DEVELOPMENT OF A METHOD FOR THE DETERMINATION OF AMOXICILLIN IN CAPSULES BY POTENTIOMETRIC TITRATION
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | The Journal of Engineering and Exact Sciences |
Texto Completo: | https://periodicos.ufv.br/jcec/article/view/2490 |
Resumo: | This work presents the determination of amoxicillin (H3Amox+) in capsules by potentiometric titration. An optimized method was done with a standard amoxicillin solution that was title with NaOH solution. The initial pH was 4.35. As expected, the first equivalence point was not observed, because the fraction of H3Amox+ was about 2.4%. Thus, HCl solution was added to the system to protonate the zwitterion H2Amox± (98%), and then visualize the first equivalence point. Two inflections were observed, the first one of the neutralization of H3Amox+ e HCl and the second one of the neutralization of the zwitterion. The equivalent volumes were estimated using the first derivative method, and the volume variation (DV) between the equivalent volumes was used to determine the amoxicillin. The results showed 99% of accuracy and coefficient of variation of 7.2%. |
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oai:ojs.periodicos.ufv.br:article/2490 |
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The Journal of Engineering and Exact Sciences |
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DEVELOPMENT OF A METHOD FOR THE DETERMINATION OF AMOXICILLIN IN CAPSULES BY POTENTIOMETRIC TITRATIONAmoxicillinPotentiometric TitrationAnalytical MethodsThis work presents the determination of amoxicillin (H3Amox+) in capsules by potentiometric titration. An optimized method was done with a standard amoxicillin solution that was title with NaOH solution. The initial pH was 4.35. As expected, the first equivalence point was not observed, because the fraction of H3Amox+ was about 2.4%. Thus, HCl solution was added to the system to protonate the zwitterion H2Amox± (98%), and then visualize the first equivalence point. Two inflections were observed, the first one of the neutralization of H3Amox+ e HCl and the second one of the neutralization of the zwitterion. The equivalent volumes were estimated using the first derivative method, and the volume variation (DV) between the equivalent volumes was used to determine the amoxicillin. The results showed 99% of accuracy and coefficient of variation of 7.2%.Universidade Federal de Viçosa - UFV2018-07-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.ufv.br/jcec/article/view/249010.18540/jcecvl4iss2pp0234-0239The Journal of Engineering and Exact Sciences; Vol. 4 No. 2 (2018); 0234-0239The Journal of Engineering and Exact Sciences; Vol. 4 Núm. 2 (2018); 0234-0239The Journal of Engineering and Exact Sciences; v. 4 n. 2 (2018); 0234-02392527-1075reponame:The Journal of Engineering and Exact Sciencesinstname:Universidade Federal de Viçosa (UFV)instacron:UFVenghttps://periodicos.ufv.br/jcec/article/view/2490/1044Cruz, Jean CastroNascimento, Mayra AparecidaTeixeira, Aline MariaOliveira, André FernandoLopes, Renata Pereirainfo:eu-repo/semantics/openAccess2018-12-05T12:57:21Zoai:ojs.periodicos.ufv.br:article/2490Revistahttp://www.seer.ufv.br/seer/rbeq2/index.php/req2/oai2527-10752527-1075opendoar:2018-12-05T12:57:21The Journal of Engineering and Exact Sciences - Universidade Federal de Viçosa (UFV)false |
dc.title.none.fl_str_mv |
DEVELOPMENT OF A METHOD FOR THE DETERMINATION OF AMOXICILLIN IN CAPSULES BY POTENTIOMETRIC TITRATION |
title |
DEVELOPMENT OF A METHOD FOR THE DETERMINATION OF AMOXICILLIN IN CAPSULES BY POTENTIOMETRIC TITRATION |
spellingShingle |
DEVELOPMENT OF A METHOD FOR THE DETERMINATION OF AMOXICILLIN IN CAPSULES BY POTENTIOMETRIC TITRATION Cruz, Jean Castro Amoxicillin Potentiometric Titration Analytical Methods |
title_short |
DEVELOPMENT OF A METHOD FOR THE DETERMINATION OF AMOXICILLIN IN CAPSULES BY POTENTIOMETRIC TITRATION |
title_full |
DEVELOPMENT OF A METHOD FOR THE DETERMINATION OF AMOXICILLIN IN CAPSULES BY POTENTIOMETRIC TITRATION |
title_fullStr |
DEVELOPMENT OF A METHOD FOR THE DETERMINATION OF AMOXICILLIN IN CAPSULES BY POTENTIOMETRIC TITRATION |
title_full_unstemmed |
DEVELOPMENT OF A METHOD FOR THE DETERMINATION OF AMOXICILLIN IN CAPSULES BY POTENTIOMETRIC TITRATION |
title_sort |
DEVELOPMENT OF A METHOD FOR THE DETERMINATION OF AMOXICILLIN IN CAPSULES BY POTENTIOMETRIC TITRATION |
author |
Cruz, Jean Castro |
author_facet |
Cruz, Jean Castro Nascimento, Mayra Aparecida Teixeira, Aline Maria Oliveira, André Fernando Lopes, Renata Pereira |
author_role |
author |
author2 |
Nascimento, Mayra Aparecida Teixeira, Aline Maria Oliveira, André Fernando Lopes, Renata Pereira |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Cruz, Jean Castro Nascimento, Mayra Aparecida Teixeira, Aline Maria Oliveira, André Fernando Lopes, Renata Pereira |
dc.subject.por.fl_str_mv |
Amoxicillin Potentiometric Titration Analytical Methods |
topic |
Amoxicillin Potentiometric Titration Analytical Methods |
description |
This work presents the determination of amoxicillin (H3Amox+) in capsules by potentiometric titration. An optimized method was done with a standard amoxicillin solution that was title with NaOH solution. The initial pH was 4.35. As expected, the first equivalence point was not observed, because the fraction of H3Amox+ was about 2.4%. Thus, HCl solution was added to the system to protonate the zwitterion H2Amox± (98%), and then visualize the first equivalence point. Two inflections were observed, the first one of the neutralization of H3Amox+ e HCl and the second one of the neutralization of the zwitterion. The equivalent volumes were estimated using the first derivative method, and the volume variation (DV) between the equivalent volumes was used to determine the amoxicillin. The results showed 99% of accuracy and coefficient of variation of 7.2%. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-07-04 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.ufv.br/jcec/article/view/2490 10.18540/jcecvl4iss2pp0234-0239 |
url |
https://periodicos.ufv.br/jcec/article/view/2490 |
identifier_str_mv |
10.18540/jcecvl4iss2pp0234-0239 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://periodicos.ufv.br/jcec/article/view/2490/1044 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Viçosa - UFV |
publisher.none.fl_str_mv |
Universidade Federal de Viçosa - UFV |
dc.source.none.fl_str_mv |
The Journal of Engineering and Exact Sciences; Vol. 4 No. 2 (2018); 0234-0239 The Journal of Engineering and Exact Sciences; Vol. 4 Núm. 2 (2018); 0234-0239 The Journal of Engineering and Exact Sciences; v. 4 n. 2 (2018); 0234-0239 2527-1075 reponame:The Journal of Engineering and Exact Sciences instname:Universidade Federal de Viçosa (UFV) instacron:UFV |
instname_str |
Universidade Federal de Viçosa (UFV) |
instacron_str |
UFV |
institution |
UFV |
reponame_str |
The Journal of Engineering and Exact Sciences |
collection |
The Journal of Engineering and Exact Sciences |
repository.name.fl_str_mv |
The Journal of Engineering and Exact Sciences - Universidade Federal de Viçosa (UFV) |
repository.mail.fl_str_mv |
|
_version_ |
1808845244290039808 |