Efeitos da intensidade do treinamento sobre parâmetros de estresse oxidativo e de perfil lipídico em camundongos LDL-/-

• Autor(a) principal: Teodoro, Bruno Gonzaga
• Data de Publicação: 2009
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: LOCUS Repositório Institucional da UFV
• Texto Completo: http://locus.ufv.br/handle/123456789/3455
• topic: Exercício aeróbico; Aterosclerose; Estresse oxidativo; Aerobic exercise; Atherosclerosis; Oxidative stress; CNPQ::CIENCIAS DA SAUDE::EDUCACAO FISICA

Atherosclerosis is a chronic-degenerative inflammatory process that occurs in blood vessels and is characterized by lipid, inflammatory cells and fibroses factors accumulation on the vessels wall. The (LDL-c) oxidation seems to be the first step to atherosclerosis. Aerobic exercise improve the organic system defense against atherosclerosis by decreasing oxidative stress and increasing anti-oxidant enzyme biosynthesis, improving blood vessels vasodilatation by nitric oxide (NO) and endothelium nitric oxide synthase (eNOS), decreasing the pro-inflammatory cytokine production and increasing anti-inflammatory factors. However, acute high intensity aerobic exercises increase the cardiovascular event risk while chronically it may affect either positively or negatively. To evaluate the effects of aerobic exercise intensity on atherosclerosis, we investigated the effects of 2 months of treadmill aerobic exercise, at light (G2) or moderate intensity (G3) in the development of atherosclerosis in LDL receptor knockout mice (LDLr-/ -) previously submitted to 3 months of high-fat high-cholesterol diet and assessing the effects of serum total cholesterol (TC), HDL-c and triglycerides (TG), oxidative damage (protein carbonyls and lipid hydroperoxides) and activity of antioxidant enzymes catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) in liver tissue, and body composition of the carcass. The results showed that G2 (0.015 ± 0.005 cm2) and G3 (0.014 ± 0.001 cm2) had a lower aortic fat deposition area than sedentary animals (G1) (0.039 ± 0.005 cm2). G2 and G3, had higher HDL-C, TG, levels, increased CAT activity, lower lipid peroxidation, carbonyl protein and fat percentage. SOD showed higher values only in G3 and GPx only in G2. It Is necessary new researches that investigate the role of high intensity aerobic exercise on atherosclerosis and molecular mechanism of how can exercise reduces lesions area.