Antifungal effect of 7-hydroxycitronellal against C. Tropicalis strains: an in vitro approach
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Bioscience journal (Online) |
Texto Completo: | https://seer.ufu.br/index.php/biosciencejournal/article/view/33851 |
Resumo: | The fungi of the genus Candida play a relevant role in the emergence of oral infections and are increasingly more frequent the cases of infections by non-albicans strains. In light of this context and the need for new alternatives to the antimicrobial therapy, the monoterpene [7-hidroxicitronelal] (7-HO) was evaluated for its antifungal effects. For the obtainment of the MIC and MFC values the broth microdilution method was used. The MIC and the MFC of this monoterpene for 60% of the tested strains was of 256µg/mL and 512µg/mL respectively. Furthermore, the standard antifungal nystatin (100UI/mL) was used as positive control for the inhibition of fungal growth. Therefore, were used 4 clinical strains of the species tropicalis (LM 06, LM 14, LM 31 and LM 36) and a standard strain (C. tropicalis ATCC 13803), originated from the Mycology collection of the Mycology Laboratory (LM) of the Health Sciences Center (CCS) of the Federal University of Paraiba (UFPB). The results obtained in this study showed fungicide activity of the compound (7-OH) against the strains of C. tropicalis. |
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Antifungal effect of 7-hydroxycitronellal against C. Tropicalis strains: an in vitro approach Efeito antifúngico do 7-hidroxicitronelal contra cepas de C. tropicalis: uma abordagem in vitroMonoterpeneNistatinAntifungalCandida tropicalisHealth SciencesThe fungi of the genus Candida play a relevant role in the emergence of oral infections and are increasingly more frequent the cases of infections by non-albicans strains. In light of this context and the need for new alternatives to the antimicrobial therapy, the monoterpene [7-hidroxicitronelal] (7-HO) was evaluated for its antifungal effects. For the obtainment of the MIC and MFC values the broth microdilution method was used. The MIC and the MFC of this monoterpene for 60% of the tested strains was of 256µg/mL and 512µg/mL respectively. Furthermore, the standard antifungal nystatin (100UI/mL) was used as positive control for the inhibition of fungal growth. Therefore, were used 4 clinical strains of the species tropicalis (LM 06, LM 14, LM 31 and LM 36) and a standard strain (C. tropicalis ATCC 13803), originated from the Mycology collection of the Mycology Laboratory (LM) of the Health Sciences Center (CCS) of the Federal University of Paraiba (UFPB). The results obtained in this study showed fungicide activity of the compound (7-OH) against the strains of C. tropicalis.Os fungos do gênero Candida tem um papel relevante no aparecimento de infecções orais e são cada vez mais frequentes os casos de infecções por cepas não-albicans. Diante deste contexto e da necessidade de novas alternativas para a terapia antimicrobiana, o monoterpeno [7-hidroxicitronelal] (7-HO) foi avaliado pelos seus efeitos antifúngicos. Para a obtenção dos valores da CIM e da CFM foi utilizado o método da microdiluição em caldo. A CIM e a CFM deste monoterpeno para 60% das cepas testadas foram de 256µg/mL e 512µg/mL respectivamente. Além disso, o antifúngico padrão nistatina (100UI/mL) foi utilizado como controle positivo para inibir o crescimento fúngico. Por tanto, foram utilizadas 4 cepas clínicas da espécie tropicalis (LM 06, LM 14, LM 31 e LM 36) e uma cepa padrão (C. tropicalis ATCC 13803), oriundas da Micoteca do Laboratório de Micologia (LM) do Centro de Ciências da Saúde (CCS) da Universidade Federal da Paraíba (UFPB). Os resultados obtidos neste estudo mostraram atividade fungicida do composto (7-OH) contra as cepas de C. tropicalis.EDUFU2017-02-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://seer.ufu.br/index.php/biosciencejournal/article/view/3385110.14393/BJ-v33n1a2017-33851Bioscience Journal ; Vol. 33 No. 1 (2017): Jan./Feb.; 204-208Bioscience Journal ; v. 33 n. 1 (2017): Jan./Feb.; 204-2081981-3163reponame:Bioscience journal (Online)instname:Universidade Federal de Uberlândia (UFU)instacron:UFUenghttps://seer.ufu.br/index.php/biosciencejournal/article/view/33851/19779Brazil; ContemporaryCopyright (c) 2017 Abrahão Alves Oliveira Filho, Heloísa Mara Batista Fernandes de Oliveira, Cássio Ilan Soares Medeiros, Hilzeth de Luna Freire Pessôa, José Pinto de Siqueira Júnior, Edeltrudes de Oliveira Limahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessOliveira Filho, Abrahão AlvesFernandes de Oliveira, Heloísa Mara BatistaSoares Medeiros, Cássio IlanPessôa, Hilzeth de Luna FreireJúnior, José Pinto de SiqueiraLima, Edeltrudes de Oliveira2022-02-16T14:41:16Zoai:ojs.www.seer.ufu.br:article/33851Revistahttps://seer.ufu.br/index.php/biosciencejournalPUBhttps://seer.ufu.br/index.php/biosciencejournal/oaibiosciencej@ufu.br||1981-31631516-3725opendoar:2022-02-16T14:41:16Bioscience journal (Online) - Universidade Federal de Uberlândia (UFU)false |
dc.title.none.fl_str_mv |
Antifungal effect of 7-hydroxycitronellal against C. Tropicalis strains: an in vitro approach Efeito antifúngico do 7-hidroxicitronelal contra cepas de C. tropicalis: uma abordagem in vitro |
title |
Antifungal effect of 7-hydroxycitronellal against C. Tropicalis strains: an in vitro approach |
spellingShingle |
Antifungal effect of 7-hydroxycitronellal against C. Tropicalis strains: an in vitro approach Oliveira Filho, Abrahão Alves Monoterpene Nistatin Antifungal Candida tropicalis Health Sciences |
title_short |
Antifungal effect of 7-hydroxycitronellal against C. Tropicalis strains: an in vitro approach |
title_full |
Antifungal effect of 7-hydroxycitronellal against C. Tropicalis strains: an in vitro approach |
title_fullStr |
Antifungal effect of 7-hydroxycitronellal against C. Tropicalis strains: an in vitro approach |
title_full_unstemmed |
Antifungal effect of 7-hydroxycitronellal against C. Tropicalis strains: an in vitro approach |
title_sort |
Antifungal effect of 7-hydroxycitronellal against C. Tropicalis strains: an in vitro approach |
author |
Oliveira Filho, Abrahão Alves |
author_facet |
Oliveira Filho, Abrahão Alves Fernandes de Oliveira, Heloísa Mara Batista Soares Medeiros, Cássio Ilan Pessôa, Hilzeth de Luna Freire Júnior, José Pinto de Siqueira Lima, Edeltrudes de Oliveira |
author_role |
author |
author2 |
Fernandes de Oliveira, Heloísa Mara Batista Soares Medeiros, Cássio Ilan Pessôa, Hilzeth de Luna Freire Júnior, José Pinto de Siqueira Lima, Edeltrudes de Oliveira |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Oliveira Filho, Abrahão Alves Fernandes de Oliveira, Heloísa Mara Batista Soares Medeiros, Cássio Ilan Pessôa, Hilzeth de Luna Freire Júnior, José Pinto de Siqueira Lima, Edeltrudes de Oliveira |
dc.subject.por.fl_str_mv |
Monoterpene Nistatin Antifungal Candida tropicalis Health Sciences |
topic |
Monoterpene Nistatin Antifungal Candida tropicalis Health Sciences |
description |
The fungi of the genus Candida play a relevant role in the emergence of oral infections and are increasingly more frequent the cases of infections by non-albicans strains. In light of this context and the need for new alternatives to the antimicrobial therapy, the monoterpene [7-hidroxicitronelal] (7-HO) was evaluated for its antifungal effects. For the obtainment of the MIC and MFC values the broth microdilution method was used. The MIC and the MFC of this monoterpene for 60% of the tested strains was of 256µg/mL and 512µg/mL respectively. Furthermore, the standard antifungal nystatin (100UI/mL) was used as positive control for the inhibition of fungal growth. Therefore, were used 4 clinical strains of the species tropicalis (LM 06, LM 14, LM 31 and LM 36) and a standard strain (C. tropicalis ATCC 13803), originated from the Mycology collection of the Mycology Laboratory (LM) of the Health Sciences Center (CCS) of the Federal University of Paraiba (UFPB). The results obtained in this study showed fungicide activity of the compound (7-OH) against the strains of C. tropicalis. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-02-09 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://seer.ufu.br/index.php/biosciencejournal/article/view/33851 10.14393/BJ-v33n1a2017-33851 |
url |
https://seer.ufu.br/index.php/biosciencejournal/article/view/33851 |
identifier_str_mv |
10.14393/BJ-v33n1a2017-33851 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://seer.ufu.br/index.php/biosciencejournal/article/view/33851/19779 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.coverage.none.fl_str_mv |
Brazil; Contemporary |
dc.publisher.none.fl_str_mv |
EDUFU |
publisher.none.fl_str_mv |
EDUFU |
dc.source.none.fl_str_mv |
Bioscience Journal ; Vol. 33 No. 1 (2017): Jan./Feb.; 204-208 Bioscience Journal ; v. 33 n. 1 (2017): Jan./Feb.; 204-208 1981-3163 reponame:Bioscience journal (Online) instname:Universidade Federal de Uberlândia (UFU) instacron:UFU |
instname_str |
Universidade Federal de Uberlândia (UFU) |
instacron_str |
UFU |
institution |
UFU |
reponame_str |
Bioscience journal (Online) |
collection |
Bioscience journal (Online) |
repository.name.fl_str_mv |
Bioscience journal (Online) - Universidade Federal de Uberlândia (UFU) |
repository.mail.fl_str_mv |
biosciencej@ufu.br|| |
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1797069076961427456 |