Avaliação da aterosclerose nas artérias ilíacas de pacientes autopsiados

Detalhes bibliográficos
Autor(a) principal: TORQUATO, Bianca Gonçalves Silva
Data de Publicação: 2019
Tipo de documento: Tese
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFTM
Texto Completo: http://bdtd.uftm.edu.br/handle/tede/867
Resumo: Introdução: a doença cardiovascular aterosclerótica nas artérias ilíacas ocorre de maneira assintomática e está associada a aterosclerose sistêmica, o que contribui para os elevados índices de mortalidade. Objetivos: foi avaliar a intensidade macroscópica e microscópica da aterosclerose; mensurar a espessura das camadas íntima e média; quantificar a porcentagem de depósito lipídico e de fibras colágenas, de artérias ilíacas direita e esquerda, e associar esses dados a fatores de risco como envelhecimento; sexo e causa de morte. Métodos: foram obtidos 202 fragmentos de artérias ilíacas direita e esquerda de pacientes autopsiados. Para a classificação da intensidade da aterosclerose foi considerada a extensão de estrias lipídicas, de placas ateromatosas, de fibrose e de calcificação. Na macroscopia, por meio de uma escala de 12,0cm foi registrado um ponto correspondente a intensidade da aterosclerose. A classificação foi discreta, de 0,1cm a 4,0cm; moderada, de 4,1cm a 7,0cm e acentuada de 7,1cm a 12,0cm. Na microscopia, os fragmentos foram corados por hematoxilina e eosina e analisados ao microscópio de luz, sendo o acometimento discreto, quando menor que 25%; moderado, entre 26% a 50% e acentuado quando acima de 50%. Para a mensuração da espessura das camadas íntima e média foi feita a coloração por Verhoeff e para o depósito lipídico, o Sudan Vermelho. Ambas as análises foram feitas no software Axion Vision®. A porcentagem de fibras colágenas foi realizada no software Leica Qwin Plus®, sendo as lâminas coradas pelo Picrossírius. Para análise estatística foi utilizado o software graphPad Prism®. Resultados: a intensidade macroscópica e microscópica da aterosclerose; o espessamento das camadas íntima e média; a porcentagem de depósito lipídico e de fibras colágenas se correlacionaram de forma positiva e significativa com a idade, sendo significativamente maiores no sexo masculino e na causa de morte cardiovascular. Conclusão: os diferentes métodos usados fornecem novas aplicações para uma avaliação mais sensível dos grupos de risco e das alterações precoces associadas à aterosclerose pré-clínica nas artérias ilíacas.
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spelling Avaliação da aterosclerose nas artérias ilíacas de pacientes autopsiadosArtéria ilíaca.Aterosclerose.Grupos de risco.Autópsia.Iliac artery.Atherosclerosis.Risk groups.Autopsy.Ciências da SaúdeIntrodução: a doença cardiovascular aterosclerótica nas artérias ilíacas ocorre de maneira assintomática e está associada a aterosclerose sistêmica, o que contribui para os elevados índices de mortalidade. Objetivos: foi avaliar a intensidade macroscópica e microscópica da aterosclerose; mensurar a espessura das camadas íntima e média; quantificar a porcentagem de depósito lipídico e de fibras colágenas, de artérias ilíacas direita e esquerda, e associar esses dados a fatores de risco como envelhecimento; sexo e causa de morte. Métodos: foram obtidos 202 fragmentos de artérias ilíacas direita e esquerda de pacientes autopsiados. Para a classificação da intensidade da aterosclerose foi considerada a extensão de estrias lipídicas, de placas ateromatosas, de fibrose e de calcificação. Na macroscopia, por meio de uma escala de 12,0cm foi registrado um ponto correspondente a intensidade da aterosclerose. A classificação foi discreta, de 0,1cm a 4,0cm; moderada, de 4,1cm a 7,0cm e acentuada de 7,1cm a 12,0cm. Na microscopia, os fragmentos foram corados por hematoxilina e eosina e analisados ao microscópio de luz, sendo o acometimento discreto, quando menor que 25%; moderado, entre 26% a 50% e acentuado quando acima de 50%. Para a mensuração da espessura das camadas íntima e média foi feita a coloração por Verhoeff e para o depósito lipídico, o Sudan Vermelho. Ambas as análises foram feitas no software Axion Vision®. A porcentagem de fibras colágenas foi realizada no software Leica Qwin Plus®, sendo as lâminas coradas pelo Picrossírius. Para análise estatística foi utilizado o software graphPad Prism®. Resultados: a intensidade macroscópica e microscópica da aterosclerose; o espessamento das camadas íntima e média; a porcentagem de depósito lipídico e de fibras colágenas se correlacionaram de forma positiva e significativa com a idade, sendo significativamente maiores no sexo masculino e na causa de morte cardiovascular. Conclusão: os diferentes métodos usados fornecem novas aplicações para uma avaliação mais sensível dos grupos de risco e das alterações precoces associadas à aterosclerose pré-clínica nas artérias ilíacas.Introduction: Atherosclerotic cardiovascular disease in the iliac arteries occurs asymptomatically and is associated with systemic atherosclerosis, which contributes to high mortality rates. Objectives: to evaluate the macroscopic and microscopic intensity of atherosclerosis; measure the thickness of the intima and middle layers; quantify the percentage of lipid deposits and collagen fibers, right and left iliac arteries, and associate these data with risk factors such as aging; sex and cause of death. Methods: 202 fragments of right and left iliac arteries were obtained from autopsied patients. For the classification of the intensity of atherosclerosis, we considered the extension of lipid streaks, atheromatous plaques, fibrosis and calcification. In macroscopy, a point corresponding to the intensity of atherosclerosis was recorded using a 12.0cm scale. The classification was discrete, from 0.1cm to 4.0cm; resistant front, easy peel-and-stick back No minimum order Small, 3.8 cm (sheet of 20) In the microscopy, the fragments were stained with hematoxylin and eosin and analyzed under a light microscope, being the discrete involvement, when less than 25%; moderate, between 26% and 50%, and accentuated when above 50%. In order to measure the thickness of the intima and medium layers, Verhoeff staining and the Red Sudan lipid deposit were made. Both analyzes were done in Axion Vision® software. The percentage of collagen fibers was performed in the Leica Qwin Plus® software, with the blades stained by Picrossírius. For statistical analysis, graphPad Prism® software was used. Results: the macroscopic and microscopic intensity of atherosclerosis; thickening of the intima and middle layers; the percentage of lipid deposits and collagen fibers correlated positively and significantly with age, being significantly higher in males and in the cause of cardiovascular death. Conclusion: The different methods used provide new applications for a more sensitive assessment of the risk groups and early changes associated with preclinical atherosclerosis in the iliac arteries.Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorFundação de Amparo à Pesquisa do Estado de Minas GeraisUniversidade Federal do Triângulo MineiroFundação de Ensino e Pesquisa de UberabaConselho Nacional de Desenvolvimento Científico e TecnológicoUniversidade Federal do Triângulo MineiroInstituto de Ciências da Saúde - ICS::Programa de Pós-Graduação em Ciências da SaúdeBrasilUFTMPrograma de Pós-Graduação em Ciências da SaúdeFERRAZ, Mara Lúcia da Fonseca64044270600http://lattes.cnpq.br/9852478909273401TEIXEIRA, Vicente de Paula Antunes19278063649http://lattes.cnpq.br/6788700810093027TORQUATO, Bianca Gonçalves Silva2019-09-19T18:21:35Z2019-06-18info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisapplication/pdfapplication/pdfTORQUATO, Bianca Gonçalves Silva. Avaliação da aterosclerose nas artérias ilíacas de pacientes autopsiados. 2019. 68f . Tese (Doutorado em Ciências da Saúde) - Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal do Triângulo Mineiro, Uberaba, 2019 .http://bdtd.uftm.edu.br/handle/tede/867porABEDINZADEH, N.; PEDRAM, B.; SADEGHIAN, Y.; NODUSHAN, S. M.; GILASGAR, M.; DARVISH, M.; MOKARIZADEH, A. A histopathological analysis of the epidemiology of coronary atherosclerosis: an autopsy study. Diagn Pathol, vol.3, p.87, 2015. ABOYANS, V.; RICCO, J. B.; BARTELINK, M. E. L.; BJÖRCK, M.; BRODMANN, M.; COHNERT, T.; COLLET, J. P.; CZERNY, M.; DE CARLO, M.; DEBUS, S.; ESPINOLA-KLEIN, C.; KAHAN, T.; KOWNATOR, S.; MAZZOLAI, L.; NAYLOR, A. R.; ROFFI, M.; RÖTHER, J.; SPRYNGER, M.; TENDERA, M.; TEPE, G.; VENERMO, M.; VLACHOPOULOS, C.; DESORMAIS, I. ESC Guidelines on the Diagnosis and Treatment of Peripheral Arterial Diseases, in collaboration with the European Society for Vascular Surgery (ESVS): Document covering atherosclerotic disease of extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteriesEndorsed by: the European Stroke Organization (ESO)The Task Force for the Diagnosis and Treatment of Peripheral Arterial Diseases of the European Society of Cardiology (ESC) and of the European Society for Vascular Surgery (ESVS). Eur Heart J, vol. 39, p.763-816, 2018. ADIGUZEL, E.; AHMAD, P. J.; FRANCO, C.; BENDECK, M. P. Collagens in the progression and complications of atherosclerosis Vasc. Med, vol.14, p.73-89, 2009. ALLISON, M. A.; HIS, S.; WASSEL, C. L.; MORGAN, C.; IX, J. H.; WRIGHT, C. M.; CRIQUI, M. H. Calcified atherosclerosis in different vascular beds and the risk of mortality. Send to Arterioscler Thromb Vasc Biol. Volume 32(1), p.140-6, 2012. ALLISON, M. A.; HIS, S.; WASSEL, C. L.; MORGAN, C.; IX, J. H.; WRIGHT, C. M.; CRIQUI, M. H. Calcified atherosclerosis in different vascular beds and the risk of mortality. Calcified atherosclerosis in different vascular beds and the risk of mortality. Arterioscler Thromb Vasc Biol, vol. 32, p.140-6, 2012. ALVES, B.G.; SILVA, I; ALMEIDA, M.S. Manual para elaboração de trabalhos acadêmicos baseado nas normas de documentação da ABNT / Universidade Federal do Triângulo Mineiro, Biblioteca Universitária, 2013. AMATO M1, MONTORSI P, RAVANI A, OLDANI E, GALLI S, RAVAGNANI PM, TREMOLI E, BALDASSARRE D. Carotid intima-media thickness by B-mode ultrasound as surrogate of coronary atherosclerosis: correlation with quantitative coronary angiography and coronary intravascular ultrasound findings. Eur Heart J, volume 28, p.2094e101, 2007. ANSARDAMAVANDI, A.; TAFAZZOLI-SHADPOUR, M.; OMIDVAR, R.; JAHANZAD, I. Quantification of effects of cancer on elastic properties of breast tissue by atomic force microscopy. J Mech Behav Biomed Mater. volume 60, p.234–242, 2016. ANTONIOU, G. A.; GEORGIADIS, G. S.; ANTONIOU, S. A.; MAKAR, R. R.; SMOUT, J. D.; TORELLA, F. Bypass surgery for chronic lower limb ischaemia. Cochrane Database Syst Rev, vol.4, p.2000, 2017. ASHCROFT, G. S; KIELTY, C. M; HORAN, M. A; FERGUSON, M. W. Age-related changes in the temporal and spatial distributions of fibrillin and elastin mRNAs and proteins in acute cutaneous wounds of healthy humans. J Pathol, Edinburh, v.183, p.80-9, 1997. BASTIEN, M.; POIRIER, P.; LEMIEUX, I.; DESPREÂS, J. P. Overview of epidemiology and contribution of obesity to cardiovascular disease. Prog Cardiovasc Dis. Volume 56(4), p.369-81, 2014. BENJAMIN, E. J.; MUNTNER, P.; ALONSO, A.; BITTENCOURT, M. S.; CALLAWAY, C. W.; CARSON, A. P.; CHAMBERLAIN, A. M.; CHANG, A. R.; CHENG, S.; DAS, S. R.; DELLING, F. N.; DJOUSSE, L.; ELKIND, M. S. V.; FERGUSON, J. F.; FORNAGE, M.; JORDAN, L. C.; KHAN, S. S.; KISSELA, B. M.; KNUTSON, K. L.; KWAN, T. W.; LACKLAND, D. T.; LEWIS, T. T.; LICHTMAN, J. H.; LONGENECKER, C. T.; LOOP, M. S.; LUTSEY, P. L.; MARTIN, S. S.; MATSUSHITA, K.; MORAN, A. E.; MUSSOLINO, M. E.; O'FLAHERTY, M.; PANDEY, A.; PERAK, A. M.; ROSAMOND, W. D.; ROTH, G. A.; SAMPSON, U. K. A.; SATOU, G. M.; SCHROEDER, E. B.; SHAH, S. H.; SPARTANO, N. L.; STOKES, A.; TIRSCHWELL, D. L.; TSAO, C. W.; TURAKHIA, M. P.; VANWAGNER, L. B.; WILKINS, J. T.; WONG, S. S.; VIRANI, S. S. Heart disease and stroke Statistics-2019 update: a report from the american heart association. Circulation, vol.139, p.e56-e66, 2019. BENNETT, M. R.; SINHA, S.; OWENS, G. K. Vascular Smooth Muscle Cells in Atherosclerosis. Circ Res. Volume 118, p.692–702, 2016. BOTS, M. L.; HOES, A. W.; KOUDSTAAL, P. J.; HOFMAN, A.; GROBBEE, D. E. Common carotid intima-media thickness and risk of stroke and myocardial infarction: the Rotterdam Study. Circulation, volume 96, p.1432e7, 1997. BRANDES, R. P.; FLEMING, I.; BUSSE, R. Endothelial aging. Cardiovasc Res, vol.66, p.286-294, 2004. BROWN, A. J.; TENG, Z.; EVANS, P. C.; GILLARD, J. H.; SAMADY, H.; BENNETT, M. R. Role of biomechanical forces in the natural history of coronary atherosclerosis. Nat Rev Cardiol. volume13, p.210–220, 2016. CAGLE JR, S. D.; COOPERSTEIN, N. Coronary artery disease: diagnosis and management. Primary Care: Clinics in Office Practice, vol. 45, no. 1, pp. 45–61, 2018. CANTO, J. G.; KIEFE, C. I.; ROGERS, W. J.; PETERSON, E. D.; FREDERICK, P. D.; FRENCH, W. J.; GIBSON, C. M.; POLLACK, C. V. JR.; ORNATO, J. P.; ZALENSKI, R. J.; PENNEY, J.; TIEFENBRUNN, A. J.; GREENLAND, P.; NRMI Investigators. Number of coronary heart disease risk factors and mortality in patients with first myocardial infarction. JAMA. Volume 16;306(19), p.2120-7, 2011. CECCHETTO, G.; BAJANOWSKI, T.; CECCHI, R.; FAVRETTO, D.; GRABHERR, S.; ISHIKAWA, T.; KONDO, T.; MONTISCI, M.; PFEIFFER, H.; BONATI, M. R.; SHOKRY, D.; VENNEMANN, M.; FERRARA, S. D. Back to the Future - Part 1. The medico-legal autopsy from ancient civilization to the post-genomic era. Int J Legal Med, vol 4, p.1069-1083, 2017. CHEN, H. Y.; ENGERT, J. C.; THANASSOULIS, G. Risk factors for valvular calcification. Curr Opin Endocrinol Diabetes Obes, vol.26, p.1-7, 2019. CHO, K. I.; KIM, B. H.; KIM, H. S.; HEO, J. H. Low carotid artery wall shear stress is associated with significant coronary artery disease in patients with chest pain. J Artheroscler Thromb, vol.23, p.297-308, 2016. CHRYSOHOOU, C.; KOLLIA, N.; TOUSOULIS, D. The link between depression and atherosclerosis through the pathways of inflammation and endothelium dysfunction. Maturitas, vol. 109, pp. 1–5, 2018. CIFKOVA, R.; PITHA, J.; KRAJCOVIECHOVA, A.; KRALIKOVA, E. Is the impact of conventional risk factors the same in men and women? Plea for a more gender-specific approach. Int J Cardiol, vol.S0167-5273, p.37008-6, 2019. CILLA, M.; PENA, E.; MARTINEZ, M. A. ET AL. Comparison of the vulnerability risk for positive versus negative atheroma plaque morphology. J Biomech. volume 46, p.1248–1254, 2013. CUNNINGHAM, K. S.; GOTLIEB, A. I. The role of shear stress in the pathogenesis of atherosclerosis. Lab Invest, vol. 85, p.9-23, 2005. DATASUS. As causas de morte no Brasil em 2016 segundo o SUS. Disponível em: https://www.nexojornal.com.br/grafico/2018/07/23/As-causas-de-morte-no-Brasil-em-2016-segundo-o-SUS Acesso em: outubro/2018. DATE, K. Aortoiliac aneurysm with congenital right pelvic kidney. 2014. Disponível em: <http://link.springer.com/article/10.1007/s00380-014-0483-x>. Acesso em: 24 out. 2018. DRON, J. S.; HEGELE, R. A. Genetics of Triglycerides and the Risk of Atherosclerosis. Curr Atheroscler Rep, vol.19, p.31, 2017. DUA, A.; LEE, C. J. Epidemiology of peripheral arterial disease and critical limb ischemia. Tech Vasc Interv Radiol, vol. 19, p.91-95, 2016. DUQUE, F.L.V. Aterosclerose: Aterogênese e fatores de risco. Rev. angiol. cir. vasc., 29 v.7, n.2, 1998. DUVALL, W. L. Cardiovascular disease in women. Mt Sinay J Med, vol.70, p.293–305, 2003. EVERAGE, N. J.; LINKLETTER, C. D.; GJELSVIK, A.; MCGARVEY, S. T.; LOUCKS, E. B. Social and behavioral risk marker clustering associated with biological risk factors for coronary heart disease: NHANES 2001–2004. Biomed Res Int., p. 389853, 2014. FERNANDEZ-FRIERA, L.; PENALVO, J. L.; FERNANDEZ-ORTIZ, A.; IBANEZ, B.; LOPEZ-MELGAR, B.; LACLAUSTRA, M.; OLIVA, B.; MOCOROA, A.; MENDIGUREN, J.; MARTINEZ, D. E.; VEGA, V.; GARCIA, L.; MOLINA, J.; SANCHEZ-GONZALEZ, J.; GUZMAN, G.; ALONSO-FARTO, J. C.; GUALLAR, E.; CIVEIRA, F.; SILLESEN, H.; POCOCK, S.; ORDOVAS, J. M.; SANZ, G.; JIMENEZ-BORREGUERO, L. J.; FUSTER, V. Prevalence, vascular distribution, and multiterritorial extent of subclinical atherosclerosis in a middle-aged cohort: The PESA (Progression of Early Subclinical Atherosclerosis) Study. Circulation, vol.131, p.2104-2113, 2015. FERRAZ, M. L. F.; NASCIMENTO, D. M. S.; RORATO, J. P. H.; ESPINDULA, A. P.; OLIVEIRA, L. F.; RAMALHO, L. S.; SOARES, M. H.; CAVELLANI, C. L.; OLIVEIRA, F. A.; PEREIRA, S. A. L.; CORRÊA, R. R. M.; TEIXEIRA, V. P. A. Correlation of lifetime progress of atherosclerosis and morphologic markers of severity in humans: new tools for a more sensitive evaluation. Clinics, volume 67(9), p.1071-1075, 2012. FINE, L. J.; PHILOGENE, G. S.; GRAMLING, R.; COUPS, E. J.; SINHA, S. Prevalence of multiple chronic disease risk factors. 2001 National Health Interview Survey. Am. J. Prev. Med., volume 27 (2 Suppl), p. 18-24, 2004. FOWKES, F. G.; LOW, L. P.; TUTA, S.; KOZAK, J.; AGATHA investigators. Ankle-brachial index and extent of atherothrombosis in 8891 patients with or at risk of vascular disease: results of the international AGATHA study. Eur Heart J, vol. 27, p.1861-7, 2006. FU, J.; BONDER, M. J.; CENIT, M. C.; TIGCHELAAR, E. F.; MAATMAN, A.; DEKENS, J. A.; BRANDSMA, E.; MARCZYNSKA, J.; IMHANN, F.; WEERSMA, R. K.; FRANKE, L.; POON, T. W.; XAVIER, R. J.; GEVERS, D.; HOFKER, M. H.; WIJMENGA, C.; ZHERNAKOVA, A. The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood Lipids. Circ Res, vol.117, p.817-24, 2015. GARCÍA-GONZÁLEZ, V.; DELGADO-COELLO, B.; PÉREZ-TORRES, A.; MAS-OLIVA, J. Reality of a vaccine in the prevention and treatment of atherosclerosis. Archives of Medical Research, vol. 46, no. 5, pp. 427–437, 2015. GARDNER, E.; GRAY, D.J.; O'RAHILLY, R. Anatomia Estudo Regional do Corpo Humano. 5ª ed. Rio de Janeiro. Guanabara Koogan. p. 679-680, 1999. GO, A. S.; MOZAFFARIAN, D.; ROGER, V L.; BENJAMIN, E. J.; BERRY, J. D.; BLAHA, M. J.; DAI, S.; FORD, E. S.; FOX, C. S.; FRANCO, S.; FULLERTON, H. J.; GILLESPIE, C.; HAILPERN, S. M.; HEIT, J. A.; HOWARD, V. J.; HUFFMAN, M. D.; JUDD, S. E.; KISSELA, B. M.; KITTNER, S. J.; LACKLAND, D. T.; LICHTMAN, J. H.; LISABETH, L. D.; MACKEY, R. H.; MAGID, D. J.; MARCUS, G. M.; MARELLI, A.; MATCHAR, D. B.; MCGUIRE, D. K.; MOHLER, E. R.; MOY, C. S.; MUSSOLINO, M. E.; NEUMAR, R. W.; NICHOL, G.; PANDEY, D. K.; PAYNTER, N. P.; REEVES, M. J.; SORLIE, P. D.; STEIN, J.; TOWFIGHI, A.; TURAN, T. N.; VIRANI, S. S.; WONG, N. D.; WOO, D.; TURNER, M. B.; AMERICAN HEART ASSOCIATION STATISTICS COMMITTEE AND STROKE STATISTICS SUBCOMMITTEE. Executive summary: heart disease and stroke statistics–2014 update: a report from the American Heart Association. Circulation, vol.129, p.399–410, 2014. GONZALEZ, L.; TRIGATTI, B. L. Macrophage apoptosis and necrotic core development in atherosclerosis: a rapidly advancing field with clinical relevance to imaging and therapy. Canadian Journal of Cardiology, vol. 33, no. 3, pp. 303–312, 2017. GOOTY, V. D.; SINAIKO, A. R.; RYDER, J. R.; DENGEL, D. R.; JACOBS, D. R. JR.; STEINBERGER, J. Association between carotid intima media thickness, age, and cardiovascular risk factors in children and adolescents. Metab Syndr Relat Disord, vol. 16, p.122-126, 2018. HANDELSMAN, Y.; SHAPIRO, M. D. TRIGLYCERIDES, ATHEROSCLEROSIS, AND CARDIOVASCULAR OUTCOME STUDIES: FOCUS ON OMEGA-3 FATTY ACIDS. Endocr Pract, vol.23, p.100-112, 2017. HANSSON, G. K. Inflammation, atherosclerosis and coronary artery disease. N Engl J Med, volume 352, p.1685-95, 2005. HANSSON, G. K., LIBBY, P. The immune response in atherosclerosis: a double-edged sword. Nature Reviews Immunology, volume 6, p.508-19, 2006. HANSSON, G.K. Atherosclerosis – An immune disease – The Anitschkov Lecture 2007. Atherosclerosis, p 2-10, 2009. HEISTAD DD. Unstable coronary-artery plaques. N Engl J Med, volume 349, p.2285-7, 2003. HENDRIKS, E. J.; BEULENS, J. W.; DE JONG, P. A.; VAN DER SCHOUW, Y. T.; SUN, W. N.; WRIGHT, C. M.; CRIQUI, M. H.; ALLISON, M. A.; IX, J. H. Calcification of the splenic, iliac, and breast arteries and risk of all-cause and cardiovascular mortality. Atherosclerosis, vol. 259, p.120-127, 2017. HENDRIKS, E. J.; DE JONG, P. A.; VAN DER GRAAF, Y.; MALI, W. P.; VAN DER SCHOUW, Y. T.; BEULENS, J. W. Breast arterial calcifications: a systematic review and meta-analysis of their determinants and their association with cardiovascular events. Atherosclerosis, vol. 239, p.11-20, 2015. HO, J. S.; CANNADAY, J. J.; BARLOW, C. E.; MITCHELL, T. L.; COOPER, K. H.; FITZGERALD, S. J. Relation of the number of metabolic syndrome risk factors with all-cause and cardiovascular mortality. Am. J. Cardiol., volume 102 (6), pp. 689-692, 2008. HORIMATSU, T.; FUJII, K.; FUKUNAGA, M.; MIKI, K.; NISHIMURA, M.; NAITO, Y.; SHIBUYA, M.; IMANAKA, T.; KAWAI, K.; TAMARU, H.; SUMIYOSHI, A.; SAITA, T.; MASUYAMA, T.; ISHIHARA, M. The distribution of calcified nodule and plaque rupture in patients with peripheral artery disease: an intravascular ultrasound analysis. Heart Vessels, vol. 32, p.1161-1168, 2017. HUANG, L. C.; LIN, R. T.; CHEN, C. F.; CHEN, C. H.; JUO, S. H.; LIN, H. F. Predictors of carotid intima-media thickness and plaque progression in a Chinese population. J Atheroscler Thromb, vol.23, p.940-949, 2016. IWAKIRI, T.; YANO, Y.; SATO, Y.; HATAKEYAMA, K.; MARUTSUKA, K.; FUJIMOTO, S.; KITAMURA, K.; KARIO, K.; ASADA, Y. Usefulness of carotid intima-media thickness measurement as an indicator of generalized atherosclerosis: findings from autopsy analysis. Atherosclerosis. Olume 225 (2), p.359-62, 2012. IWAMOTO, A.; KAJIKAWA, M.; MARUHASHI, T.; IWAMOTO, Y.; ODA, N.; KISHIMOTO, S.; MATSUI, S.; KIHARA, Y.; CHAYAMA, K.; GOTO, C.; NOMA, K.; AIBARA, Y.; NAKASHIMA, A.; HIGASHI, Y. Vascular function and intima-media thickness of a leg artery in peripheral artery disease: a comparison of Buerger disease and atherosclerotic peripheral artery disease. J Atheroscler Thromb, vol.23, p.1261-1269, 2016. KADOYA, Y.; KENZAKA, T.; NAITO, D.; ZEN, K.; MATOBA, S. Pseudo aortoiliac bifurcation" leading to significant plaque shifting in the endovascular treatment of an aortoiliac bifurcation lesion: a case report. BMC Cardiovasc Disord, vol. 17, p.179, 2017. KARLSON, B. W.; PALMER, M. K.; NICHOLLS, S. J.; BARTER, P. J.; LUNDMAN, P. Effects of age, gender and statin dose on lipid levels: Results from the VOYAGER meta-analysis database. Atherosclerosis, vol.265, p.54-59, 2017. KHALIL, F.M.; WAGNER, W.D.; GOLDBERG, I.J. Molecular Interactions Leading to Lipoprotein Retention and the Initiation of Atherosclerosis. Arterioscler. Thromb. Vasc. Biol. volume 24, p.2211–2218, 2004. KING, L. S.; MEEHAN, M. C. A history of the autopsy. A review. Am J Pathol, vol. 73, p. 514–544, 1973. KUMAR, V.; ABBAS, A. K.; FAUSTO, N. Doenças da imunidade. In: Bases Patológicas das Doenças. 7.ed. Rio de Janeiro: Elsevier, cap.6, p.267, 2005. LEE, J. J.; PEDLEY, A.; WEINBERG, I.; BRITTON, K. A.; MASSARO, J. M.; HOFFMANN, U.; MANDERS, E.; FOX, C. S.; MURABITO, J. M. Relation of Iliac Artery Calcium With Adiposity Measures and Peripheral Artery Disease. Am J Cardiol, vol. 119, p.1217-1223, 2017. LEECH, R. M.; MCNAUGHTON, S. A.; TIMPERIO, A. The clustering of diet, physical activity and sedentary behavior in children and adolescents: a review. Int. J. Behav. Nutr. Phys. Act., volume 11, p. 4, 2014. LEENING, M. J. G.; FERKET, B. S.; STEYERBERG, E. W.; KAVOUSI, M.; DECKERS, J. W.; NIEBOER, D.; HEERINGA, J.; PORTEGIES, M. L. P.; HOFMAN, A.; IKRAM, M. A.; HUNINK, M. G. M.; FRANCO, O. H.; STRICKER, B. H.; WITTEMAN, J. C. M.; ROOS-HESSELINK, J. W. Sex differences in lifetime risk and first manifestation of cardiovascular disease: prospective population based cohort study. BMJ, vol.349, p.g5992, 2014. LI, C.; FORD, E. S.; MOKDAD, A. H.; BALLUZ, L. S.; BROWN, D. W.; GILES, W. H. Clustering of cardiovascular disease risk factors and health-related quality of life among US adults. Value Heal J Int Soc Pharmacoeconomics Outcomes Res., volume 11 (4), pp. 689-699, 2008. LIU, C. Elastic properties of peripheral arteries in heart failure patients in comparison with normal subjects. The Journal of Physiological Sciences, volume 63, n. 3, p.195-201, 2013. LIU, J.; ZENG, F. F.; LIU, Z. M.; ZHANG, C. X.; LING, W. H.; CHEN, Y. M. Effects of blood triglycerides on cardiovascular and all-cause mortality: a systematic review and meta-analysis of 61 prospective studies. Lipids Health Dis, vol.12, p.159, 2013. MA, N.; JIANG, W. J.; LOU, X. ET AL. Arterial remodeling of advanced basilar atherosclerosis: a 3-tesla MRI study. Neurology. Volume 75, p.253–258, 2010. MACCHI, V.; MUNARI, P. F.; BRIZZI, E.; PARENTI, A.; DE CARO, R. Workshop in clinical anatomy for residents in gynecology and obstetrics. Clin Anat, vol. 16, p. 440–447, 2003. MADHAVAN, M. V.; TARIGOPULA, M.; MINTZ, G. S.; MAEHARA, A.; STONE, G. W.; GÉNÉREUX, P. Coronary artery calcification: pathogenesis and prognostic implications. J. Am. Coll. Cardiol, vol. 63, p.1703-1714, 2014. MAIOLINO, G.; ROSSITTO, G.; CAIELLI, P.; BISOGNI, V.; ROSSI, G.P.; CALA, L.A. The Role of Oxidized Low-Density Lipoproteins in Atherosclerosis: The Myths and the Facts. Mediat. Inflamm. Volume 13, (7):714653, 2013. MATHUR, P.; OSTADAL, B.; ROMEO, F.; MEHTA, J. L. Gender-Related Differences in Atherosclerosis. Cardiovasc Drugs Ther, vol.29, p.319-27, 2015. MATTHAN, N. R.; JALBERT, S. M.; BARRETT, P. H.; DOLNIKOWSKI, G. G.; SCHAEFER, E. J.; LICHTENSTEIN, A. H. Gender-specific differences in the kinetics of nonfasting TRL, IDL, and LDL apolipoprotein B-100 in men and premenopausal women. Arterioscler Thromb Vasc Biol., vol.28, p.1838-43, 2008. MC AULEY, M. T.; MOONEY, K. M. Computationally modeling lipid metabolism and aging: a mini-review. Comput Struct Biotechnol J, vol.13, p.38-46, 2014. MENDELSOHN, M. E.; KARAS, R. H. Molecular and cellular basis of cardiovascular gender differences. Science, vol. 308, p.1583-1587, 2005. METZE, K. Artérias, Veias e Linfáticos. In: BRASILEIRO FILHO, G. (Org.). Bogliolo Patologia. 7ª. ed. Rios de Janeiro: Guanabara Koogan, cap. 1, p. 457, 2006. MIEDEMA, M. D.; LOPEZ, F. L.; BLAHA, M. J.; VIRANI, S. S.; CORESH, J.; BALLANTYNE, C. M.; FOLSOM, A. R. Eligibility for statin therapy according to new cholesterol guidelines and prevalent use of medication to lower lipid levels in an older US cohort: the Atherosclerosis Risk in Communities Study Cohort. JAMA Intern. Med., vol.175, p.138-140, 2015. MITA, T.; KATAKAMI, N.; SHIRAIWA, T.; YOSHII, H.; GOSHO, M.; SHIMOMURA, I.; WATADA, H. Changes in carotid intima-media thickening in patients with type 2 diabetes mellitus: subanalysis of the Sitagliptin Preventive Study of Intima-Media Thickness Evaluation. J Diabetes Investig, vol.8, p.254–5, 2017. MOLLOY, K. J.; THOMPSON, M. M.; JONES, J. L.; SCHWALBE, E. C.; BELL, P. R.; NAYLOR, A. R.; LOFTUS, I. M.. Unstable carotid plaques exhibit raised matrix metalloproteinase-8 activity. Circulation, volume 110, p.337-43, 2004. MOORE, Keith L. Anatomia Orientada para a Prática Clínica. 7ed. Rio de Janeiro: Guanabara Koogan, p.347, 2014. MOZAFFARIAN, D.; BENJAMIN, E. J.; GO, A. S.; ARNETT, D. K.; BLAHA, M. J.; CUSHMAN, M.; DE FERRANTI, S.; DESPRÉS, J. P.; FULLERTON, H. J.; HOWARD, V. J.; HUFFMAN, M. D.; JUDD, S. E.; KISSELA, B. M.; LACKLAND, D. T.; LICHTMAN, J. H.; LISABETH, L. D.; LIU, S.; MACKEY, R. H.; MATCHAR, D. B.; MCGUIRE, D. K.; MOHLER, E. R. 3RD.; MOY, C. S.; MUNTNER, P.; MUSSOLINO, M. E.; NASIR, K.; NEUMAR, R.W.; NICHOL, G.; PALANIAPPAN, L.; PANDEY, D. K.; REEVES, M. J.; RODRIGUEZ, C. J.; SORLIE, P. D.; STEIN, J.; TOWFIGHI, A.; TURAN, T. N.; VIRANI, S. S.; WILLEY, J. Z.; WOO, D.; YEH, R. W.; TURNER, M. B. Heart disease and stroke statistics—2015 update: a report from the American heart association. Circulation, volume 131 (4), p. 29-e322, 2015. NAKAGAWA, K.; NAKASHIMA, Y. Pathologic intimal thickening in human atherosclerosis is formed by extracellular accumulation of plasma-derived lipids and dispersion of intimal smooth muscle cells. Atherosclerosis, vol. 274, p.235-242, 2018. NAKAMURA, E.; SATO, Y.; IWAKIRI, T.; YAMASHITA, A.; MORIGUCHI-GOTO, S.; MAEKAWA, K.; GI, T.; ASADA, Y. Asymptomatic Plaques of Lower Peripheral Arteries and Their Association with Cardiovascular Disease: An Autopsy Study. J Atheroscler Thromb, vol.24, p.921-927, 2017. NAKASHIMA, Y.; CHEN, Y.X.; KINUKAWA, N.; SUEISHI, K. Distributions of diffuse intimal thickening in human arteries: preferential expression in atherosclerosis-prone arteries from an early age. Virchows Arch. v.3, p.279-288, 2002. NAKAZAWA, G.; YAZDANI, S. K.; FINN, A. V.; VORPAHL, M.; KOLODGIE, F. D.; VIRMAN, R. Pathological findings at bifurcation lesions: the impact of flow distribution on atherosclerosis and arterial healing after stent implantation. J Am Coll Cardiol, vol. 55, p.1679-1687, 2010. NAPOLI, C. Childhood infection and endothelial dysfunction: A potential link in atherosclerosis. American Heart Association Journals, volume 111, p.1568-1570, 2007. NAQVI, T. Z.; MENDOZA, F.; RAFII, F.; GRANSAR, H.; GUERRA, M.; LEPOR, N.; BERMAN, D. S.; SHAH, P. K. High prevalence of ultrasound detected carotid atherosclerosis in subjects with low Framingham risk score: potential implications for screening for subclinical atherosclerosis. J Am Soc Echocardiogr, vol.23, p.809-15, 2010. NATIONAL INSTITUTES OF HEALTH, 2014. Atherosclerosis. Disponível em: <http://www.nlm.nih.gov/medlineplus/atherosclerosis.html>. Acesso em: outubro 2018. NEZU, T.; HOSOMI, N.; AOKI, S.; MATSUMOTO, M. Carotid intima-media thickness for atherosclerosis. J Atheroscler Thromb, vol. 23, p.18-31, 2016. NICHOLS, M; TOWNSEND, N; SCARBOROUGH, P; RAYNER, M. Cardiovascular disease in Europe 2014: epidemiological update Euro Heart J, 35:2950-9, 2014. NISHIHIRA, K.; YASUDA, S. Histopathology of Asymptomatic Iliac Atherosclerosis: From Autopsy to Practice. J Atheroscler Thromb, vol. 24, p.910-911, 2017. OKURA, H.; ASAWA, K.; KUBO, T.; TAGUCHI, H.; TODA, I.; YOSHIYAMA, M. Incidence and predictors of plaque rupture in the peripheral arteries. Circ Cardiovasc Interv, vol. 3, p.63–70, 2010. ORGANIZAÇÃO PAN-AMERICANA DA SAÚDE; ORGANIZAÇÃO MUNDIAL DA SAÚDE – OPAS/OMS. As 10 principais causas de morte no mundo em 2016. Disponível em: https://www.paho.org/bra/index.php?option=com_content&view=article&id=5638:10-principais-causas-de-morte-no-mundo&Itemid=0 Acesso em: outubro 2018. OSTADAL, B.; OSTADAL, P. Sex-based differences in cardiac ischaemic injury and protection: therapeutic implications. BJP, vol. 171, p.541–54, 2014. PAUL, T. K.; SRINIVASAN, S. R.; CHEN, W.; LI, S.; BOND, M. G.; TANG, R.; BERENSON, G. S. Impact of multiple cardiovascular risk factors on femoral artery intima-media thickness in asymptomatic young adults (the Bogalusa Heart Study). Am J Cardiol. volume 15;95(4), p.469-73, 2005. PENG, J.; LUO, F.; RUAN, G.; PENG, R.; LI, X. Hypertriglyceridemia and atherosclerosis. Lipids Health Dis, v.16, n.(1), p.233, 2017. PETERS, S. A.; GROBBEE, D. E.; BOTS, M. L. Carotid intima–media thickness: a suitable alternative for cardiovascular risk as outcome? Eur J Cardiovasc Prev Rehabil, vol.18, p.167–74, 2011. PIRES, S.L.; GAGLIARDI, R.J.; GORZONI, M.L. Estudo das freqüências dos principais fatores de risco para acidente vascular cerebral isquêmico em idosos. Arq. Neuro-Psiquiatr. [online], v.62, n.3b, p. 844-851, 2004. PRUISSEN, D. M.; GERRITSEN, S. A.; PRINSEN, T. J.; DIJK, J. M.; KAPPELLE, L. J.; ALGRA, A. SMART Study Group. Carotid intima-media thickness is different in large- and small-vessel ischemic stroke: the SMART study. Stroke, volume 38, p.1371e3, 2007. RAMALHO, L. S.; OLIVEIRA, L. F.; CAVELLANI, C. L.; FERRAZ, M. L. F.; OLIVEIRA, F. A.; CORRÊA, R. R. M.; TEIXEIRA, V. P. A.; PEREIRA, S. L. A. Role of mast cell chymase and tryptase in the progression of atherosclerosis: study in 44 autopsied cases. Ann Diagn Pathol, vol.17, p.28-31, 2013. REAMY, B. V.; WILLIAMS, P. M.; KUCKEL, D. P. Prevention of cardiovascular disease. Primary Care: Clinics in Office Practice, vol. 45, no. 1, pp. 25–44, 2018. REIMANN, C.; BRANGSCH, J.; COLLETINI, F.; WALTER, T.; HAMM, B.; BOTNAR, R. M.; MAKOWSKI, M. R. Molecular imaging of the extracellular matrix in the context of atherosclerosis. Adv Drug Deliv Rev, vol.113, p.49-60, 2017. REZVANI-SHARIF1, A.; TAFAZZOLI-SHADPOUR, M.; AVOLIO, A. Progressive changes of elastic moduli of arterial wall and atherosclerotic plaque components during plaque development in human coronary arteries. Med Biol Eng Comput. 2019. ROSS, R. Atherosclerosis–an inflammatory disease. N Engl J Med, vol. 340, p.115–26, 1999. S. KATSUDA, Y. OKADA, T. MINAMOTO, Y. ODA, Y. MATSUI, I. NAKANISHI Collagens in human atherosclerosis. Immunohistochemical analysis using collagen type-specific antibodies Arterioscler. Thromb., 12 (1992), pp. 494-502. SAMPSON, U. K.; NORMAN, P. E.; FOWKES, F. G.; ABOYANS, V.; YANNA, S. O. N. G.; HARRELL, F. E. J. R.; FOROUZANFAR, M. H.; NAGHAVI, M.; DENENBERG, J. O.; MCDERMOTT, M. M.; CRIQUI, M. H.; MENSAH, G. A.; EZZATI, M.; MURRAY, C. Global and regional burden of aortic dissection and aneurysms: mortality trends in 21 world regions, 1990 to 2010. Glob Heart, vol. 9, p.171-180, 2014. SCHOENHAGEN, P.; NISSEN, S. E.; TUZCU, E. M. Coronary arterial remodeling: from bench to bedside. Curr Atheroscler Rep. volume 5, p.150–154. 2003. SCHWARTZ, S. M.; VIRMANI, R. D.; ROSENFELD, M. E. The good smooth musclecellsinatheroscle-rosis. Curr.Atheroscler.Rep, vol.2, p.422–429, 2000. SHERWOOD, L. Fisiologia Humana – Das células aos sistemas. 7ed. São Paulo, p.347-348, 2011. SIGVANT, B.; LUNDIN, F.; WAHLBERG, E. The Risk of Disease Progression in Peripheral Arterial Disease is Higher than Expected: A Meta-Analysis of ortality and Disease Progression in Peripheral Arterial Disease. J Vasc Endovasc Surg, vol. 51, p.395-403, 2016. SINGH, B.R.; MENGI, S.A.; XU, Y.J.; ARNEJA, A.S.; DHALLA, N.S. Pathogenesis of Atherosclerosis: A Multifactorial Process. Exp. Clin. Cardiol. Volume 7, p.40–53, 2002. STARY, H. C.; CHANDLER, A. B.; DINSMORE, R. E.; FUSTER, V.; GLAGOV, S.; INSULL, W. JR.; ROSENFELD, M. E.; SCHWARTZ, C. J.; WAGNER, W. D.; WISSLER, R. W. A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis: a report from the Committee on Vascular Lesions of the Council on Atherosclerosis, American Heart Association. Circulation, volume 92, p.1355-74, 1995. STROBL, F. F.; ROMINGER, A.; WOLPERS, S.; RIST, C.; BAMBERG, F.; THIERFELDER, K. M.; NIKOLAOU, K.; UEBLEIS, C.; HACKER, M.; REISER, M. F.; SAAM, T. Impact of cardiovascular risk factors on vessel wall inflammation and calcified plaque burden differs across vascular beds: a PET-CT study. Int J Cardiovasc Imaging, vol. 29, p.1899-908, 2013. STRONG, J.P. Atherosclerotic lesions. Natural history, risk factors, and topography. Arch Pathol Lab Med., v.116, n.12, p. 1268-1275, 1992. SUCIU, C. F.; PRETE, M.; RUSCITTI, P.; FAVOINO, E.; GIACOMELLI, R.; PEROSA, F. Oxidized low density lipoproteins: the bridge between atherosclerosis and autoimmunity. Possible implications in accelerated atherosclerosis and for immune intervention in autoimmune rheumatic disorders. Autoimmunity Reviews, vol. 17, no. 4, pp. 366–375, 2018. SUH, B.; SONG, Y. S.; SHIN, D. W.; LIM, J.; KIM, H.; MIN, S. H.; LEE, S. P.; PARK, E. A.; LEE, W.; LEE, H.; PARK, J. H.; CHO, B. Incidentally detected atherosclerosis in the abdominal aorta or its major branches on computed tomography is highly associated with coronary heart disease in asymptomatic adults. J Cardiovasc Comput Tomogr, vol. 12, p.305-311, 2018. SWIFT, M. E.; KLEIMANN, H. K.; DIPIETRO, L. A. Impared wound repair and delayed angiogenesis in aged mice. Lab Invest, v.79, n.12, p.1479-93, 1999. TAKAHARA, M.; IIDA, O.; SOGA, Y.; KODAMA, A.; AZUMA, N. Absence of preceding intermittent claudication and its associated clinical freatures in patients with critical limb ischemia. J Atheroscler Thromb, vol.22, p.718-725, 2015. TARÍN, C.; GOMEZ, M.; CALVO, E.; LÓPEZ, J.A.; ZARAGOZA, C. Endothelial nitric oxide deficiency reduces MMP-13-mediated cleavage of ICAM-1 in vascular endothelium: A role in atherosclerosis. Arterioscler. Thromb. Vasc. Biol. V.29, p.27-32, 2009. THOMPSON, R. C.; ALLAM, A. H.; LOMBARDI, G. P.; WANN, L. S.; SUTHERLAND, M. L.; SUTHERLAND, J. D.; SOLIMAN, M. AT.; FROHLICH, B.; MININBERG, D. T.; MONGE, J. M.; VALLODOLID, C. M.; COX, S. L.; EL-MAKSOUD, G. A.; BADR, I.; MIYAMOTO, M. I.; EL-DIN, A. EH. N.; NARULA, J.; FINCH, C. E.; THOMAS, G. S.; Atherosclerosis across 4000 years of human history: the Horus study of four ancient populations. The Lancet. V.381, p.1211-1222, 2013. TOTH, P. P. Triglyceride-rich lipoproteins as a causal factor for cardiovascular disease. Vasc Health Risk Manag, vol.12, p.171-183, 2016. TOWNSEND, N.; WILLIAMS, J.; BHATNAGAR, P.; WICKRAMASINGHE, K.; RAYNER, M. Cardiovascular disease statistics British Heart Foundation: London, British Heart Foundation: London, British Heart Foundation, London (2014). Disponível em: https://researchportal.bath.ac.uk/en/publications/cardiovascular-disease-statistics-2014 Acessado em: 18/02/2019. URSCHEL, K.; CICHA, I.; DANIEL, W. G.; GARLICHS, C. D. Shear stress patterns affect the secreted chemokine profile in endothelial cells. Clin. Hemorheol. Microcirc, vol.50, p.143–152, 2012. WANG, X.; MAGKOS, F.; MITTENDORFER, B. Sex differences in lipid and lipoprotein metabolism: it's not just about sex hormones. J. Clin. Endocrinol. Metab., vol.96 p.885-893, 2011. WHO. Obesity and overweight: World Health Organization; 2016 [cited 2016 July]. Disponível em: http://www.who.int/en/news-room/fact-sheets/detail/obesity-and-overweight Acessado em: outubro 2018. WICKSTRÖM, J. E.; JALKANEN, J. M.; VENERMO, M.; HAKOVIRTA, H. H. Crural Index and extensive atherosclerosis of crural vessels are associated with long-term cardiovascular mortality in patients with symptomatic peripheral artery disease. Atherosclerosis, vol. 264, p.44-50, 2017. WILLECKE, F.; YUAN, C.; OKA, K.; CHAN, L.; HU, Y.; BARNHART, S.; BORNFELDT, K. E.; GOLDBERG, I. J.; FISHER, E. A. Effects of High Fat Feeding and Diabetes on Regression of Atherosclerosis Induced by Low-Density Lipoprotein Receptor Gene Therapy in LDL Receptor-Deficient Mice. PLoS One, vol.10, p.e0128996, 2015. WISNIEWSKA, A.; OLSZANECKI, R.; TOTON-Z˙ URANSKA, J.; KUS, K.; STACHOWICZ, A.; SUSKI, M.; GE˛BSKA, A.; GAJDA, M.; JAWIEN, J.; KORBUT, R. Anti-Atherosclerotic Action of Agmatine in ApoE-Knockout Mice. Int. J. Mol. Sci. volume 18, p.1706, 2017. WU, M. Y.; LI, C. J.; HOU, M. F.; CHU, P. Y. New Insights into the Role of Inflammation in the Pathogenesis of Atherosclerosis. Send to Int J Mol Sci. volume 18 (10), p.E2034, 2017. ZAVATTA, M.; MELL, M. W. A national Vascular Quality Initiative database comparison of hybrid and open repair for aortoiliac-femoral occlusive disease. J Vasc Surg, vol.67, p.199-205, 2018.http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UFTMinstname:Universidade Federal do Triangulo Mineiro (UFTM)instacron:UFTM2019-09-20T04:00:21Zoai:bdtd.uftm.edu.br:tede/867Biblioteca Digital de Teses e Dissertaçõeshttp://bdtd.uftm.edu.br/PUBhttp://bdtd.uftm.edu.br/oai/requestbdtd@uftm.edu.br||bdtd@uftm.edu.bropendoar:2019-09-20T04:00:21Biblioteca Digital de Teses e Dissertações da UFTM - Universidade Federal do Triangulo Mineiro (UFTM)false
dc.title.none.fl_str_mv Avaliação da aterosclerose nas artérias ilíacas de pacientes autopsiados
title Avaliação da aterosclerose nas artérias ilíacas de pacientes autopsiados
spellingShingle Avaliação da aterosclerose nas artérias ilíacas de pacientes autopsiados
TORQUATO, Bianca Gonçalves Silva
Artéria ilíaca.
Aterosclerose.
Grupos de risco.
Autópsia.
Iliac artery.
Atherosclerosis.
Risk groups.
Autopsy.
Ciências da Saúde
title_short Avaliação da aterosclerose nas artérias ilíacas de pacientes autopsiados
title_full Avaliação da aterosclerose nas artérias ilíacas de pacientes autopsiados
title_fullStr Avaliação da aterosclerose nas artérias ilíacas de pacientes autopsiados
title_full_unstemmed Avaliação da aterosclerose nas artérias ilíacas de pacientes autopsiados
title_sort Avaliação da aterosclerose nas artérias ilíacas de pacientes autopsiados
author TORQUATO, Bianca Gonçalves Silva
author_facet TORQUATO, Bianca Gonçalves Silva
author_role author
dc.contributor.none.fl_str_mv FERRAZ, Mara Lúcia da Fonseca
64044270600
http://lattes.cnpq.br/9852478909273401
TEIXEIRA, Vicente de Paula Antunes
19278063649
http://lattes.cnpq.br/6788700810093027
dc.contributor.author.fl_str_mv TORQUATO, Bianca Gonçalves Silva
dc.subject.por.fl_str_mv Artéria ilíaca.
Aterosclerose.
Grupos de risco.
Autópsia.
Iliac artery.
Atherosclerosis.
Risk groups.
Autopsy.
Ciências da Saúde
topic Artéria ilíaca.
Aterosclerose.
Grupos de risco.
Autópsia.
Iliac artery.
Atherosclerosis.
Risk groups.
Autopsy.
Ciências da Saúde
description Introdução: a doença cardiovascular aterosclerótica nas artérias ilíacas ocorre de maneira assintomática e está associada a aterosclerose sistêmica, o que contribui para os elevados índices de mortalidade. Objetivos: foi avaliar a intensidade macroscópica e microscópica da aterosclerose; mensurar a espessura das camadas íntima e média; quantificar a porcentagem de depósito lipídico e de fibras colágenas, de artérias ilíacas direita e esquerda, e associar esses dados a fatores de risco como envelhecimento; sexo e causa de morte. Métodos: foram obtidos 202 fragmentos de artérias ilíacas direita e esquerda de pacientes autopsiados. Para a classificação da intensidade da aterosclerose foi considerada a extensão de estrias lipídicas, de placas ateromatosas, de fibrose e de calcificação. Na macroscopia, por meio de uma escala de 12,0cm foi registrado um ponto correspondente a intensidade da aterosclerose. A classificação foi discreta, de 0,1cm a 4,0cm; moderada, de 4,1cm a 7,0cm e acentuada de 7,1cm a 12,0cm. Na microscopia, os fragmentos foram corados por hematoxilina e eosina e analisados ao microscópio de luz, sendo o acometimento discreto, quando menor que 25%; moderado, entre 26% a 50% e acentuado quando acima de 50%. Para a mensuração da espessura das camadas íntima e média foi feita a coloração por Verhoeff e para o depósito lipídico, o Sudan Vermelho. Ambas as análises foram feitas no software Axion Vision®. A porcentagem de fibras colágenas foi realizada no software Leica Qwin Plus®, sendo as lâminas coradas pelo Picrossírius. Para análise estatística foi utilizado o software graphPad Prism®. Resultados: a intensidade macroscópica e microscópica da aterosclerose; o espessamento das camadas íntima e média; a porcentagem de depósito lipídico e de fibras colágenas se correlacionaram de forma positiva e significativa com a idade, sendo significativamente maiores no sexo masculino e na causa de morte cardiovascular. Conclusão: os diferentes métodos usados fornecem novas aplicações para uma avaliação mais sensível dos grupos de risco e das alterações precoces associadas à aterosclerose pré-clínica nas artérias ilíacas.
publishDate 2019
dc.date.none.fl_str_mv 2019-09-19T18:21:35Z
2019-06-18
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv TORQUATO, Bianca Gonçalves Silva. Avaliação da aterosclerose nas artérias ilíacas de pacientes autopsiados. 2019. 68f . Tese (Doutorado em Ciências da Saúde) - Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal do Triângulo Mineiro, Uberaba, 2019 .
http://bdtd.uftm.edu.br/handle/tede/867
identifier_str_mv TORQUATO, Bianca Gonçalves Silva. Avaliação da aterosclerose nas artérias ilíacas de pacientes autopsiados. 2019. 68f . Tese (Doutorado em Ciências da Saúde) - Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal do Triângulo Mineiro, Uberaba, 2019 .
url http://bdtd.uftm.edu.br/handle/tede/867
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv ABEDINZADEH, N.; PEDRAM, B.; SADEGHIAN, Y.; NODUSHAN, S. M.; GILASGAR, M.; DARVISH, M.; MOKARIZADEH, A. A histopathological analysis of the epidemiology of coronary atherosclerosis: an autopsy study. Diagn Pathol, vol.3, p.87, 2015. ABOYANS, V.; RICCO, J. B.; BARTELINK, M. E. L.; BJÖRCK, M.; BRODMANN, M.; COHNERT, T.; COLLET, J. P.; CZERNY, M.; DE CARLO, M.; DEBUS, S.; ESPINOLA-KLEIN, C.; KAHAN, T.; KOWNATOR, S.; MAZZOLAI, L.; NAYLOR, A. R.; ROFFI, M.; RÖTHER, J.; SPRYNGER, M.; TENDERA, M.; TEPE, G.; VENERMO, M.; VLACHOPOULOS, C.; DESORMAIS, I. ESC Guidelines on the Diagnosis and Treatment of Peripheral Arterial Diseases, in collaboration with the European Society for Vascular Surgery (ESVS): Document covering atherosclerotic disease of extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteriesEndorsed by: the European Stroke Organization (ESO)The Task Force for the Diagnosis and Treatment of Peripheral Arterial Diseases of the European Society of Cardiology (ESC) and of the European Society for Vascular Surgery (ESVS). Eur Heart J, vol. 39, p.763-816, 2018. ADIGUZEL, E.; AHMAD, P. J.; FRANCO, C.; BENDECK, M. P. Collagens in the progression and complications of atherosclerosis Vasc. Med, vol.14, p.73-89, 2009. ALLISON, M. A.; HIS, S.; WASSEL, C. L.; MORGAN, C.; IX, J. H.; WRIGHT, C. M.; CRIQUI, M. H. Calcified atherosclerosis in different vascular beds and the risk of mortality. Send to Arterioscler Thromb Vasc Biol. Volume 32(1), p.140-6, 2012. ALLISON, M. A.; HIS, S.; WASSEL, C. L.; MORGAN, C.; IX, J. H.; WRIGHT, C. M.; CRIQUI, M. H. Calcified atherosclerosis in different vascular beds and the risk of mortality. Calcified atherosclerosis in different vascular beds and the risk of mortality. Arterioscler Thromb Vasc Biol, vol. 32, p.140-6, 2012. ALVES, B.G.; SILVA, I; ALMEIDA, M.S. Manual para elaboração de trabalhos acadêmicos baseado nas normas de documentação da ABNT / Universidade Federal do Triângulo Mineiro, Biblioteca Universitária, 2013. AMATO M1, MONTORSI P, RAVANI A, OLDANI E, GALLI S, RAVAGNANI PM, TREMOLI E, BALDASSARRE D. Carotid intima-media thickness by B-mode ultrasound as surrogate of coronary atherosclerosis: correlation with quantitative coronary angiography and coronary intravascular ultrasound findings. Eur Heart J, volume 28, p.2094e101, 2007. ANSARDAMAVANDI, A.; TAFAZZOLI-SHADPOUR, M.; OMIDVAR, R.; JAHANZAD, I. Quantification of effects of cancer on elastic properties of breast tissue by atomic force microscopy. J Mech Behav Biomed Mater. volume 60, p.234–242, 2016. ANTONIOU, G. A.; GEORGIADIS, G. S.; ANTONIOU, S. A.; MAKAR, R. R.; SMOUT, J. D.; TORELLA, F. Bypass surgery for chronic lower limb ischaemia. Cochrane Database Syst Rev, vol.4, p.2000, 2017. ASHCROFT, G. S; KIELTY, C. M; HORAN, M. A; FERGUSON, M. W. Age-related changes in the temporal and spatial distributions of fibrillin and elastin mRNAs and proteins in acute cutaneous wounds of healthy humans. J Pathol, Edinburh, v.183, p.80-9, 1997. BASTIEN, M.; POIRIER, P.; LEMIEUX, I.; DESPREÂS, J. P. Overview of epidemiology and contribution of obesity to cardiovascular disease. Prog Cardiovasc Dis. Volume 56(4), p.369-81, 2014. BENJAMIN, E. J.; MUNTNER, P.; ALONSO, A.; BITTENCOURT, M. S.; CALLAWAY, C. W.; CARSON, A. P.; CHAMBERLAIN, A. M.; CHANG, A. R.; CHENG, S.; DAS, S. R.; DELLING, F. N.; DJOUSSE, L.; ELKIND, M. S. V.; FERGUSON, J. F.; FORNAGE, M.; JORDAN, L. C.; KHAN, S. S.; KISSELA, B. M.; KNUTSON, K. L.; KWAN, T. W.; LACKLAND, D. T.; LEWIS, T. T.; LICHTMAN, J. H.; LONGENECKER, C. T.; LOOP, M. S.; LUTSEY, P. L.; MARTIN, S. S.; MATSUSHITA, K.; MORAN, A. E.; MUSSOLINO, M. E.; O'FLAHERTY, M.; PANDEY, A.; PERAK, A. M.; ROSAMOND, W. D.; ROTH, G. A.; SAMPSON, U. K. A.; SATOU, G. M.; SCHROEDER, E. B.; SHAH, S. H.; SPARTANO, N. L.; STOKES, A.; TIRSCHWELL, D. L.; TSAO, C. W.; TURAKHIA, M. P.; VANWAGNER, L. B.; WILKINS, J. T.; WONG, S. S.; VIRANI, S. S. Heart disease and stroke Statistics-2019 update: a report from the american heart association. Circulation, vol.139, p.e56-e66, 2019. BENNETT, M. R.; SINHA, S.; OWENS, G. K. Vascular Smooth Muscle Cells in Atherosclerosis. Circ Res. Volume 118, p.692–702, 2016. BOTS, M. L.; HOES, A. W.; KOUDSTAAL, P. J.; HOFMAN, A.; GROBBEE, D. E. Common carotid intima-media thickness and risk of stroke and myocardial infarction: the Rotterdam Study. Circulation, volume 96, p.1432e7, 1997. BRANDES, R. P.; FLEMING, I.; BUSSE, R. Endothelial aging. Cardiovasc Res, vol.66, p.286-294, 2004. BROWN, A. J.; TENG, Z.; EVANS, P. C.; GILLARD, J. H.; SAMADY, H.; BENNETT, M. R. Role of biomechanical forces in the natural history of coronary atherosclerosis. Nat Rev Cardiol. volume13, p.210–220, 2016. CAGLE JR, S. D.; COOPERSTEIN, N. Coronary artery disease: diagnosis and management. Primary Care: Clinics in Office Practice, vol. 45, no. 1, pp. 45–61, 2018. CANTO, J. G.; KIEFE, C. I.; ROGERS, W. J.; PETERSON, E. D.; FREDERICK, P. D.; FRENCH, W. J.; GIBSON, C. M.; POLLACK, C. V. JR.; ORNATO, J. P.; ZALENSKI, R. J.; PENNEY, J.; TIEFENBRUNN, A. J.; GREENLAND, P.; NRMI Investigators. Number of coronary heart disease risk factors and mortality in patients with first myocardial infarction. JAMA. Volume 16;306(19), p.2120-7, 2011. CECCHETTO, G.; BAJANOWSKI, T.; CECCHI, R.; FAVRETTO, D.; GRABHERR, S.; ISHIKAWA, T.; KONDO, T.; MONTISCI, M.; PFEIFFER, H.; BONATI, M. R.; SHOKRY, D.; VENNEMANN, M.; FERRARA, S. D. Back to the Future - Part 1. The medico-legal autopsy from ancient civilization to the post-genomic era. Int J Legal Med, vol 4, p.1069-1083, 2017. CHEN, H. Y.; ENGERT, J. C.; THANASSOULIS, G. Risk factors for valvular calcification. Curr Opin Endocrinol Diabetes Obes, vol.26, p.1-7, 2019. CHO, K. I.; KIM, B. H.; KIM, H. S.; HEO, J. H. Low carotid artery wall shear stress is associated with significant coronary artery disease in patients with chest pain. J Artheroscler Thromb, vol.23, p.297-308, 2016. CHRYSOHOOU, C.; KOLLIA, N.; TOUSOULIS, D. The link between depression and atherosclerosis through the pathways of inflammation and endothelium dysfunction. Maturitas, vol. 109, pp. 1–5, 2018. CIFKOVA, R.; PITHA, J.; KRAJCOVIECHOVA, A.; KRALIKOVA, E. Is the impact of conventional risk factors the same in men and women? Plea for a more gender-specific approach. Int J Cardiol, vol.S0167-5273, p.37008-6, 2019. CILLA, M.; PENA, E.; MARTINEZ, M. A. ET AL. Comparison of the vulnerability risk for positive versus negative atheroma plaque morphology. J Biomech. volume 46, p.1248–1254, 2013. CUNNINGHAM, K. S.; GOTLIEB, A. I. The role of shear stress in the pathogenesis of atherosclerosis. Lab Invest, vol. 85, p.9-23, 2005. DATASUS. As causas de morte no Brasil em 2016 segundo o SUS. Disponível em: https://www.nexojornal.com.br/grafico/2018/07/23/As-causas-de-morte-no-Brasil-em-2016-segundo-o-SUS Acesso em: outubro/2018. DATE, K. Aortoiliac aneurysm with congenital right pelvic kidney. 2014. Disponível em: <http://link.springer.com/article/10.1007/s00380-014-0483-x>. Acesso em: 24 out. 2018. DRON, J. S.; HEGELE, R. A. Genetics of Triglycerides and the Risk of Atherosclerosis. Curr Atheroscler Rep, vol.19, p.31, 2017. DUA, A.; LEE, C. J. Epidemiology of peripheral arterial disease and critical limb ischemia. Tech Vasc Interv Radiol, vol. 19, p.91-95, 2016. DUQUE, F.L.V. Aterosclerose: Aterogênese e fatores de risco. Rev. angiol. cir. vasc., 29 v.7, n.2, 1998. DUVALL, W. L. Cardiovascular disease in women. Mt Sinay J Med, vol.70, p.293–305, 2003. EVERAGE, N. J.; LINKLETTER, C. D.; GJELSVIK, A.; MCGARVEY, S. T.; LOUCKS, E. B. Social and behavioral risk marker clustering associated with biological risk factors for coronary heart disease: NHANES 2001–2004. Biomed Res Int., p. 389853, 2014. FERNANDEZ-FRIERA, L.; PENALVO, J. L.; FERNANDEZ-ORTIZ, A.; IBANEZ, B.; LOPEZ-MELGAR, B.; LACLAUSTRA, M.; OLIVA, B.; MOCOROA, A.; MENDIGUREN, J.; MARTINEZ, D. E.; VEGA, V.; GARCIA, L.; MOLINA, J.; SANCHEZ-GONZALEZ, J.; GUZMAN, G.; ALONSO-FARTO, J. C.; GUALLAR, E.; CIVEIRA, F.; SILLESEN, H.; POCOCK, S.; ORDOVAS, J. M.; SANZ, G.; JIMENEZ-BORREGUERO, L. J.; FUSTER, V. Prevalence, vascular distribution, and multiterritorial extent of subclinical atherosclerosis in a middle-aged cohort: The PESA (Progression of Early Subclinical Atherosclerosis) Study. Circulation, vol.131, p.2104-2113, 2015. FERRAZ, M. L. F.; NASCIMENTO, D. M. S.; RORATO, J. P. H.; ESPINDULA, A. P.; OLIVEIRA, L. F.; RAMALHO, L. S.; SOARES, M. H.; CAVELLANI, C. L.; OLIVEIRA, F. A.; PEREIRA, S. A. L.; CORRÊA, R. R. M.; TEIXEIRA, V. P. A. Correlation of lifetime progress of atherosclerosis and morphologic markers of severity in humans: new tools for a more sensitive evaluation. Clinics, volume 67(9), p.1071-1075, 2012. FINE, L. J.; PHILOGENE, G. S.; GRAMLING, R.; COUPS, E. J.; SINHA, S. Prevalence of multiple chronic disease risk factors. 2001 National Health Interview Survey. Am. J. Prev. Med., volume 27 (2 Suppl), p. 18-24, 2004. FOWKES, F. G.; LOW, L. P.; TUTA, S.; KOZAK, J.; AGATHA investigators. Ankle-brachial index and extent of atherothrombosis in 8891 patients with or at risk of vascular disease: results of the international AGATHA study. Eur Heart J, vol. 27, p.1861-7, 2006. FU, J.; BONDER, M. J.; CENIT, M. C.; TIGCHELAAR, E. F.; MAATMAN, A.; DEKENS, J. A.; BRANDSMA, E.; MARCZYNSKA, J.; IMHANN, F.; WEERSMA, R. K.; FRANKE, L.; POON, T. W.; XAVIER, R. J.; GEVERS, D.; HOFKER, M. H.; WIJMENGA, C.; ZHERNAKOVA, A. The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood Lipids. Circ Res, vol.117, p.817-24, 2015. GARCÍA-GONZÁLEZ, V.; DELGADO-COELLO, B.; PÉREZ-TORRES, A.; MAS-OLIVA, J. Reality of a vaccine in the prevention and treatment of atherosclerosis. Archives of Medical Research, vol. 46, no. 5, pp. 427–437, 2015. GARDNER, E.; GRAY, D.J.; O'RAHILLY, R. Anatomia Estudo Regional do Corpo Humano. 5ª ed. Rio de Janeiro. Guanabara Koogan. p. 679-680, 1999. GO, A. S.; MOZAFFARIAN, D.; ROGER, V L.; BENJAMIN, E. J.; BERRY, J. D.; BLAHA, M. J.; DAI, S.; FORD, E. S.; FOX, C. S.; FRANCO, S.; FULLERTON, H. J.; GILLESPIE, C.; HAILPERN, S. M.; HEIT, J. A.; HOWARD, V. J.; HUFFMAN, M. D.; JUDD, S. E.; KISSELA, B. M.; KITTNER, S. J.; LACKLAND, D. T.; LICHTMAN, J. H.; LISABETH, L. D.; MACKEY, R. H.; MAGID, D. J.; MARCUS, G. M.; MARELLI, A.; MATCHAR, D. B.; MCGUIRE, D. K.; MOHLER, E. R.; MOY, C. S.; MUSSOLINO, M. E.; NEUMAR, R. W.; NICHOL, G.; PANDEY, D. K.; PAYNTER, N. P.; REEVES, M. J.; SORLIE, P. D.; STEIN, J.; TOWFIGHI, A.; TURAN, T. N.; VIRANI, S. S.; WONG, N. D.; WOO, D.; TURNER, M. B.; AMERICAN HEART ASSOCIATION STATISTICS COMMITTEE AND STROKE STATISTICS SUBCOMMITTEE. Executive summary: heart disease and stroke statistics–2014 update: a report from the American Heart Association. Circulation, vol.129, p.399–410, 2014. GONZALEZ, L.; TRIGATTI, B. L. Macrophage apoptosis and necrotic core development in atherosclerosis: a rapidly advancing field with clinical relevance to imaging and therapy. Canadian Journal of Cardiology, vol. 33, no. 3, pp. 303–312, 2017. GOOTY, V. D.; SINAIKO, A. R.; RYDER, J. R.; DENGEL, D. R.; JACOBS, D. R. JR.; STEINBERGER, J. Association between carotid intima media thickness, age, and cardiovascular risk factors in children and adolescents. Metab Syndr Relat Disord, vol. 16, p.122-126, 2018. HANDELSMAN, Y.; SHAPIRO, M. D. TRIGLYCERIDES, ATHEROSCLEROSIS, AND CARDIOVASCULAR OUTCOME STUDIES: FOCUS ON OMEGA-3 FATTY ACIDS. Endocr Pract, vol.23, p.100-112, 2017. HANSSON, G. K. Inflammation, atherosclerosis and coronary artery disease. N Engl J Med, volume 352, p.1685-95, 2005. HANSSON, G. K., LIBBY, P. The immune response in atherosclerosis: a double-edged sword. Nature Reviews Immunology, volume 6, p.508-19, 2006. HANSSON, G.K. Atherosclerosis – An immune disease – The Anitschkov Lecture 2007. Atherosclerosis, p 2-10, 2009. HEISTAD DD. Unstable coronary-artery plaques. N Engl J Med, volume 349, p.2285-7, 2003. HENDRIKS, E. J.; BEULENS, J. W.; DE JONG, P. A.; VAN DER SCHOUW, Y. T.; SUN, W. N.; WRIGHT, C. M.; CRIQUI, M. H.; ALLISON, M. A.; IX, J. H. Calcification of the splenic, iliac, and breast arteries and risk of all-cause and cardiovascular mortality. Atherosclerosis, vol. 259, p.120-127, 2017. HENDRIKS, E. J.; DE JONG, P. A.; VAN DER GRAAF, Y.; MALI, W. P.; VAN DER SCHOUW, Y. T.; BEULENS, J. W. Breast arterial calcifications: a systematic review and meta-analysis of their determinants and their association with cardiovascular events. Atherosclerosis, vol. 239, p.11-20, 2015. HO, J. S.; CANNADAY, J. J.; BARLOW, C. E.; MITCHELL, T. L.; COOPER, K. H.; FITZGERALD, S. J. Relation of the number of metabolic syndrome risk factors with all-cause and cardiovascular mortality. Am. J. Cardiol., volume 102 (6), pp. 689-692, 2008. HORIMATSU, T.; FUJII, K.; FUKUNAGA, M.; MIKI, K.; NISHIMURA, M.; NAITO, Y.; SHIBUYA, M.; IMANAKA, T.; KAWAI, K.; TAMARU, H.; SUMIYOSHI, A.; SAITA, T.; MASUYAMA, T.; ISHIHARA, M. The distribution of calcified nodule and plaque rupture in patients with peripheral artery disease: an intravascular ultrasound analysis. Heart Vessels, vol. 32, p.1161-1168, 2017. HUANG, L. C.; LIN, R. T.; CHEN, C. F.; CHEN, C. H.; JUO, S. H.; LIN, H. F. Predictors of carotid intima-media thickness and plaque progression in a Chinese population. J Atheroscler Thromb, vol.23, p.940-949, 2016. IWAKIRI, T.; YANO, Y.; SATO, Y.; HATAKEYAMA, K.; MARUTSUKA, K.; FUJIMOTO, S.; KITAMURA, K.; KARIO, K.; ASADA, Y. Usefulness of carotid intima-media thickness measurement as an indicator of generalized atherosclerosis: findings from autopsy analysis. Atherosclerosis. Olume 225 (2), p.359-62, 2012. IWAMOTO, A.; KAJIKAWA, M.; MARUHASHI, T.; IWAMOTO, Y.; ODA, N.; KISHIMOTO, S.; MATSUI, S.; KIHARA, Y.; CHAYAMA, K.; GOTO, C.; NOMA, K.; AIBARA, Y.; NAKASHIMA, A.; HIGASHI, Y. Vascular function and intima-media thickness of a leg artery in peripheral artery disease: a comparison of Buerger disease and atherosclerotic peripheral artery disease. J Atheroscler Thromb, vol.23, p.1261-1269, 2016. KADOYA, Y.; KENZAKA, T.; NAITO, D.; ZEN, K.; MATOBA, S. Pseudo aortoiliac bifurcation" leading to significant plaque shifting in the endovascular treatment of an aortoiliac bifurcation lesion: a case report. BMC Cardiovasc Disord, vol. 17, p.179, 2017. KARLSON, B. W.; PALMER, M. K.; NICHOLLS, S. J.; BARTER, P. J.; LUNDMAN, P. Effects of age, gender and statin dose on lipid levels: Results from the VOYAGER meta-analysis database. Atherosclerosis, vol.265, p.54-59, 2017. KHALIL, F.M.; WAGNER, W.D.; GOLDBERG, I.J. Molecular Interactions Leading to Lipoprotein Retention and the Initiation of Atherosclerosis. Arterioscler. Thromb. Vasc. Biol. volume 24, p.2211–2218, 2004. KING, L. S.; MEEHAN, M. C. A history of the autopsy. A review. Am J Pathol, vol. 73, p. 514–544, 1973. KUMAR, V.; ABBAS, A. K.; FAUSTO, N. Doenças da imunidade. In: Bases Patológicas das Doenças. 7.ed. Rio de Janeiro: Elsevier, cap.6, p.267, 2005. LEE, J. J.; PEDLEY, A.; WEINBERG, I.; BRITTON, K. A.; MASSARO, J. M.; HOFFMANN, U.; MANDERS, E.; FOX, C. S.; MURABITO, J. M. Relation of Iliac Artery Calcium With Adiposity Measures and Peripheral Artery Disease. Am J Cardiol, vol. 119, p.1217-1223, 2017. LEECH, R. M.; MCNAUGHTON, S. A.; TIMPERIO, A. The clustering of diet, physical activity and sedentary behavior in children and adolescents: a review. Int. J. Behav. Nutr. Phys. Act., volume 11, p. 4, 2014. LEENING, M. J. G.; FERKET, B. S.; STEYERBERG, E. W.; KAVOUSI, M.; DECKERS, J. W.; NIEBOER, D.; HEERINGA, J.; PORTEGIES, M. L. P.; HOFMAN, A.; IKRAM, M. A.; HUNINK, M. G. M.; FRANCO, O. H.; STRICKER, B. H.; WITTEMAN, J. C. M.; ROOS-HESSELINK, J. W. Sex differences in lifetime risk and first manifestation of cardiovascular disease: prospective population based cohort study. BMJ, vol.349, p.g5992, 2014. LI, C.; FORD, E. S.; MOKDAD, A. H.; BALLUZ, L. S.; BROWN, D. W.; GILES, W. H. Clustering of cardiovascular disease risk factors and health-related quality of life among US adults. Value Heal J Int Soc Pharmacoeconomics Outcomes Res., volume 11 (4), pp. 689-699, 2008. LIU, C. Elastic properties of peripheral arteries in heart failure patients in comparison with normal subjects. The Journal of Physiological Sciences, volume 63, n. 3, p.195-201, 2013. LIU, J.; ZENG, F. F.; LIU, Z. M.; ZHANG, C. X.; LING, W. H.; CHEN, Y. M. Effects of blood triglycerides on cardiovascular and all-cause mortality: a systematic review and meta-analysis of 61 prospective studies. Lipids Health Dis, vol.12, p.159, 2013. MA, N.; JIANG, W. J.; LOU, X. ET AL. Arterial remodeling of advanced basilar atherosclerosis: a 3-tesla MRI study. Neurology. Volume 75, p.253–258, 2010. MACCHI, V.; MUNARI, P. F.; BRIZZI, E.; PARENTI, A.; DE CARO, R. Workshop in clinical anatomy for residents in gynecology and obstetrics. Clin Anat, vol. 16, p. 440–447, 2003. MADHAVAN, M. V.; TARIGOPULA, M.; MINTZ, G. S.; MAEHARA, A.; STONE, G. W.; GÉNÉREUX, P. Coronary artery calcification: pathogenesis and prognostic implications. J. Am. Coll. Cardiol, vol. 63, p.1703-1714, 2014. MAIOLINO, G.; ROSSITTO, G.; CAIELLI, P.; BISOGNI, V.; ROSSI, G.P.; CALA, L.A. The Role of Oxidized Low-Density Lipoproteins in Atherosclerosis: The Myths and the Facts. Mediat. Inflamm. Volume 13, (7):714653, 2013. MATHUR, P.; OSTADAL, B.; ROMEO, F.; MEHTA, J. L. Gender-Related Differences in Atherosclerosis. Cardiovasc Drugs Ther, vol.29, p.319-27, 2015. MATTHAN, N. R.; JALBERT, S. M.; BARRETT, P. H.; DOLNIKOWSKI, G. G.; SCHAEFER, E. J.; LICHTENSTEIN, A. H. Gender-specific differences in the kinetics of nonfasting TRL, IDL, and LDL apolipoprotein B-100 in men and premenopausal women. Arterioscler Thromb Vasc Biol., vol.28, p.1838-43, 2008. MC AULEY, M. T.; MOONEY, K. M. Computationally modeling lipid metabolism and aging: a mini-review. Comput Struct Biotechnol J, vol.13, p.38-46, 2014. MENDELSOHN, M. E.; KARAS, R. H. Molecular and cellular basis of cardiovascular gender differences. Science, vol. 308, p.1583-1587, 2005. METZE, K. Artérias, Veias e Linfáticos. In: BRASILEIRO FILHO, G. (Org.). Bogliolo Patologia. 7ª. ed. Rios de Janeiro: Guanabara Koogan, cap. 1, p. 457, 2006. MIEDEMA, M. D.; LOPEZ, F. L.; BLAHA, M. J.; VIRANI, S. S.; CORESH, J.; BALLANTYNE, C. M.; FOLSOM, A. R. Eligibility for statin therapy according to new cholesterol guidelines and prevalent use of medication to lower lipid levels in an older US cohort: the Atherosclerosis Risk in Communities Study Cohort. JAMA Intern. Med., vol.175, p.138-140, 2015. MITA, T.; KATAKAMI, N.; SHIRAIWA, T.; YOSHII, H.; GOSHO, M.; SHIMOMURA, I.; WATADA, H. Changes in carotid intima-media thickening in patients with type 2 diabetes mellitus: subanalysis of the Sitagliptin Preventive Study of Intima-Media Thickness Evaluation. J Diabetes Investig, vol.8, p.254–5, 2017. MOLLOY, K. J.; THOMPSON, M. M.; JONES, J. L.; SCHWALBE, E. C.; BELL, P. R.; NAYLOR, A. R.; LOFTUS, I. M.. Unstable carotid plaques exhibit raised matrix metalloproteinase-8 activity. Circulation, volume 110, p.337-43, 2004. MOORE, Keith L. Anatomia Orientada para a Prática Clínica. 7ed. Rio de Janeiro: Guanabara Koogan, p.347, 2014. MOZAFFARIAN, D.; BENJAMIN, E. J.; GO, A. S.; ARNETT, D. K.; BLAHA, M. J.; CUSHMAN, M.; DE FERRANTI, S.; DESPRÉS, J. P.; FULLERTON, H. J.; HOWARD, V. J.; HUFFMAN, M. D.; JUDD, S. E.; KISSELA, B. M.; LACKLAND, D. T.; LICHTMAN, J. H.; LISABETH, L. D.; LIU, S.; MACKEY, R. H.; MATCHAR, D. B.; MCGUIRE, D. K.; MOHLER, E. R. 3RD.; MOY, C. S.; MUNTNER, P.; MUSSOLINO, M. E.; NASIR, K.; NEUMAR, R.W.; NICHOL, G.; PALANIAPPAN, L.; PANDEY, D. K.; REEVES, M. J.; RODRIGUEZ, C. J.; SORLIE, P. D.; STEIN, J.; TOWFIGHI, A.; TURAN, T. N.; VIRANI, S. S.; WILLEY, J. Z.; WOO, D.; YEH, R. W.; TURNER, M. B. Heart disease and stroke statistics—2015 update: a report from the American heart association. Circulation, volume 131 (4), p. 29-e322, 2015. NAKAGAWA, K.; NAKASHIMA, Y. Pathologic intimal thickening in human atherosclerosis is formed by extracellular accumulation of plasma-derived lipids and dispersion of intimal smooth muscle cells. Atherosclerosis, vol. 274, p.235-242, 2018. NAKAMURA, E.; SATO, Y.; IWAKIRI, T.; YAMASHITA, A.; MORIGUCHI-GOTO, S.; MAEKAWA, K.; GI, T.; ASADA, Y. Asymptomatic Plaques of Lower Peripheral Arteries and Their Association with Cardiovascular Disease: An Autopsy Study. J Atheroscler Thromb, vol.24, p.921-927, 2017. NAKASHIMA, Y.; CHEN, Y.X.; KINUKAWA, N.; SUEISHI, K. Distributions of diffuse intimal thickening in human arteries: preferential expression in atherosclerosis-prone arteries from an early age. Virchows Arch. v.3, p.279-288, 2002. NAKAZAWA, G.; YAZDANI, S. K.; FINN, A. V.; VORPAHL, M.; KOLODGIE, F. D.; VIRMAN, R. Pathological findings at bifurcation lesions: the impact of flow distribution on atherosclerosis and arterial healing after stent implantation. J Am Coll Cardiol, vol. 55, p.1679-1687, 2010. NAPOLI, C. Childhood infection and endothelial dysfunction: A potential link in atherosclerosis. American Heart Association Journals, volume 111, p.1568-1570, 2007. NAQVI, T. Z.; MENDOZA, F.; RAFII, F.; GRANSAR, H.; GUERRA, M.; LEPOR, N.; BERMAN, D. S.; SHAH, P. K. High prevalence of ultrasound detected carotid atherosclerosis in subjects with low Framingham risk score: potential implications for screening for subclinical atherosclerosis. J Am Soc Echocardiogr, vol.23, p.809-15, 2010. NATIONAL INSTITUTES OF HEALTH, 2014. Atherosclerosis. Disponível em: <http://www.nlm.nih.gov/medlineplus/atherosclerosis.html>. Acesso em: outubro 2018. NEZU, T.; HOSOMI, N.; AOKI, S.; MATSUMOTO, M. Carotid intima-media thickness for atherosclerosis. J Atheroscler Thromb, vol. 23, p.18-31, 2016. NICHOLS, M; TOWNSEND, N; SCARBOROUGH, P; RAYNER, M. Cardiovascular disease in Europe 2014: epidemiological update Euro Heart J, 35:2950-9, 2014. NISHIHIRA, K.; YASUDA, S. Histopathology of Asymptomatic Iliac Atherosclerosis: From Autopsy to Practice. J Atheroscler Thromb, vol. 24, p.910-911, 2017. OKURA, H.; ASAWA, K.; KUBO, T.; TAGUCHI, H.; TODA, I.; YOSHIYAMA, M. Incidence and predictors of plaque rupture in the peripheral arteries. Circ Cardiovasc Interv, vol. 3, p.63–70, 2010. ORGANIZAÇÃO PAN-AMERICANA DA SAÚDE; ORGANIZAÇÃO MUNDIAL DA SAÚDE – OPAS/OMS. As 10 principais causas de morte no mundo em 2016. Disponível em: https://www.paho.org/bra/index.php?option=com_content&view=article&id=5638:10-principais-causas-de-morte-no-mundo&Itemid=0 Acesso em: outubro 2018. OSTADAL, B.; OSTADAL, P. Sex-based differences in cardiac ischaemic injury and protection: therapeutic implications. BJP, vol. 171, p.541–54, 2014. PAUL, T. K.; SRINIVASAN, S. R.; CHEN, W.; LI, S.; BOND, M. G.; TANG, R.; BERENSON, G. S. Impact of multiple cardiovascular risk factors on femoral artery intima-media thickness in asymptomatic young adults (the Bogalusa Heart Study). Am J Cardiol. volume 15;95(4), p.469-73, 2005. PENG, J.; LUO, F.; RUAN, G.; PENG, R.; LI, X. Hypertriglyceridemia and atherosclerosis. Lipids Health Dis, v.16, n.(1), p.233, 2017. PETERS, S. A.; GROBBEE, D. E.; BOTS, M. L. Carotid intima–media thickness: a suitable alternative for cardiovascular risk as outcome? Eur J Cardiovasc Prev Rehabil, vol.18, p.167–74, 2011. PIRES, S.L.; GAGLIARDI, R.J.; GORZONI, M.L. Estudo das freqüências dos principais fatores de risco para acidente vascular cerebral isquêmico em idosos. Arq. Neuro-Psiquiatr. [online], v.62, n.3b, p. 844-851, 2004. PRUISSEN, D. M.; GERRITSEN, S. A.; PRINSEN, T. J.; DIJK, J. M.; KAPPELLE, L. J.; ALGRA, A. SMART Study Group. Carotid intima-media thickness is different in large- and small-vessel ischemic stroke: the SMART study. Stroke, volume 38, p.1371e3, 2007. RAMALHO, L. S.; OLIVEIRA, L. F.; CAVELLANI, C. L.; FERRAZ, M. L. F.; OLIVEIRA, F. A.; CORRÊA, R. R. M.; TEIXEIRA, V. P. A.; PEREIRA, S. L. A. Role of mast cell chymase and tryptase in the progression of atherosclerosis: study in 44 autopsied cases. Ann Diagn Pathol, vol.17, p.28-31, 2013. REAMY, B. V.; WILLIAMS, P. M.; KUCKEL, D. P. Prevention of cardiovascular disease. Primary Care: Clinics in Office Practice, vol. 45, no. 1, pp. 25–44, 2018. REIMANN, C.; BRANGSCH, J.; COLLETINI, F.; WALTER, T.; HAMM, B.; BOTNAR, R. M.; MAKOWSKI, M. R. Molecular imaging of the extracellular matrix in the context of atherosclerosis. Adv Drug Deliv Rev, vol.113, p.49-60, 2017. REZVANI-SHARIF1, A.; TAFAZZOLI-SHADPOUR, M.; AVOLIO, A. Progressive changes of elastic moduli of arterial wall and atherosclerotic plaque components during plaque development in human coronary arteries. Med Biol Eng Comput. 2019. ROSS, R. Atherosclerosis–an inflammatory disease. N Engl J Med, vol. 340, p.115–26, 1999. S. KATSUDA, Y. OKADA, T. MINAMOTO, Y. ODA, Y. MATSUI, I. NAKANISHI Collagens in human atherosclerosis. Immunohistochemical analysis using collagen type-specific antibodies Arterioscler. Thromb., 12 (1992), pp. 494-502. SAMPSON, U. K.; NORMAN, P. E.; FOWKES, F. G.; ABOYANS, V.; YANNA, S. O. N. G.; HARRELL, F. E. J. R.; FOROUZANFAR, M. H.; NAGHAVI, M.; DENENBERG, J. O.; MCDERMOTT, M. M.; CRIQUI, M. H.; MENSAH, G. A.; EZZATI, M.; MURRAY, C. Global and regional burden of aortic dissection and aneurysms: mortality trends in 21 world regions, 1990 to 2010. Glob Heart, vol. 9, p.171-180, 2014. SCHOENHAGEN, P.; NISSEN, S. E.; TUZCU, E. M. Coronary arterial remodeling: from bench to bedside. Curr Atheroscler Rep. volume 5, p.150–154. 2003. SCHWARTZ, S. M.; VIRMANI, R. D.; ROSENFELD, M. E. The good smooth musclecellsinatheroscle-rosis. Curr.Atheroscler.Rep, vol.2, p.422–429, 2000. SHERWOOD, L. Fisiologia Humana – Das células aos sistemas. 7ed. São Paulo, p.347-348, 2011. SIGVANT, B.; LUNDIN, F.; WAHLBERG, E. The Risk of Disease Progression in Peripheral Arterial Disease is Higher than Expected: A Meta-Analysis of ortality and Disease Progression in Peripheral Arterial Disease. J Vasc Endovasc Surg, vol. 51, p.395-403, 2016. SINGH, B.R.; MENGI, S.A.; XU, Y.J.; ARNEJA, A.S.; DHALLA, N.S. Pathogenesis of Atherosclerosis: A Multifactorial Process. Exp. Clin. Cardiol. Volume 7, p.40–53, 2002. STARY, H. C.; CHANDLER, A. B.; DINSMORE, R. E.; FUSTER, V.; GLAGOV, S.; INSULL, W. JR.; ROSENFELD, M. E.; SCHWARTZ, C. J.; WAGNER, W. D.; WISSLER, R. W. A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis: a report from the Committee on Vascular Lesions of the Council on Atherosclerosis, American Heart Association. Circulation, volume 92, p.1355-74, 1995. STROBL, F. F.; ROMINGER, A.; WOLPERS, S.; RIST, C.; BAMBERG, F.; THIERFELDER, K. M.; NIKOLAOU, K.; UEBLEIS, C.; HACKER, M.; REISER, M. F.; SAAM, T. Impact of cardiovascular risk factors on vessel wall inflammation and calcified plaque burden differs across vascular beds: a PET-CT study. Int J Cardiovasc Imaging, vol. 29, p.1899-908, 2013. STRONG, J.P. Atherosclerotic lesions. Natural history, risk factors, and topography. Arch Pathol Lab Med., v.116, n.12, p. 1268-1275, 1992. SUCIU, C. F.; PRETE, M.; RUSCITTI, P.; FAVOINO, E.; GIACOMELLI, R.; PEROSA, F. Oxidized low density lipoproteins: the bridge between atherosclerosis and autoimmunity. Possible implications in accelerated atherosclerosis and for immune intervention in autoimmune rheumatic disorders. Autoimmunity Reviews, vol. 17, no. 4, pp. 366–375, 2018. SUH, B.; SONG, Y. S.; SHIN, D. W.; LIM, J.; KIM, H.; MIN, S. H.; LEE, S. P.; PARK, E. A.; LEE, W.; LEE, H.; PARK, J. H.; CHO, B. Incidentally detected atherosclerosis in the abdominal aorta or its major branches on computed tomography is highly associated with coronary heart disease in asymptomatic adults. J Cardiovasc Comput Tomogr, vol. 12, p.305-311, 2018. SWIFT, M. E.; KLEIMANN, H. K.; DIPIETRO, L. A. Impared wound repair and delayed angiogenesis in aged mice. Lab Invest, v.79, n.12, p.1479-93, 1999. TAKAHARA, M.; IIDA, O.; SOGA, Y.; KODAMA, A.; AZUMA, N. Absence of preceding intermittent claudication and its associated clinical freatures in patients with critical limb ischemia. J Atheroscler Thromb, vol.22, p.718-725, 2015. TARÍN, C.; GOMEZ, M.; CALVO, E.; LÓPEZ, J.A.; ZARAGOZA, C. Endothelial nitric oxide deficiency reduces MMP-13-mediated cleavage of ICAM-1 in vascular endothelium: A role in atherosclerosis. Arterioscler. Thromb. Vasc. Biol. V.29, p.27-32, 2009. THOMPSON, R. C.; ALLAM, A. H.; LOMBARDI, G. P.; WANN, L. S.; SUTHERLAND, M. L.; SUTHERLAND, J. D.; SOLIMAN, M. AT.; FROHLICH, B.; MININBERG, D. T.; MONGE, J. M.; VALLODOLID, C. M.; COX, S. L.; EL-MAKSOUD, G. A.; BADR, I.; MIYAMOTO, M. I.; EL-DIN, A. EH. N.; NARULA, J.; FINCH, C. E.; THOMAS, G. S.; Atherosclerosis across 4000 years of human history: the Horus study of four ancient populations. The Lancet. V.381, p.1211-1222, 2013. TOTH, P. P. Triglyceride-rich lipoproteins as a causal factor for cardiovascular disease. Vasc Health Risk Manag, vol.12, p.171-183, 2016. TOWNSEND, N.; WILLIAMS, J.; BHATNAGAR, P.; WICKRAMASINGHE, K.; RAYNER, M. Cardiovascular disease statistics British Heart Foundation: London, British Heart Foundation: London, British Heart Foundation, London (2014). Disponível em: https://researchportal.bath.ac.uk/en/publications/cardiovascular-disease-statistics-2014 Acessado em: 18/02/2019. URSCHEL, K.; CICHA, I.; DANIEL, W. G.; GARLICHS, C. D. Shear stress patterns affect the secreted chemokine profile in endothelial cells. Clin. Hemorheol. Microcirc, vol.50, p.143–152, 2012. WANG, X.; MAGKOS, F.; MITTENDORFER, B. Sex differences in lipid and lipoprotein metabolism: it's not just about sex hormones. J. Clin. Endocrinol. Metab., vol.96 p.885-893, 2011. WHO. Obesity and overweight: World Health Organization; 2016 [cited 2016 July]. Disponível em: http://www.who.int/en/news-room/fact-sheets/detail/obesity-and-overweight Acessado em: outubro 2018. WICKSTRÖM, J. E.; JALKANEN, J. M.; VENERMO, M.; HAKOVIRTA, H. H. Crural Index and extensive atherosclerosis of crural vessels are associated with long-term cardiovascular mortality in patients with symptomatic peripheral artery disease. Atheroscl
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dc.publisher.none.fl_str_mv Universidade Federal do Triângulo Mineiro
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Brasil
UFTM
Programa de Pós-Graduação em Ciências da Saúde
publisher.none.fl_str_mv Universidade Federal do Triângulo Mineiro
Instituto de Ciências da Saúde - ICS::Programa de Pós-Graduação em Ciências da Saúde
Brasil
UFTM
Programa de Pós-Graduação em Ciências da Saúde
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