Cicatrização e influência da polihexanida tópica no processo de reparação de feridas cutâneas induzidas em papagaio-verdadeiro (Amazona aestiva) (Linnaeus, 1758)

• Autor(a) principal: Silva, Juliana Macedo Magnino
• Data de Publicação: 2012
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Institucional da UFU
• Texto Completo: https://repositorio.ufu.br/handle/123456789/13044; https://doi.org/10.14393/ufu.di.2012.245
• topic: Aves; pele; PHMB; processo cicatricial; Papagaio (Ave); Cicatrização de feridas; Birds; healing process; PHMB; skin; CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA

The purposes of this study were to describe macro and microscopic patterns of cutaneous wound healing on Blue-fronted parrots and to evaluate the influence of the polihexanide compound in this process. An experiment has been taken place within 20 animals sorted into 5 groups. After the anesthetic induction, two small pieces of skin within 8,0 mm diameter were taken from their chest. A histological evaluation were carried out in 4 groups and in the 5th one an macroscopic and morfometric analyses. The wounds of the right hand side were treated with sodium chloric solution at 0,9% and the left hand side applied polihexanide gel solution at 0,1%. For histological evaluation, the cuts were collected in the following days: 3, 7, 14 and 21. After macro and microscopic analyses no significant pattern were observed among the treatments. In the first day, the wounds were reddish and bleeding though no caseous secretion was seen. By the 4th day tissue granulation started to develop. The cutaneous regeneration were observed in the 21st day and the hauling a bit later, in the 25th. The microscopic results of the 3rd and 7th days befitted the healing sore process phase. In the 14th day lymphocytes have been seen mainly. The blood vessels were maintained congested and the neovascularization were observed intensely in the 3rd and 7th days. Along with healing process evolution, epidermal ulceration was not observed. The re-epithelization process has started on the 21st day within epithelial tissue recovering half of the wound area. The inflammation and healing process of the Amazona aestiva came together and its recovery patterns were similar to the ones reported on mammals. Daily wound antisepsis prevented microorganism proliferation. The use of polyhexamethylene biguanide hydrochloride (PHMB) has not improved the cutaneous recovery process significantly on Blue-fronted parrots.