Elevation of HbA1c in hyperglycemic women with decreased iron involves increased osmotic stability and volume variability (RDW) of red cells

Detalhes bibliográficos
Autor(a) principal: Silva, Breno Batista da
Data de Publicação: 2020
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositório Institucional da UFU
Texto Completo: https://repositorio.ufu.br/handle/123456789/30259
http://doi.org/10.14393/ufu.di.2020.641
Resumo: Background: Glycated hemoglobin (HbA1c) concentrations are associated not only with glucose, but also with iron levels, and this requires careful clinical attention, especially in hyperglycemic individuals. Objective: This study aimed to analyze the associations of anthropometric, inflammatory, regulatory, metabolic, and hematologic variables with iron status and HbA1c levels in hyperglycemic women. Methods: A total of 143 (68 normoglycemic and 75 hyperglycemic) women participated in this prospective cross-sectional study. Comparisons between groups used the Mann-Whitney test, and the search for associations between pairs of variables used the Spearman correlation method. Results: In hyperglycemic women, decreased iron associates with increased HbA1c, and these changes are both associated with inflammatory status and involve decreased intracellular hemoglobin concentration (MCHC), which in turn, involves enhanced osmotic stability (dX) and volume variability (RDW) of erythrocytes, as well as decreased hemoglobin catabolism. This decreased hemoglobin catabolism does not seem to be solely a process associated with diminished intracellular concentrations of this protein since it is associated with inflammatory status and decreased LDL-cholesterol. Conclusion: In hyperglycemic women, the elevation of HbA1c with decreased iron is linked with obesity-associated inflammation and involves changes associated with increased osmotic stability and distribution width (RDW) in red cells.
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spelling Elevation of HbA1c in hyperglycemic women with decreased iron involves increased osmotic stability and volume variability (RDW) of red cellsA elevação de HbA1c em mulheres hiperglicêmicas com níveis diminuídos de ferro envolve aumento da estabilidade osmótica e da variabilidade de volume (RDW) de células vermelhasObesityInflammationHyperglycemiaGlycated HemoglobinIron deficiencyErythrocytesObesidadeInflamaçãoHiperglicemiaHemoglobina glicadaDeficiência de ferroEritrócitosEstabilidade osmóticaCNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICAGenéticaBackground: Glycated hemoglobin (HbA1c) concentrations are associated not only with glucose, but also with iron levels, and this requires careful clinical attention, especially in hyperglycemic individuals. Objective: This study aimed to analyze the associations of anthropometric, inflammatory, regulatory, metabolic, and hematologic variables with iron status and HbA1c levels in hyperglycemic women. Methods: A total of 143 (68 normoglycemic and 75 hyperglycemic) women participated in this prospective cross-sectional study. Comparisons between groups used the Mann-Whitney test, and the search for associations between pairs of variables used the Spearman correlation method. Results: In hyperglycemic women, decreased iron associates with increased HbA1c, and these changes are both associated with inflammatory status and involve decreased intracellular hemoglobin concentration (MCHC), which in turn, involves enhanced osmotic stability (dX) and volume variability (RDW) of erythrocytes, as well as decreased hemoglobin catabolism. This decreased hemoglobin catabolism does not seem to be solely a process associated with diminished intracellular concentrations of this protein since it is associated with inflammatory status and decreased LDL-cholesterol. Conclusion: In hyperglycemic women, the elevation of HbA1c with decreased iron is linked with obesity-associated inflammation and involves changes associated with increased osmotic stability and distribution width (RDW) in red cells.CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoDissertação (Mestrado)Introdução: As concentrações de hemoglobina glicada (HbA1c) estão associadas não apenas à glicose, mas também aos níveis de ferro, e isso requer atenção clínica cuidadosa, especialmente em indivíduos hiperglicêmicos. Objetivo: Este estudo teve como objetivo analisar as associações de variáveis antropométricas, inflamatórias, regulatórias, metabólicas e hematológicas, com indicadores do status do ferro e níveis de HbA1c em mulheres hiperglicêmicas. Métodos: Participaram deste estudo transversal prospectivo 143 mulheres (68 normoglicêmicas e 75 hiperglicêmicas). As comparações entre os grupos utilizaram o teste de Mann-Whitney e a busca de associações entre pares de variáveis utilizou o método de correlação de Spearman. Resultados: Em mulheres hiperglicêmicas, a diminuição de ferro associa-se ao aumento da HbA1c, e essas alterações estão ambas associadas ao estado inflamatório e envolvem diminuição da concentração de hemoglobina intracelular (CHCM), que por sua vez, envolve aumento da estabilidade osmótica (dX) e da variabilidade de volume (RDW) de eritrócitos, bem como diminuição do catabolismo da hemoglobina. Essa diminuição do catabolismo da hemoglobina não parece ser apenas um processo associado à diminuição das concentrações intracelulares dessa proteína, uma vez que está associada ao estado inflamatório e à diminuição de LDL-colesterol. Conclusão: Em mulheres hiperglicêmicas, a elevação da HbA1c com a diminuição do ferro está ligada à inflamação associada à obesidade e envolve mudanças associadas ao aumento da estabilidade osmótica e à variabilidade de volume (RDW) de eritrócitos.2022-10-23Universidade Federal de UberlândiaBrasilPrograma de Pós-graduação em Genética e BioquímicaCheik, Nadia Carlahttp://lattes.cnpq.br/2879799494543129Silva, Nilson Penhahttp://lattes.cnpq.br/4510680230895111Bernardino Neto, Morunhttp://lattes.cnpq.br/1364859879844183Rodrigues, RicardoSilva, Breno Batista da2020-11-04T00:15:59Z2020-11-04T00:15:59Z2020-09-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfSILVA, Breno Batista da. Elevation of HbA1c in hyperglycemic women with decreased iron involves increased osmotic stability and volume variability (RDW) of red cells. 2020. 39 f. Dissertação (Mestrado em Genética e Bioquímica) - Universidade Federal de Uberlândia, Uberlândia, 2020. DOI http://doi.org/10.14393/ufu.di.2020.641https://repositorio.ufu.br/handle/123456789/30259http://doi.org/10.14393/ufu.di.2020.641enginfo:eu-repo/semantics/embargoedAccessreponame:Repositório Institucional da UFUinstname:Universidade Federal de Uberlândia (UFU)instacron:UFU2022-07-26T19:21:46Zoai:repositorio.ufu.br:123456789/30259Repositório InstitucionalONGhttp://repositorio.ufu.br/oai/requestdiinf@dirbi.ufu.bropendoar:2022-07-26T19:21:46Repositório Institucional da UFU - Universidade Federal de Uberlândia (UFU)false
dc.title.none.fl_str_mv Elevation of HbA1c in hyperglycemic women with decreased iron involves increased osmotic stability and volume variability (RDW) of red cells
A elevação de HbA1c em mulheres hiperglicêmicas com níveis diminuídos de ferro envolve aumento da estabilidade osmótica e da variabilidade de volume (RDW) de células vermelhas
title Elevation of HbA1c in hyperglycemic women with decreased iron involves increased osmotic stability and volume variability (RDW) of red cells
spellingShingle Elevation of HbA1c in hyperglycemic women with decreased iron involves increased osmotic stability and volume variability (RDW) of red cells
Silva, Breno Batista da
Obesity
Inflammation
Hyperglycemia
Glycated Hemoglobin
Iron deficiency
Erythrocytes
Obesidade
Inflamação
Hiperglicemia
Hemoglobina glicada
Deficiência de ferro
Eritrócitos
Estabilidade osmótica
CNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICA
Genética
title_short Elevation of HbA1c in hyperglycemic women with decreased iron involves increased osmotic stability and volume variability (RDW) of red cells
title_full Elevation of HbA1c in hyperglycemic women with decreased iron involves increased osmotic stability and volume variability (RDW) of red cells
title_fullStr Elevation of HbA1c in hyperglycemic women with decreased iron involves increased osmotic stability and volume variability (RDW) of red cells
title_full_unstemmed Elevation of HbA1c in hyperglycemic women with decreased iron involves increased osmotic stability and volume variability (RDW) of red cells
title_sort Elevation of HbA1c in hyperglycemic women with decreased iron involves increased osmotic stability and volume variability (RDW) of red cells
author Silva, Breno Batista da
author_facet Silva, Breno Batista da
author_role author
dc.contributor.none.fl_str_mv Cheik, Nadia Carla
http://lattes.cnpq.br/2879799494543129
Silva, Nilson Penha
http://lattes.cnpq.br/4510680230895111
Bernardino Neto, Morun
http://lattes.cnpq.br/1364859879844183
Rodrigues, Ricardo
dc.contributor.author.fl_str_mv Silva, Breno Batista da
dc.subject.por.fl_str_mv Obesity
Inflammation
Hyperglycemia
Glycated Hemoglobin
Iron deficiency
Erythrocytes
Obesidade
Inflamação
Hiperglicemia
Hemoglobina glicada
Deficiência de ferro
Eritrócitos
Estabilidade osmótica
CNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICA
Genética
topic Obesity
Inflammation
Hyperglycemia
Glycated Hemoglobin
Iron deficiency
Erythrocytes
Obesidade
Inflamação
Hiperglicemia
Hemoglobina glicada
Deficiência de ferro
Eritrócitos
Estabilidade osmótica
CNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICA
Genética
description Background: Glycated hemoglobin (HbA1c) concentrations are associated not only with glucose, but also with iron levels, and this requires careful clinical attention, especially in hyperglycemic individuals. Objective: This study aimed to analyze the associations of anthropometric, inflammatory, regulatory, metabolic, and hematologic variables with iron status and HbA1c levels in hyperglycemic women. Methods: A total of 143 (68 normoglycemic and 75 hyperglycemic) women participated in this prospective cross-sectional study. Comparisons between groups used the Mann-Whitney test, and the search for associations between pairs of variables used the Spearman correlation method. Results: In hyperglycemic women, decreased iron associates with increased HbA1c, and these changes are both associated with inflammatory status and involve decreased intracellular hemoglobin concentration (MCHC), which in turn, involves enhanced osmotic stability (dX) and volume variability (RDW) of erythrocytes, as well as decreased hemoglobin catabolism. This decreased hemoglobin catabolism does not seem to be solely a process associated with diminished intracellular concentrations of this protein since it is associated with inflammatory status and decreased LDL-cholesterol. Conclusion: In hyperglycemic women, the elevation of HbA1c with decreased iron is linked with obesity-associated inflammation and involves changes associated with increased osmotic stability and distribution width (RDW) in red cells.
publishDate 2020
dc.date.none.fl_str_mv 2020-11-04T00:15:59Z
2020-11-04T00:15:59Z
2020-09-30
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv SILVA, Breno Batista da. Elevation of HbA1c in hyperglycemic women with decreased iron involves increased osmotic stability and volume variability (RDW) of red cells. 2020. 39 f. Dissertação (Mestrado em Genética e Bioquímica) - Universidade Federal de Uberlândia, Uberlândia, 2020. DOI http://doi.org/10.14393/ufu.di.2020.641
https://repositorio.ufu.br/handle/123456789/30259
http://doi.org/10.14393/ufu.di.2020.641
identifier_str_mv SILVA, Breno Batista da. Elevation of HbA1c in hyperglycemic women with decreased iron involves increased osmotic stability and volume variability (RDW) of red cells. 2020. 39 f. Dissertação (Mestrado em Genética e Bioquímica) - Universidade Federal de Uberlândia, Uberlândia, 2020. DOI http://doi.org/10.14393/ufu.di.2020.641
url https://repositorio.ufu.br/handle/123456789/30259
http://doi.org/10.14393/ufu.di.2020.641
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Uberlândia
Brasil
Programa de Pós-graduação em Genética e Bioquímica
publisher.none.fl_str_mv Universidade Federal de Uberlândia
Brasil
Programa de Pós-graduação em Genética e Bioquímica
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFU
instname:Universidade Federal de Uberlândia (UFU)
instacron:UFU
instname_str Universidade Federal de Uberlândia (UFU)
instacron_str UFU
institution UFU
reponame_str Repositório Institucional da UFU
collection Repositório Institucional da UFU
repository.name.fl_str_mv Repositório Institucional da UFU - Universidade Federal de Uberlândia (UFU)
repository.mail.fl_str_mv diinf@dirbi.ufu.br
_version_ 1805569632439894016

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