Voluntary exercise delays heart failure onset in rats with pulmonary artery hypertension
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | LOCUS Repositório Institucional da UFV |
Texto Completo: | https://doi.org/10.1152/ajpheart.00262.2015 http://www.locus.ufv.br/handle/123456789/19586 |
Resumo: | Increased physical activity is recommended for the general population and for patients with many diseases because of its health benefits but can be contraindicated if it is thought to be a risk for serious cardiovascular events. One such condition is pulmonary artery hypertension (PAH). PAH and right ventricular failure was induced in rats by a single injection of monocrotaline (MCT). MCT rats with voluntary access to a running wheel ran on average 2 km/day. The time for half the animals to develop heart failure signs (median survival time) was 28 days (exercise failure group), significantly longer than sedentary animals (sedentary failure group, 23 days). The contractility of single failing myocytes in response to increasing demand (stimulation frequency) was significantly impaired compared with that in both sedentary control and exercising control myocytes. However, myocytes from exercising MCT rats, tested at 23 days (exercise + MCT group), showed responses intermediate to the control (sedentary control and exercising control) and failing (sedentary failure and exercise failure) groups. We conclude that voluntary exercise is beneficial to rats with heart failure induced by PAH, and this is evidence to support the consideration of appropriate exercise regimes for potentially vulnerable groups. |
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Voluntary exercise delays heart failure onset in rats with pulmonary artery hypertensionExerciseHeart failureMonocrotalineMyocyteIncreased physical activity is recommended for the general population and for patients with many diseases because of its health benefits but can be contraindicated if it is thought to be a risk for serious cardiovascular events. One such condition is pulmonary artery hypertension (PAH). PAH and right ventricular failure was induced in rats by a single injection of monocrotaline (MCT). MCT rats with voluntary access to a running wheel ran on average 2 km/day. The time for half the animals to develop heart failure signs (median survival time) was 28 days (exercise failure group), significantly longer than sedentary animals (sedentary failure group, 23 days). The contractility of single failing myocytes in response to increasing demand (stimulation frequency) was significantly impaired compared with that in both sedentary control and exercising control myocytes. However, myocytes from exercising MCT rats, tested at 23 days (exercise + MCT group), showed responses intermediate to the control (sedentary control and exercising control) and failing (sedentary failure and exercise failure) groups. We conclude that voluntary exercise is beneficial to rats with heart failure induced by PAH, and this is evidence to support the consideration of appropriate exercise regimes for potentially vulnerable groups.American Journal of Physiology-Heart and Circulatory Physiology2018-05-16T10:54:36Z2018-05-16T10:54:36Z2015-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlepdfapplication/pdf1522-1539https://doi.org/10.1152/ajpheart.00262.2015http://www.locus.ufv.br/handle/123456789/19586engVolume 309, Issue 3, Pages 421-424, August 2015American Physiological Societyinfo:eu-repo/semantics/openAccessNatali, Antonio J.Fowler, Ewan D.Calaghan, Sarah C.White, Edreponame:LOCUS Repositório Institucional da UFVinstname:Universidade Federal de Viçosa (UFV)instacron:UFV2024-07-12T07:37:27Zoai:locus.ufv.br:123456789/19586Repositório InstitucionalPUBhttps://www.locus.ufv.br/oai/requestfabiojreis@ufv.bropendoar:21452024-07-12T07:37:27LOCUS Repositório Institucional da UFV - Universidade Federal de Viçosa (UFV)false |
dc.title.none.fl_str_mv |
Voluntary exercise delays heart failure onset in rats with pulmonary artery hypertension |
title |
Voluntary exercise delays heart failure onset in rats with pulmonary artery hypertension |
spellingShingle |
Voluntary exercise delays heart failure onset in rats with pulmonary artery hypertension Natali, Antonio J. Exercise Heart failure Monocrotaline Myocyte |
title_short |
Voluntary exercise delays heart failure onset in rats with pulmonary artery hypertension |
title_full |
Voluntary exercise delays heart failure onset in rats with pulmonary artery hypertension |
title_fullStr |
Voluntary exercise delays heart failure onset in rats with pulmonary artery hypertension |
title_full_unstemmed |
Voluntary exercise delays heart failure onset in rats with pulmonary artery hypertension |
title_sort |
Voluntary exercise delays heart failure onset in rats with pulmonary artery hypertension |
author |
Natali, Antonio J. |
author_facet |
Natali, Antonio J. Fowler, Ewan D. Calaghan, Sarah C. White, Ed |
author_role |
author |
author2 |
Fowler, Ewan D. Calaghan, Sarah C. White, Ed |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Natali, Antonio J. Fowler, Ewan D. Calaghan, Sarah C. White, Ed |
dc.subject.por.fl_str_mv |
Exercise Heart failure Monocrotaline Myocyte |
topic |
Exercise Heart failure Monocrotaline Myocyte |
description |
Increased physical activity is recommended for the general population and for patients with many diseases because of its health benefits but can be contraindicated if it is thought to be a risk for serious cardiovascular events. One such condition is pulmonary artery hypertension (PAH). PAH and right ventricular failure was induced in rats by a single injection of monocrotaline (MCT). MCT rats with voluntary access to a running wheel ran on average 2 km/day. The time for half the animals to develop heart failure signs (median survival time) was 28 days (exercise failure group), significantly longer than sedentary animals (sedentary failure group, 23 days). The contractility of single failing myocytes in response to increasing demand (stimulation frequency) was significantly impaired compared with that in both sedentary control and exercising control myocytes. However, myocytes from exercising MCT rats, tested at 23 days (exercise + MCT group), showed responses intermediate to the control (sedentary control and exercising control) and failing (sedentary failure and exercise failure) groups. We conclude that voluntary exercise is beneficial to rats with heart failure induced by PAH, and this is evidence to support the consideration of appropriate exercise regimes for potentially vulnerable groups. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-08-01 2018-05-16T10:54:36Z 2018-05-16T10:54:36Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
1522-1539 https://doi.org/10.1152/ajpheart.00262.2015 http://www.locus.ufv.br/handle/123456789/19586 |
identifier_str_mv |
1522-1539 |
url |
https://doi.org/10.1152/ajpheart.00262.2015 http://www.locus.ufv.br/handle/123456789/19586 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Volume 309, Issue 3, Pages 421-424, August 2015 |
dc.rights.driver.fl_str_mv |
American Physiological Society info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
American Physiological Society |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
pdf application/pdf |
dc.publisher.none.fl_str_mv |
American Journal of Physiology-Heart and Circulatory Physiology |
publisher.none.fl_str_mv |
American Journal of Physiology-Heart and Circulatory Physiology |
dc.source.none.fl_str_mv |
reponame:LOCUS Repositório Institucional da UFV instname:Universidade Federal de Viçosa (UFV) instacron:UFV |
instname_str |
Universidade Federal de Viçosa (UFV) |
instacron_str |
UFV |
institution |
UFV |
reponame_str |
LOCUS Repositório Institucional da UFV |
collection |
LOCUS Repositório Institucional da UFV |
repository.name.fl_str_mv |
LOCUS Repositório Institucional da UFV - Universidade Federal de Viçosa (UFV) |
repository.mail.fl_str_mv |
fabiojreis@ufv.br |
_version_ |
1822610646404956160 |