Atividade ansiol?tica e antidepressiva do extrato bruto das partes a?reas da Kielmeyera rubriflora em camundongos

Detalhes bibliográficos
Autor(a) principal: Pimenta, Amine Becheleni
Data de Publicação: 2014
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Repositório Institucional da UFVJM
Texto Completo: http://acervo.ufvjm.edu.br/jspui/handle/1/765
Resumo: ?rea de concentra??o: Farmacologia.
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spelling Pimenta, Amine BecheleniSantos, Cynthia Fernandes FerreiraOliveira, Guilherme Nogueira Mendes deRocha, Alessandra DuarteSantos, Cynthia Fernandes FerreiraUniversidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM)Seixas, S?rgio Ricardo Stuckert2015-12-02T16:37:34Z2015-12-02T16:37:34Z20142014-12-19PIMENTA, Amine Becheleni. Atividade ansiol?tica e antidepressiva do extrato bruto das partes a?reas da Kielmeyera rubriflora em camundongos. 2014. 98 [2] p. Disserta??o (Mestrado) ? Programa de P?s-gradua??o em Ci?ncias Farmac?uticas, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, 2014.http://acervo.ufvjm.edu.br/jspui/handle/1/765?rea de concentra??o: Farmacologia.As plantas do g?nero Kielmeyera, cujos efeitos farmacol?gicos j? foram demonstrados, s?o plantas nativas da regi?o do Vale do Jequitinhonha e conhecidas como Pau Santo. A Kielmeyera rubriflora ? utilizada na medicina caseira, entretanto, at? o momento n?o existem dados dispon?veis na literatura de estudos farmacol?gicos a seu respeito. O objetivo do trabalho foi avaliar os efeitos ansiol?ticos e antidepressivos do extrato bruto das partes a?reas da K. rubriflora sobre a atividade do sistema nervoso central (SNC) de camundongos su??os albinos machos. O extrato bruto das partes a?reas foi administrado via oral nas doses de 100 mg/Kg, 250 mg/Kg e 500 mg/Kg em camundongos albinos, su??os, machos, com idade entre 9 e 13 semanas, com peso entre 25 e 40 g. Foram utilizados os testes de triagem farmacol?gica comportamental (agudo), movimenta??o espont?nea (agudo), potencializa??o do tempo de sono induzido por tiopental s?dico (agudo), placa perfurada (agudo), labirinto em cruz elevado (agudo), nado for?ado (cr?nico) e suspens?o da cauda (cr?nico). Na de triagem farmacol?gica comportamental, foram detectados efeitos de depress?o do SNC pela dose de 100mg/Kg e de est?mulo do SNC nas doses de 250 e 500 mg/Kg. O tempo de sono que foi reduzido pelo extrato em 20 e 26% nas doses de 100 e 500 mg/Kg respectivamente. A ambula??o foi significativamente aumentada nas doses de 100 e 500 mg/Kg sugerindo efeito ansiol?tico e significativamente diminu?da na dose de 250 mg sugerindo efeito sedativo. As propriedades ansiol?ticas foram investigadas nos testes da placa perfurada e do labirinto em cruz elevado, onde houve diminui??o do tempo de perman?ncia nos bra?os fechados com a doses de 100mg/Kg e aumento significativo de entradas no bra?o aberto na doses de 250mg/Kg sugerindo atividade ansiol?tica nestas doses. No teste da placa perfurada houve diminui??o significativa de mergulhos de cabe?a na dose de 250mg/Kg e 500mg/Kg sugerindo a??o sedativa e aumento significativo de mergulhos de cabe?a na dose de 100 mg/Kg sugerindo a??o ansiol?tica. A atividade antidepressiva foi investigada com os testes de suspens?o da cauda e nado for?ado. No teste da suspens?o da cauda houve diminui??o dose-dependente, por?m n?o significativa do tempo de imobilidade. No teste de nado for?ado houve diminui??o significativa do tempo de imobilidade em todas as doses investigadas sugerindo atividade antidepressiva, principalmente na dose de 100 mg/Kg. Sendo assim os dados encontrados sugerem a??o sedativa, ansiol?tica e antidepressiva dose-dependente do extrato bruto da Kielmeyera rubriflora.Submitted by Nivaldo Melo (nivaldo.melo@ufvjm.edu.br) on 2015-11-30T16:02:46Z No. of bitstreams: 2 amine_becheleni_pimenta.pdf: 1766840 bytes, checksum: 6c26ee2619fece6619b42bf5cce87cb9 (MD5) license_rdf: 23898 bytes, checksum: e363e809996cf46ada20da1accfcd9c7 (MD5)Approved for entry into archive by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2015-12-02T16:37:33Z (GMT) No. of bitstreams: 2 amine_becheleni_pimenta.pdf: 1766840 bytes, checksum: 6c26ee2619fece6619b42bf5cce87cb9 (MD5) license_rdf: 23898 bytes, checksum: e363e809996cf46ada20da1accfcd9c7 (MD5)Made available in DSpace on 2015-12-02T16:37:34Z (GMT). No. of bitstreams: 2 amine_becheleni_pimenta.pdf: 1766840 bytes, checksum: 6c26ee2619fece6619b42bf5cce87cb9 (MD5) license_rdf: 23898 bytes, checksum: e363e809996cf46ada20da1accfcd9c7 (MD5) Previous issue date: 2014Disserta??o (Mestrado) ? Programa de P?s-gradua??o em Ci?ncias Farmac?uticas, Universidade Federal dos Vales do Jequitinhonha e Mucuri, 2014.ABSTRACT The plants of the genus Kielmeyera, whose pharmacological effects have been reported, are native to the Vale do Jequitinhonha region and are known as ?Pau Santo?. The Kielmeyera rubriflora is used in folk medicine; however, no data are available in the literature on pharmacological studies regarding this species. The aim of the study was to evaluate the anxiolytics and antidepressants effects of the crude extract from the aerial parts of K. rubriflora activity on the central nervous system (CNS) of Swiss albino male mice. The crude extract of the aerial parts was administered orally at doses of 100 mg/kg, 250 mg/kg and 500 mg/kg to albino Swiss, male mice, between 9 and 13 weeks of age, weighing between 25 and 40 g. Behavioral pharmacological screening (acute), spontaneous movement (acute), potentiation of sleeping time induced by sodium thiopental (acute), elevated plus maze (acute), hole board (acute), forced swimming (chronic) and tail suspension (chronic) tests were performed. In the behavioral pharmacological screening of CNS depression, effects were detected with the 100 mg/kg dose, and CNS stimulation was detected with the doses of 250 and 500 mg/kg. The duration of sleep was reduced by the extract at 20 and 26% with doses 100 and 500 mg/kg, respectively. The ambulation was significantly higher at doses of 100 and 500 mg/kg, suggesting an anxiolytic effect, and significantly lower at a dose of 250 mg, suggesting a sedative effect. Anxiolytic properties were investigated in the tests of the hole board and the elevated plus maze, where there is less time spent in the closed arms with doses of 100 mg/kg and a significant increase in open arms entries with doses of 250 mg/kg, suggesting an anxiolytic activity with these doses. In the hole board test, head dipping decreased significantly with doses of 250 mg/kg and 500 mg/kg, suggesting a sedative action. A significant increase in head dipping was observed with the doses of 100 mg/Kg, suggesting na anxiolytic action. The antidepressant activity was investigated with the tail suspension and forced swim tests. In the tail suspension test, a dose-dependent, but not significant, decrease in the immobility time, was observed. In the forced swim test, a significantly lower immobility time was observed at all the doses, suggesting an antidepressant activity, especially at a dose of 100 mg / kg. Thus, the data suggests a sedative, anxiolytic and antidepressant dose-dependent action of the crude extract of Kielmeyera rubriflora.porUFVJMA concess?o da licen?a deste item refere-se ao ? termo de autoriza??o impresso assinado pelo autor, assim como na licen?a Creative Commons, com as seguintes condi??es: Na qualidade de titular dos direitos de autor da publica??o, autorizo a Universidade Federal dos Vales do Jequitinhonha e Mucuri e o IBICT a disponibilizar por meio de seus reposit?rios, sem ressarcimento dos direitos autorais, de acordo com a Lei n? 9610/98, o texto integral da obra disponibilizada, conforme permiss?es assinaladas, para fins de leitura, impress?o e/ou download, a t?tulo de divulga??o da produ??o cient?fica brasileira, e preserva??o, a partir desta data.info:eu-repo/semantics/openAccessAtividade ansiol?tica e antidepressiva do extrato bruto das partes a?reas da Kielmeyera rubriflora em camundongosinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisKielmeyera rubrifloraAnsiol?ticaSedativaAntidepressivaSNCreponame:Repositório Institucional da UFVJMinstname:Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM)instacron:UFVJMTEXTamine_becheleni_pimenta.pdf.txtamine_becheleni_pimenta.pdf.txtExtracted texttext/plain163985http://acervo.ufvjm.edu.br/jspui/bitstream/1/765/6/amine_becheleni_pimenta.pdf.txt5ade0d537289f38858df6ac1345ad208MD56LICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Atividade ansiol?tica e antidepressiva do extrato bruto das partes a?reas da Kielmeyera rubriflora em camundongos
title Atividade ansiol?tica e antidepressiva do extrato bruto das partes a?reas da Kielmeyera rubriflora em camundongos
spellingShingle Atividade ansiol?tica e antidepressiva do extrato bruto das partes a?reas da Kielmeyera rubriflora em camundongos
Pimenta, Amine Becheleni
Kielmeyera rubriflora
Ansiol?tica
Sedativa
Antidepressiva
SNC
title_short Atividade ansiol?tica e antidepressiva do extrato bruto das partes a?reas da Kielmeyera rubriflora em camundongos
title_full Atividade ansiol?tica e antidepressiva do extrato bruto das partes a?reas da Kielmeyera rubriflora em camundongos
title_fullStr Atividade ansiol?tica e antidepressiva do extrato bruto das partes a?reas da Kielmeyera rubriflora em camundongos
title_full_unstemmed Atividade ansiol?tica e antidepressiva do extrato bruto das partes a?reas da Kielmeyera rubriflora em camundongos
title_sort Atividade ansiol?tica e antidepressiva do extrato bruto das partes a?reas da Kielmeyera rubriflora em camundongos
author Pimenta, Amine Becheleni
author_facet Pimenta, Amine Becheleni
author_role author
dc.contributor.references.none.fl_str_mv Santos, Cynthia Fernandes Ferreira
Oliveira, Guilherme Nogueira Mendes de
Rocha, Alessandra Duarte
dc.contributor.advisorco.none.fl_str_mv Santos, Cynthia Fernandes Ferreira
dc.contributor.institution.pt_BR.fl_str_mv Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM)
dc.contributor.author.fl_str_mv Pimenta, Amine Becheleni
dc.contributor.advisor1.fl_str_mv Seixas, S?rgio Ricardo Stuckert
contributor_str_mv Seixas, S?rgio Ricardo Stuckert
dc.subject.keyword.pt_BR.fl_str_mv Kielmeyera rubriflora
Ansiol?tica
Sedativa
Antidepressiva
SNC
topic Kielmeyera rubriflora
Ansiol?tica
Sedativa
Antidepressiva
SNC
description ?rea de concentra??o: Farmacologia.
publishDate 2014
dc.date.submitted.none.fl_str_mv 2014-12-19
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-12-02T16:37:34Z
dc.date.available.fl_str_mv 2015-12-02T16:37:34Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
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dc.identifier.citation.fl_str_mv PIMENTA, Amine Becheleni. Atividade ansiol?tica e antidepressiva do extrato bruto das partes a?reas da Kielmeyera rubriflora em camundongos. 2014. 98 [2] p. Disserta??o (Mestrado) ? Programa de P?s-gradua??o em Ci?ncias Farmac?uticas, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, 2014.
dc.identifier.uri.fl_str_mv http://acervo.ufvjm.edu.br/jspui/handle/1/765
identifier_str_mv PIMENTA, Amine Becheleni. Atividade ansiol?tica e antidepressiva do extrato bruto das partes a?reas da Kielmeyera rubriflora em camundongos. 2014. 98 [2] p. Disserta??o (Mestrado) ? Programa de P?s-gradua??o em Ci?ncias Farmac?uticas, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, 2014.
url http://acervo.ufvjm.edu.br/jspui/handle/1/765
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv UFVJM
publisher.none.fl_str_mv UFVJM
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFVJM
instname:Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM)
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instname_str Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM)
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institution UFVJM
reponame_str Repositório Institucional da UFVJM
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