In vitro trypanocidal evaluation of pinane derivatives from essential oils of ripe fruits from Schinus terebinthifolius Raddi (Anacardiaceae)

• Autor(a) principal: Sartorelli, Patricia
• Data de Publicação: 2012
• Outros Autores: Santana, Jefferson S., Guadagnin, Rafael C., Lago, João Henrique G., Pinto, Érika G., Tempone, André G., Stefani, Hélio A., Soares, Marisi G., Silva, Adalberto M. da
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: LOCUS Repositório Institucional da UFV
• Texto Completo: http://dx.doi.org/10.1590/S0100-40422012000400017; http://www.locus.ufv.br/handle/123456789/17330
• topic: Schinus terebinthifolius Raddi; Anacardiaceae; Trypanocidal activity

Essential oils of ripe fruits from Schinus terebinthifolius (Anacardiaceae), obtained using a pilot extractor and a Clevenger apparatus were chemically characterized. Due the high amount of (-)- α-pinene in both oils, this monoterpene was tested against the protozoan parasite Trypanosoma cruzi, showing a moderate potential (IC50 63.56 µg/mL) when compared to benznidazole (IC50 43.14 µg/mL). Otherwise, (-)- α-pinene oxide did not showed anti-trypanosomal activity (IC50 > 400 µg/mL) while (-)-pinane showed an IC50 of 56.50 µg/mL. The obtained results indicated that the epoxydation of α-pinene results to the loss of the anti-parasitic activity while its hydrogenation product, contributed slightly to the increased activity.