Voluntary exercise delays heart failure onset in rats with pulmonary artery hypertension

Detalhes bibliográficos
Autor(a) principal: Natali, Antonio J.
Data de Publicação: 2015
Outros Autores: Fowler, Ewan D., Calaghan, Sarah C., White, Ed
Tipo de documento: Artigo
Idioma: eng
Título da fonte: LOCUS Repositório Institucional da UFV
Texto Completo: https://doi.org/10.1152/ajpheart.00262.2015
http://www.locus.ufv.br/handle/123456789/19586
Resumo: Increased physical activity is recommended for the general population and for patients with many diseases because of its health benefits but can be contraindicated if it is thought to be a risk for serious cardiovascular events. One such condition is pulmonary artery hypertension (PAH). PAH and right ventricular failure was induced in rats by a single injection of monocrotaline (MCT). MCT rats with voluntary access to a running wheel ran on average 2 km/day. The time for half the animals to develop heart failure signs (median survival time) was 28 days (exercise failure group), significantly longer than sedentary animals (sedentary failure group, 23 days). The contractility of single failing myocytes in response to increasing demand (stimulation frequency) was significantly impaired compared with that in both sedentary control and exercising control myocytes. However, myocytes from exercising MCT rats, tested at 23 days (exercise + MCT group), showed responses intermediate to the control (sedentary control and exercising control) and failing (sedentary failure and exercise failure) groups. We conclude that voluntary exercise is beneficial to rats with heart failure induced by PAH, and this is evidence to support the consideration of appropriate exercise regimes for potentially vulnerable groups.
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spelling Voluntary exercise delays heart failure onset in rats with pulmonary artery hypertensionExerciseHeart failureMonocrotalineMyocyteIncreased physical activity is recommended for the general population and for patients with many diseases because of its health benefits but can be contraindicated if it is thought to be a risk for serious cardiovascular events. One such condition is pulmonary artery hypertension (PAH). PAH and right ventricular failure was induced in rats by a single injection of monocrotaline (MCT). MCT rats with voluntary access to a running wheel ran on average 2 km/day. The time for half the animals to develop heart failure signs (median survival time) was 28 days (exercise failure group), significantly longer than sedentary animals (sedentary failure group, 23 days). The contractility of single failing myocytes in response to increasing demand (stimulation frequency) was significantly impaired compared with that in both sedentary control and exercising control myocytes. However, myocytes from exercising MCT rats, tested at 23 days (exercise + MCT group), showed responses intermediate to the control (sedentary control and exercising control) and failing (sedentary failure and exercise failure) groups. We conclude that voluntary exercise is beneficial to rats with heart failure induced by PAH, and this is evidence to support the consideration of appropriate exercise regimes for potentially vulnerable groups.American Journal of Physiology-Heart and Circulatory Physiology2018-05-16T10:54:36Z2018-05-16T10:54:36Z2015-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlepdfapplication/pdf1522-1539https://doi.org/10.1152/ajpheart.00262.2015http://www.locus.ufv.br/handle/123456789/19586engVolume 309, Issue 3, Pages 421-424, August 2015American Physiological Societyinfo:eu-repo/semantics/openAccessNatali, Antonio J.Fowler, Ewan D.Calaghan, Sarah C.White, Edreponame:LOCUS Repositório Institucional da UFVinstname:Universidade Federal de Viçosa (UFV)instacron:UFV2024-07-12T07:37:27Zoai:locus.ufv.br:123456789/19586Repositório InstitucionalPUBhttps://www.locus.ufv.br/oai/requestfabiojreis@ufv.bropendoar:21452024-07-12T07:37:27LOCUS Repositório Institucional da UFV - Universidade Federal de Viçosa (UFV)false
dc.title.none.fl_str_mv Voluntary exercise delays heart failure onset in rats with pulmonary artery hypertension
title Voluntary exercise delays heart failure onset in rats with pulmonary artery hypertension
spellingShingle Voluntary exercise delays heart failure onset in rats with pulmonary artery hypertension
Natali, Antonio J.
Exercise
Heart failure
Monocrotaline
Myocyte
title_short Voluntary exercise delays heart failure onset in rats with pulmonary artery hypertension
title_full Voluntary exercise delays heart failure onset in rats with pulmonary artery hypertension
title_fullStr Voluntary exercise delays heart failure onset in rats with pulmonary artery hypertension
title_full_unstemmed Voluntary exercise delays heart failure onset in rats with pulmonary artery hypertension
title_sort Voluntary exercise delays heart failure onset in rats with pulmonary artery hypertension
author Natali, Antonio J.
author_facet Natali, Antonio J.
Fowler, Ewan D.
Calaghan, Sarah C.
White, Ed
author_role author
author2 Fowler, Ewan D.
Calaghan, Sarah C.
White, Ed
author2_role author
author
author
dc.contributor.author.fl_str_mv Natali, Antonio J.
Fowler, Ewan D.
Calaghan, Sarah C.
White, Ed
dc.subject.por.fl_str_mv Exercise
Heart failure
Monocrotaline
Myocyte
topic Exercise
Heart failure
Monocrotaline
Myocyte
description Increased physical activity is recommended for the general population and for patients with many diseases because of its health benefits but can be contraindicated if it is thought to be a risk for serious cardiovascular events. One such condition is pulmonary artery hypertension (PAH). PAH and right ventricular failure was induced in rats by a single injection of monocrotaline (MCT). MCT rats with voluntary access to a running wheel ran on average 2 km/day. The time for half the animals to develop heart failure signs (median survival time) was 28 days (exercise failure group), significantly longer than sedentary animals (sedentary failure group, 23 days). The contractility of single failing myocytes in response to increasing demand (stimulation frequency) was significantly impaired compared with that in both sedentary control and exercising control myocytes. However, myocytes from exercising MCT rats, tested at 23 days (exercise + MCT group), showed responses intermediate to the control (sedentary control and exercising control) and failing (sedentary failure and exercise failure) groups. We conclude that voluntary exercise is beneficial to rats with heart failure induced by PAH, and this is evidence to support the consideration of appropriate exercise regimes for potentially vulnerable groups.
publishDate 2015
dc.date.none.fl_str_mv 2015-08-01
2018-05-16T10:54:36Z
2018-05-16T10:54:36Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv 1522-1539
https://doi.org/10.1152/ajpheart.00262.2015
http://www.locus.ufv.br/handle/123456789/19586
identifier_str_mv 1522-1539
url https://doi.org/10.1152/ajpheart.00262.2015
http://www.locus.ufv.br/handle/123456789/19586
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Volume 309, Issue 3, Pages 421-424, August 2015
dc.rights.driver.fl_str_mv American Physiological Society
info:eu-repo/semantics/openAccess
rights_invalid_str_mv American Physiological Society
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv pdf
application/pdf
dc.publisher.none.fl_str_mv American Journal of Physiology-Heart and Circulatory Physiology
publisher.none.fl_str_mv American Journal of Physiology-Heart and Circulatory Physiology
dc.source.none.fl_str_mv reponame:LOCUS Repositório Institucional da UFV
instname:Universidade Federal de Viçosa (UFV)
instacron:UFV
instname_str Universidade Federal de Viçosa (UFV)
instacron_str UFV
institution UFV
reponame_str LOCUS Repositório Institucional da UFV
collection LOCUS Repositório Institucional da UFV
repository.name.fl_str_mv LOCUS Repositório Institucional da UFV - Universidade Federal de Viçosa (UFV)
repository.mail.fl_str_mv fabiojreis@ufv.br
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