Análise do polimorfismo T-786C do gene da óxido nítrico sintase na Doença Arterial Coronariana (DAC)
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Tipo de documento: | Trabalho de conclusão de curso |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFU |
Texto Completo: | https://repositorio.ufu.br/handle/123456789/27918 |
Resumo: | Currently, cardiovascular diseases (CVDs) are the leading cause of mortality in the world. Among all CVDs, the coronary artery disease (CAD) stands out, as it is the most common and the leading cause of death of them. CAD is characterized by insufficient blood supply to the cardiac cells due to the development of thrombi and atheromatous plaque in the coronary artery. The disease has a multifactorial characteristic, therefore, not only the environmental conditions can promote its development but also the genetic inheritance of the individual. This study aims to clarify, or at least in part, the influence of the T-786C gene on CAD manifestation. This polymorphism decreases the formation of nitric oxide (NO) in the cardiovascular system by altering the endothelial nitric oxide synthase (eNOS) production. This study was performed in 124 individuals and the results indicated a significant association (p = 0.0105) and dependence (p = 0.0102) between the polymorphism in individuals with CAD in comparison to the control group. In addition, it was found a positive correlation between the development of the cardiovascular disease and the age advancing due to the cumulative characteristic of the pathology. Summing up, it is extremely important to detect early CAD pacients to define risk groups and provide a better approach in the prevention and treatment of the disease. |
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Análise do polimorfismo T-786C do gene da óxido nítrico sintase na Doença Arterial Coronariana (DAC)PolimorfismoDoença Arterial CoronarianaT-786CÓxido nítricoÓxido nítrico sintaseCNPQ::CIENCIAS DA SAUDE::SAUDE COLETIVA::MEDICINA PREVENTIVACurrently, cardiovascular diseases (CVDs) are the leading cause of mortality in the world. Among all CVDs, the coronary artery disease (CAD) stands out, as it is the most common and the leading cause of death of them. CAD is characterized by insufficient blood supply to the cardiac cells due to the development of thrombi and atheromatous plaque in the coronary artery. The disease has a multifactorial characteristic, therefore, not only the environmental conditions can promote its development but also the genetic inheritance of the individual. This study aims to clarify, or at least in part, the influence of the T-786C gene on CAD manifestation. This polymorphism decreases the formation of nitric oxide (NO) in the cardiovascular system by altering the endothelial nitric oxide synthase (eNOS) production. This study was performed in 124 individuals and the results indicated a significant association (p = 0.0105) and dependence (p = 0.0102) between the polymorphism in individuals with CAD in comparison to the control group. In addition, it was found a positive correlation between the development of the cardiovascular disease and the age advancing due to the cumulative characteristic of the pathology. Summing up, it is extremely important to detect early CAD pacients to define risk groups and provide a better approach in the prevention and treatment of the disease.UFU - Universidade Federal de UberlândiaTrabalho de Conclusão de Curso (Graduação)Atualmente as doenças cardiovasculares (DCVs) são a principal causa de mortalidade no mundo. Dentre as DCVs, destaca-se a doença arterial coronariana (DAC), por ser a que acomete um maior número de indivíduos e a que mais causa óbitos. A DAC caracteriza-se pela insuficiência de suprimento sanguíneo às células cardíacas devido ao desenvolvimento placas de ateroma e de trombos na artéria coronariana. A doença possui um caráter multifatorial, sendo assim, não só as condições ambientais podem propiciar seu desenvolvimento, como também a herança genética do indivíduo. Este estudo contribui para elucidar, ao menos em parte, a influência do polimorfismo T-786C do gene da óxido nítrico sintase na manifestação da DAC. É sabido que a presença deste polimorfismo reduz a produção de óxido nítrico (NO) no sistema cardiovascular por alterar a atividade da óxido nítrico sintase endotelial (eNOS). Neste estudo foram estudados 124 indivíduos e os resultados indicaram associação significativa (p=0,0105) e dependência (p=0,0102) do polimorfismo em pacientes caso em relação aos pacientes controle. Além disso, encontrou-se uma correlação positiva entre o surgimento da doença cardiovascular e o avanço da faixa etária devido ao caráter cumulativo da patologia. Com isso, torna-se de suma importância a detecção precoce da DAC e a estratificação de grupos de alto risco para a melhor abordagem no tratamento e prevenção da enfermidadeUniversidade Federal de UberlândiaBrasilBiomedicinaCordeiro, Elisângela Rosahttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4700333A8&tokenCaptchar=03AOLTBLRxRBMg8EVI2dtyMt65sRkIjRWRi1kqYhQV_WWMxp4UZ_2Ko3gIoB_6MFc_TkBz72fc0pwRrUoTcbFXqfMzcz2W-wsWdOEPMpNmvp7ihlIv12If78Jr94V7N8hvK6a97MNsN-hRXVCVKL-_GOHmLVDiXatQIb8ONu9v-dScBGP6WtMEnGctYUzlnTraLQe5EYb2c7myDHopYGRnpnnztRHegIQGwyyqaF6TuBtCq41CDyWJ22TB06SwUeHQexxAf9KhL5rpByTBz-7A7Su7vs8-nsjuVXymmCDWyvOLfgntdpetoWDl_DBMDpEtTkQ4YwAardOj1Vf2L-kbmKjadkmtGzBq_P6n_EbIH9XeuagW3BigFzVP21qRzA2DVsYyEiKGkMjqxF9o0C1ZeuhTkQclTmeHENtGRfwyujenOIblpxCssNlQ8jc9YBYx2yVh0p0HH1aUJu8z0lOYAKDYHx9qzOaru-WMwj2_FvUFeudJT5X9PK7ROEmAd3Yj5ng4N0tuOttmFu9iCkx_LmuiF1D4Fw9gagSilva, Luiz Borges Bispo dahttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4739008D6&tokenCaptchar=03AOLTBLQD3SRTAv1g6X2cnZ-qMvKL06U98fPWydDikpTffuXg75ggQgrqtPRX2onGoxTYnpAbfbX7jYWqdTPH7FMC2Crpieh58OEDgAm1ErQy1TMd28R5CReGWborp2cNIgLsu8rNEiaWkGY6w9DD2wHn6ZJWpNqGii0wrZpnTDMkaj05JK_CzYgTmMsYHnUjH19D2ei5OZv-XcIDjbxjzA43PO__TIxIw1G0EIk2qElUluBRmiUoyW1lzvsxr7i4ET4AAVo1PsZ8b7K1xk__mCz9BR9L_CpXrYlX0Xrac_zpROu315QHwNY2_CWKJ90Hf42LbCKZ5R5BQwH9H5OEiJqlnQbmXUzi5iP7-ooNXqRgm_5iPdUEkM5-mGTnqAXyriPKMbnY0hFbbRIlK63h3rLZmtPg90ufmT4TTCsI6bbBDo9vrk4mHaQn5id6z-TPOeFm0siPRy_TxZFH-8k5HdQXYfMzALUu5XMGhyOjfNhNbaF9krhxogJsP3nv6TQojCg0qRxTZ6VI7iJXZketwrcZL8hkC-UnqwGuzman, Valeska Barceloshttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4700787J7&tokenCaptchar=03AOLTBLRKZankdXMdr02QmI28RMYkF_MmFzWH1vZdLMoBeByWMWRYDHqOI9wWR1R1pty4E59NR3c1LvFWM5audL8krR1_P7M2mJhcy1n0eDNa2n7_kPnFtH5cVhj63aQyng3nKotwG4udqVyow1yMmO4kpt4MpCmvvw0M37DZM67OE4G_u6nTGSwlBHuUpSxU9sJhrA41PmUcYxc8KQaN_tIIZHymVeXtCYnanVCS-v4w1mxslQH2pUWlEhKU-ZxXKjZwUj8Dtm3aIO7ZuSNf0cUDtVTc6CEpOztyLGWWGPGzEfdrkVHgTjarR9WvxnE8rUwEbc6_D7kYr1ZszdWo8Vl3u-VsvOM7lv8plyVnP7C5jCHdbAMGFCBTspRcjI8lgPMwoL7WCvYw2yR0ARhVXQ3RLzYhRoPZbRNEjO6znO83yAWm6VLKs1-Ii8fQfupeOyfQLB4gnZAS9kUkxMVbCgktsWJu8Cg1Uj2YmvaR81tLokNsWErl0fexs4nam1psVuoN_AO29IAo8PyrSFeLy5oFNT9fE68ZAAJasinevicius, Gabriel Oliveira2019-12-20T16:18:34Z2019-12-20T16:18:34Z2019-12-13info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bachelorThesisapplication/pdfJASINEVICIUS, Gabriel Oliveira. Análise do polimorfismo T-786C do gene da óxido nítrico sintase na Doença Arterial Coronariana (DAC). 2019. 23 f. Trabalho de Conclusão de Curso (Graduação em Biomedicina) – Universidade Federal de Uberlândia, Uberlândia, 2019.https://repositorio.ufu.br/handle/123456789/27918porinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFUinstname:Universidade Federal de Uberlândia (UFU)instacron:UFU2019-12-21T06:15:54Zoai:repositorio.ufu.br:123456789/27918Repositório InstitucionalONGhttp://repositorio.ufu.br/oai/requestdiinf@dirbi.ufu.bropendoar:2019-12-21T06:15:54Repositório Institucional da UFU - Universidade Federal de Uberlândia (UFU)false |
dc.title.none.fl_str_mv |
Análise do polimorfismo T-786C do gene da óxido nítrico sintase na Doença Arterial Coronariana (DAC) |
title |
Análise do polimorfismo T-786C do gene da óxido nítrico sintase na Doença Arterial Coronariana (DAC) |
spellingShingle |
Análise do polimorfismo T-786C do gene da óxido nítrico sintase na Doença Arterial Coronariana (DAC) Jasinevicius, Gabriel Oliveira Polimorfismo Doença Arterial Coronariana T-786C Óxido nítrico Óxido nítrico sintase CNPQ::CIENCIAS DA SAUDE::SAUDE COLETIVA::MEDICINA PREVENTIVA |
title_short |
Análise do polimorfismo T-786C do gene da óxido nítrico sintase na Doença Arterial Coronariana (DAC) |
title_full |
Análise do polimorfismo T-786C do gene da óxido nítrico sintase na Doença Arterial Coronariana (DAC) |
title_fullStr |
Análise do polimorfismo T-786C do gene da óxido nítrico sintase na Doença Arterial Coronariana (DAC) |
title_full_unstemmed |
Análise do polimorfismo T-786C do gene da óxido nítrico sintase na Doença Arterial Coronariana (DAC) |
title_sort |
Análise do polimorfismo T-786C do gene da óxido nítrico sintase na Doença Arterial Coronariana (DAC) |
author |
Jasinevicius, Gabriel Oliveira |
author_facet |
Jasinevicius, Gabriel Oliveira |
author_role |
author |
dc.contributor.none.fl_str_mv |
Cordeiro, Elisângela Rosa http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4700333A8&tokenCaptchar=03AOLTBLRxRBMg8EVI2dtyMt65sRkIjRWRi1kqYhQV_WWMxp4UZ_2Ko3gIoB_6MFc_TkBz72fc0pwRrUoTcbFXqfMzcz2W-wsWdOEPMpNmvp7ihlIv12If78Jr94V7N8hvK6a97MNsN-hRXVCVKL-_GOHmLVDiXatQIb8ONu9v-dScBGP6WtMEnGctYUzlnTraLQe5EYb2c7myDHopYGRnpnnztRHegIQGwyyqaF6TuBtCq41CDyWJ22TB06SwUeHQexxAf9KhL5rpByTBz-7A7Su7vs8-nsjuVXymmCDWyvOLfgntdpetoWDl_DBMDpEtTkQ4YwAardOj1Vf2L-kbmKjadkmtGzBq_P6n_EbIH9XeuagW3BigFzVP21qRzA2DVsYyEiKGkMjqxF9o0C1ZeuhTkQclTmeHENtGRfwyujenOIblpxCssNlQ8jc9YBYx2yVh0p0HH1aUJu8z0lOYAKDYHx9qzOaru-WMwj2_FvUFeudJT5X9PK7ROEmAd3Yj5ng4N0tuOttmFu9iCkx_LmuiF1D4Fw9gag Silva, Luiz Borges Bispo da http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4739008D6&tokenCaptchar=03AOLTBLQD3SRTAv1g6X2cnZ-qMvKL06U98fPWydDikpTffuXg75ggQgrqtPRX2onGoxTYnpAbfbX7jYWqdTPH7FMC2Crpieh58OEDgAm1ErQy1TMd28R5CReGWborp2cNIgLsu8rNEiaWkGY6w9DD2wHn6ZJWpNqGii0wrZpnTDMkaj05JK_CzYgTmMsYHnUjH19D2ei5OZv-XcIDjbxjzA43PO__TIxIw1G0EIk2qElUluBRmiUoyW1lzvsxr7i4ET4AAVo1PsZ8b7K1xk__mCz9BR9L_CpXrYlX0Xrac_zpROu315QHwNY2_CWKJ90Hf42LbCKZ5R5BQwH9H5OEiJqlnQbmXUzi5iP7-ooNXqRgm_5iPdUEkM5-mGTnqAXyriPKMbnY0hFbbRIlK63h3rLZmtPg90ufmT4TTCsI6bbBDo9vrk4mHaQn5id6z-TPOeFm0siPRy_TxZFH-8k5HdQXYfMzALUu5XMGhyOjfNhNbaF9krhxogJsP3nv6TQojCg0qRxTZ6VI7iJXZketwrcZL8hkC-Unqw Guzman, Valeska Barcelos http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4700787J7&tokenCaptchar=03AOLTBLRKZankdXMdr02QmI28RMYkF_MmFzWH1vZdLMoBeByWMWRYDHqOI9wWR1R1pty4E59NR3c1LvFWM5audL8krR1_P7M2mJhcy1n0eDNa2n7_kPnFtH5cVhj63aQyng3nKotwG4udqVyow1yMmO4kpt4MpCmvvw0M37DZM67OE4G_u6nTGSwlBHuUpSxU9sJhrA41PmUcYxc8KQaN_tIIZHymVeXtCYnanVCS-v4w1mxslQH2pUWlEhKU-ZxXKjZwUj8Dtm3aIO7ZuSNf0cUDtVTc6CEpOztyLGWWGPGzEfdrkVHgTjarR9WvxnE8rUwEbc6_D7kYr1ZszdWo8Vl3u-VsvOM7lv8plyVnP7C5jCHdbAMGFCBTspRcjI8lgPMwoL7WCvYw2yR0ARhVXQ3RLzYhRoPZbRNEjO6znO83yAWm6VLKs1-Ii8fQfupeOyfQLB4gnZAS9kUkxMVbCgktsWJu8Cg1Uj2YmvaR81tLokNsWErl0fexs4nam1psVuoN_AO29IAo8PyrSFeLy5oFNT9fE68ZAA |
dc.contributor.author.fl_str_mv |
Jasinevicius, Gabriel Oliveira |
dc.subject.por.fl_str_mv |
Polimorfismo Doença Arterial Coronariana T-786C Óxido nítrico Óxido nítrico sintase CNPQ::CIENCIAS DA SAUDE::SAUDE COLETIVA::MEDICINA PREVENTIVA |
topic |
Polimorfismo Doença Arterial Coronariana T-786C Óxido nítrico Óxido nítrico sintase CNPQ::CIENCIAS DA SAUDE::SAUDE COLETIVA::MEDICINA PREVENTIVA |
description |
Currently, cardiovascular diseases (CVDs) are the leading cause of mortality in the world. Among all CVDs, the coronary artery disease (CAD) stands out, as it is the most common and the leading cause of death of them. CAD is characterized by insufficient blood supply to the cardiac cells due to the development of thrombi and atheromatous plaque in the coronary artery. The disease has a multifactorial characteristic, therefore, not only the environmental conditions can promote its development but also the genetic inheritance of the individual. This study aims to clarify, or at least in part, the influence of the T-786C gene on CAD manifestation. This polymorphism decreases the formation of nitric oxide (NO) in the cardiovascular system by altering the endothelial nitric oxide synthase (eNOS) production. This study was performed in 124 individuals and the results indicated a significant association (p = 0.0105) and dependence (p = 0.0102) between the polymorphism in individuals with CAD in comparison to the control group. In addition, it was found a positive correlation between the development of the cardiovascular disease and the age advancing due to the cumulative characteristic of the pathology. Summing up, it is extremely important to detect early CAD pacients to define risk groups and provide a better approach in the prevention and treatment of the disease. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-12-20T16:18:34Z 2019-12-20T16:18:34Z 2019-12-13 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/bachelorThesis |
format |
bachelorThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
JASINEVICIUS, Gabriel Oliveira. Análise do polimorfismo T-786C do gene da óxido nítrico sintase na Doença Arterial Coronariana (DAC). 2019. 23 f. Trabalho de Conclusão de Curso (Graduação em Biomedicina) – Universidade Federal de Uberlândia, Uberlândia, 2019. https://repositorio.ufu.br/handle/123456789/27918 |
identifier_str_mv |
JASINEVICIUS, Gabriel Oliveira. Análise do polimorfismo T-786C do gene da óxido nítrico sintase na Doença Arterial Coronariana (DAC). 2019. 23 f. Trabalho de Conclusão de Curso (Graduação em Biomedicina) – Universidade Federal de Uberlândia, Uberlândia, 2019. |
url |
https://repositorio.ufu.br/handle/123456789/27918 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Uberlândia Brasil Biomedicina |
publisher.none.fl_str_mv |
Universidade Federal de Uberlândia Brasil Biomedicina |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFU instname:Universidade Federal de Uberlândia (UFU) instacron:UFU |
instname_str |
Universidade Federal de Uberlândia (UFU) |
instacron_str |
UFU |
institution |
UFU |
reponame_str |
Repositório Institucional da UFU |
collection |
Repositório Institucional da UFU |
repository.name.fl_str_mv |
Repositório Institucional da UFU - Universidade Federal de Uberlândia (UFU) |
repository.mail.fl_str_mv |
diinf@dirbi.ufu.br |
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1813711510307864576 |