Clinical and epidemiological profile of children and adolescents submitted to the hematopoietic cell transplantation
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Bioscience journal (Online) |
Texto Completo: | https://seer.ufu.br/index.php/biosciencejournal/article/view/36227 |
Resumo: | The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. To characterize the clinical and epidemiological profile of children and adolescents submitted to HSCT at a referral service in the state of Rio Grande do Norte. This is a quantitative, retrospective, observational, descriptive and analytical quantitative approach approaching the medical records of children and adolescents submitted to HSCT in a referral hospital service for this type of transplantation in the state of Rio Grande do Sul North (RN). The final sample consisted of 35 records patients aged between 2 and 18 years old who underwent HSCT from February 2008 to December 2015 and who presented the data necessary for the study. The records analyzed showed a little majority of male patients (51.42%) and 60.00% of these men were students and 71.42% lived in the state of the Rio Grande do Norte. According to the clinical characteristics, 34.3% of the patients had Acute Lymphoblastic Leukemia and 25.71% had Acute Myeloid Leukemia as the main diagnosis. Gastrointestinal toxicities were the most frequent (97.1%) and all patients received antineoplastic/chemotherapeutic and antiemetic treatment. The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. Septsis was the most frequent cause of death (60%). The profile of the clinical variables presented by the children and adolescents of this study shows that the most prevalent diagnosis was ALL, the most frequent toxicities were gastrointestinal, cardiac, respiratory and hematological, the most common HSCT was allogeneic peripheral blood and the greatest cause of mortality was sepsis. These data are similar to studies conducted in North America, Europe and Asia. |
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Clinical and epidemiological profile of children and adolescents submitted to the hematopoietic cell transplantationPerfil clínico e epidemiológico de crianças e adolescentes submetidos ao transplante de células-tronco hematopoéticasHematopoietic Stem Cell TransplantationBone Marrow TransplantationChildAdolescentEpidemiologyHealth SciencesThe Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. To characterize the clinical and epidemiological profile of children and adolescents submitted to HSCT at a referral service in the state of Rio Grande do Norte. This is a quantitative, retrospective, observational, descriptive and analytical quantitative approach approaching the medical records of children and adolescents submitted to HSCT in a referral hospital service for this type of transplantation in the state of Rio Grande do Sul North (RN). The final sample consisted of 35 records patients aged between 2 and 18 years old who underwent HSCT from February 2008 to December 2015 and who presented the data necessary for the study. The records analyzed showed a little majority of male patients (51.42%) and 60.00% of these men were students and 71.42% lived in the state of the Rio Grande do Norte. According to the clinical characteristics, 34.3% of the patients had Acute Lymphoblastic Leukemia and 25.71% had Acute Myeloid Leukemia as the main diagnosis. Gastrointestinal toxicities were the most frequent (97.1%) and all patients received antineoplastic/chemotherapeutic and antiemetic treatment. The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. Septsis was the most frequent cause of death (60%). The profile of the clinical variables presented by the children and adolescents of this study shows that the most prevalent diagnosis was ALL, the most frequent toxicities were gastrointestinal, cardiac, respiratory and hematological, the most common HSCT was allogeneic peripheral blood and the greatest cause of mortality was sepsis. These data are similar to studies conducted in North America, Europe and Asia.O Transplante de Células-Tronco Hematopoéticas (TCTH) é utilizado em crianças como um tratamento definitivo para várias doenças oncológicas, imunodeficiências, hemoglobinopatias, malignidades que envolvem o sistema hematológico, distúrbios de metabolismo congênito, entre outros. Caracterizar o perfil clínico e epidemiológico de crianças e adolescentes submetidos ao TCTH em um serviço de referência do estado do Rio Grande do Norte. Trata de um estudo epidemiológico de abordagem quantitativa, do tipo coorte retrospectiva, observacional, descritivo e analítico onde foram abordados os prontuários de crianças e adolescentes submetidos ao TCTH em um serviço hospitalar de referência para esse tipo de transplante no estado do Rio Grande do Norte (RN). A amostra final foi composta por 35 prontuários de pacientes com idade entre dois e 18 anos que realizaram o TCTH no período de fevereiro de 2008 a dezembro de 2015 e que apresentavam os dados necessários ao estudo. Do total de prontuários analisados houve discreta maioria de pacientes do sexo masculino (51,42%). Destes, 60,00% eram estudantes e 71,42% residiam no estado do RN. De acordo com as características clínicas, 34,3% apresentaram como diagnóstico principal a Leucemia Linfoblástica Aguda e 25,71% a Leucemia Mieloide Aguda. As toxicidades gastrointestinais foram as que mais ocorreram (97,1%) e todos receberam tratamento com antineoplásicos/quimioterápicos e antieméticos. O TCTH alogênico foi o mais frequentemente realizado (57,14%) e a fonte de CPH mais utilizada foi o sangue periférico (54,29%) e 5,71% desenvolveram a Doença do Enxerto Contra Hospedeiro (DECH), dos quais um foi acometido por DECH aguda e outro pela forma crônica. A causa de morte com maior frequência foi a sepse (60%). O perfil das variáveis clínicas apresentadas pelas crianças e adolescents desta pesquisa mostram que o diagnóstico mais prevalente foi o de LLA, as toxicidades que mais ocorreram foram as gastrointestinais, cardíacas, respiratórias e hematológicas, o TCTH mais realizado foi o alogênico de sangue periférico e a maior causa de mortalidade foi a sepse. Tais dados se assemelham aos estudos realizados na América do Norte, Europa e Ásia.EDUFU2019-12-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://seer.ufu.br/index.php/biosciencejournal/article/view/3622710.14393/BJ-v35n5a2019-36227Bioscience Journal ; Vol. 35 No. 5 (2019): Sept./Oct.; 1622-1632 Bioscience Journal ; v. 35 n. 5 (2019): Sept./Oct.; 1622-1632 1981-3163reponame:Bioscience journal (Online)instname:Universidade Federal de Uberlândia (UFU)instacron:UFUenghttps://seer.ufu.br/index.php/biosciencejournal/article/view/36227/27087Malásia; ContemporaryCopyright (c) 2019 Wanessa da Silva Peres Bezerra, Marcos Antonio Ferreira Júnior, Isabelle Campos de Azevedo, Mayk Penze Cardoso, Andreia Insabralde de Queiroz Cardoso, Oleci Pereira Frota, Maria Lúcia Ivo, Vanessa Giavarotti Taboza Flores, Elenilda de Andrade Pereira Gonçalveshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessBezerra, Wanessa da Silva PeresFerreira Júnior, Marcos AntonioAzevedo, Isabelle Campos deCardoso, Mayk PenzeCardoso, Andreia Insabralde de QueirozFrota, Oleci PereiraIvo, Maria LúciaFlores, Vanessa Giavarotti TabozaGonçalves, Elenilda de Andrade Pereira2022-01-26T11:26:01Zoai:ojs.www.seer.ufu.br:article/36227Revistahttps://seer.ufu.br/index.php/biosciencejournalPUBhttps://seer.ufu.br/index.php/biosciencejournal/oaibiosciencej@ufu.br||1981-31631516-3725opendoar:2022-01-26T11:26:01Bioscience journal (Online) - Universidade Federal de Uberlândia (UFU)false |
dc.title.none.fl_str_mv |
Clinical and epidemiological profile of children and adolescents submitted to the hematopoietic cell transplantation Perfil clínico e epidemiológico de crianças e adolescentes submetidos ao transplante de células-tronco hematopoéticas |
title |
Clinical and epidemiological profile of children and adolescents submitted to the hematopoietic cell transplantation |
spellingShingle |
Clinical and epidemiological profile of children and adolescents submitted to the hematopoietic cell transplantation Bezerra, Wanessa da Silva Peres Hematopoietic Stem Cell Transplantation Bone Marrow Transplantation Child Adolescent Epidemiology Health Sciences |
title_short |
Clinical and epidemiological profile of children and adolescents submitted to the hematopoietic cell transplantation |
title_full |
Clinical and epidemiological profile of children and adolescents submitted to the hematopoietic cell transplantation |
title_fullStr |
Clinical and epidemiological profile of children and adolescents submitted to the hematopoietic cell transplantation |
title_full_unstemmed |
Clinical and epidemiological profile of children and adolescents submitted to the hematopoietic cell transplantation |
title_sort |
Clinical and epidemiological profile of children and adolescents submitted to the hematopoietic cell transplantation |
author |
Bezerra, Wanessa da Silva Peres |
author_facet |
Bezerra, Wanessa da Silva Peres Ferreira Júnior, Marcos Antonio Azevedo, Isabelle Campos de Cardoso, Mayk Penze Cardoso, Andreia Insabralde de Queiroz Frota, Oleci Pereira Ivo, Maria Lúcia Flores, Vanessa Giavarotti Taboza Gonçalves, Elenilda de Andrade Pereira |
author_role |
author |
author2 |
Ferreira Júnior, Marcos Antonio Azevedo, Isabelle Campos de Cardoso, Mayk Penze Cardoso, Andreia Insabralde de Queiroz Frota, Oleci Pereira Ivo, Maria Lúcia Flores, Vanessa Giavarotti Taboza Gonçalves, Elenilda de Andrade Pereira |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Bezerra, Wanessa da Silva Peres Ferreira Júnior, Marcos Antonio Azevedo, Isabelle Campos de Cardoso, Mayk Penze Cardoso, Andreia Insabralde de Queiroz Frota, Oleci Pereira Ivo, Maria Lúcia Flores, Vanessa Giavarotti Taboza Gonçalves, Elenilda de Andrade Pereira |
dc.subject.por.fl_str_mv |
Hematopoietic Stem Cell Transplantation Bone Marrow Transplantation Child Adolescent Epidemiology Health Sciences |
topic |
Hematopoietic Stem Cell Transplantation Bone Marrow Transplantation Child Adolescent Epidemiology Health Sciences |
description |
The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. To characterize the clinical and epidemiological profile of children and adolescents submitted to HSCT at a referral service in the state of Rio Grande do Norte. This is a quantitative, retrospective, observational, descriptive and analytical quantitative approach approaching the medical records of children and adolescents submitted to HSCT in a referral hospital service for this type of transplantation in the state of Rio Grande do Sul North (RN). The final sample consisted of 35 records patients aged between 2 and 18 years old who underwent HSCT from February 2008 to December 2015 and who presented the data necessary for the study. The records analyzed showed a little majority of male patients (51.42%) and 60.00% of these men were students and 71.42% lived in the state of the Rio Grande do Norte. According to the clinical characteristics, 34.3% of the patients had Acute Lymphoblastic Leukemia and 25.71% had Acute Myeloid Leukemia as the main diagnosis. Gastrointestinal toxicities were the most frequent (97.1%) and all patients received antineoplastic/chemotherapeutic and antiemetic treatment. The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. Septsis was the most frequent cause of death (60%). The profile of the clinical variables presented by the children and adolescents of this study shows that the most prevalent diagnosis was ALL, the most frequent toxicities were gastrointestinal, cardiac, respiratory and hematological, the most common HSCT was allogeneic peripheral blood and the greatest cause of mortality was sepsis. These data are similar to studies conducted in North America, Europe and Asia. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-12-02 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://seer.ufu.br/index.php/biosciencejournal/article/view/36227 10.14393/BJ-v35n5a2019-36227 |
url |
https://seer.ufu.br/index.php/biosciencejournal/article/view/36227 |
identifier_str_mv |
10.14393/BJ-v35n5a2019-36227 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://seer.ufu.br/index.php/biosciencejournal/article/view/36227/27087 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.coverage.none.fl_str_mv |
Malásia; Contemporary |
dc.publisher.none.fl_str_mv |
EDUFU |
publisher.none.fl_str_mv |
EDUFU |
dc.source.none.fl_str_mv |
Bioscience Journal ; Vol. 35 No. 5 (2019): Sept./Oct.; 1622-1632 Bioscience Journal ; v. 35 n. 5 (2019): Sept./Oct.; 1622-1632 1981-3163 reponame:Bioscience journal (Online) instname:Universidade Federal de Uberlândia (UFU) instacron:UFU |
instname_str |
Universidade Federal de Uberlândia (UFU) |
instacron_str |
UFU |
institution |
UFU |
reponame_str |
Bioscience journal (Online) |
collection |
Bioscience journal (Online) |
repository.name.fl_str_mv |
Bioscience journal (Online) - Universidade Federal de Uberlândia (UFU) |
repository.mail.fl_str_mv |
biosciencej@ufu.br|| |
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1797069065974448128 |