Effects of Rooibos (Aspalathus linearis) on the Testicular Parenchyma of Adult BALB/C Mice Submitted to a Hypercaloric Diet
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Bioscience journal (Online) |
Texto Completo: | https://seer.ufu.br/index.php/biosciencejournal/article/view/64537 |
Resumo: | Oxidative stress due to obesity plays a detrimental role in the testicular microenvironment and sperm parameters. We explored the impact of a hypercaloric diet in male BALB/c mice as a condition to trigger damage to the spermatogenic process and the antioxidant effect of Aspalathus linearis as well. We used a hypercaloric diet in animals divided into 3 groups: Control, Hypercaloric diet control (HC) and Hypercaloric diet and Rooibos infusion (HCR). Morphometric parameters, enzyme dosages, cell viability, and tubular histopathology were evaluated. Body weight increased in HCR animals at weeks 3, 4, and 8. We found a reduction in seminiferous epithelium height, with an increase in the tubular diameter of the HCR group. Catalase levels were lower in HC and HCR, while carbonyl protein was decreased in HC. We estimate that it induces oxidative stress (OS) capable of affecting the seminiferous epithelium and that the infusion of A. linearis does not demonstrate a potential benefit in cell preservation. |
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Effects of Rooibos (Aspalathus linearis) on the Testicular Parenchyma of Adult BALB/C Mice Submitted to a Hypercaloric DietEfeitos do Rooibos (Aspalathus linearis) no Parênquima Testicular de Camundongos BALB/C Adultos Submetidos à Dieta HipercalóricaHigh fat dietObesityOxidative stressReproductionTestis. Biological sciences Health SciencesOxidative stress due to obesity plays a detrimental role in the testicular microenvironment and sperm parameters. We explored the impact of a hypercaloric diet in male BALB/c mice as a condition to trigger damage to the spermatogenic process and the antioxidant effect of Aspalathus linearis as well. We used a hypercaloric diet in animals divided into 3 groups: Control, Hypercaloric diet control (HC) and Hypercaloric diet and Rooibos infusion (HCR). Morphometric parameters, enzyme dosages, cell viability, and tubular histopathology were evaluated. Body weight increased in HCR animals at weeks 3, 4, and 8. We found a reduction in seminiferous epithelium height, with an increase in the tubular diameter of the HCR group. Catalase levels were lower in HC and HCR, while carbonyl protein was decreased in HC. We estimate that it induces oxidative stress (OS) capable of affecting the seminiferous epithelium and that the infusion of A. linearis does not demonstrate a potential benefit in cell preservation.O estresse oxidativo devido à obesidade desempenha um papel prejudicial no microambiente testicular e nos parâmetros espermáticos. Exploramos o impacto de uma dieta hipercalórica em camundongos machos BALB/c como condição para desencadear danos ao processo espermatogênico e testamos o efeito antioxidante de Aspalathus linearis. Utilizou-se dieta hipercalórica em animais divididos em 3 grupos: Controle, HC e HCR. Foram avaliados parâmetros morfométricos, dosagens de enzimas, viabilidade celular e histopatologia tubular. O peso corporal aumentou nos animais HCR nas semanas 3, 4 e 8. Encontramos redução na altura do epitélio seminífero, com aumento do diâmetro tubular do grupo HCR. Os níveis de catalase foram menores em HC e HCR, enquanto a proteína carbonil foi diminuída em HC. Estimamos que induz OS capaz de afetar o epitélio seminífero e que a infusão de A. linearis não demonstra um benefício potencial na preservação celularUniversidade Federal de Uberlândia2023-02-24info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://seer.ufu.br/index.php/biosciencejournal/article/view/6453710.14393/BJ-v39n0a2023-64537Bioscience Journal ; Vol. 39 (2023): Continuous Publication; e39030Bioscience Journal ; v. 39 (2023): Continuous Publication; e390301981-3163reponame:Bioscience journal (Online)instname:Universidade Federal de Uberlândia (UFU)instacron:UFUenghttps://seer.ufu.br/index.php/biosciencejournal/article/view/64537/35646Brazil; Contemporary Copyright (c) 2023 Hilara Niemeyer Ruas, João Vitor Lopes-Ferreira, Fernanda Carolina Ribeiro Dias, Maria Emília Soares Martins dos Santos, Angelica de Oliveira Gomes, Mariella Bontempo Freitas, Marcos de Lucca Moreira Gomeshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessNiemeyer Ruas, HilaraLopes-Ferreira, João Vitor Dias, Fernanda Carolina Ribeiro Santos, Maria Emília Soares Martins dos Gomes, Angelica de Oliveira Freitas, Mariella BontempoGomes, Marcos de Lucca Moreira2024-01-31T19:16:18Zoai:ojs.www.seer.ufu.br:article/64537Revistahttps://seer.ufu.br/index.php/biosciencejournalPUBhttps://seer.ufu.br/index.php/biosciencejournal/oaibiosciencej@ufu.br||1981-31631516-3725opendoar:2024-01-31T19:16:18Bioscience journal (Online) - Universidade Federal de Uberlândia (UFU)false |
dc.title.none.fl_str_mv |
Effects of Rooibos (Aspalathus linearis) on the Testicular Parenchyma of Adult BALB/C Mice Submitted to a Hypercaloric Diet Efeitos do Rooibos (Aspalathus linearis) no Parênquima Testicular de Camundongos BALB/C Adultos Submetidos à Dieta Hipercalórica |
title |
Effects of Rooibos (Aspalathus linearis) on the Testicular Parenchyma of Adult BALB/C Mice Submitted to a Hypercaloric Diet |
spellingShingle |
Effects of Rooibos (Aspalathus linearis) on the Testicular Parenchyma of Adult BALB/C Mice Submitted to a Hypercaloric Diet Niemeyer Ruas, Hilara High fat diet Obesity Oxidative stress Reproduction Testis. Biological sciences Health Sciences |
title_short |
Effects of Rooibos (Aspalathus linearis) on the Testicular Parenchyma of Adult BALB/C Mice Submitted to a Hypercaloric Diet |
title_full |
Effects of Rooibos (Aspalathus linearis) on the Testicular Parenchyma of Adult BALB/C Mice Submitted to a Hypercaloric Diet |
title_fullStr |
Effects of Rooibos (Aspalathus linearis) on the Testicular Parenchyma of Adult BALB/C Mice Submitted to a Hypercaloric Diet |
title_full_unstemmed |
Effects of Rooibos (Aspalathus linearis) on the Testicular Parenchyma of Adult BALB/C Mice Submitted to a Hypercaloric Diet |
title_sort |
Effects of Rooibos (Aspalathus linearis) on the Testicular Parenchyma of Adult BALB/C Mice Submitted to a Hypercaloric Diet |
author |
Niemeyer Ruas, Hilara |
author_facet |
Niemeyer Ruas, Hilara Lopes-Ferreira, João Vitor Dias, Fernanda Carolina Ribeiro Santos, Maria Emília Soares Martins dos Gomes, Angelica de Oliveira Freitas, Mariella Bontempo Gomes, Marcos de Lucca Moreira |
author_role |
author |
author2 |
Lopes-Ferreira, João Vitor Dias, Fernanda Carolina Ribeiro Santos, Maria Emília Soares Martins dos Gomes, Angelica de Oliveira Freitas, Mariella Bontempo Gomes, Marcos de Lucca Moreira |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Niemeyer Ruas, Hilara Lopes-Ferreira, João Vitor Dias, Fernanda Carolina Ribeiro Santos, Maria Emília Soares Martins dos Gomes, Angelica de Oliveira Freitas, Mariella Bontempo Gomes, Marcos de Lucca Moreira |
dc.subject.por.fl_str_mv |
High fat diet Obesity Oxidative stress Reproduction Testis. Biological sciences Health Sciences |
topic |
High fat diet Obesity Oxidative stress Reproduction Testis. Biological sciences Health Sciences |
description |
Oxidative stress due to obesity plays a detrimental role in the testicular microenvironment and sperm parameters. We explored the impact of a hypercaloric diet in male BALB/c mice as a condition to trigger damage to the spermatogenic process and the antioxidant effect of Aspalathus linearis as well. We used a hypercaloric diet in animals divided into 3 groups: Control, Hypercaloric diet control (HC) and Hypercaloric diet and Rooibos infusion (HCR). Morphometric parameters, enzyme dosages, cell viability, and tubular histopathology were evaluated. Body weight increased in HCR animals at weeks 3, 4, and 8. We found a reduction in seminiferous epithelium height, with an increase in the tubular diameter of the HCR group. Catalase levels were lower in HC and HCR, while carbonyl protein was decreased in HC. We estimate that it induces oxidative stress (OS) capable of affecting the seminiferous epithelium and that the infusion of A. linearis does not demonstrate a potential benefit in cell preservation. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-02-24 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://seer.ufu.br/index.php/biosciencejournal/article/view/64537 10.14393/BJ-v39n0a2023-64537 |
url |
https://seer.ufu.br/index.php/biosciencejournal/article/view/64537 |
identifier_str_mv |
10.14393/BJ-v39n0a2023-64537 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://seer.ufu.br/index.php/biosciencejournal/article/view/64537/35646 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.coverage.none.fl_str_mv |
Brazil; Contemporary |
dc.publisher.none.fl_str_mv |
Universidade Federal de Uberlândia |
publisher.none.fl_str_mv |
Universidade Federal de Uberlândia |
dc.source.none.fl_str_mv |
Bioscience Journal ; Vol. 39 (2023): Continuous Publication; e39030 Bioscience Journal ; v. 39 (2023): Continuous Publication; e39030 1981-3163 reponame:Bioscience journal (Online) instname:Universidade Federal de Uberlândia (UFU) instacron:UFU |
instname_str |
Universidade Federal de Uberlândia (UFU) |
instacron_str |
UFU |
institution |
UFU |
reponame_str |
Bioscience journal (Online) |
collection |
Bioscience journal (Online) |
repository.name.fl_str_mv |
Bioscience journal (Online) - Universidade Federal de Uberlândia (UFU) |
repository.mail.fl_str_mv |
biosciencej@ufu.br|| |
_version_ |
1797069065233104896 |