Risk factors for human Mycobacterium bovis infections in an urban area of Brazil

Detalhes bibliográficos
Autor(a) principal: Moreira, Maria Aparecida Scatamburlo
Data de Publicação: 2018
Outros Autores: Silva, Marcio Roberto, Rocha, Adalgiza da Silva, Araújo, Flábio Ribeiro, Fonseca-Júnior, Antônio Augusto, Alencar, Andrea Padilha de, Suffys, Philip Noel, Costa, Ronaldo Rodrigues da, Guimarães, Mark Drew Crosland
Tipo de documento: Artigo
Idioma: eng
Título da fonte: LOCUS Repositório Institucional da UFV
Texto Completo: http://dx.doi.org/10.1590/0074-02760170445
http://www.locus.ufv.br/handle/123456789/24367
Resumo: The World Health Organization (WHO) has classified human zoonotic tuberculosis (TB) due to Mycobacterium bovis as a neglected issue in the developing world. In a recent cross-sectional study in Brazil, three of 189 TB patients presented with a coinfection of M. bovis and M. tuberculosis and were selected as cases for this study.The aim was to evaluate risk factors (RF) for zoonotic TB in an urban area of Brazil in order to guide preventive programmes.A matched case-control study was carried out nested within a cross-sectional study. For each of the three cases, 14 age- and sex-matched controls (TB due to M. tuberculosis) were selected.Zoonotic potential exposures (ZE) and extrapulmonary TB (EPTB) were independently associated with zoonotic TB in multivariate analyses. ZE by occupation and consumption of raw milk and derivative products that place individuals in direct and indirect contact with animals and their excretions/secretions increase the risk for zoonotic TB in Brazil, especially among those with EPTB. Therefore, measures such as efficient control of bovine TB, distribution of pasteurised milk and its derivative products, and the diagnosis and monitoring of zoonotic TB in humans are essential steps, especially in developing countries where bovine TB is enzootic, and further studies are necessary.
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spelling Moreira, Maria Aparecida ScatamburloSilva, Marcio RobertoRocha, Adalgiza da SilvaAraújo, Flábio RibeiroFonseca-Júnior, Antônio AugustoAlencar, Andrea Padilha deSuffys, Philip NoelCosta, Ronaldo Rodrigues daMoreira, Maria Aparecida ScatamburloGuimarães, Mark Drew Crosland2019-04-08T16:45:09Z2019-04-08T16:45:09Z201816788060http://dx.doi.org/10.1590/0074-02760170445http://www.locus.ufv.br/handle/123456789/24367The World Health Organization (WHO) has classified human zoonotic tuberculosis (TB) due to Mycobacterium bovis as a neglected issue in the developing world. In a recent cross-sectional study in Brazil, three of 189 TB patients presented with a coinfection of M. bovis and M. tuberculosis and were selected as cases for this study.The aim was to evaluate risk factors (RF) for zoonotic TB in an urban area of Brazil in order to guide preventive programmes.A matched case-control study was carried out nested within a cross-sectional study. For each of the three cases, 14 age- and sex-matched controls (TB due to M. tuberculosis) were selected.Zoonotic potential exposures (ZE) and extrapulmonary TB (EPTB) were independently associated with zoonotic TB in multivariate analyses. ZE by occupation and consumption of raw milk and derivative products that place individuals in direct and indirect contact with animals and their excretions/secretions increase the risk for zoonotic TB in Brazil, especially among those with EPTB. Therefore, measures such as efficient control of bovine TB, distribution of pasteurised milk and its derivative products, and the diagnosis and monitoring of zoonotic TB in humans are essential steps, especially in developing countries where bovine TB is enzootic, and further studies are necessary.engMemórias do Instituto Oswaldo Cruzv. 113, n. 8, e170445, p. 01- 06, 2018TuberculosisZoonosesRisk factorsRisk factors for human Mycobacterium bovis infections in an urban area of Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfinfo:eu-repo/semantics/openAccessreponame:LOCUS Repositório Institucional da UFVinstname:Universidade Federal de Viçosa (UFV)instacron:UFVORIGINALartigo.pdfartigo.pdftexto completoapplication/pdf276361https://locus.ufv.br//bitstream/123456789/24367/1/artigo.pdf8a628773f74e31875851ac67d868e322MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://locus.ufv.br//bitstream/123456789/24367/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52123456789/243672019-04-08 13:45:09.792oai:locus.ufv.br:123456789/24367Tk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=Repositório InstitucionalPUBhttps://www.locus.ufv.br/oai/requestfabiojreis@ufv.bropendoar:21452019-04-08T16:45:09LOCUS Repositório Institucional da UFV - Universidade Federal de Viçosa (UFV)false
dc.title.pt-BR.fl_str_mv Risk factors for human Mycobacterium bovis infections in an urban area of Brazil
title Risk factors for human Mycobacterium bovis infections in an urban area of Brazil
spellingShingle Risk factors for human Mycobacterium bovis infections in an urban area of Brazil
Moreira, Maria Aparecida Scatamburlo
Tuberculosis
Zoonoses
Risk factors
title_short Risk factors for human Mycobacterium bovis infections in an urban area of Brazil
title_full Risk factors for human Mycobacterium bovis infections in an urban area of Brazil
title_fullStr Risk factors for human Mycobacterium bovis infections in an urban area of Brazil
title_full_unstemmed Risk factors for human Mycobacterium bovis infections in an urban area of Brazil
title_sort Risk factors for human Mycobacterium bovis infections in an urban area of Brazil
author Moreira, Maria Aparecida Scatamburlo
author_facet Moreira, Maria Aparecida Scatamburlo
Silva, Marcio Roberto
Rocha, Adalgiza da Silva
Araújo, Flábio Ribeiro
Fonseca-Júnior, Antônio Augusto
Alencar, Andrea Padilha de
Suffys, Philip Noel
Costa, Ronaldo Rodrigues da
Guimarães, Mark Drew Crosland
author_role author
author2 Silva, Marcio Roberto
Rocha, Adalgiza da Silva
Araújo, Flábio Ribeiro
Fonseca-Júnior, Antônio Augusto
Alencar, Andrea Padilha de
Suffys, Philip Noel
Costa, Ronaldo Rodrigues da
Guimarães, Mark Drew Crosland
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Moreira, Maria Aparecida Scatamburlo
Silva, Marcio Roberto
Rocha, Adalgiza da Silva
Araújo, Flábio Ribeiro
Fonseca-Júnior, Antônio Augusto
Alencar, Andrea Padilha de
Suffys, Philip Noel
Costa, Ronaldo Rodrigues da
Moreira, Maria Aparecida Scatamburlo
Guimarães, Mark Drew Crosland
dc.subject.pt-BR.fl_str_mv Tuberculosis
Zoonoses
Risk factors
topic Tuberculosis
Zoonoses
Risk factors
description The World Health Organization (WHO) has classified human zoonotic tuberculosis (TB) due to Mycobacterium bovis as a neglected issue in the developing world. In a recent cross-sectional study in Brazil, three of 189 TB patients presented with a coinfection of M. bovis and M. tuberculosis and were selected as cases for this study.The aim was to evaluate risk factors (RF) for zoonotic TB in an urban area of Brazil in order to guide preventive programmes.A matched case-control study was carried out nested within a cross-sectional study. For each of the three cases, 14 age- and sex-matched controls (TB due to M. tuberculosis) were selected.Zoonotic potential exposures (ZE) and extrapulmonary TB (EPTB) were independently associated with zoonotic TB in multivariate analyses. ZE by occupation and consumption of raw milk and derivative products that place individuals in direct and indirect contact with animals and their excretions/secretions increase the risk for zoonotic TB in Brazil, especially among those with EPTB. Therefore, measures such as efficient control of bovine TB, distribution of pasteurised milk and its derivative products, and the diagnosis and monitoring of zoonotic TB in humans are essential steps, especially in developing countries where bovine TB is enzootic, and further studies are necessary.
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-04-08T16:45:09Z
dc.date.available.fl_str_mv 2019-04-08T16:45:09Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/0074-02760170445
http://www.locus.ufv.br/handle/123456789/24367
dc.identifier.issn.none.fl_str_mv 16788060
identifier_str_mv 16788060
url http://dx.doi.org/10.1590/0074-02760170445
http://www.locus.ufv.br/handle/123456789/24367
dc.language.iso.fl_str_mv eng
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dc.relation.ispartofseries.pt-BR.fl_str_mv v. 113, n. 8, e170445, p. 01- 06, 2018
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dc.publisher.none.fl_str_mv Memórias do Instituto Oswaldo Cruz
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dc.source.none.fl_str_mv reponame:LOCUS Repositório Institucional da UFV
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