Bone mineral density of rat femurs after hindlimb unloading and different physical rehabilitation programs

Detalhes bibliográficos
Autor(a) principal: Barbosa,Adelton Andrade
Data de Publicação: 2011
Outros Autores: Del Carlo,Ricardo Junqueira, Galvão,Simone Rezende, Vilela,Marcelo José, Louzada,Mário Jefferson Quirino, Brito,Ana Flora Sousa, Natali,Antonio José
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Ceres
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-737X2011000400001
Resumo: Bone weakening can occur due to the absence of load on the skeleton or even short periods of decreased physical activity. Therefore, musculoskeletal diseases that involve temporary immobilization by casts, inactivity or tension increases the risk of fractures. Physical activity is the most studied procedure both to prevent damage and to restore bone structure. The present study aimed at evaluating, by bone densitometry on rat femurs, the influence of hindlimb unloading and later running activity on treadmill or free movement. Sixty-four Wistar rats were used, aged 65 days with a mean corporal mass of 316.11g, randomly divided into eight experimental groups: group 1, the suspended control with seven animals under hindlimb unloading regimen for 28 days, then euthanized; groups 2 and 3, the trained suspended comprising of 7 and five animals, respectively, subjected to hindlimb unloading for 28 days, followed by treadmill exercise for 28 days (group 2) or 56 days (group 3), then euthanized; groups 4 and 5, designated free suspended, comprised of 7 animals each under hindlimb unloading regimen for 28 days followed by free activity in cages for 28 days (group 4) or 56 days (group 5), then euthanized; groups 6, 7 and 8, negative controls, each with 8 animals allowed to free activity in cages and euthanized at the ages of 93, 121 and 149 days, respectively. Bone mineral density (BMD) of the left femur was analyzed by bone densitometry. Unloading by tail-suspension decreased BMD while treadmill training and free activity in cages promoted its recovery in a similar way and over time.
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spelling Bone mineral density of rat femurs after hindlimb unloading and different physical rehabilitation programsPhysical trainingphysical rehabilitationbone mineral densityBone weakening can occur due to the absence of load on the skeleton or even short periods of decreased physical activity. Therefore, musculoskeletal diseases that involve temporary immobilization by casts, inactivity or tension increases the risk of fractures. Physical activity is the most studied procedure both to prevent damage and to restore bone structure. The present study aimed at evaluating, by bone densitometry on rat femurs, the influence of hindlimb unloading and later running activity on treadmill or free movement. Sixty-four Wistar rats were used, aged 65 days with a mean corporal mass of 316.11g, randomly divided into eight experimental groups: group 1, the suspended control with seven animals under hindlimb unloading regimen for 28 days, then euthanized; groups 2 and 3, the trained suspended comprising of 7 and five animals, respectively, subjected to hindlimb unloading for 28 days, followed by treadmill exercise for 28 days (group 2) or 56 days (group 3), then euthanized; groups 4 and 5, designated free suspended, comprised of 7 animals each under hindlimb unloading regimen for 28 days followed by free activity in cages for 28 days (group 4) or 56 days (group 5), then euthanized; groups 6, 7 and 8, negative controls, each with 8 animals allowed to free activity in cages and euthanized at the ages of 93, 121 and 149 days, respectively. Bone mineral density (BMD) of the left femur was analyzed by bone densitometry. Unloading by tail-suspension decreased BMD while treadmill training and free activity in cages promoted its recovery in a similar way and over time.Universidade Federal de Viçosa2011-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-737X2011000400001Revista Ceres v.58 n.4 2011reponame:Revista Ceresinstname:Universidade Federal de Viçosa (UFV)instacron:UFV10.1590/S0034-737X2011000400001info:eu-repo/semantics/openAccessBarbosa,Adelton AndradeDel Carlo,Ricardo JunqueiraGalvão,Simone RezendeVilela,Marcelo JoséLouzada,Mário Jefferson QuirinoBrito,Ana Flora SousaNatali,Antonio Joséeng2011-09-16T00:00:00ZRevista
dc.title.none.fl_str_mv Bone mineral density of rat femurs after hindlimb unloading and different physical rehabilitation programs
title Bone mineral density of rat femurs after hindlimb unloading and different physical rehabilitation programs
spellingShingle Bone mineral density of rat femurs after hindlimb unloading and different physical rehabilitation programs
Barbosa,Adelton Andrade
Physical training
physical rehabilitation
bone mineral density
title_short Bone mineral density of rat femurs after hindlimb unloading and different physical rehabilitation programs
title_full Bone mineral density of rat femurs after hindlimb unloading and different physical rehabilitation programs
title_fullStr Bone mineral density of rat femurs after hindlimb unloading and different physical rehabilitation programs
title_full_unstemmed Bone mineral density of rat femurs after hindlimb unloading and different physical rehabilitation programs
title_sort Bone mineral density of rat femurs after hindlimb unloading and different physical rehabilitation programs
author Barbosa,Adelton Andrade
author_facet Barbosa,Adelton Andrade
Del Carlo,Ricardo Junqueira
Galvão,Simone Rezende
Vilela,Marcelo José
Louzada,Mário Jefferson Quirino
Brito,Ana Flora Sousa
Natali,Antonio José
author_role author
author2 Del Carlo,Ricardo Junqueira
Galvão,Simone Rezende
Vilela,Marcelo José
Louzada,Mário Jefferson Quirino
Brito,Ana Flora Sousa
Natali,Antonio José
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Barbosa,Adelton Andrade
Del Carlo,Ricardo Junqueira
Galvão,Simone Rezende
Vilela,Marcelo José
Louzada,Mário Jefferson Quirino
Brito,Ana Flora Sousa
Natali,Antonio José
dc.subject.por.fl_str_mv Physical training
physical rehabilitation
bone mineral density
topic Physical training
physical rehabilitation
bone mineral density
dc.description.none.fl_txt_mv Bone weakening can occur due to the absence of load on the skeleton or even short periods of decreased physical activity. Therefore, musculoskeletal diseases that involve temporary immobilization by casts, inactivity or tension increases the risk of fractures. Physical activity is the most studied procedure both to prevent damage and to restore bone structure. The present study aimed at evaluating, by bone densitometry on rat femurs, the influence of hindlimb unloading and later running activity on treadmill or free movement. Sixty-four Wistar rats were used, aged 65 days with a mean corporal mass of 316.11g, randomly divided into eight experimental groups: group 1, the suspended control with seven animals under hindlimb unloading regimen for 28 days, then euthanized; groups 2 and 3, the trained suspended comprising of 7 and five animals, respectively, subjected to hindlimb unloading for 28 days, followed by treadmill exercise for 28 days (group 2) or 56 days (group 3), then euthanized; groups 4 and 5, designated free suspended, comprised of 7 animals each under hindlimb unloading regimen for 28 days followed by free activity in cages for 28 days (group 4) or 56 days (group 5), then euthanized; groups 6, 7 and 8, negative controls, each with 8 animals allowed to free activity in cages and euthanized at the ages of 93, 121 and 149 days, respectively. Bone mineral density (BMD) of the left femur was analyzed by bone densitometry. Unloading by tail-suspension decreased BMD while treadmill training and free activity in cages promoted its recovery in a similar way and over time.
description Bone weakening can occur due to the absence of load on the skeleton or even short periods of decreased physical activity. Therefore, musculoskeletal diseases that involve temporary immobilization by casts, inactivity or tension increases the risk of fractures. Physical activity is the most studied procedure both to prevent damage and to restore bone structure. The present study aimed at evaluating, by bone densitometry on rat femurs, the influence of hindlimb unloading and later running activity on treadmill or free movement. Sixty-four Wistar rats were used, aged 65 days with a mean corporal mass of 316.11g, randomly divided into eight experimental groups: group 1, the suspended control with seven animals under hindlimb unloading regimen for 28 days, then euthanized; groups 2 and 3, the trained suspended comprising of 7 and five animals, respectively, subjected to hindlimb unloading for 28 days, followed by treadmill exercise for 28 days (group 2) or 56 days (group 3), then euthanized; groups 4 and 5, designated free suspended, comprised of 7 animals each under hindlimb unloading regimen for 28 days followed by free activity in cages for 28 days (group 4) or 56 days (group 5), then euthanized; groups 6, 7 and 8, negative controls, each with 8 animals allowed to free activity in cages and euthanized at the ages of 93, 121 and 149 days, respectively. Bone mineral density (BMD) of the left femur was analyzed by bone densitometry. Unloading by tail-suspension decreased BMD while treadmill training and free activity in cages promoted its recovery in a similar way and over time.
publishDate 2011
dc.date.none.fl_str_mv 2011-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-737X2011000400001
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-737X2011000400001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0034-737X2011000400001
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Universidade Federal de Viçosa
publisher.none.fl_str_mv Universidade Federal de Viçosa
dc.source.none.fl_str_mv Revista Ceres v.58 n.4 2011
reponame:Revista Ceres
instname:Universidade Federal de Viçosa (UFV)
instacron:UFV
instname_str Universidade Federal de Viçosa (UFV)
instacron_str UFV
institution UFV
reponame_str Revista Ceres
collection Revista Ceres
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repository.mail.fl_str_mv
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