Caracteriza??o de amostras de coca?na apreendidas no munic?pio de Diamantina, Minas Gerais
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFVJM |
Texto Completo: | http://acervo.ufvjm.edu.br/jspui/handle/1/1571 |
Resumo: | Linha de pesquisa: Tecnologia e vigil?ncia em sa?de. |
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Oliveira, Anderson Caldeira deSantos, Ant?nio SousaCarneiro, GuilhermeMorais, Harriman AleyUniversidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM)Santos, Ant?nio Sousa2018-01-19T17:14:17Z2018-01-19T17:14:17Z20172017-06-21OLIVEIRA, Anderson Caldeira de. Caracteriza??o de amostras de coca?na apreendidas no munic?pio de Diamantina, Minas Gerais. 2017. 109 p. Disserta??o (Mestrado Profissional) ? Programa de P?s-Gradua??o em Sa?de, Sociedade e Ambiente, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, 2017.http://acervo.ufvjm.edu.br/jspui/handle/1/1571Linha de pesquisa: Tecnologia e vigil?ncia em sa?de.O Brasil encontra-se entre os pa?ses de maior consumo de coca?na no mundo. As quest?es relacionadas ao uso da coca?na provocam preocupa??es, uma vez que s?o acompanhadas de consequ?ncias que atingem m?ltiplas dimens?es da sociedade moderna. Os problemas associados ao tr?fico e ao consumo de drogas est?o difundidos por todo o pa?s, alcan?ando, inclusive, munic?pios de pequeno porte. A presen?a de adulterantes pode ocasionar rea??es inesperadas bem como potencializar os danos ? sa?de dos usu?rios. Este trabalho teve como objetivo caracterizar amostras de coca?na apreendidas no munic?pio de Diamantina, Minas Gerais, quanto ao teor de coca?na e presen?a de adulterantes. Em uma primeira etapa do trabalho, foi validada uma metodologia anal?tica para quantifica??o de coca?na em amostras apreendidas com uso da Cromatografia Gasosa acoplada ? Espectrometria de Massas com monitoramento de ?ons selecionados (selected-ion monitoring - SIM) (CG-EM-SIM). Em uma segunda etapa, foram analisadas cento e vinte e nove amostras, sendo destas sessenta e sete apreendidas na forma de p? e sessenta e duas como crack. Foram realizadas an?lises para a identifica??o de adulterantes e para determina??o do teor de coca?na nas amostras, sendo a identifica??o de adulterantes realizada por Cromatografia Gasosa acoplada Espectrometria de Massas (CG-EM), no modo full scan, e a quantifica??o da coca?na por CG-EM?SIM. Foi realizada a compara??o do teor m?dio entre as amostras apreendidas na forma p? e de crack pelo teste U de Mann-Whitney. A fenacetina foi o principal adulterante encontrado. Outros adulterantes como benzoca?na, cafe?na, levamisol, lidoca?na e proca?na tamb?m foram detectados. As amostras apreendidas como crack apresentaram not?rio predom?nio da fenacetina como adulterante. O teor de coca?na das amostras estudadas apresentou varia??o dentro de um amplo intervalo (0-93%). Os teores m?dios de coca?na observados para as formas de p? e de crack foram, respectivamente, 31,7% e 54,3%, sendo tais valores estatisticamente distintos. A vigil?ncia em rela??o ?s caracter?sticas de drogas il?citas deve ser uma atividade cont?nua para fornecer aos ?rg?os de controle e de sa?de p?blica elementos de aux?lio ?s atividades de repress?o e tamb?m para tomadas de decis?o e de diagn?stico por parte dos profissionais de sa?de que lidam com atendimento aos usu?rios de drogas. As informa??es obtidas neste trabalho poder?o contribuir para futuras a??es de educa??o e conscientiza??o em rela??o aos riscos associados ao uso de drogas.Submitted by Jos? Henrique Henrique (jose.neves@ufvjm.edu.br) on 2018-01-10T19:40:05Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) anderson_caldeira_oliveira.pdf: 1872739 bytes, checksum: 55f5678427b28e816e057b67c0d0cecc (MD5)Approved for entry into archive by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2018-01-19T17:14:17Z (GMT) No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) anderson_caldeira_oliveira.pdf: 1872739 bytes, checksum: 55f5678427b28e816e057b67c0d0cecc (MD5)Made available in DSpace on 2018-01-19T17:14:17Z (GMT). No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) anderson_caldeira_oliveira.pdf: 1872739 bytes, checksum: 55f5678427b28e816e057b67c0d0cecc (MD5) Previous issue date: 2017Disserta??o (Mestrado Profissional) ? Programa de P?s-Gradua??o em Sa?de, Sociedade e Ambiente, Universidade Federal dos Vales do Jequitinhonha e Mucuri, 2017.Brazil is among the countries with the highest cocaine use in the world. The issues related to cocaine use raise concerns, since they are accompanied by consequences that affect the modern society multiple dimensions. The problems associated with illicit trafficking and drug abuse are widespread throughout the country, reaching small towns. The adulterants presence can cause unexpected reactions as well as potentiate the damages to the users? health. This study aimed to characterize the cocaine samples seized in Diamantina, Minas Gerais, Brazil, regarding the cocaine content and the adulterants presence. In the study?s first phase, an analytical methodology was validated for the cocaine quantification in samples seized using Gas Chromatography coupled to a Mass Spectrometry with Selected-Ion Monitoring (GC-MS-SIM). In a second phase, one hundred and twenty-nine samples were analyzed, from which sixty-seven were seized as powder and sixty-two as crack. Analyzes were performed to identify adulterants and to determine the cocaine content in the samples. The identification of adulterants were carried out by a Gas Chromatography coupled to a Mass Spectrometry (GC-MS) in the full scan mode, and quantification of cocaine contend by GC-MS-SIM. The mean content comparison between the samples seized as powder and crack was performed by the Mann-Whitney U test. Phenacetin was the main adulterant found. Other adulterants such as benzocaine, caffeine, levamisole, lidocaine and procaine were also detected. The samples seized as crack showed a predominance of phenacetin as adulterant. The cocaine content of the samples studied varied within a wide range (0-93%). The average cocaine contents observed for the powder and crack forms were, respectively, 31,7% and 54,3%, and these values were statistically different. The surveillance in relation to the illicit drugs characteristics should be a continuous activity to provide control to the public health agencies with support elements for repression activities, as well as decision-making and diagnosis by the health professionals dealing with the drug users? care. The information obtained in this study may contribute to the future education and awareness actions regarding the risks associated with the drug use.porUFVJMA concess?o da licen?a deste item refere-se ao ? termo de autoriza??o impresso assinado pelo autor, assim como na licen?a Creative Commons, com as seguintes condi??es: Na qualidade de titular dos direitos de autor da publica??o, autorizo a Universidade Federal dos Vales do Jequitinhonha e Mucuri e o IBICT a disponibilizar por meio de seus reposit?rios, sem ressarcimento dos direitos autorais, de acordo com a Lei n? 9610/98, o texto integral da obra disponibilizada, conforme permiss?es assinaladas, para fins de leitura, impress?o e/ou download, a t?tulo de divulga??o da produ??o cient?fica brasileira, e preserva??o, a partir desta data.info:eu-repo/semantics/openAccessCaracteriza??o de amostras de coca?na apreendidas no munic?pio de Diamantina, Minas Geraisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisAdulterantesCG-EMCoca?naValida??o intralaboratorialAdulterantsCocaineGC-MSIn-house validationreponame:Repositório Institucional da UFVJMinstname:Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM)instacron:UFVJMTEXTanderson_caldeira_oliveira.pdf.txtanderson_caldeira_oliveira.pdf.txtExtracted texttext/plain179727http://acervo.ufvjm.edu.br/jspui/bitstream/1/1571/6/anderson_caldeira_oliveira.pdf.txt5c8db5d01715e2901c9d8dbae0c1bcafMD56LICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv |
Caracteriza??o de amostras de coca?na apreendidas no munic?pio de Diamantina, Minas Gerais |
title |
Caracteriza??o de amostras de coca?na apreendidas no munic?pio de Diamantina, Minas Gerais |
spellingShingle |
Caracteriza??o de amostras de coca?na apreendidas no munic?pio de Diamantina, Minas Gerais Oliveira, Anderson Caldeira de Adulterantes CG-EM Coca?na Valida??o intralaboratorial Adulterants Cocaine GC-MS In-house validation |
title_short |
Caracteriza??o de amostras de coca?na apreendidas no munic?pio de Diamantina, Minas Gerais |
title_full |
Caracteriza??o de amostras de coca?na apreendidas no munic?pio de Diamantina, Minas Gerais |
title_fullStr |
Caracteriza??o de amostras de coca?na apreendidas no munic?pio de Diamantina, Minas Gerais |
title_full_unstemmed |
Caracteriza??o de amostras de coca?na apreendidas no munic?pio de Diamantina, Minas Gerais |
title_sort |
Caracteriza??o de amostras de coca?na apreendidas no munic?pio de Diamantina, Minas Gerais |
author |
Oliveira, Anderson Caldeira de |
author_facet |
Oliveira, Anderson Caldeira de |
author_role |
author |
dc.contributor.references.none.fl_str_mv |
Santos, Ant?nio Sousa Carneiro, Guilherme Morais, Harriman Aley |
dc.contributor.institution.pt_BR.fl_str_mv |
Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM) |
dc.contributor.author.fl_str_mv |
Oliveira, Anderson Caldeira de |
dc.contributor.advisor1.fl_str_mv |
Santos, Ant?nio Sousa |
contributor_str_mv |
Santos, Ant?nio Sousa |
dc.subject.keyword.pt_BR.fl_str_mv |
Adulterantes CG-EM Coca?na Valida??o intralaboratorial |
topic |
Adulterantes CG-EM Coca?na Valida??o intralaboratorial Adulterants Cocaine GC-MS In-house validation |
dc.subject.keyword.en.fl_str_mv |
Adulterants Cocaine GC-MS In-house validation |
description |
Linha de pesquisa: Tecnologia e vigil?ncia em sa?de. |
publishDate |
2017 |
dc.date.submitted.none.fl_str_mv |
2017-06-21 |
dc.date.issued.fl_str_mv |
2017 |
dc.date.accessioned.fl_str_mv |
2018-01-19T17:14:17Z |
dc.date.available.fl_str_mv |
2018-01-19T17:14:17Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
OLIVEIRA, Anderson Caldeira de. Caracteriza??o de amostras de coca?na apreendidas no munic?pio de Diamantina, Minas Gerais. 2017. 109 p. Disserta??o (Mestrado Profissional) ? Programa de P?s-Gradua??o em Sa?de, Sociedade e Ambiente, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, 2017. |
dc.identifier.uri.fl_str_mv |
http://acervo.ufvjm.edu.br/jspui/handle/1/1571 |
identifier_str_mv |
OLIVEIRA, Anderson Caldeira de. Caracteriza??o de amostras de coca?na apreendidas no munic?pio de Diamantina, Minas Gerais. 2017. 109 p. Disserta??o (Mestrado Profissional) ? Programa de P?s-Gradua??o em Sa?de, Sociedade e Ambiente, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, 2017. |
url |
http://acervo.ufvjm.edu.br/jspui/handle/1/1571 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
UFVJM |
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UFVJM |
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reponame:Repositório Institucional da UFVJM instname:Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM) instacron:UFVJM |
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Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM) |
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UFVJM |
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Repositório Institucional da UFVJM |
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