Expression analysis of m6A-related genes in various tissues of Meishan pigs at different developmental stages
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | LOCUS Repositório Institucional da UFV |
Texto Completo: | https://locus.ufv.br//handle/123456789/31087 https://doi.org/10.37496/rbz5220210149 |
Resumo: | To characterize the N6-methyladenosine (m6 A)-related gene expression profiles in various tissues of Meishan pigs at different stages, m6 A modificationrelated genes (METTL3, METTL14, METTL16, WTAP, RBM15, and FTO) were detected from newborn to physical maturity of Meishan pigs at eight important developmental stages (1, 7, 14, 21, 28, 35, 134, and 158 days old). The expression of m6 A-related genes was tissue-specific. Furthermore, the level of METTL3 messenger RNA (mRNA) was higher on day 35 than in other stages in most tissues, and the expression of METTL14 increased after day 35, and FTO exhibited a peak on day 14 in muscle, intestine, lymph nodes, thymus, and kidney. This study provided a reference for an in-depth study of the expression patterns of m6 A modification-related genes in Meishan pigs |
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Cao, YananZhang, ShuoshuoWang, GuangzhengZhang, ShuaiBao, WenbinWu, Shenglong2023-06-21T17:06:30Z2023-06-21T17:06:30Z2023-04-10Cao, Y. N.; Zhang, S. S.; Wang, G. Z.; Zhang, S.; Bao, W. B. and Wu, S. L. 2023. Expression analysis of m6 A-related genes in various tissues of Meishan pigs at different developmental stages. Revista Brasileira de Zootecnia 52:e202101491806-9290https://locus.ufv.br//handle/123456789/31087https://doi.org/10.37496/rbz5220210149To characterize the N6-methyladenosine (m6 A)-related gene expression profiles in various tissues of Meishan pigs at different stages, m6 A modificationrelated genes (METTL3, METTL14, METTL16, WTAP, RBM15, and FTO) were detected from newborn to physical maturity of Meishan pigs at eight important developmental stages (1, 7, 14, 21, 28, 35, 134, and 158 days old). The expression of m6 A-related genes was tissue-specific. Furthermore, the level of METTL3 messenger RNA (mRNA) was higher on day 35 than in other stages in most tissues, and the expression of METTL14 increased after day 35, and FTO exhibited a peak on day 14 in muscle, intestine, lymph nodes, thymus, and kidney. This study provided a reference for an in-depth study of the expression patterns of m6 A modification-related genes in Meishan pigsengBrazilian Journal of Animal ScienceR. Bras. Zootec., 52:e20210149, 2023Creative Commons Attribution Licenseinfo:eu-repo/semantics/openAccessFTOMETTL3tissue expression profileweaned pigletsExpression analysis of m6A-related genes in various tissues of Meishan pigs at different developmental stagesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlereponame:LOCUS Repositório Institucional da UFVinstname:Universidade Federal de Viçosa (UFV)instacron:UFVORIGINAL1806-9290-rbz-47-e20170019.pdf1806-9290-rbz-47-e20170019.pdfartigoapplication/pdf1583285https://locus.ufv.br//bitstream/123456789/31087/1/1806-9290-rbz-47-e20170019.pdfabd2d005482f2dae5d5b6327feb1fe0dMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://locus.ufv.br//bitstream/123456789/31087/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52123456789/310872023-06-21 14:06:31.332oai:locus.ufv.br:123456789/31087Tk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=Repositório InstitucionalPUBhttps://www.locus.ufv.br/oai/requestfabiojreis@ufv.bropendoar:21452023-06-21T17:06:31LOCUS Repositório Institucional da UFV - Universidade Federal de Viçosa (UFV)false |
dc.title.en.fl_str_mv |
Expression analysis of m6A-related genes in various tissues of Meishan pigs at different developmental stages |
title |
Expression analysis of m6A-related genes in various tissues of Meishan pigs at different developmental stages |
spellingShingle |
Expression analysis of m6A-related genes in various tissues of Meishan pigs at different developmental stages Cao, Yanan FTO METTL3 tissue expression profile weaned piglets |
title_short |
Expression analysis of m6A-related genes in various tissues of Meishan pigs at different developmental stages |
title_full |
Expression analysis of m6A-related genes in various tissues of Meishan pigs at different developmental stages |
title_fullStr |
Expression analysis of m6A-related genes in various tissues of Meishan pigs at different developmental stages |
title_full_unstemmed |
Expression analysis of m6A-related genes in various tissues of Meishan pigs at different developmental stages |
title_sort |
Expression analysis of m6A-related genes in various tissues of Meishan pigs at different developmental stages |
author |
Cao, Yanan |
author_facet |
Cao, Yanan Zhang, Shuoshuo Wang, Guangzheng Zhang, Shuai Bao, Wenbin Wu, Shenglong |
author_role |
author |
author2 |
Zhang, Shuoshuo Wang, Guangzheng Zhang, Shuai Bao, Wenbin Wu, Shenglong |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Cao, Yanan Zhang, Shuoshuo Wang, Guangzheng Zhang, Shuai Bao, Wenbin Wu, Shenglong |
dc.subject.eng.fl_str_mv |
FTO METTL3 tissue expression profile weaned piglets |
topic |
FTO METTL3 tissue expression profile weaned piglets |
description |
To characterize the N6-methyladenosine (m6 A)-related gene expression profiles in various tissues of Meishan pigs at different stages, m6 A modificationrelated genes (METTL3, METTL14, METTL16, WTAP, RBM15, and FTO) were detected from newborn to physical maturity of Meishan pigs at eight important developmental stages (1, 7, 14, 21, 28, 35, 134, and 158 days old). The expression of m6 A-related genes was tissue-specific. Furthermore, the level of METTL3 messenger RNA (mRNA) was higher on day 35 than in other stages in most tissues, and the expression of METTL14 increased after day 35, and FTO exhibited a peak on day 14 in muscle, intestine, lymph nodes, thymus, and kidney. This study provided a reference for an in-depth study of the expression patterns of m6 A modification-related genes in Meishan pigs |
publishDate |
2023 |
dc.date.accessioned.fl_str_mv |
2023-06-21T17:06:30Z |
dc.date.available.fl_str_mv |
2023-06-21T17:06:30Z |
dc.date.issued.fl_str_mv |
2023-04-10 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Cao, Y. N.; Zhang, S. S.; Wang, G. Z.; Zhang, S.; Bao, W. B. and Wu, S. L. 2023. Expression analysis of m6 A-related genes in various tissues of Meishan pigs at different developmental stages. Revista Brasileira de Zootecnia 52:e20210149 |
dc.identifier.uri.fl_str_mv |
https://locus.ufv.br//handle/123456789/31087 |
dc.identifier.issn.none.fl_str_mv |
1806-9290 |
dc.identifier.doi.pt-BR.fl_str_mv |
https://doi.org/10.37496/rbz5220210149 |
identifier_str_mv |
Cao, Y. N.; Zhang, S. S.; Wang, G. Z.; Zhang, S.; Bao, W. B. and Wu, S. L. 2023. Expression analysis of m6 A-related genes in various tissues of Meishan pigs at different developmental stages. Revista Brasileira de Zootecnia 52:e20210149 1806-9290 |
url |
https://locus.ufv.br//handle/123456789/31087 https://doi.org/10.37496/rbz5220210149 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartofseries.pt-BR.fl_str_mv |
R. Bras. Zootec., 52:e20210149, 2023 |
dc.rights.driver.fl_str_mv |
Creative Commons Attribution License info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Creative Commons Attribution License |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Brazilian Journal of Animal Science |
publisher.none.fl_str_mv |
Brazilian Journal of Animal Science |
dc.source.none.fl_str_mv |
reponame:LOCUS Repositório Institucional da UFV instname:Universidade Federal de Viçosa (UFV) instacron:UFV |
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Universidade Federal de Viçosa (UFV) |
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UFV |
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LOCUS Repositório Institucional da UFV |
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LOCUS Repositório Institucional da UFV |
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