Nanoesferas de blendas de poli(3-hidroxibutirato)/ poli-?-caprolactona contendo sinvastatina: desenvolvimento e caracteriza??o f?sico-qu?mica

Detalhes bibliográficos
Autor(a) principal: Malaquias, Dalila Pinto
Data de Publicação: 2015
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Repositório Institucional da UFVJM
Texto Completo: http://acervo.ufvjm.edu.br/jspui/handle/1/2813
Resumo: Disponibiliza??o do conte?do parcial, conforme Termo de Autoriza??o do trabalho datado de 14/06/2016.
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spelling Malaquias, Dalila PintoLeite, Elaine AmaralVerly, Rodrigo MoreiraRoa, Juan Pedro BretasCarvalho J?nior, ?lvaro Dutra deCarvalho J?nior, ?lvaro Dutra deUniversidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM)Leite, Elaine Amaral2022-04-07T12:01:58Z2022-04-07T12:01:58Z20152015-11-06MALAQUIAS, Dalila Pinto. Nanoesferas de blendas de poli(3-hidroxibutirato)/ poli-?-caprolactona contendo sinvastatina: desenvolvimento e caracteriza??o f?sico-qu?mica. 2015. 103 p. Disserta??o (Mestrado em Ci?ncias Farmac?uticas) ? Programa de P?s-gradua??o em Ci?ncias Farmac?uticas, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, 2015.http://acervo.ufvjm.edu.br/jspui/handle/1/2813Disponibiliza??o do conte?do parcial, conforme Termo de Autoriza??o do trabalho datado de 14/06/2016.Sistemas de libera??o controlada s?o capazes de modificar a taxa de libera??o de f?rmacos e direcion?-los aos locais de a??o espec?ficos, tornando-os mais eficazes al?m de reduzir a ocorr?ncia de efeitos adversos, o que aumenta a aceitabilidade do tratamento pelo paciente. Pol?meros biocompat?veis, seus copol?meros e blendas t?m apresentado vantagens na forma??o destes sistemas mostrando resposta positiva quanto ao aprimoramento da terap?utica. O presente estudo visou desenvolver nanoesferas a partir de blendas de poli- (3- hidroxibutirato) (PHB) e poli-(?-caprolactona) (PCL) e avaliar o seu potencial como carreadoras de sinvastatina. Para tanto, par?metros f?sico-quimicos como tamanho, ?ndice de polidispers?o, potencial zeta, quantidade de f?rmaco encapsulada, libera??o in vitro e morfologia foram avaliados. As nanoesferas contendo sinvastatina foram preparadas pela t?cnica emuls?o/evapora??o do solvente, variando-se a quantidade de sinvastatina adicionada na formula??o. O doseamento foi realizado por cromatografia liquida de alta efici?ncia, ap?s valida??o pr?via do m?todo anal?tico. A formula??o que obteve maior quantidade de f?rmaco associado apresentou di?metro m?dio 265 ? 10 nm com polidispers?o m?dia de 0,091 ? 0,026. Esses valores revelam um sistema nanom?trico, com uma distribui??o estreita de tamanho e uma homogeneidade das nanoesferas. O potencial zeta m?dio foi de - 31,8 ? 3,59 mV, sugestivo de predom?nio de for?as repulsivas, as quais previnem agrega??es em fun??o da colis?o entre as part?culas. Os resultados de DSC e libera??o in vitro sugerem transporte por difus?o e a maior parte do f?rmaco estar associada ? superf?cie da esfera. Os testes de estabilidade preliminar n?o indicam degrada??o dos componentes e aglomera??o das part?culas. A an?lise morfol?gica das nanoesferas, realizada por microscopia de for?a at?mica demonstrou a presen?a de part?culas esf?ricas e de superf?cie rugosa. Dessa forma, os dados sugerem que a prepara??o de nanoesferas utilizando a blenda PHB-PCL ? um sistema promissor para carrear a sinvastatina.Submitted by Jos? Henrique Henrique (jose.neves@ufvjm.edu.br) on 2022-04-07T12:01:18Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) dalila_pinto_malaquias_parcial.pdf: 183034 bytes, checksum: bdf99341d9c5b7788e8f6a7056cf3b94 (MD5)Approved for entry into archive by Jos? Henrique Henrique (jose.neves@ufvjm.edu.br) on 2022-04-07T12:01:58Z (GMT) No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) dalila_pinto_malaquias_parcial.pdf: 183034 bytes, checksum: bdf99341d9c5b7788e8f6a7056cf3b94 (MD5)Made available in DSpace on 2022-04-07T12:01:58Z (GMT). No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) dalila_pinto_malaquias_parcial.pdf: 183034 bytes, checksum: bdf99341d9c5b7788e8f6a7056cf3b94 (MD5) Previous issue date: 2015Disserta??o (Mestrado) ? Programa de P?s-gradua??o em Ci?ncias Farmac?uticas, Universidade Federal dos Vales do Jequitinhonha e Mucuri, 2015.Controlled release systems are able to modify the release rate of pharmaceuticals and direct them to specific sites of action, making them more effective and reducing the occurrence of adverse effects, which increases the acceptability of treatment by the patient. Biocompatible polymers, their copolymers and blends have shown advantages in the formation of these systems, presenting positive response regarding the improvement of therapy. This study aimed to develop nanospheres from blends of poly (3-hydroxybutyrate) (PHB) and poly (?- caprolactone) (PCL) and evaluate their potential as simvastatin carriers. Therefore, physical and chemical parameters such as size, polydispersity index, zeta potential, the amount of encapsulated pharmaceutical, in vitro release and morphology were evaluated. The nanospheres containing simvastatin were prepared by the emulsion/evaporation technique of the solvent, by varying the amount of simvastatin added to the formulation. The dosing was performed by high-performance liquid chromatography, after prior validation of the analytical method. The formulation that obtained a higher amount of associated pharmaceutical presented an average diameter of 265 ? 10 nm with an average of 0.091 ? 0.026 polydispersity. These values show a nanometric system with a narrow distribution size and an uniformity of nanospheres. The average zeta potential was -31.8 ? 3.59 mV, suggesting the predominance of repulsive forces, which prevent aggregation due to the collision between the particles. The DSC results and in vitro release suggest transport by diffusion and the fact that most of the pharmaceutical is linked to the sphere surface. Preliminary stability tests do not show degradation of the components and agglomeration of the particles. Morphological analysis of nanospheres, performed by atomic force microscopy demonstrated the presence of spherical particles and rough surface. Therefore, the data suggest that the preparation of nanospheres using the PHB-PCL blend is a promising system for carrying simvastatin.porUFVJMA concess?o da licen?a deste item refere-se ao ? termo de autoriza??o impresso assinado pelo autor, assim como na licen?a Creative Commons, com as seguintes condi??es: Na qualidade de titular dos direitos de autor da publica??o, autorizo a Universidade Federal dos Vales do Jequitinhonha e Mucuri e o IBICT a disponibilizar por meio de seus reposit?rios, sem ressarcimento dos direitos autorais, de acordo com a Lei n? 9610/98, o texto integral da obra disponibilizada, conforme permiss?es assinaladas, para fins de leitura, impress?o e/ou download, a t?tulo de divulga??o da produ??o cient?fica brasileira, e preserva??o, a partir desta data.info:eu-repo/semantics/openAccessNanoesferas de blendas de poli(3-hidroxibutirato)/ poli-?-caprolactona contendo sinvastatina: desenvolvimento e caracteriza??o f?sico-qu?micainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisNanoesferasBlenda PHB/PCLSinvastatinaNanospherePHB/PCL blendSimvastatinreponame:Repositório Institucional da UFVJMinstname:Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM)instacron:UFVJMTEXTdalila_pinto_malaquias_parcial.pdf.txtdalila_pinto_malaquias_parcial.pdf.txtExtracted texttext/plain24127http://acervo.ufvjm.edu.br/jspui/bitstream/1/2813/6/dalila_pinto_malaquias_parcial.pdf.txt488ef86b1cc8a2ab8cf66cf3cbcc8d0aMD56LICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Nanoesferas de blendas de poli(3-hidroxibutirato)/ poli-?-caprolactona contendo sinvastatina: desenvolvimento e caracteriza??o f?sico-qu?mica
title Nanoesferas de blendas de poli(3-hidroxibutirato)/ poli-?-caprolactona contendo sinvastatina: desenvolvimento e caracteriza??o f?sico-qu?mica
spellingShingle Nanoesferas de blendas de poli(3-hidroxibutirato)/ poli-?-caprolactona contendo sinvastatina: desenvolvimento e caracteriza??o f?sico-qu?mica
Malaquias, Dalila Pinto
Nanoesferas
Blenda PHB/PCL
Sinvastatina
Nanosphere
PHB/PCL blend
Simvastatin
title_short Nanoesferas de blendas de poli(3-hidroxibutirato)/ poli-?-caprolactona contendo sinvastatina: desenvolvimento e caracteriza??o f?sico-qu?mica
title_full Nanoesferas de blendas de poli(3-hidroxibutirato)/ poli-?-caprolactona contendo sinvastatina: desenvolvimento e caracteriza??o f?sico-qu?mica
title_fullStr Nanoesferas de blendas de poli(3-hidroxibutirato)/ poli-?-caprolactona contendo sinvastatina: desenvolvimento e caracteriza??o f?sico-qu?mica
title_full_unstemmed Nanoesferas de blendas de poli(3-hidroxibutirato)/ poli-?-caprolactona contendo sinvastatina: desenvolvimento e caracteriza??o f?sico-qu?mica
title_sort Nanoesferas de blendas de poli(3-hidroxibutirato)/ poli-?-caprolactona contendo sinvastatina: desenvolvimento e caracteriza??o f?sico-qu?mica
author Malaquias, Dalila Pinto
author_facet Malaquias, Dalila Pinto
author_role author
dc.contributor.referee.none.fl_str_mv Leite, Elaine Amaral
Verly, Rodrigo Moreira
Roa, Juan Pedro Bretas
Carvalho J?nior, ?lvaro Dutra de
dc.contributor.advisorco.none.fl_str_mv Carvalho J?nior, ?lvaro Dutra de
dc.contributor.institution.pt_BR.fl_str_mv Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM)
dc.contributor.author.fl_str_mv Malaquias, Dalila Pinto
dc.contributor.advisor1.fl_str_mv Leite, Elaine Amaral
contributor_str_mv Leite, Elaine Amaral
dc.subject.keyword.pt_BR.fl_str_mv Nanoesferas
Blenda PHB/PCL
Sinvastatina
topic Nanoesferas
Blenda PHB/PCL
Sinvastatina
Nanosphere
PHB/PCL blend
Simvastatin
dc.subject.keyword.en.fl_str_mv Nanosphere
PHB/PCL blend
Simvastatin
description Disponibiliza??o do conte?do parcial, conforme Termo de Autoriza??o do trabalho datado de 14/06/2016.
publishDate 2015
dc.date.submitted.none.fl_str_mv 2015-11-06
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2022-04-07T12:01:58Z
dc.date.available.fl_str_mv 2022-04-07T12:01:58Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv MALAQUIAS, Dalila Pinto. Nanoesferas de blendas de poli(3-hidroxibutirato)/ poli-?-caprolactona contendo sinvastatina: desenvolvimento e caracteriza??o f?sico-qu?mica. 2015. 103 p. Disserta??o (Mestrado em Ci?ncias Farmac?uticas) ? Programa de P?s-gradua??o em Ci?ncias Farmac?uticas, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, 2015.
dc.identifier.uri.fl_str_mv http://acervo.ufvjm.edu.br/jspui/handle/1/2813
identifier_str_mv MALAQUIAS, Dalila Pinto. Nanoesferas de blendas de poli(3-hidroxibutirato)/ poli-?-caprolactona contendo sinvastatina: desenvolvimento e caracteriza??o f?sico-qu?mica. 2015. 103 p. Disserta??o (Mestrado em Ci?ncias Farmac?uticas) ? Programa de P?s-gradua??o em Ci?ncias Farmac?uticas, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, 2015.
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language por
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dc.publisher.none.fl_str_mv UFVJM
publisher.none.fl_str_mv UFVJM
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFVJM
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institution UFVJM
reponame_str Repositório Institucional da UFVJM
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