Regeneration of peripheral nerve fibres following Haloxon-induced degeneration

Detalhes bibliográficos
Autor(a) principal: Souza, Maria Veronica de
Data de Publicação: 1995
Outros Autores: Graça, Dominguita Luhers, Ferrão, Sandro Narciso Nunes, Contesini, Emerson Antônio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: LOCUS Repositório Institucional da UFV
Texto Completo: http://dx.doi.org/10.11606/issn.2318-3659.v33i4p231-234
http://www.locus.ufv.br/handle/123456789/16885
Resumo: Delayed neurotoxicity has been associated with organophosphorus poisoning for years. In order to study such condition in sheep, 11 animals were given either one or two high doses of Haloxon. Exposed sheep were observed daily and between 16 and 25 days after adm inistration neurological signs as incoordination and ataxia were detected in six of them. Biopsies of tibial and laryngeal nerves were performed as soon as neurotoxicity was diagnosed, and after death fragm ents of selected nerves were collected together with CNS tissues for light and electron microscopy and teased fiber studies. Laryngeal, tibial and sciatic nerves showed the most pronouced changes, consisting chiefly of wallerian degeneration that was seen either as a single fiber or as a com plete fascicle feature. Exams performed after death clearly showed regenerating fascicles with axonal sprouts growing within a Schwann cell old basal lamina, and some thinly myelinated axonal sprouts.
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spelling Regeneration of peripheral nerve fibres following Haloxon-induced degenerationHaloxonPoisoningSheepNeurotoxinsNerve regenerationDelayed neurotoxicity has been associated with organophosphorus poisoning for years. In order to study such condition in sheep, 11 animals were given either one or two high doses of Haloxon. Exposed sheep were observed daily and between 16 and 25 days after adm inistration neurological signs as incoordination and ataxia were detected in six of them. Biopsies of tibial and laryngeal nerves were performed as soon as neurotoxicity was diagnosed, and after death fragm ents of selected nerves were collected together with CNS tissues for light and electron microscopy and teased fiber studies. Laryngeal, tibial and sciatic nerves showed the most pronouced changes, consisting chiefly of wallerian degeneration that was seen either as a single fiber or as a com plete fascicle feature. Exams performed after death clearly showed regenerating fascicles with axonal sprouts growing within a Schwann cell old basal lamina, and some thinly myelinated axonal sprouts.Eventos de neurotoxicidade tardia têm sido freqüentemente associados com intoxicação crônica por organofosforados. Com a finalidade de estudar essa condição em ovelhas, 11 animais receberam uma ou duas doses de 353 ou 500 mg/kg de Haloxon via oral. Os animais intoxicados foram observados diariamente e, entre 16 e 25 dias após a intoxicação, sinais neurológicos de incoordenação e ataxia foram detectados em seis deles. Foram realizadas biópsias de nervos tibiais e laríngeos tão logo a neurotoxicidade foi diagnosticada e, após a morte, fragmentos de nervos periféricos selecionados foram colhidos, juntamente com o sistema nervoso central, para estudos de microscopia óptica, eletrônica de transmissão e de fibras desfiadas. Os nervos tibiais, laríngeos e ciáticos mostraram as alterações mais pronunciadas, que consistiram em degeneração walleriana, ora de uma única fibra, ora de todo um fascículo. Após a morte, exames histológicos revelaram fibras em regeneração com brotamentos axonais crescendo dentro de membranas de células de Schwann, alguns exibindo bainhas finas de mielina.Brazilian Journal of Veterinary Research and Animal Science2018-01-29T13:30:31Z2018-01-29T13:30:31Z1995-11-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlepdfapplication/pdf1678-4456http://dx.doi.org/10.11606/issn.2318-3659.v33i4p231-234http://www.locus.ufv.br/handle/123456789/16885engv.33, n.4, p.231-234, 1996Souza, Maria Veronica deGraça, Dominguita LuhersFerrão, Sandro Narciso NunesContesini, Emerson Antônioinfo:eu-repo/semantics/openAccessreponame:LOCUS Repositório Institucional da UFVinstname:Universidade Federal de Viçosa (UFV)instacron:UFV2024-07-12T07:18:55Zoai:locus.ufv.br:123456789/16885Repositório InstitucionalPUBhttps://www.locus.ufv.br/oai/requestfabiojreis@ufv.bropendoar:21452024-07-12T07:18:55LOCUS Repositório Institucional da UFV - Universidade Federal de Viçosa (UFV)false
dc.title.none.fl_str_mv Regeneration of peripheral nerve fibres following Haloxon-induced degeneration
title Regeneration of peripheral nerve fibres following Haloxon-induced degeneration
spellingShingle Regeneration of peripheral nerve fibres following Haloxon-induced degeneration
Souza, Maria Veronica de
Haloxon
Poisoning
Sheep
Neurotoxins
Nerve regeneration
title_short Regeneration of peripheral nerve fibres following Haloxon-induced degeneration
title_full Regeneration of peripheral nerve fibres following Haloxon-induced degeneration
title_fullStr Regeneration of peripheral nerve fibres following Haloxon-induced degeneration
title_full_unstemmed Regeneration of peripheral nerve fibres following Haloxon-induced degeneration
title_sort Regeneration of peripheral nerve fibres following Haloxon-induced degeneration
author Souza, Maria Veronica de
author_facet Souza, Maria Veronica de
Graça, Dominguita Luhers
Ferrão, Sandro Narciso Nunes
Contesini, Emerson Antônio
author_role author
author2 Graça, Dominguita Luhers
Ferrão, Sandro Narciso Nunes
Contesini, Emerson Antônio
author2_role author
author
author
dc.contributor.author.fl_str_mv Souza, Maria Veronica de
Graça, Dominguita Luhers
Ferrão, Sandro Narciso Nunes
Contesini, Emerson Antônio
dc.subject.por.fl_str_mv Haloxon
Poisoning
Sheep
Neurotoxins
Nerve regeneration
topic Haloxon
Poisoning
Sheep
Neurotoxins
Nerve regeneration
description Delayed neurotoxicity has been associated with organophosphorus poisoning for years. In order to study such condition in sheep, 11 animals were given either one or two high doses of Haloxon. Exposed sheep were observed daily and between 16 and 25 days after adm inistration neurological signs as incoordination and ataxia were detected in six of them. Biopsies of tibial and laryngeal nerves were performed as soon as neurotoxicity was diagnosed, and after death fragm ents of selected nerves were collected together with CNS tissues for light and electron microscopy and teased fiber studies. Laryngeal, tibial and sciatic nerves showed the most pronouced changes, consisting chiefly of wallerian degeneration that was seen either as a single fiber or as a com plete fascicle feature. Exams performed after death clearly showed regenerating fascicles with axonal sprouts growing within a Schwann cell old basal lamina, and some thinly myelinated axonal sprouts.
publishDate 1995
dc.date.none.fl_str_mv 1995-11-15
2018-01-29T13:30:31Z
2018-01-29T13:30:31Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv 1678-4456
http://dx.doi.org/10.11606/issn.2318-3659.v33i4p231-234
http://www.locus.ufv.br/handle/123456789/16885
identifier_str_mv 1678-4456
url http://dx.doi.org/10.11606/issn.2318-3659.v33i4p231-234
http://www.locus.ufv.br/handle/123456789/16885
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv v.33, n.4, p.231-234, 1996
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv pdf
application/pdf
dc.publisher.none.fl_str_mv Brazilian Journal of Veterinary Research and Animal Science
publisher.none.fl_str_mv Brazilian Journal of Veterinary Research and Animal Science
dc.source.none.fl_str_mv reponame:LOCUS Repositório Institucional da UFV
instname:Universidade Federal de Viçosa (UFV)
instacron:UFV
instname_str Universidade Federal de Viçosa (UFV)
instacron_str UFV
institution UFV
reponame_str LOCUS Repositório Institucional da UFV
collection LOCUS Repositório Institucional da UFV
repository.name.fl_str_mv LOCUS Repositório Institucional da UFV - Universidade Federal de Viçosa (UFV)
repository.mail.fl_str_mv fabiojreis@ufv.br
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