Granuloma lepróide canino: epidemiologia, histopatologia e biologia molecular - estudo retrospectivo de 38 casos

• Autor(a) principal: Acha, Lívia Maria Rosa
• Data de Publicação: 2009
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: LOCUS Repositório Institucional da UFV
• Texto Completo: http://locus.ufv.br/handle/123456789/4976
• topic: Cão; Granuloma; Micobacteriose; Dogs; Granuloma; Mycobacterium murphy; CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA

Thirty eight cases of canine leproid granuloma (CLG) were diagnosed between 2000 and 2008. Diagnosis was based on clinical and histopathological findings along with acid fast bacilli in skin sections. The lesions included papules, plaques and nodules, with or without ulceration, localized mainly on the pinna. Boxers, short haired and large breeds dogs were the most affected. The dogs were otherwise healthy, with no recurrence, and the prognosis was good. Histopathological findings included a nodular to diffuse granulomatous or pyogranulomatous and lymphoplasmocytic inflammatory infiltrate, with or without necrosis, localized in the dermis or subcutaneous tissue. The bacillar loading and morphology were variable among lesions. There were not significant correlations between bacterial load and histopathological pattern, main inflammatory infiltration, necrosis or the numbers of giant cells. Correlation between giant cells and histopathological pattern was not observed as well. In the majority of cases, PCR assay identified Mycobacterium murphy as the main etiologic agent for the CLG. However, others Mycobacterium species were also involved as causative agent.