Produção e caracterização de matrizes modelo de triacetatos de celulose obtidos da palha de milho e diacetato comercial para liberação controlada de naproxeno
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFU |
Texto Completo: | https://repositorio.ufu.br/handle/123456789/17533 https://doi.org/10.14393/ufu.te.2015.155 |
Resumo: | In this work the cellulose acetate produced by homogeneous acetylation of cellulose extracted from corn stover was used to produce model systems for controlled release of Naproxen in the form of membranes and microparticles. The commercial cellulose diacetate was used as standard material in the production of membranes, and microparticles. The triacetates hydrolyzed and unhydrolyzed cellulose produced from corn stover presented degree of substitution of 2.53 ± 0.16 and 2.79 ± 0.35 respectively. The membranes were produced using the formulation acetate / solvent/naproxen to symmetric membranes acetate/solvent/water/naproxen for asymmetric membranes. The materials were characterized by scanning electron microscopy, differential scanning calorimetry and thermogravimetry, and was later evaluated the drug release kinetics. The hydrolysis process for obtaining corn straw triacetate impaired physical stability of the matrices produced with this derivative, which showed extremely fragile and brittle, making it unsuitable for use in controlled release systems. The release assays were performed with unhydrolyzed triacetate and commercial systems diacetate and the percentage of naproxen released was obtained by square wave voltammetry. For both polymers, the asymmetric membranes had higher cumulative percentage of drug released as compared to symmetric membranes. Asymmetric membranes diacetate reached about 80% release and that release was 30% to symmetric membranes. In the preparation of the microparticles were taken formulations acetate/solvent/naproxen acetate/ solvent/pore forming agent/naproxen. As solvents were used as dichloromethane for dioxane triacetate and diacetate for commercial as pore formers were inserted in formulations polyethylene glycol and water. Systems were prepared with different concentrations of naproxen in the ratio w/w acetate:drug 10:1, 2:1 and 1:1. The thermal analysis showed that the improved composition of the system polymer/drug was 10:1 w/w, since the drug does not appear melting peaks showing that the drug is molecularly dispersed in the polymer matrix. The kinetic model of drug release is broadcast solution. The particles produced with triacetate showed a release exceeding drug the particle produced commercially diacetate, where particles produced diacetate had a mean release of 2%, while the particles produced with modified triaceato reached about 25% release, featuring differences the interaction between the transparencies and the drug as well as increased stiffness of the particles produced with commercial diacetate. Modifications to polietilenogilicol and water in the particles with triacetate increased the release of naproxen, the release of the modified particles became 13% more than the release of the non-modified particles. The results show that the morphological changes in the controlled release systems are effective considering the increase in the percentage of drug release. |
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2016-06-22T18:49:02Z2016-04-072016-06-22T18:49:02Z2015-12-04ALVES, Janainne Nunes. Produção e caracterização de matrizes modelo de triacetatos de celulose obtidos da palha de milho e diacetato comercial para liberação controlada de naproxeno. 2015. 147 f. Tese (Doutorado em Ciências Exatas e da Terra) - Universidade Federal de Uberlândia, Uberlândia, 2015. Disponível em: https://doi.org/10.14393/ufu.te.2015.155https://repositorio.ufu.br/handle/123456789/17533https://doi.org/10.14393/ufu.te.2015.155In this work the cellulose acetate produced by homogeneous acetylation of cellulose extracted from corn stover was used to produce model systems for controlled release of Naproxen in the form of membranes and microparticles. The commercial cellulose diacetate was used as standard material in the production of membranes, and microparticles. The triacetates hydrolyzed and unhydrolyzed cellulose produced from corn stover presented degree of substitution of 2.53 ± 0.16 and 2.79 ± 0.35 respectively. The membranes were produced using the formulation acetate / solvent/naproxen to symmetric membranes acetate/solvent/water/naproxen for asymmetric membranes. The materials were characterized by scanning electron microscopy, differential scanning calorimetry and thermogravimetry, and was later evaluated the drug release kinetics. The hydrolysis process for obtaining corn straw triacetate impaired physical stability of the matrices produced with this derivative, which showed extremely fragile and brittle, making it unsuitable for use in controlled release systems. The release assays were performed with unhydrolyzed triacetate and commercial systems diacetate and the percentage of naproxen released was obtained by square wave voltammetry. For both polymers, the asymmetric membranes had higher cumulative percentage of drug released as compared to symmetric membranes. Asymmetric membranes diacetate reached about 80% release and that release was 30% to symmetric membranes. In the preparation of the microparticles were taken formulations acetate/solvent/naproxen acetate/ solvent/pore forming agent/naproxen. As solvents were used as dichloromethane for dioxane triacetate and diacetate for commercial as pore formers were inserted in formulations polyethylene glycol and water. Systems were prepared with different concentrations of naproxen in the ratio w/w acetate:drug 10:1, 2:1 and 1:1. The thermal analysis showed that the improved composition of the system polymer/drug was 10:1 w/w, since the drug does not appear melting peaks showing that the drug is molecularly dispersed in the polymer matrix. The kinetic model of drug release is broadcast solution. The particles produced with triacetate showed a release exceeding drug the particle produced commercially diacetate, where particles produced diacetate had a mean release of 2%, while the particles produced with modified triaceato reached about 25% release, featuring differences the interaction between the transparencies and the drug as well as increased stiffness of the particles produced with commercial diacetate. Modifications to polietilenogilicol and water in the particles with triacetate increased the release of naproxen, the release of the modified particles became 13% more than the release of the non-modified particles. The results show that the morphological changes in the controlled release systems are effective considering the increase in the percentage of drug release.Neste trabalho o acetato de celulose produzido através da acetilação homogênea da celulose extraída da palha de milho, foi empregado na produção de sistemas modelos para liberação controlada de Naproxeno, na forma de membranas e micropartículas. O diacetato de celulose comercial foi empregado como material padrão na produção de membranas e micropartículas. Os triacetatos de celulose hidrolisado e não hidrolisado produzidos a partir da palha de milho apresentaram graus de substituição de 2,53±0,16 e 2,79 ± 0,35 respectivamente. As membranas foram produzidas utilizando a formulação acetato/solvente/naproxeno para membranas simétricas e acetato/solvente/água/naproxeno para membranas assimétricas. Os materiais foram caracterizados por microscopia eletrônica de varredura, calorimetria exploratória diferencial e termogravimetria, e posteriormente foi avaliada a cinética de liberação do fármaco. O processo de hidrólise para obtenção do triacetato da palha de milho prejudicou a estabilidade física das matrizes produzidas com este derivado, que se apresentaram extremamente frágeis e quebradiças, se tornando inadequadas ao uso em sistemas de liberação controlada. Os ensaios de liberação foram realizados com os sistemas triacetato não hidrolisado e diacetato comercial, e a porcentagem de naproxeno liberado foi obtida por voltametria de onda quadrada. Para ambos os polímeros, as membranas assimétricas apresentaram maior porcentagem acumulada de fármaco liberado comparativamente as membranas simétricas. As membranas assimétricas de diacetato atingiram cerca de 80% de liberação e esta liberação chegou a 30% para membranas simétricas. Na preparação das micropartículas foram adotadas as formulações acetato/solvente/naproxeno e acetato/solvente/agente formador de poros/naproxeno. Como solventes foram utilizados o diclorometano para o triacetato e o dioxano para o diacetato comercial, como agentes formadores de poros foram inseridos nas formulações o polietilenoglicol e a água. Foram preparados sistemas com diferentes concentrações de naproxeno na proporção m/m acetato:fármaco 10:1, 2:1 e 1:1. As análises térmicas mostraram que a melhor composição do sistema polímero/fármaco foi 10:1 m/m, uma vez que não aparecem picos de fusão do fármaco demonstrando que o fármaco está molecularmente disperso na matriz polimérica. O modelo cinético de liberação do fármaco é predominante de solução difusão. As partículas produzidas com triacetato apresentaram uma liberação do fármaco superior à das partículas produzidas com diacetato comercial, onde as partículas produzidas com diacetato apresentaram uma liberação média de 2%, enquanto as partículas produzidas com triaceato modificadas atingiram cerca de 25% de liberação, caracterizando diferenças na interação entre os acetatos e o fármaco, além de maior rigidez das partículas produzidas com diacetato comercial. As modificações com polietilenogilicol e água nas partículas com triacetato elevaram a liberação de naproxeno, a liberação das partículas modificadas chegou a ser 13% superior a liberação das partículas não-modificadas. Os resultados apresentados mostram que as modificações morfológicas nos sistemas de liberação controlada são eficazes considerando o aumento na porcentagem de liberação do fármaco.Doutor em Químicaapplication/pdfporUniversidade Federal de UberlândiaPrograma de Pós-graduação Multi-Institucional em Quimica (UFG - UFMS - UFU)UFUBRCiências Exatas e da TerraPalha de milhoAcetato de celuloseMembranasMicropartículasLiberação controlada de fármacosVoltametria de onda quadradaNaproxenoCorn strawCellulose acetateMembranesMicro particlesDrug deliverySquare wave voltammetryNaproxenCNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICAProdução e caracterização de matrizes modelo de triacetatos de celulose obtidos da palha de milho e diacetato comercial para liberação controlada de naproxenoinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisAssunção, Rosana Maria Nascimento dehttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4721828J3Meireles, Carla da Silvahttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4705333D9Batista, Antônio Carlos Ferreirahttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4795905Z6Otaguro, Harumihttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4791768P7Cerqueira, Daniel Alveshttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4701878Z2http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4404088P5Alves, Janainne Nunes81767554info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFUinstname:Universidade Federal de Uberlândia (UFU)instacron:UFUTHUMBNAILProducaoCaracterizacaoMatrizes.pdf.jpgProducaoCaracterizacaoMatrizes.pdf.jpgGenerated Thumbnailimage/jpeg1431https://repositorio.ufu.br/bitstream/123456789/17533/3/ProducaoCaracterizacaoMatrizes.pdf.jpge4784345789141a014159054975ffd4aMD53ORIGINALProducaoCaracterizacaoMatrizes.pdfapplication/pdf5509883https://repositorio.ufu.br/bitstream/123456789/17533/1/ProducaoCaracterizacaoMatrizes.pdfcec49425da92e91777ff6d17c10363c1MD51TEXTProducaoCaracterizacaoMatrizes.pdf.txtProducaoCaracterizacaoMatrizes.pdf.txtExtracted texttext/plain224074https://repositorio.ufu.br/bitstream/123456789/17533/2/ProducaoCaracterizacaoMatrizes.pdf.txt1aea28cf779b15f6c95808bddf6dc76aMD52123456789/175332021-03-11 17:20:34.948oai:repositorio.ufu.br:123456789/17533Repositório InstitucionalONGhttp://repositorio.ufu.br/oai/requestdiinf@dirbi.ufu.bropendoar:2021-03-11T20:20:34Repositório Institucional da UFU - Universidade Federal de Uberlândia (UFU)false |
dc.title.por.fl_str_mv |
Produção e caracterização de matrizes modelo de triacetatos de celulose obtidos da palha de milho e diacetato comercial para liberação controlada de naproxeno |
title |
Produção e caracterização de matrizes modelo de triacetatos de celulose obtidos da palha de milho e diacetato comercial para liberação controlada de naproxeno |
spellingShingle |
Produção e caracterização de matrizes modelo de triacetatos de celulose obtidos da palha de milho e diacetato comercial para liberação controlada de naproxeno Alves, Janainne Nunes Palha de milho Acetato de celulose Membranas Micropartículas Liberação controlada de fármacos Voltametria de onda quadrada Naproxeno Corn straw Cellulose acetate Membranes Micro particles Drug delivery Square wave voltammetry Naproxen CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA |
title_short |
Produção e caracterização de matrizes modelo de triacetatos de celulose obtidos da palha de milho e diacetato comercial para liberação controlada de naproxeno |
title_full |
Produção e caracterização de matrizes modelo de triacetatos de celulose obtidos da palha de milho e diacetato comercial para liberação controlada de naproxeno |
title_fullStr |
Produção e caracterização de matrizes modelo de triacetatos de celulose obtidos da palha de milho e diacetato comercial para liberação controlada de naproxeno |
title_full_unstemmed |
Produção e caracterização de matrizes modelo de triacetatos de celulose obtidos da palha de milho e diacetato comercial para liberação controlada de naproxeno |
title_sort |
Produção e caracterização de matrizes modelo de triacetatos de celulose obtidos da palha de milho e diacetato comercial para liberação controlada de naproxeno |
author |
Alves, Janainne Nunes |
author_facet |
Alves, Janainne Nunes |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Assunção, Rosana Maria Nascimento de |
dc.contributor.advisor1Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4721828J3 |
dc.contributor.referee1.fl_str_mv |
Meireles, Carla da Silva |
dc.contributor.referee1Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4705333D9 |
dc.contributor.referee2.fl_str_mv |
Batista, Antônio Carlos Ferreira |
dc.contributor.referee2Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4795905Z6 |
dc.contributor.referee3.fl_str_mv |
Otaguro, Harumi |
dc.contributor.referee3Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4791768P7 |
dc.contributor.referee4.fl_str_mv |
Cerqueira, Daniel Alves |
dc.contributor.referee4Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4701878Z2 |
dc.contributor.authorLattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4404088P5 |
dc.contributor.author.fl_str_mv |
Alves, Janainne Nunes |
contributor_str_mv |
Assunção, Rosana Maria Nascimento de Meireles, Carla da Silva Batista, Antônio Carlos Ferreira Otaguro, Harumi Cerqueira, Daniel Alves |
dc.subject.por.fl_str_mv |
Palha de milho Acetato de celulose Membranas Micropartículas Liberação controlada de fármacos Voltametria de onda quadrada Naproxeno |
topic |
Palha de milho Acetato de celulose Membranas Micropartículas Liberação controlada de fármacos Voltametria de onda quadrada Naproxeno Corn straw Cellulose acetate Membranes Micro particles Drug delivery Square wave voltammetry Naproxen CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA |
dc.subject.eng.fl_str_mv |
Corn straw Cellulose acetate Membranes Micro particles Drug delivery Square wave voltammetry Naproxen |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA |
description |
In this work the cellulose acetate produced by homogeneous acetylation of cellulose extracted from corn stover was used to produce model systems for controlled release of Naproxen in the form of membranes and microparticles. The commercial cellulose diacetate was used as standard material in the production of membranes, and microparticles. The triacetates hydrolyzed and unhydrolyzed cellulose produced from corn stover presented degree of substitution of 2.53 ± 0.16 and 2.79 ± 0.35 respectively. The membranes were produced using the formulation acetate / solvent/naproxen to symmetric membranes acetate/solvent/water/naproxen for asymmetric membranes. The materials were characterized by scanning electron microscopy, differential scanning calorimetry and thermogravimetry, and was later evaluated the drug release kinetics. The hydrolysis process for obtaining corn straw triacetate impaired physical stability of the matrices produced with this derivative, which showed extremely fragile and brittle, making it unsuitable for use in controlled release systems. The release assays were performed with unhydrolyzed triacetate and commercial systems diacetate and the percentage of naproxen released was obtained by square wave voltammetry. For both polymers, the asymmetric membranes had higher cumulative percentage of drug released as compared to symmetric membranes. Asymmetric membranes diacetate reached about 80% release and that release was 30% to symmetric membranes. In the preparation of the microparticles were taken formulations acetate/solvent/naproxen acetate/ solvent/pore forming agent/naproxen. As solvents were used as dichloromethane for dioxane triacetate and diacetate for commercial as pore formers were inserted in formulations polyethylene glycol and water. Systems were prepared with different concentrations of naproxen in the ratio w/w acetate:drug 10:1, 2:1 and 1:1. The thermal analysis showed that the improved composition of the system polymer/drug was 10:1 w/w, since the drug does not appear melting peaks showing that the drug is molecularly dispersed in the polymer matrix. The kinetic model of drug release is broadcast solution. The particles produced with triacetate showed a release exceeding drug the particle produced commercially diacetate, where particles produced diacetate had a mean release of 2%, while the particles produced with modified triaceato reached about 25% release, featuring differences the interaction between the transparencies and the drug as well as increased stiffness of the particles produced with commercial diacetate. Modifications to polietilenogilicol and water in the particles with triacetate increased the release of naproxen, the release of the modified particles became 13% more than the release of the non-modified particles. The results show that the morphological changes in the controlled release systems are effective considering the increase in the percentage of drug release. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015-12-04 |
dc.date.accessioned.fl_str_mv |
2016-06-22T18:49:02Z |
dc.date.available.fl_str_mv |
2016-04-07 2016-06-22T18:49:02Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/doctoralThesis |
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ALVES, Janainne Nunes. Produção e caracterização de matrizes modelo de triacetatos de celulose obtidos da palha de milho e diacetato comercial para liberação controlada de naproxeno. 2015. 147 f. Tese (Doutorado em Ciências Exatas e da Terra) - Universidade Federal de Uberlândia, Uberlândia, 2015. Disponível em: https://doi.org/10.14393/ufu.te.2015.155 |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufu.br/handle/123456789/17533 |
dc.identifier.doi.por.fl_str_mv |
https://doi.org/10.14393/ufu.te.2015.155 |
identifier_str_mv |
ALVES, Janainne Nunes. Produção e caracterização de matrizes modelo de triacetatos de celulose obtidos da palha de milho e diacetato comercial para liberação controlada de naproxeno. 2015. 147 f. Tese (Doutorado em Ciências Exatas e da Terra) - Universidade Federal de Uberlândia, Uberlândia, 2015. Disponível em: https://doi.org/10.14393/ufu.te.2015.155 |
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https://repositorio.ufu.br/handle/123456789/17533 https://doi.org/10.14393/ufu.te.2015.155 |
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Universidade Federal de Uberlândia |
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Ciências Exatas e da Terra |
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Universidade Federal de Uberlândia |
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