A reação "click" na síntese de 1,2,3-triazóis: aspectos químicos e aplicações

Detalhes bibliográficos
Autor(a) principal: Freitas, Luiza Baptista de Oliveira
Data de Publicação: 2011
Outros Autores: Ruela, Fernando Armini, Pereira, Guilherme Rocha, Alves, Rosemeire Brondi, Freitas, Rossimiriam Pereira de, Santos, Leandro José dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: LOCUS Repositório Institucional da UFV
Texto Completo: http://dx.doi.org/10.1590/S0100-40422011001000012
http://www.locus.ufv.br/handle/123456789/17583
Resumo: The Copper-catalyzed azide-alkyne cycloaddition (CuAAC), often referred to as "click" reaction, has become a very popular reaction in the last years. It affords exclusively 1,4-disubstituted 1,2,3-triazoles and has been widely used to connect readily accessible building blocks containing various functional groups. The great success of this reaction is based on the fact that it is general, virtually quantitative and very robuste. The scope of this copper-catalyzed synthesis is extraordinary and the reaction has found numerous applications in many research fields, including biological chemistry and materials science. In this review, the main chemical aspects and applications of the "click" reaction in the synthesis of 1,2,3-triazoles are presented.
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spelling Freitas, Luiza Baptista de OliveiraRuela, Fernando ArminiPereira, Guilherme RochaAlves, Rosemeire BrondiFreitas, Rossimiriam Pereira deSantos, Leandro José dos2018-02-15T13:32:52Z2018-02-15T13:32:52Z2011-08-090100-4042http://dx.doi.org/10.1590/S0100-40422011001000012http://www.locus.ufv.br/handle/123456789/17583The Copper-catalyzed azide-alkyne cycloaddition (CuAAC), often referred to as "click" reaction, has become a very popular reaction in the last years. It affords exclusively 1,4-disubstituted 1,2,3-triazoles and has been widely used to connect readily accessible building blocks containing various functional groups. The great success of this reaction is based on the fact that it is general, virtually quantitative and very robuste. The scope of this copper-catalyzed synthesis is extraordinary and the reaction has found numerous applications in many research fields, including biological chemistry and materials science. In this review, the main chemical aspects and applications of the "click" reaction in the synthesis of 1,2,3-triazoles are presented.engQuímica Novav. 34, n. 10, p. 1791-1804, 2011"Click" reactionCycloadditionTriazoleA reação "click" na síntese de 1,2,3-triazóis: aspectos químicos e aplicaçõesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfinfo:eu-repo/semantics/openAccessreponame:LOCUS Repositório Institucional da UFVinstname:Universidade Federal de Viçosa (UFV)instacron:UFVORIGINALartigo.pdfartigo.pdftexto completoapplication/pdf448984https://locus.ufv.br//bitstream/123456789/17583/1/artigo.pdf7865a6ffb37ed01e7fbac9d7dcb05598MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://locus.ufv.br//bitstream/123456789/17583/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52THUMBNAILartigo.pdf.jpgartigo.pdf.jpgIM Thumbnailimage/jpeg4598https://locus.ufv.br//bitstream/123456789/17583/3/artigo.pdf.jpg0976ced6fd2899f0d9f2c6a77f8969abMD53123456789/175832018-02-15 22:00:43.675oai:locus.ufv.br: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Repositório InstitucionalPUBhttps://www.locus.ufv.br/oai/requestfabiojreis@ufv.bropendoar:21452018-02-16T01:00:43LOCUS Repositório Institucional da UFV - Universidade Federal de Viçosa (UFV)false
dc.title.pt-BR.fl_str_mv A reação "click" na síntese de 1,2,3-triazóis: aspectos químicos e aplicações
title A reação "click" na síntese de 1,2,3-triazóis: aspectos químicos e aplicações
spellingShingle A reação "click" na síntese de 1,2,3-triazóis: aspectos químicos e aplicações
Freitas, Luiza Baptista de Oliveira
"Click" reaction
Cycloaddition
Triazole
title_short A reação "click" na síntese de 1,2,3-triazóis: aspectos químicos e aplicações
title_full A reação "click" na síntese de 1,2,3-triazóis: aspectos químicos e aplicações
title_fullStr A reação "click" na síntese de 1,2,3-triazóis: aspectos químicos e aplicações
title_full_unstemmed A reação "click" na síntese de 1,2,3-triazóis: aspectos químicos e aplicações
title_sort A reação "click" na síntese de 1,2,3-triazóis: aspectos químicos e aplicações
author Freitas, Luiza Baptista de Oliveira
author_facet Freitas, Luiza Baptista de Oliveira
Ruela, Fernando Armini
Pereira, Guilherme Rocha
Alves, Rosemeire Brondi
Freitas, Rossimiriam Pereira de
Santos, Leandro José dos
author_role author
author2 Ruela, Fernando Armini
Pereira, Guilherme Rocha
Alves, Rosemeire Brondi
Freitas, Rossimiriam Pereira de
Santos, Leandro José dos
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Freitas, Luiza Baptista de Oliveira
Ruela, Fernando Armini
Pereira, Guilherme Rocha
Alves, Rosemeire Brondi
Freitas, Rossimiriam Pereira de
Santos, Leandro José dos
dc.subject.pt-BR.fl_str_mv "Click" reaction
Cycloaddition
Triazole
topic "Click" reaction
Cycloaddition
Triazole
description The Copper-catalyzed azide-alkyne cycloaddition (CuAAC), often referred to as "click" reaction, has become a very popular reaction in the last years. It affords exclusively 1,4-disubstituted 1,2,3-triazoles and has been widely used to connect readily accessible building blocks containing various functional groups. The great success of this reaction is based on the fact that it is general, virtually quantitative and very robuste. The scope of this copper-catalyzed synthesis is extraordinary and the reaction has found numerous applications in many research fields, including biological chemistry and materials science. In this review, the main chemical aspects and applications of the "click" reaction in the synthesis of 1,2,3-triazoles are presented.
publishDate 2011
dc.date.issued.fl_str_mv 2011-08-09
dc.date.accessioned.fl_str_mv 2018-02-15T13:32:52Z
dc.date.available.fl_str_mv 2018-02-15T13:32:52Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0100-40422011001000012
http://www.locus.ufv.br/handle/123456789/17583
dc.identifier.issn.none.fl_str_mv 0100-4042
identifier_str_mv 0100-4042
url http://dx.doi.org/10.1590/S0100-40422011001000012
http://www.locus.ufv.br/handle/123456789/17583
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartofseries.pt-BR.fl_str_mv v. 34, n. 10, p. 1791-1804, 2011
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Química Nova
publisher.none.fl_str_mv Química Nova
dc.source.none.fl_str_mv reponame:LOCUS Repositório Institucional da UFV
instname:Universidade Federal de Viçosa (UFV)
instacron:UFV
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reponame_str LOCUS Repositório Institucional da UFV
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