New rubrolide analogues as inhibitors of photosynthesis light reactions
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | LOCUS Repositório Institucional da UFV |
Texto Completo: | https://doi.org/10.1016/j.jphotobiol.2015.02.016 http://www.locus.ufv.br/handle/123456789/19813 |
Resumo: | Natural products called rubrolides have been investigated as a model for the development of new herbi- cides that act on the photosynthesis apparatus. This study comprises a comprehensive analysis of the photosynthesis inhibitory ability of 27 new structurally diverse rubrolide analogues. In general, the results revealed that the compounds exhibited efficient inhibition of the photosynthetic process, but in some cases low water solubility may be a limiting factor. To elucidate their mode of action, the effects of the compounds on PSII and PSI, as well as their partial reaction on chloroplasts and the chlorophyll a fluorescence transients were measured. Our results showed that some of the most active rubrolide ana- logues act as a Hill reaction inhibitors at the QB level by interacting with the D1 protein at the reducing side of PSII. All of the active analogues follow Tice’s rule of 5, which indicates that these compounds pre- sent physicochemical properties suitable for herbicides. |
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Varejão, Jodieh O.S.Barbosa, Luiz C.A.Ramos, Gabriela ÁlvarezVarejão, Eduardo V.V.King-Díaz, BeatrizLotina-Hennsen, Blas2018-05-25T15:42:20Z2018-05-25T15:42:20Z2015-03-0110111344https://doi.org/10.1016/j.jphotobiol.2015.02.016http://www.locus.ufv.br/handle/123456789/19813Natural products called rubrolides have been investigated as a model for the development of new herbi- cides that act on the photosynthesis apparatus. This study comprises a comprehensive analysis of the photosynthesis inhibitory ability of 27 new structurally diverse rubrolide analogues. In general, the results revealed that the compounds exhibited efficient inhibition of the photosynthetic process, but in some cases low water solubility may be a limiting factor. To elucidate their mode of action, the effects of the compounds on PSII and PSI, as well as their partial reaction on chloroplasts and the chlorophyll a fluorescence transients were measured. Our results showed that some of the most active rubrolide ana- logues act as a Hill reaction inhibitors at the QB level by interacting with the D1 protein at the reducing side of PSII. All of the active analogues follow Tice’s rule of 5, which indicates that these compounds pre- sent physicochemical properties suitable for herbicides.engJournal of Photochemistry and Photobiology B:v. 145, p. 11-18, Abril 2015Elsevier B.V.info:eu-repo/semantics/openAccessRubrolidePhotosynthesis lightNew rubrolide analogues as inhibitors of photosynthesis light reactionsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfreponame:LOCUS Repositório Institucional da UFVinstname:Universidade Federal de Viçosa (UFV)instacron:UFVORIGINALartigo.pdfartigo.pdftexto completoapplication/pdf541497https://locus.ufv.br//bitstream/123456789/19813/1/artigo.pdf0eacb80265583b070b9924516ce426eeMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://locus.ufv.br//bitstream/123456789/19813/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52THUMBNAILartigo.pdf.jpgartigo.pdf.jpgIM Thumbnailimage/jpeg5508https://locus.ufv.br//bitstream/123456789/19813/3/artigo.pdf.jpgfcf3b4fd1cccedd1aeb7ba578303c9c1MD53123456789/198132018-05-25 23:00:43.972oai:locus.ufv.br:123456789/19813Tk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=Repositório InstitucionalPUBhttps://www.locus.ufv.br/oai/requestfabiojreis@ufv.bropendoar:21452018-05-26T02:00:43LOCUS Repositório Institucional da UFV - Universidade Federal de Viçosa (UFV)false |
dc.title.en.fl_str_mv |
New rubrolide analogues as inhibitors of photosynthesis light reactions |
title |
New rubrolide analogues as inhibitors of photosynthesis light reactions |
spellingShingle |
New rubrolide analogues as inhibitors of photosynthesis light reactions Varejão, Jodieh O.S. Rubrolide Photosynthesis light |
title_short |
New rubrolide analogues as inhibitors of photosynthesis light reactions |
title_full |
New rubrolide analogues as inhibitors of photosynthesis light reactions |
title_fullStr |
New rubrolide analogues as inhibitors of photosynthesis light reactions |
title_full_unstemmed |
New rubrolide analogues as inhibitors of photosynthesis light reactions |
title_sort |
New rubrolide analogues as inhibitors of photosynthesis light reactions |
author |
Varejão, Jodieh O.S. |
author_facet |
Varejão, Jodieh O.S. Barbosa, Luiz C.A. Ramos, Gabriela Álvarez Varejão, Eduardo V.V. King-Díaz, Beatriz Lotina-Hennsen, Blas |
author_role |
author |
author2 |
Barbosa, Luiz C.A. Ramos, Gabriela Álvarez Varejão, Eduardo V.V. King-Díaz, Beatriz Lotina-Hennsen, Blas |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Varejão, Jodieh O.S. Barbosa, Luiz C.A. Ramos, Gabriela Álvarez Varejão, Eduardo V.V. King-Díaz, Beatriz Lotina-Hennsen, Blas |
dc.subject.pt-BR.fl_str_mv |
Rubrolide Photosynthesis light |
topic |
Rubrolide Photosynthesis light |
description |
Natural products called rubrolides have been investigated as a model for the development of new herbi- cides that act on the photosynthesis apparatus. This study comprises a comprehensive analysis of the photosynthesis inhibitory ability of 27 new structurally diverse rubrolide analogues. In general, the results revealed that the compounds exhibited efficient inhibition of the photosynthetic process, but in some cases low water solubility may be a limiting factor. To elucidate their mode of action, the effects of the compounds on PSII and PSI, as well as their partial reaction on chloroplasts and the chlorophyll a fluorescence transients were measured. Our results showed that some of the most active rubrolide ana- logues act as a Hill reaction inhibitors at the QB level by interacting with the D1 protein at the reducing side of PSII. All of the active analogues follow Tice’s rule of 5, which indicates that these compounds pre- sent physicochemical properties suitable for herbicides. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015-03-01 |
dc.date.accessioned.fl_str_mv |
2018-05-25T15:42:20Z |
dc.date.available.fl_str_mv |
2018-05-25T15:42:20Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.1016/j.jphotobiol.2015.02.016 http://www.locus.ufv.br/handle/123456789/19813 |
dc.identifier.issn.none.fl_str_mv |
10111344 |
identifier_str_mv |
10111344 |
url |
https://doi.org/10.1016/j.jphotobiol.2015.02.016 http://www.locus.ufv.br/handle/123456789/19813 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartofseries.pt-BR.fl_str_mv |
v. 145, p. 11-18, Abril 2015 |
dc.rights.driver.fl_str_mv |
Elsevier B.V. info:eu-repo/semantics/openAccess |
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Elsevier B.V. |
eu_rights_str_mv |
openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Journal of Photochemistry and Photobiology B: |
publisher.none.fl_str_mv |
Journal of Photochemistry and Photobiology B: |
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LOCUS Repositório Institucional da UFV |
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LOCUS Repositório Institucional da UFV |
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