Metabolic effects of early protein undernourishment and renourishment in wistar rats
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Bioscience journal (Online) |
Texto Completo: | https://seer.ufu.br/index.php/biosciencejournal/article/view/26548 |
Resumo: | Malnutrition remains a important public health condition by affecting mostly children. The present study aimed to examine the effects of prenatal protein undernourishment and postnatal renourishment on the metabolism of pre-adult animals. Forty-five male Wistar rats originating from different litters were used. The Nourished (N, n=15) and Undernourished (U, n=30) groups were maintained on proteic and hypoproteic diets (20% and 5% casein, respectively) from the intrauterine phase until the end of the experiment. The Renourished group (R) contained 15 animals, randomly chosen from U group, that consumed the N diet beginning on day 21 (weaning). All groups were maintained until day 60. The experimental data was acquired daily for body weight, feed and water intake, feces and urine excretion. Data analysis was made with the total results and the ratio between them. The U group animals developed uniformly sparse hair late and experienced intense sweating, features that were not observed during the experiment in the R and N animals groups. The R group had the largest weight gain and feed and water intake ratio/weight at experimental period, followed by the N group animals. The final body weight and food intake decreased gradually in the order N-R-U, but none of the other parameters showed a statistical difference between the N and R animals. Compared to groups N and R, the U group animals consumed 90% and 81% more food and water, respectively. Protein undernourishment induced metabolic dysfunction in the U group animals. The similarity in the experimental parameters of the N and R groups suggests that an early feeding correction was effective in reestablishing the organic functions of the R group animals. |
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Metabolic effects of early protein undernourishment and renourishment in wistar rats UndernourishmentrefeedingmetabolismnourishmentratsBiological SciencesMalnutrition remains a important public health condition by affecting mostly children. The present study aimed to examine the effects of prenatal protein undernourishment and postnatal renourishment on the metabolism of pre-adult animals. Forty-five male Wistar rats originating from different litters were used. The Nourished (N, n=15) and Undernourished (U, n=30) groups were maintained on proteic and hypoproteic diets (20% and 5% casein, respectively) from the intrauterine phase until the end of the experiment. The Renourished group (R) contained 15 animals, randomly chosen from U group, that consumed the N diet beginning on day 21 (weaning). All groups were maintained until day 60. The experimental data was acquired daily for body weight, feed and water intake, feces and urine excretion. Data analysis was made with the total results and the ratio between them. The U group animals developed uniformly sparse hair late and experienced intense sweating, features that were not observed during the experiment in the R and N animals groups. The R group had the largest weight gain and feed and water intake ratio/weight at experimental period, followed by the N group animals. The final body weight and food intake decreased gradually in the order N-R-U, but none of the other parameters showed a statistical difference between the N and R animals. Compared to groups N and R, the U group animals consumed 90% and 81% more food and water, respectively. Protein undernourishment induced metabolic dysfunction in the U group animals. The similarity in the experimental parameters of the N and R groups suggests that an early feeding correction was effective in reestablishing the organic functions of the R group animals.EDUFU2015-09-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://seer.ufu.br/index.php/biosciencejournal/article/view/2654810.14393/BJ-v31n5a2015-26548Bioscience Journal ; Vol. 31 No. 5 (2015): Sept./Oct.; 1561-1569Bioscience Journal ; v. 31 n. 5 (2015): Sept./Oct.; 1561-15691981-3163reponame:Bioscience journal (Online)instname:Universidade Federal de Uberlândia (UFU)instacron:UFUenghttps://seer.ufu.br/index.php/biosciencejournal/article/view/26548/17146Brazil; ContemporaryCopyright (c) 2015 Josemberg da Silva Baptista, Marcelo Arthur Cavalli, Lucilene Ferreira Luiz, Diana de Oliveira Vono, Carlos Eduardo Seyfert, Sílvia de Campo Boldrini, Edson Aparecido Libertihttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessBaptista, Josemberg da SilvaCavalli, Marcelo ArthurLuiz, Lucilene FerreiraVono, Diana de OliveiraSeyfert, Carlos EduardoBoldrini, Sílvia de CampoLiberti, Edson Aparecido2022-05-19T14:50:45Zoai:ojs.www.seer.ufu.br:article/26548Revistahttps://seer.ufu.br/index.php/biosciencejournalPUBhttps://seer.ufu.br/index.php/biosciencejournal/oaibiosciencej@ufu.br||1981-31631516-3725opendoar:2022-05-19T14:50:45Bioscience journal (Online) - Universidade Federal de Uberlândia (UFU)false |
dc.title.none.fl_str_mv |
Metabolic effects of early protein undernourishment and renourishment in wistar rats |
title |
Metabolic effects of early protein undernourishment and renourishment in wistar rats |
spellingShingle |
Metabolic effects of early protein undernourishment and renourishment in wistar rats Baptista, Josemberg da Silva Undernourishment refeeding metabolism nourishment rats Biological Sciences |
title_short |
Metabolic effects of early protein undernourishment and renourishment in wistar rats |
title_full |
Metabolic effects of early protein undernourishment and renourishment in wistar rats |
title_fullStr |
Metabolic effects of early protein undernourishment and renourishment in wistar rats |
title_full_unstemmed |
Metabolic effects of early protein undernourishment and renourishment in wistar rats |
title_sort |
Metabolic effects of early protein undernourishment and renourishment in wistar rats |
author |
Baptista, Josemberg da Silva |
author_facet |
Baptista, Josemberg da Silva Cavalli, Marcelo Arthur Luiz, Lucilene Ferreira Vono, Diana de Oliveira Seyfert, Carlos Eduardo Boldrini, Sílvia de Campo Liberti, Edson Aparecido |
author_role |
author |
author2 |
Cavalli, Marcelo Arthur Luiz, Lucilene Ferreira Vono, Diana de Oliveira Seyfert, Carlos Eduardo Boldrini, Sílvia de Campo Liberti, Edson Aparecido |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Baptista, Josemberg da Silva Cavalli, Marcelo Arthur Luiz, Lucilene Ferreira Vono, Diana de Oliveira Seyfert, Carlos Eduardo Boldrini, Sílvia de Campo Liberti, Edson Aparecido |
dc.subject.por.fl_str_mv |
Undernourishment refeeding metabolism nourishment rats Biological Sciences |
topic |
Undernourishment refeeding metabolism nourishment rats Biological Sciences |
description |
Malnutrition remains a important public health condition by affecting mostly children. The present study aimed to examine the effects of prenatal protein undernourishment and postnatal renourishment on the metabolism of pre-adult animals. Forty-five male Wistar rats originating from different litters were used. The Nourished (N, n=15) and Undernourished (U, n=30) groups were maintained on proteic and hypoproteic diets (20% and 5% casein, respectively) from the intrauterine phase until the end of the experiment. The Renourished group (R) contained 15 animals, randomly chosen from U group, that consumed the N diet beginning on day 21 (weaning). All groups were maintained until day 60. The experimental data was acquired daily for body weight, feed and water intake, feces and urine excretion. Data analysis was made with the total results and the ratio between them. The U group animals developed uniformly sparse hair late and experienced intense sweating, features that were not observed during the experiment in the R and N animals groups. The R group had the largest weight gain and feed and water intake ratio/weight at experimental period, followed by the N group animals. The final body weight and food intake decreased gradually in the order N-R-U, but none of the other parameters showed a statistical difference between the N and R animals. Compared to groups N and R, the U group animals consumed 90% and 81% more food and water, respectively. Protein undernourishment induced metabolic dysfunction in the U group animals. The similarity in the experimental parameters of the N and R groups suggests that an early feeding correction was effective in reestablishing the organic functions of the R group animals. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-09-10 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://seer.ufu.br/index.php/biosciencejournal/article/view/26548 10.14393/BJ-v31n5a2015-26548 |
url |
https://seer.ufu.br/index.php/biosciencejournal/article/view/26548 |
identifier_str_mv |
10.14393/BJ-v31n5a2015-26548 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://seer.ufu.br/index.php/biosciencejournal/article/view/26548/17146 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.coverage.none.fl_str_mv |
Brazil; Contemporary |
dc.publisher.none.fl_str_mv |
EDUFU |
publisher.none.fl_str_mv |
EDUFU |
dc.source.none.fl_str_mv |
Bioscience Journal ; Vol. 31 No. 5 (2015): Sept./Oct.; 1561-1569 Bioscience Journal ; v. 31 n. 5 (2015): Sept./Oct.; 1561-1569 1981-3163 reponame:Bioscience journal (Online) instname:Universidade Federal de Uberlândia (UFU) instacron:UFU |
instname_str |
Universidade Federal de Uberlândia (UFU) |
instacron_str |
UFU |
institution |
UFU |
reponame_str |
Bioscience journal (Online) |
collection |
Bioscience journal (Online) |
repository.name.fl_str_mv |
Bioscience journal (Online) - Universidade Federal de Uberlândia (UFU) |
repository.mail.fl_str_mv |
biosciencej@ufu.br|| |
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1797069075341377536 |