Metabolic effects of early protein undernourishment and renourishment in wistar rats

Detalhes bibliográficos
Autor(a) principal: Baptista, Josemberg da Silva
Data de Publicação: 2015
Outros Autores: Cavalli, Marcelo Arthur, Luiz, Lucilene Ferreira, Vono, Diana de Oliveira, Seyfert, Carlos Eduardo, Boldrini, Sílvia de Campo, Liberti, Edson Aparecido
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Bioscience journal (Online)
Texto Completo: https://seer.ufu.br/index.php/biosciencejournal/article/view/26548
Resumo: Malnutrition remains a important public health condition by affecting mostly children. The present study aimed to examine the effects of prenatal protein undernourishment and postnatal renourishment on the metabolism of pre-adult animals. Forty-five male Wistar rats originating from different litters were used. The Nourished (N, n=15) and Undernourished (U, n=30) groups were maintained on proteic and hypoproteic diets (20% and 5% casein, respectively) from the intrauterine phase until the end of the experiment. The Renourished group (R) contained 15 animals, randomly chosen from U group, that consumed the N diet beginning on day 21 (weaning). All groups were maintained until day 60. The experimental data was acquired daily for body weight, feed and water intake, feces and urine excretion. Data analysis was made with the total results and the ratio between them. The U group animals developed uniformly sparse hair late and experienced intense sweating, features that were not observed during the experiment in the R and N animals groups. The R group had the largest weight gain and feed and water intake ratio/weight at experimental period, followed by the N group animals. The final body weight and food intake decreased gradually in the order N-R-U, but none of the other parameters showed a statistical difference between the N and R animals. Compared to groups N and R, the U group animals consumed 90% and 81% more food and water, respectively. Protein undernourishment induced metabolic dysfunction in the U group animals. The similarity in the experimental parameters of the N and R groups suggests that an early feeding correction was effective in reestablishing the organic functions of the R group animals.
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spelling Metabolic effects of early protein undernourishment and renourishment in wistar rats UndernourishmentrefeedingmetabolismnourishmentratsBiological SciencesMalnutrition remains a important public health condition by affecting mostly children. The present study aimed to examine the effects of prenatal protein undernourishment and postnatal renourishment on the metabolism of pre-adult animals. Forty-five male Wistar rats originating from different litters were used. The Nourished (N, n=15) and Undernourished (U, n=30) groups were maintained on proteic and hypoproteic diets (20% and 5% casein, respectively) from the intrauterine phase until the end of the experiment. The Renourished group (R) contained 15 animals, randomly chosen from U group, that consumed the N diet beginning on day 21 (weaning). All groups were maintained until day 60. The experimental data was acquired daily for body weight, feed and water intake, feces and urine excretion. Data analysis was made with the total results and the ratio between them. The U group animals developed uniformly sparse hair late and experienced intense sweating, features that were not observed during the experiment in the R and N animals groups. The R group had the largest weight gain and feed and water intake ratio/weight at experimental period, followed by the N group animals. The final body weight and food intake decreased gradually in the order N-R-U, but none of the other parameters showed a statistical difference between the N and R animals. Compared to groups N and R, the U group animals consumed 90% and 81% more food and water, respectively. Protein undernourishment induced metabolic dysfunction in the U group animals. The similarity in the experimental parameters of the N and R groups suggests that an early feeding correction was effective in reestablishing the organic functions of the R group animals.EDUFU2015-09-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://seer.ufu.br/index.php/biosciencejournal/article/view/2654810.14393/BJ-v31n5a2015-26548Bioscience Journal ; Vol. 31 No. 5 (2015): Sept./Oct.; 1561-1569Bioscience Journal ; v. 31 n. 5 (2015): Sept./Oct.; 1561-15691981-3163reponame:Bioscience journal (Online)instname:Universidade Federal de Uberlândia (UFU)instacron:UFUenghttps://seer.ufu.br/index.php/biosciencejournal/article/view/26548/17146Brazil; ContemporaryCopyright (c) 2015 Josemberg da Silva Baptista, Marcelo Arthur Cavalli, Lucilene Ferreira Luiz, Diana de Oliveira Vono, Carlos Eduardo Seyfert, Sílvia de Campo Boldrini, Edson Aparecido Libertihttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessBaptista, Josemberg da SilvaCavalli, Marcelo ArthurLuiz, Lucilene FerreiraVono, Diana de OliveiraSeyfert, Carlos EduardoBoldrini, Sílvia de CampoLiberti, Edson Aparecido2022-05-19T14:50:45Zoai:ojs.www.seer.ufu.br:article/26548Revistahttps://seer.ufu.br/index.php/biosciencejournalPUBhttps://seer.ufu.br/index.php/biosciencejournal/oaibiosciencej@ufu.br||1981-31631516-3725opendoar:2022-05-19T14:50:45Bioscience journal (Online) - Universidade Federal de Uberlândia (UFU)false
dc.title.none.fl_str_mv Metabolic effects of early protein undernourishment and renourishment in wistar rats
title Metabolic effects of early protein undernourishment and renourishment in wistar rats
spellingShingle Metabolic effects of early protein undernourishment and renourishment in wistar rats
Baptista, Josemberg da Silva
Undernourishment
refeeding
metabolism
nourishment
rats
Biological Sciences
title_short Metabolic effects of early protein undernourishment and renourishment in wistar rats
title_full Metabolic effects of early protein undernourishment and renourishment in wistar rats
title_fullStr Metabolic effects of early protein undernourishment and renourishment in wistar rats
title_full_unstemmed Metabolic effects of early protein undernourishment and renourishment in wistar rats
title_sort Metabolic effects of early protein undernourishment and renourishment in wistar rats
author Baptista, Josemberg da Silva
author_facet Baptista, Josemberg da Silva
Cavalli, Marcelo Arthur
Luiz, Lucilene Ferreira
Vono, Diana de Oliveira
Seyfert, Carlos Eduardo
Boldrini, Sílvia de Campo
Liberti, Edson Aparecido
author_role author
author2 Cavalli, Marcelo Arthur
Luiz, Lucilene Ferreira
Vono, Diana de Oliveira
Seyfert, Carlos Eduardo
Boldrini, Sílvia de Campo
Liberti, Edson Aparecido
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Baptista, Josemberg da Silva
Cavalli, Marcelo Arthur
Luiz, Lucilene Ferreira
Vono, Diana de Oliveira
Seyfert, Carlos Eduardo
Boldrini, Sílvia de Campo
Liberti, Edson Aparecido
dc.subject.por.fl_str_mv Undernourishment
refeeding
metabolism
nourishment
rats
Biological Sciences
topic Undernourishment
refeeding
metabolism
nourishment
rats
Biological Sciences
description Malnutrition remains a important public health condition by affecting mostly children. The present study aimed to examine the effects of prenatal protein undernourishment and postnatal renourishment on the metabolism of pre-adult animals. Forty-five male Wistar rats originating from different litters were used. The Nourished (N, n=15) and Undernourished (U, n=30) groups were maintained on proteic and hypoproteic diets (20% and 5% casein, respectively) from the intrauterine phase until the end of the experiment. The Renourished group (R) contained 15 animals, randomly chosen from U group, that consumed the N diet beginning on day 21 (weaning). All groups were maintained until day 60. The experimental data was acquired daily for body weight, feed and water intake, feces and urine excretion. Data analysis was made with the total results and the ratio between them. The U group animals developed uniformly sparse hair late and experienced intense sweating, features that were not observed during the experiment in the R and N animals groups. The R group had the largest weight gain and feed and water intake ratio/weight at experimental period, followed by the N group animals. The final body weight and food intake decreased gradually in the order N-R-U, but none of the other parameters showed a statistical difference between the N and R animals. Compared to groups N and R, the U group animals consumed 90% and 81% more food and water, respectively. Protein undernourishment induced metabolic dysfunction in the U group animals. The similarity in the experimental parameters of the N and R groups suggests that an early feeding correction was effective in reestablishing the organic functions of the R group animals.
publishDate 2015
dc.date.none.fl_str_mv 2015-09-10
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://seer.ufu.br/index.php/biosciencejournal/article/view/26548
10.14393/BJ-v31n5a2015-26548
url https://seer.ufu.br/index.php/biosciencejournal/article/view/26548
identifier_str_mv 10.14393/BJ-v31n5a2015-26548
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://seer.ufu.br/index.php/biosciencejournal/article/view/26548/17146
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.coverage.none.fl_str_mv Brazil; Contemporary
dc.publisher.none.fl_str_mv EDUFU
publisher.none.fl_str_mv EDUFU
dc.source.none.fl_str_mv Bioscience Journal ; Vol. 31 No. 5 (2015): Sept./Oct.; 1561-1569
Bioscience Journal ; v. 31 n. 5 (2015): Sept./Oct.; 1561-1569
1981-3163
reponame:Bioscience journal (Online)
instname:Universidade Federal de Uberlândia (UFU)
instacron:UFU
instname_str Universidade Federal de Uberlândia (UFU)
instacron_str UFU
institution UFU
reponame_str Bioscience journal (Online)
collection Bioscience journal (Online)
repository.name.fl_str_mv Bioscience journal (Online) - Universidade Federal de Uberlândia (UFU)
repository.mail.fl_str_mv biosciencej@ufu.br||
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