be better than spirometry to detect early ventilatory impairment caused by OEPM. We selected 135 male workers with at least one year of exposure. After collection of self-reported socioeconomic status, educational level, and cardiovascular risk data, participants underwent spirometry, CPET, body composition assessment (bioelectrical impedance), and triaxial accelerometry (for level of physical activity in daily life). CPET was performed using a ramp protocol on a treadmill. Metabolic, cardiovascular, ventilatory, and submaximal relationships were measured. We compared 52 exposed to 83 non-exposed workers. Multiple linear regressions were developed using spirometry and CPET variables as outcomes and OEPM as the main predictor, and adjusted by the main covariates. Our results showed that OEPM was associated with significant reductions in peak minute ventilation, peak tidal volume, and breathing reserve index. Exposed participants presented shallower slope of Delta VT/Delta ln<(V)over dot>E (breathing pattern), i.e., increased tachypneic breathing pattern. The OEPM explained 7.4% of the Delta VT/Delta ln<(V)over dot>E variability. We found no significant influence of spirometric indices after multiple linear regressions. We conclude that CPET might be a more sensitive feature of assessing early pulmonary impairment related to OEPM. Our cross-sectional results suggested that CPET is a promising tool for the screening of asymptomatic male workers. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2020-07-02T18:51:58Z |
dc.date.available.fl_str_mv |
2020-07-02T18:51:58Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Brazilian Journal of Medical and Biological Research. Sao Paulo, v. 51, n. 5, p. -, 2018. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/53797 https://dx.doi.org/10.1590/1414-431X20186486 |
dc.identifier.issn.none.fl_str_mv |
0100-879X |
dc.identifier.file.none.fl_str_mv |
WOS000428568600001.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1590/1414-431X20186486 |
dc.identifier.wos.none.fl_str_mv |
WOS:000428568600001 |
identifier_str_mv |
Brazilian Journal of Medical and Biological Research. Sao Paulo, v. 51, n. 5, p. -, 2018. 0100-879X WOS000428568600001.pdf 10.1590/1414-431X20186486 WOS:000428568600001 |
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https://repositorio.unifesp.br/handle/11600/53797 https://dx.doi.org/10.1590/1414-431X20186486 |
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Brazilian Journal of Medical and Biological Research |
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Assoc Bras Divulg Cientifica |
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Assoc Bras Divulg Cientifica |
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