Antimicrobial and synergistic activity of 2, 2', 4- trihydroxybenzophenone against bacterial pathogens of poultry
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | LOCUS Repositório Institucional da UFV |
Texto Completo: | http://dx.doi.org/10.3389/fmicb.2019.00490 http://www.locus.ufv.br/handle/123456789/24482 |
Resumo: | In poultry farming, the spread of bacterial pathogens results in disease outbreaks causing significant economic losses to this industry. Many of these pathogenic bacteria are zoonotic and have a substantial impact on public health. Antimicrobials are essential for the prevention and treatment of these bacterial infections. However, the indiscriminate use of these agents provides favorable conditions for selection, propagation and persistence of bacteria and development of antimicrobial resistance. We developed a new antimicrobial candidate that could be used alone or in synergy with research protocols for therapeutic, prophylactic and growth promoter uses in the poultry industry. The present study aimed at evaluating the antimicrobial activity of the synthetic compound 2,2 ,4-trihydroxybenzophenone against pathogenic bacteria that cause important diseases in poultry and public health. We tested the hemolytic effect of this compound, studied its synergistic effect with conventional antimicrobials and analyzed the site of action on the bacteria. The results of our study showed antimicrobial activity of benzophenone against Gram-positive and Gram-negative bacteria with a similar effect in ATCC (American type culture collection) and field isolates. This compound was non- hemolytic. 2,2 ,4- trihydroxybenzophenone acted on the bacterial cell wall. We identified the synergistic effect between 2,2 ,4-trihydroxybenzophenone and bacitracin, this effect indicate that antimicrobial synergism may be useful for the treatment of necrotic enteritis in poultry. This compound may also be used as a growth promoter by reducing the dose of bacitracin and thus decreasing the pressure of bacterial resistance in poultry which would circumvent the development of cross-resistance in humans. |
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Aranda, Martha Isabel RealpeGómez, Gabriel Andres TafurBarros, Mariana deSantos, Marcelo Henrique dosOliveira, Leandro Licursi dePena, Junnia LuisaMoreira, Maria Aparecida Scatamburlo2019-04-11T14:24:00Z2019-04-11T14:24:00Z2019-031664-302Xhttp://dx.doi.org/10.3389/fmicb.2019.00490http://www.locus.ufv.br/handle/123456789/24482In poultry farming, the spread of bacterial pathogens results in disease outbreaks causing significant economic losses to this industry. Many of these pathogenic bacteria are zoonotic and have a substantial impact on public health. Antimicrobials are essential for the prevention and treatment of these bacterial infections. However, the indiscriminate use of these agents provides favorable conditions for selection, propagation and persistence of bacteria and development of antimicrobial resistance. We developed a new antimicrobial candidate that could be used alone or in synergy with research protocols for therapeutic, prophylactic and growth promoter uses in the poultry industry. The present study aimed at evaluating the antimicrobial activity of the synthetic compound 2,2 ,4-trihydroxybenzophenone against pathogenic bacteria that cause important diseases in poultry and public health. We tested the hemolytic effect of this compound, studied its synergistic effect with conventional antimicrobials and analyzed the site of action on the bacteria. The results of our study showed antimicrobial activity of benzophenone against Gram-positive and Gram-negative bacteria with a similar effect in ATCC (American type culture collection) and field isolates. This compound was non- hemolytic. 2,2 ,4- trihydroxybenzophenone acted on the bacterial cell wall. We identified the synergistic effect between 2,2 ,4-trihydroxybenzophenone and bacitracin, this effect indicate that antimicrobial synergism may be useful for the treatment of necrotic enteritis in poultry. This compound may also be used as a growth promoter by reducing the dose of bacitracin and thus decreasing the pressure of bacterial resistance in poultry which would circumvent the development of cross-resistance in humans.engFrontiers in MicrobiologyVolume 10, Article 490, Pages 1- 10, March 2019Poultry diseasesBenzophenoneAntimicrobial agentsDrug synergismsBactericideAntimicrobial and synergistic activity of 2, 2', 4- trihydroxybenzophenone against bacterial pathogens of poultryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfinfo:eu-repo/semantics/openAccessreponame:LOCUS Repositório Institucional da UFVinstname:Universidade Federal de Viçosa (UFV)instacron:UFVORIGINALartigo.pdfartigo.pdftexto completoapplication/pdf1518328https://locus.ufv.br//bitstream/123456789/24482/1/artigo.pdfb2c695a928b7edc3a5280fef003a673fMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://locus.ufv.br//bitstream/123456789/24482/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52123456789/244822019-04-11 11:26:38.923oai:locus.ufv.br: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Repositório InstitucionalPUBhttps://www.locus.ufv.br/oai/requestfabiojreis@ufv.bropendoar:21452019-04-11T14:26:38LOCUS Repositório Institucional da UFV - Universidade Federal de Viçosa (UFV)false |
dc.title.en.fl_str_mv |
Antimicrobial and synergistic activity of 2, 2', 4- trihydroxybenzophenone against bacterial pathogens of poultry |
title |
Antimicrobial and synergistic activity of 2, 2', 4- trihydroxybenzophenone against bacterial pathogens of poultry |
spellingShingle |
Antimicrobial and synergistic activity of 2, 2', 4- trihydroxybenzophenone against bacterial pathogens of poultry Aranda, Martha Isabel Realpe Poultry diseases Benzophenone Antimicrobial agents Drug synergisms Bactericide |
title_short |
Antimicrobial and synergistic activity of 2, 2', 4- trihydroxybenzophenone against bacterial pathogens of poultry |
title_full |
Antimicrobial and synergistic activity of 2, 2', 4- trihydroxybenzophenone against bacterial pathogens of poultry |
title_fullStr |
Antimicrobial and synergistic activity of 2, 2', 4- trihydroxybenzophenone against bacterial pathogens of poultry |
title_full_unstemmed |
Antimicrobial and synergistic activity of 2, 2', 4- trihydroxybenzophenone against bacterial pathogens of poultry |
title_sort |
Antimicrobial and synergistic activity of 2, 2', 4- trihydroxybenzophenone against bacterial pathogens of poultry |
author |
Aranda, Martha Isabel Realpe |
author_facet |
Aranda, Martha Isabel Realpe Gómez, Gabriel Andres Tafur Barros, Mariana de Santos, Marcelo Henrique dos Oliveira, Leandro Licursi de Pena, Junnia Luisa Moreira, Maria Aparecida Scatamburlo |
author_role |
author |
author2 |
Gómez, Gabriel Andres Tafur Barros, Mariana de Santos, Marcelo Henrique dos Oliveira, Leandro Licursi de Pena, Junnia Luisa Moreira, Maria Aparecida Scatamburlo |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Aranda, Martha Isabel Realpe Gómez, Gabriel Andres Tafur Barros, Mariana de Santos, Marcelo Henrique dos Oliveira, Leandro Licursi de Pena, Junnia Luisa Moreira, Maria Aparecida Scatamburlo |
dc.subject.pt-BR.fl_str_mv |
Poultry diseases Benzophenone Antimicrobial agents Drug synergisms Bactericide |
topic |
Poultry diseases Benzophenone Antimicrobial agents Drug synergisms Bactericide |
description |
In poultry farming, the spread of bacterial pathogens results in disease outbreaks causing significant economic losses to this industry. Many of these pathogenic bacteria are zoonotic and have a substantial impact on public health. Antimicrobials are essential for the prevention and treatment of these bacterial infections. However, the indiscriminate use of these agents provides favorable conditions for selection, propagation and persistence of bacteria and development of antimicrobial resistance. We developed a new antimicrobial candidate that could be used alone or in synergy with research protocols for therapeutic, prophylactic and growth promoter uses in the poultry industry. The present study aimed at evaluating the antimicrobial activity of the synthetic compound 2,2 ,4-trihydroxybenzophenone against pathogenic bacteria that cause important diseases in poultry and public health. We tested the hemolytic effect of this compound, studied its synergistic effect with conventional antimicrobials and analyzed the site of action on the bacteria. The results of our study showed antimicrobial activity of benzophenone against Gram-positive and Gram-negative bacteria with a similar effect in ATCC (American type culture collection) and field isolates. This compound was non- hemolytic. 2,2 ,4- trihydroxybenzophenone acted on the bacterial cell wall. We identified the synergistic effect between 2,2 ,4-trihydroxybenzophenone and bacitracin, this effect indicate that antimicrobial synergism may be useful for the treatment of necrotic enteritis in poultry. This compound may also be used as a growth promoter by reducing the dose of bacitracin and thus decreasing the pressure of bacterial resistance in poultry which would circumvent the development of cross-resistance in humans. |
publishDate |
2019 |
dc.date.accessioned.fl_str_mv |
2019-04-11T14:24:00Z |
dc.date.available.fl_str_mv |
2019-04-11T14:24:00Z |
dc.date.issued.fl_str_mv |
2019-03 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3389/fmicb.2019.00490 http://www.locus.ufv.br/handle/123456789/24482 |
dc.identifier.issn.none.fl_str_mv |
1664-302X |
identifier_str_mv |
1664-302X |
url |
http://dx.doi.org/10.3389/fmicb.2019.00490 http://www.locus.ufv.br/handle/123456789/24482 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
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Volume 10, Article 490, Pages 1- 10, March 2019 |
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openAccess |
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Frontiers in Microbiology |
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Frontiers in Microbiology |
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