Síntese, caracterização, atividade antifúngica e antibacteriana de complexos de zinco (II) e níquel (II) contendo ligantes ditiocarbimatos e tritiocarbimatos

• Autor(a) principal: Castro, Rodrigo Antunes e
• Data de Publicação: 2013
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: LOCUS Repositório Institucional da UFV
• Texto Completo: http://locus.ufv.br/handle/123456789/2149
• topic: Ditiocarbimatos; Fungicidas; Bactericidas; Dithiocarbimates; Fungicides; Bactericides; CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA::QUIMICA INORGANICA

This work describes the synthesis of 20 tetraphenylphosphonium salts of zinc(II) and nickel(II) complexes containing dithiocarbimate and trithiocarbimate ligands derived from sulfonamides, in which 12 have not yet been described in the literature. These compounds were characterized by electronic, vibrational and nuclear magnetic resonance spectroscopies, hi-resolution mass spectrometry, and elemental analyses of C, H, N, Zn and Ni. The sulfonamides not commercially available were obtained from the reactions between the corresponding sulfonyl chlorides and ammonia. Potassium dithiocarbimates were obtained from the reaction of the sulfonamides with carbon disulfide and potassium hydroxide. The potassium dithiocarbimates reacted with zinc acetate or nickel sulfate and tetraphenylphosphonium chloride yielding complex salts with the formulae (PPh4)2[M(RSO2N=CS2)2] (M = Zn or Ni; R = methyl, ethyl, phenyl, 2-methylphenyl and 4- methylphenyl). The reactions of the zinc complexes with sulfur produced tetraphenylphosphonium salts of zinc trithiocarbimates, (PPh4)2[Zn(RSO2N=CS3)2]. Mixed nickel complexes with dithiocarbimates and trithiocarbimates, (PPh4)2[Ni(RSO2N=CS2)(RSO2N=CS3)], were obtained from the zinc trithiocarbimates in reaction with nickel(II) sulfate. All complexes were active against the fungi Botrytis cinerea, Colletotrichum acutatum, Candida albicans (ATCC 10231) and Candida tropicalis (Squibb 750), and the bacteria Escherichia coli (ATCC 11229) and Staphylococcus aureus (ATCC 25921).