ANTIMICROBIAL EFFECT OF OLIGOMERIC COPPER(II) DERIVATIVES OF BIS(PYRIMIDIN-2-YLTHIO)- AND BIS(4,6-DIMETHYLPYRIMIDIN-2-YLTHIO)ALKANES

• Autor(a) principal: Silva, Ricardo Soares Mota
• Data de Publicação: 2016
• Outros Autores: Souza, Márcia Cristina de, Berlini, Lilian, Maia, José Roberto da Silveira, Diniz, Renata, Speziali, Nivaldo Lúcio, Dhingra, Onkar Dev, Ferraz, Vanny Perpetua
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: The Journal of Engineering and Exact Sciences
• Texto Completo: https://periodicos.ufv.br/jcec/article/view/2446941602022016001
• topic: Antimicrobial activity; Bis(pyrimidin-2-ylthio)alkanes; Oligomeric copper(II) complexes; Bactericide; Fungicide; Antimicrobial activity; Bis(pyrimidin-2-ylthio)alkanes; Oligomeric copper(II) complexes; Bactericide; Fungicide.

A novel series of copper(II) derivatives of bis(pyrimidin-2-ylthio)- and bis(4,6-dimethylpyrimidin-2-ylthio)alkane of general formula [CuxCly(L)z]n {x = 1, y = 2, z = 1, L = ptm (1), pte (2), dptm (4), dpte (5), dpth (6); x = 2, y = 4, z = 3, L = pth (3) were tested for antimicrobial activity. These complexes were characterized by elemental analysis, infrared spectroscopy (IR) and gel permeation chromatography (GPC). Complex-4, 5 and 6 have the metal at the center of a square planar geometry and in complex-1, 2 and 3 the metal is at the center a square pyramidal geometry. The structure of complex-4, determined by X-ray diffraction analysis, shows this compound as an oligomer with one-dimensional chain in zigzag conformation. The high average molecular mass (Mw) of these copper(II) complexes confirms their oligomeric character. Although the free ligands were inactive agaisnt the microorganisms tested, the copper(II) derivatives showed good antifungal and antibacterial inhibition against C. albicans, C. tropicalis, S. aureus and E. coli, more effective than Nystatin and Norfloxacin.