Paradoxical effect of a pequi oil-rich diet on the development of atherosclerosis: balance between antioxidant and hyperlipidemic properties

Detalhes bibliográficos
Autor(a) principal: Peluzio, M.C.G.
Data de Publicação: 2012
Outros Autores: Aguilar, E.C., Jascolka, T.L., Teixeira, L.G., Lages, P.C., Ribeiro, A.C.C., Vieira, E.L.M., Alvarez-Leite, J.I.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: LOCUS Repositório Institucional da UFV
Texto Completo: http://dx.doi.org/10.1590/S0100-879X2012007500074
http://www.locus.ufv.br/handle/123456789/17906
Resumo: O artigo não contém resumo em português.
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spelling Paradoxical effect of a pequi oil-rich diet on the development of atherosclerosis: balance between antioxidant and hyperlipidemic propertiesPequi oilFatty acidLipidsAtherosclerosisOxidative stressCholesterolO artigo não contém resumo em português.Pequi is the fruit of Caryocar brasiliense and its oil has a high concentration of monounsaturated and saturated fatty acids, which are anti- and pro-atherogenic agents, respectively, and of carotenoids, which give it antioxidant properties. Our objective was to study the effect of the intake of a cholesterol-rich diet supplemented with pequi oil, compared to the same diet containing soybean oil, on atherosclerosis development, and oxidative stress in atherosclerosis-susceptible LDL receptor-deficient mice (LDLr -/-, C57BL/6-background). Female mice were fed a cholesterol-rich diet containing 7% soybean oil (Soybean group, N = 12) or 7% pequi oil (Pequi group, N = 12) for 6 weeks. The Pequi group presented a more atherogenic lipid profile and more advanced atherosclerotic lesions in the aortic root compared to the Soybean group. However, the Pequi group presented a less advanced lesion in the aorta than the Soybean group and showed lower lipid peroxidation (Soybean group: 50.2 ± 7.1; Pequi group: 30.0 ± 4.8 µmol MDA/mg protein) and anti-oxidized LDL autoantibodies (Soybean group: 35.7 ± 9.4; Pequi group: 15.6 ± 3.7 arbitrary units). Peritoneal macrophages from the Pequi group stimulated with zymosan showed a reduction in the release of reactive oxygen species compared to the Soybean group. Our data suggest that a pequi oil-rich diet slows atherogenesis in the initial stages, possibly due to its antioxidant activity. However, the increase of serum cholesterol induces a more prominent LDL migration toward the intimae of arteries, increasing the advanced atherosclerotic plaque. In conclusion, pequi oil associated with an atherogenic diet worsens the lipid profile and accelerates the formation of advanced atherosclerotic lesions despite its antioxidant action.Brazilian Journal of Medical and Biological Research2018-02-26T10:45:46Z2018-02-26T10:45:46Z2012-05-10info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlepdfapplication/pdf1414431Xhttp://dx.doi.org/10.1590/S0100-879X2012007500074http://www.locus.ufv.br/handle/123456789/17906engv. 45, n. 7, p. 601-609, Julho 2012Peluzio, M.C.G.Aguilar, E.C.Jascolka, T.L.Teixeira, L.G.Lages, P.C.Ribeiro, A.C.C.Vieira, E.L.M.Alvarez-Leite, J.I.info:eu-repo/semantics/openAccessreponame:LOCUS Repositório Institucional da UFVinstname:Universidade Federal de Viçosa (UFV)instacron:UFV2024-07-12T08:17:45Zoai:locus.ufv.br:123456789/17906Repositório InstitucionalPUBhttps://www.locus.ufv.br/oai/requestfabiojreis@ufv.bropendoar:21452024-07-12T08:17:45LOCUS Repositório Institucional da UFV - Universidade Federal de Viçosa (UFV)false
dc.title.none.fl_str_mv Paradoxical effect of a pequi oil-rich diet on the development of atherosclerosis: balance between antioxidant and hyperlipidemic properties
title Paradoxical effect of a pequi oil-rich diet on the development of atherosclerosis: balance between antioxidant and hyperlipidemic properties
spellingShingle Paradoxical effect of a pequi oil-rich diet on the development of atherosclerosis: balance between antioxidant and hyperlipidemic properties
Peluzio, M.C.G.
Pequi oil
Fatty acid
Lipids
Atherosclerosis
Oxidative stress
Cholesterol
title_short Paradoxical effect of a pequi oil-rich diet on the development of atherosclerosis: balance between antioxidant and hyperlipidemic properties
title_full Paradoxical effect of a pequi oil-rich diet on the development of atherosclerosis: balance between antioxidant and hyperlipidemic properties
title_fullStr Paradoxical effect of a pequi oil-rich diet on the development of atherosclerosis: balance between antioxidant and hyperlipidemic properties
title_full_unstemmed Paradoxical effect of a pequi oil-rich diet on the development of atherosclerosis: balance between antioxidant and hyperlipidemic properties
title_sort Paradoxical effect of a pequi oil-rich diet on the development of atherosclerosis: balance between antioxidant and hyperlipidemic properties
author Peluzio, M.C.G.
author_facet Peluzio, M.C.G.
Aguilar, E.C.
Jascolka, T.L.
Teixeira, L.G.
Lages, P.C.
Ribeiro, A.C.C.
Vieira, E.L.M.
Alvarez-Leite, J.I.
author_role author
author2 Aguilar, E.C.
Jascolka, T.L.
Teixeira, L.G.
Lages, P.C.
Ribeiro, A.C.C.
Vieira, E.L.M.
Alvarez-Leite, J.I.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Peluzio, M.C.G.
Aguilar, E.C.
Jascolka, T.L.
Teixeira, L.G.
Lages, P.C.
Ribeiro, A.C.C.
Vieira, E.L.M.
Alvarez-Leite, J.I.
dc.subject.por.fl_str_mv Pequi oil
Fatty acid
Lipids
Atherosclerosis
Oxidative stress
Cholesterol
topic Pequi oil
Fatty acid
Lipids
Atherosclerosis
Oxidative stress
Cholesterol
description O artigo não contém resumo em português.
publishDate 2012
dc.date.none.fl_str_mv 2012-05-10
2018-02-26T10:45:46Z
2018-02-26T10:45:46Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv 1414431X
http://dx.doi.org/10.1590/S0100-879X2012007500074
http://www.locus.ufv.br/handle/123456789/17906
identifier_str_mv 1414431X
url http://dx.doi.org/10.1590/S0100-879X2012007500074
http://www.locus.ufv.br/handle/123456789/17906
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv v. 45, n. 7, p. 601-609, Julho 2012
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv pdf
application/pdf
dc.publisher.none.fl_str_mv Brazilian Journal of Medical and Biological Research
publisher.none.fl_str_mv Brazilian Journal of Medical and Biological Research
dc.source.none.fl_str_mv reponame:LOCUS Repositório Institucional da UFV
instname:Universidade Federal de Viçosa (UFV)
instacron:UFV
instname_str Universidade Federal de Viçosa (UFV)
instacron_str UFV
institution UFV
reponame_str LOCUS Repositório Institucional da UFV
collection LOCUS Repositório Institucional da UFV
repository.name.fl_str_mv LOCUS Repositório Institucional da UFV - Universidade Federal de Viçosa (UFV)
repository.mail.fl_str_mv fabiojreis@ufv.br
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